Apoplexy, Pituitary

The sudden loss of blood supply to the PITUITARY GLAND, leading to tissue NECROSIS and loss of function (PANHYPOPITUITARISM). The most common cause is hemorrhage or INFARCTION of a PITUITARY ADENOMA. It can also result from acute hemorrhage into SELLA TURCICA due to HEAD TRAUMA; INTRACRANIAL HYPERTENSION; or other acute effects of central nervous system hemorrhage. Clinical signs include severe HEADACHE; HYPOTENSION; bilateral visual disturbances; UNCONSCIOUSNESS; and COMA.

Synonym
Apoplexy, Pituitary
Pituitary Apoplexy

Excerpt	Reference
"Pituitary apoplexy is a serious complication in about 3% of patients with a pituitary adenoma."	( Pincus, SM; Roelfsema, F; van den Berg, G; van Dulken, H; Veldhuis, JD, 1998)
"Pituitary apoplexy is an acute infarction of pituitary gland, and potentially life-threatening condition that may be highly variable in its clinical presentation."	( Carter, WA; Cho, AS; Lee, CC, 2000)
"Pituitary apoplexy is a sight-threatening syndrome in which a pituitary adenoma undergoes sudden enlargement as a result of haemorrhage, infarction or both."	( Coroneo, MT; Francis, IC; Watson, SL, 2002)
"The symptoms of pituitary apoplexy are typically impressive and are relieved by urgent transsphenoidal decompression."	( Anstadt, MR; Mattke, AF; Vender, JR, 2002)
"Pituitary apoplexy is a rare and underdiagnosed clinical syndrome."	( Floridi, P; Marroni, M; Perriello, G; Santeusanio, F; Stagni, G; Valente, M, 2003)
"In conclusion, pituitary apoplexy is rare in children but should be considered if a patient suffers from headache, vomiting, and visual deficit."	( Chuang, H; Jung, SM; Lo, FS; Van, YH; Yang, MH, 2003)
"Pituitary apoplexy is a rare clinical syndrome caused by sudden haemorrhaging or infarction of the pituitary gland, generally within a pituitary adenoma."	( Chanson, P; Ducreux, D; Lepeintre, JF, 2004)
"Pituitary apoplexy is a potentially life threatening medical emergency."	( Davis, A; Goel, S; Lavis, V; Picolos, M; Wang, M, 2006)
"Pituitary apoplexy is a rare and life-threatening clinical condition caused by hemorrhage and/or infarction of the pituitary gland or adenoma."	( Balarini Lima, GA; Dos Santos Silva, CM; Filho, PN; Gadelha, MR; Machado, Ede O, 2008)
"Pituitary apoplexy is a rare medical emergency which results from hemorrhage or infarction in the pituitary gland."	( Chng, E; Dalan, R, 2013)
"Pituitary apoplexy is a rare event in which the pituitary gland undergoes infarction or haemorrhage, most commonly in the setting of an underlying tumour."	( Watson, V, 2015)
"Pituitary apoplexy is a rare complication of the initial administration of leuprolide acetate."	( Fabiano, AJ; George, S, 2016)
"Pituitary apoplexy is a medical condition that needs urgent diagnosis and treatment."	( Bayraktaroglu, T; Gul, S; Kuzu, F; Unal, M, 2018)
"Pituitary apoplexy is a rare endocrine emergency."	( Mishra, S; Mittal, A; Rajput, R; Yadav, K, 2019)
"EEA for pituitary apoplexy is effective in rapidly improving headache and visual symptoms."	( Bonney, PA; Carmichael, J; Chesney, K; Jason Liu, CS; Memel, Z; Pangal, DJ; Shiroishi, M; Strickland, BA; Zada, G, 2020)

Excerpt	Reference
"The syndrome of pituitary apoplexy has been reported to occur after the administration of several different medications."	( Jamal, S; Morsi, A; Silverberg, JD, 1996)
"Pituitary apoplexy has been reported following cardiac bypass surgery."	( Coroneo, MT; Francis, IC; Watson, SL, 2002)
"Pituitary apoplexy has been reported to occur spontaneously in the majority of cases or in association with various inducing factors."	( Matsuda, H; Matsumi, J; Matsusaki, T; Mizobuchi, S; Morimatsu, H; Morita, K; Sato, K; Sato, T; Yagi, T, 2011)
"Pituitary apoplexy has been reported after leuprolide therapy."	( Babbo, A; Bajramovic, S; Chandler, JP; Garnett, J; Kalapurakal, GT; Kalapurakal, JA; Liu, B, 2014)

Excerpt	Reference
"The syndrome of pituitary apoplexy has been reported to occur after the administration of several different medications."	( Jamal, S; Morsi, A; Silverberg, JD, 1996)
"A case of pituitary apoplexy occurring after Gd-DTPA-administration for contrast enhanced MRI in a patient with an hGH-producing macro-adenoma is presented."	( Klingmüller, D; Kristof, RA; Schramm, J; Springer, W; Wichers, M, 1997)
"A diagnosis of pituitary apoplexy was made and she was treated conservatively with dexamethasone."	( Papanicolaou, DA; Patronas, N; Rotman-Pikielny, P, 2003)
"We report a case of delayed onset pituitary apoplexy following GnRHA therapy."	( Cherukuri, RK; Moses, RG; Nasser, E; Sinnadurai, M, 2010)
"Postoperative DI associated with pituitary apoplexy during pregnancy should be treated by DDAVP, which is not affected by placental vasopressinase secretion."	( Hamada, J; Hayashi, Y; Kita, D; Sano, H; Tachibana, O; Takamura, T, 2012)
"We report a patient with pituitary apoplexy following this therapy as a rare complication and review the related literature."	( Iizuka, H; Koya, D; Nakagawa, A; Sasagawa, Y; Tachibana, O, 2015)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	5 (3.85)	23.3326
1990's	21 (16.15)	12.5806
2000's	41 (31.54)	18.1394
2010's	44 (33.85)	28.8240
2020's	19 (14.62)	9.53

Drug	Relationship Strength	Studies	Trials
pentetic acid	low	2	0
dipyridamole	low	1	0
gentamicin	low	1	0
lidocaine	low	2	0
indomethacin	low	1	0
temozolomide	low	1	0
thyroxine	medium	17	1
prednisone	low	1	0
penicillin g	low	1	0
triiodothyronine	low	1	0
levodopa	low	1	0
cytarabine	low	1	0
methylprednisolone	low	3	0
isosorbide dinitrate	low	2	0
dexamethasone 21-phosphate	low	1	0
cyproterone acetate	low	1	0
gadolinium	low	1	0
isosorbide-5-mononitrate	low	1	0
lisuride	low	2	0
bromocriptine	low	12	0
fludrocortisone	low	1	0
propiconazole	low	2	0
cabergoline	low	12	0
clopidogrel	low	1	0
regadenoson	low	1	0
cortisone	low	3	0
oxytocin	low	1	0
dironyl	low	2	0
leuprolide	low	12	0
enclomiphene	low	1	0
lithium	low	1	0
phenylephrine hydrochloride	low	4	0
deamino arginine vasopressin	low	4	0
goserelin	low	4	0
gadolinium dtpa	low	4	0
ergoline	low	8	0
osi 930	low	1	0
rivaroxaban	low	1	0
pituitrin	low	1	0
atrial natriuretic factor	low	1	0
cardiovascular agents	low	1	0
trelstar	low	3	0
warfarin	low	1	0
dacarbazine	low	1	0
vardenafil dihydrochloride	low	1	0

Protein Targets (913)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	9	0	0	9
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	5	0	0	5
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, HADH2 protein	6	0	0	6
Chain B, HADH2 protein	6	0	0	6
Chain A, 2-oxoglutarate Oxygenase	8	0	0	8
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	3	0	0	3
thioredoxin reductase	10	0	0	10
GLS protein	5	0	0	5
AR protein	18	0	0	18
aldehyde dehydrogenase 1 family, member A1	8	0	0	8
thyroid stimulating hormone receptor	6	0	0	6
hypothetical protein, conserved	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	13	0	0	13
EWS/FLI fusion protein	9	0	0	9
glucocorticoid receptor [Homo sapiens]	16	0	0	16
retinoic acid nuclear receptor alpha variant 1	9	0	0	9
estrogen-related nuclear receptor alpha	14	0	0	14
estrogen nuclear receptor alpha	20	0	0	20
cytochrome P450 2D6	5	0	0	5
glucocerebrosidase	3	0	0	3
peroxisome proliferator-activated receptor delta	9	0	0	9
Rac1 protein	0	0	1	1
IDH1	6	0	0	6
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
euchromatic histone-lysine N-methyltransferase 2	12	0	0	12
Bloom syndrome protein isoform 1	5	0	0	5
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	2	0	0	2
DNA polymerase iota isoform a (long)	6	0	0	6
DNA polymerase kappa isoform 1	6	0	0	6
muscarinic acetylcholine receptor M1	5	0	0	5
lethal factor (plasmid)	2	0	0	2
Prostaglandin-H2 D-isomerase	0	2	0	2
ATP-binding cassette sub-family C member 3	0	11	0	11
Multidrug resistance-associated protein 4	0	11	0	11
Solute carrier family 22 member 6	0	3	0	3
Prostaglandin G/H synthase 1	0	2	0	3
Prostaglandin G/H synthase 2	0	2	0	3
Bile salt export pump	0	15	0	15
Epidermal growth factor receptor	0	4	1	5
Carbonic anhydrase 1	0	3	0	4
Carbonic anhydrase 2	0	3	0	4
Fatty acid-binding protein, liver	0	1	0	1
Integrin beta-3	0	1	0	1
Myeloperoxidase	0	1	0	1
Prostaglandin G/H synthase 1	0	3	0	4
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	0	1	0	1
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	4	0	4
Adenosine receptor A1	0	4	0	5
Adenosine receptor A2a	0	4	0	5
Substance-P receptor	0	2	0	2
Prostaglandin G/H synthase 2	0	4	1	5
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	4	0	0	4
Ras-related protein Rab-2A	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	4	1	1	6
Prostaglandin G/H synthase 2	0	3	0	3
Rho-associated protein kinase 2	0	2	0	2
Nicotinate phosphoribosyltransferase	0	2	0	2
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	11	0	11
Sigma non-opioid intracellular receptor 1	0	4	1	5
Sigma non-opioid intracellular receptor 1	0	0	1	1
Atrial natriuretic peptide receptor 1	0	0	1	1
Atrial natriuretic peptide receptor 1	0	0	1	1
Chain A, Diaminopimelate decarboxylase	0	1	0	1
Chain B, Diaminopimelate decarboxylase	0	1	0	1
Chain A, Ferritin light chain	3	0	0	3
phosphopantetheinyl transferase	5	0	0	5
RAR-related orphan receptor gamma	13	0	0	13
NFKB1 protein, partial	2	0	0	2
GLI family zinc finger 3	10	0	0	10
estrogen receptor 2 (ER beta)	7	0	0	7
bromodomain adjacent to zinc finger domain 2B	5	0	0	5
arylsulfatase A	3	0	0	3
peripheral myelin protein 22 isoform 1	5	0	0	5
geminin	14	0	0	14
muscleblind-like protein 1 isoform 1	5	0	0	5
lamin isoform A-delta10	11	0	0	11
TAR DNA-binding protein 43	4	0	0	4
ATP-dependent phosphofructokinase	6	0	0	6
Genome polyprotein	0	1	1	2
dopamine D1 receptor	3	0	0	3
ATAD5 protein, partial	3	0	0	3
Fumarate hydratase	2	0	0	2
TDP1 protein	16	0	0	16
regulator of G-protein signaling 4	3	0	0	3
pregnane X nuclear receptor	12	0	0	12
G	8	0	0	8
polyprotein	2	0	0	2
peroxisome proliferator activated receptor gamma	11	0	0	11
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	8	0	0	8
D(1A) dopamine receptor	3	0	0	3
vitamin D3 receptor isoform VDRA	5	0	0	5
chromobox protein homolog 1	9	0	0	9
thyroid hormone receptor beta isoform 2	13	0	0	13
serine/threonine-protein kinase mTOR isoform 1	3	0	0	3
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	7	0	0	7
5-hydroxytryptamine receptor 4	0	6	0	6
Interferon beta	10	0	0	10
HLA class I histocompatibility antigen, B alpha chain	8	0	0	8
Cellular tumor antigen p53	13	0	0	13
ATP-dependent translocase ABCB1	0	1	0	1
ATP-dependent translocase ABCB1	0	3	0	3
Beta-1 adrenergic receptor	0	4	0	4
Cytochrome P450 3A4	0	4	0	4
5-hydroxytryptamine receptor 1A	0	3	1	4
Alpha-2A adrenergic receptor	0	6	0	6
D(2) dopamine receptor	0	4	2	6
Androgen receptor	0	6	0	6
Alpha-2B adrenergic receptor	0	6	0	6
Alpha-2C adrenergic receptor	0	6	0	6
D	0	3	0	3
D(3) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 1A	0	6	0	6
Alpha-2B adrenergic receptor	0	2	0	2
ATP-dependent translocase ABCB1	0	1	0	1
D(1A) dopamine receptor	0	4	0	4
Alpha-2C adrenergic receptor	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	4	0	4
D(1B) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 2A	0	6	2	8
5-hydroxytryptamine receptor 2C	0	6	2	8
5-hydroxytryptamine receptor 1B	0	5	0	5
D(4) dopamine receptor	0	1	0	1
D(3) dopamine receptor	0	6	0	6
Alpha-synuclein	1	1	0	2
5-hydroxytryptamine receptor 2B	0	7	1	8
5-hydroxytryptamine receptor 6	0	6	0	6
D(2) dopamine receptor	0	3	2	5
Inositol hexakisphosphate kinase 1	8	0	0	8
ATPase family AAA domain-containing protein 5	6	0	0	6
Ataxin-2	7	0	0	7
cytochrome P450 2C9, partial	8	0	0	8
acetylcholinesterase	3	0	0	3
thyroid stimulating hormone receptor	5	0	0	5
Spike glycoprotein	7	0	0	7
Histamine H3 receptor	0	1	0	1
nonstructural protein 1	5	0	0	5
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	4	0	0	4
Cytochrome P450 2C8	0	1	0	1
Cytochrome P450 2B6	0	1	0	1
Liver carboxylesterase 1	0	0	0	2
Sodium-dependent serotonin transporter	0	6	0	6
Cytochrome P450 2C19	0	1	0	1
Rap guanine nucleotide exchange factor 4	2	0	0	2
P2Y purinoceptor 12	0	1	0	1
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	0	2	0	2
Amyloid-beta precursor protein	0	1	0	1
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	0	1
5-hydroxytryptamine receptor 2C	0	2	0	2
Tryptophan 5-hydroxylase 1	0	1	0	1
5-hydroxytryptamine receptor 2A	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
Sodium-dependent noradrenaline transporter	0	4	0	4
Sodium-dependent dopamine transporter	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	2	0	2
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 1F	0	1	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
5-hydroxytryptamine receptor 6	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	3
5-hydroxytryptamine receptor 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	2
5-hydroxytryptamine receptor 3A	0	1	0	1
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit epsilon	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	1	0	2
Glutamate receptor ionotropic, NMDA 2B	0	1	0	2
Glutamate receptor ionotropic, NMDA 2C	0	1	0	2
Sodium-dependent dopamine transporter	0	4	0	4
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
Potassium voltage-gated channel subfamily H member 2	0	4	0	4
Leukotriene B4 receptor 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	0	2
Sodium-dependent dopamine transporter	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	1	0	2
5-hydroxytryptamine receptor 4	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	1	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	0	2
5-hydroxytryptamine receptor 3B	0	1	0	1
Leukotriene B4 receptor 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	2
Gamma-aminobutyric acid receptor subunit theta	0	2	0	2
Transporter	0	2	0	2
endonuclease IV	3	0	0	3
pregnane X receptor	4	0	0	4
progesterone receptor	10	0	0	10
retinoid X nuclear receptor alpha	6	0	0	6
vitamin D (1,25- dihydroxyvitamin D3) receptor	8	0	0	8
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	5	0	0	5
v-jun sarcoma virus 17 oncogene homolog (avian)	5	0	0	5
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
heat shock protein beta-1	4	0	0	4
flap endonuclease 1	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 1	10	0	0	10
survival motor neuron protein isoform d	3	0	0	3
cytochrome P450 3A4 isoform 1	4	0	0	4
M-phase phosphoprotein 8	4	0	0	4
Gamma-aminobutyric acid receptor subunit pi	4	0	1	5
Glucocorticoid receptor	0	8	1	9
Sex hormone-binding globulin	0	0	1	1
Glycine receptor subunit alpha-1	0	8	0	8
Corticosteroid-binding globulin	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	4	0	1	5
Gamma-aminobutyric acid receptor subunit delta	4	0	1	5
Gamma-aminobutyric acid receptor subunit gamma-2	4	0	1	5
Gamma-aminobutyric acid receptor subunit alpha-5	4	0	1	5
Gamma-aminobutyric acid receptor subunit alpha-3	4	0	1	5
Glycine receptor subunit beta	0	8	0	8
Glycine receptor subunit alpha-2	0	8	0	8
Gamma-aminobutyric acid receptor subunit gamma-1	4	0	1	5
Gamma-aminobutyric acid receptor subunit alpha-2	4	0	1	5
Glycine receptor subunit alpha-3	0	8	0	8
Gamma-aminobutyric acid receptor subunit alpha-4	4	0	1	5
Gamma-aminobutyric acid receptor subunit gamma-3	4	0	1	5
Gamma-aminobutyric acid receptor subunit alpha-6	4	0	1	5
Gamma-aminobutyric acid receptor subunit beta-3	4	0	1	5
Gamma-aminobutyric acid receptor subunit beta-2	4	0	1	5
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
GABA theta subunit	4	0	1	5
Multidrug and toxin extrusion protein 1	0	4	0	4
Gamma-aminobutyric acid receptor subunit epsilon	4	0	1	5
Chain A, Beta-lactamase	7	0	0	7
Chain A, Cruzipain	2	0	0	2
SMAD family member 2	4	0	0	4
USP1 protein, partial	6	0	0	6
SMAD family member 3	4	0	0	4
Smad3	3	0	0	3
nuclear receptor subfamily 1, group I, member 3	6	0	0	6
farnesoid X nuclear receptor	5	0	0	5
67.9K protein	4	0	0	4
aryl hydrocarbon receptor	7	0	0	7
activating transcription factor 6	3	0	0	3
nuclear receptor subfamily 1, group I, member 2	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 2	5	0	0	6
nuclear receptor ROR-gamma isoform 1	6	0	0	6
peripheral myelin protein 22	7	0	0	7
Progesterone receptor	0	1	0	1
Androgen receptor	0	3	1	4
Adenosine receptor A2b	0	1	0	1
Mu-type opioid receptor	0	2	0	2
ORF73	0	0	1	1
glp-1 receptor, partial	5	0	0	5
LMP1 [Human herpesvirus 4]	0	0	0	2
Histone H2A.x	2	0	0	2
thyroid hormone receptor beta isoform a	7	0	0	7
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Thymidine kinase 2, mitochondrial	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	4	0	0	4
Thymidine kinase, cytosolic	0	1	0	1
Thymidine kinase	0	1	0	1
Thymidylate synthase	0	0	0	1
Thymidine kinase	0	1	0	1
Glutamate receptor 2	4	0	0	4
Deoxycytidine kinase	0	0	1	2
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	1	0	2
D(1A) dopamine receptor	1	0	0	1
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Thymidine kinase	0	1	0	1
Deoxynucleoside kinase	0	1	0	1
hypoxia-inducible factor 1 alpha subunit	4	0	0	4
Matrix metalloproteinase-9	0	1	0	1
Inositol monophosphatase 1	2	0	0	2
Isocitrate lyase	0	1	0	1
Vasopressin V2 receptor	0	2	2	4
Oxytocin receptor	0	2	3	5
Vasopressin V1a receptor	0	3	2	5
Vasopressin V1b receptor	0	2	2	4
Translocator protein	0	1	0	1
Vasopressin V2 receptor	0	2	1	3
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
acid sphingomyelinase	1	0	0	1
RGS12	1	0	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
Microtubule-associated protein tau	3	0	0	3
Thrombopoietin	1	0	0	1
DNA polymerase III, partial	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	6	0	0	6
isocitrate dehydrogenase 1, partial	1	0	0	1
LANA	0	0	0	1
NPYLR7B	0	0	1	1
thyrotropin-releasing hormone receptor	1	0	0	1
serine-protein kinase ATM isoform a	1	0	0	1
cytochrome P450 2D6 isoform 1	2	0	0	2
lysosomal alpha-glucosidase preproprotein	2	0	0	2
cytochrome P450 2C19 precursor	2	0	0	2
cytochrome P450 2C9 precursor	2	0	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	1	0	0	1
importin subunit beta-1 isoform 1	3	0	0	3
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
serine/threonine-protein kinase PLK1	2	0	0	2
eyes absent homolog 2 isoform a	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	2
snurportin-1	3	0	0	3
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
tumor susceptibility gene 101 protein	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
histone acetyltransferase KAT2A isoform 1	1	0	0	1
caspase-1 isoform alpha precursor	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
kelch-like ECH-associated protein 1	0	0	0	2
neuropeptide S receptor isoform A	3	0	0	3
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Solute carrier family 22 member 1	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	0	0	3
Multidrug resistance-associated protein 5	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	2	0	2
Rap guanine nucleotide exchange factor 3	2	0	0	2
Neuronal acetylcholine receptor subunit alpha-4	2	1	0	3
Neuronal acetylcholine receptor subunit beta-2	2	1	0	3
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	0	1	0	1
Histamine H2 receptor	4	0	0	4
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Caspase-7	1	0	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	1	0	1
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
Exopolyphosphatase PRUNE1	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Equilibrative nucleoside transporter 1	0	2	0	2
Single-stranded DNA cytosine deaminase	1	0	0	1
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 7B	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
Phosphodiesterase	0	1	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	3	0	0	3
apical membrane antigen 1, AMA1	4	0	0	4
mu-type opioid receptor isoform MOR-1	0	0	2	2
Vpr	2	0	0	2
D(3) dopamine receptor isoform e	1	0	0	1
5-hydroxytryptamine receptor 2A	0	0	2	2
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
protein AF-9 isoform a	0	0	0	1
Estrogen receptor	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Tyrosine-protein kinase Fyn	0	2	1	3
Aldo-keto reductase family 1 member B1	0	2	0	2
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Adenosine receptor A3	0	3	0	3
Cytochrome P450 2D6	0	2	0	2
Muscarinic acetylcholine receptor M1	0	2	0	2
Beta-3 adrenergic receptor	0	2	0	2
Alpha-1B adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
Substance-K receptor	0	2	0	2
C-8 sterol isomerase	0	1	0	1
Alpha-1A adrenergic receptor	0	2	0	2
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
GALC protein	3	0	0	3
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	3	0	0	3
Luciferase	2	0	0	2
Parkin	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
ras-related protein Rab-9A	1	0	0	1
Prostaglandin E synthase	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Cytochrome c oxidase subunit 2	0	1	0	1
Phospholipase A2, major isoenzyme	0	1	0	1
Albumin	0	1	2	3
Procathepsin L	0	1	0	1
Interleukin-8	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	2
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member C4	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Thromboxane-A synthase	0	1	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Caspase-1	0	0	0	1
Nitric oxide synthase, inducible	0	1	0	1
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Bifunctional epoxide hydrolase 2	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	5	5
Aldo-keto reductase family 1 member C3	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
C-X-C chemokine receptor type 3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Guanine nucleotide-binding protein G	3	0	0	3
Prostaglandin D2 receptor	0	2	0	2
Solute carrier organic anion transporter family member 1A3	0	1	0	3
Lactoylglutathione lyase	0	1	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Sigma intracellular receptor 2	0	1	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Solute carrier family 22 member 8	0	2	0	2
Dehydrogenase/reductase SDR family member 9	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	3
Cytosolic phospholipase A2 gamma	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
Solute carrier organic anion transporter family member 1B1	0	2	0	4
Gonadotropin-releasing hormone receptor	0	1	0	1
Gonadotropin-releasing hormone receptor	0	2	0	2
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
15-lipoxygenase, partial	2	0	0	2
WRN	1	0	0	1
integrase, partial	0	1	0	1
lens epithelium-derived growth factor p75	0	1	0	1
pyruvate kinase	1	0	0	1
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
DNA polymerase eta isoform 1	2	0	0	2
Polyphenol oxidase 2	0	0	0	1
Carbonic anhydrase 12	0	1	0	2
Plasma kallikrein	0	0	0	1
Tyrosine-protein kinase Lck	0	2	1	3
Carbonic anhydrase 3	0	0	0	1
Tyrosinase	0	1	0	1
Carbonic anhydrase 4	0	0	0	1
Carbonic anhydrase 6	0	0	0	1
Carbonic anhydrase 5A, mitochondrial	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase 7	0	0	0	1
Solute carrier family 15 member 1	0	2	0	2
Carbonic anhydrase	0	0	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
SLC16A10 protein	0	0	0	1
Carbonic anhydrase 9	0	1	0	2
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Monocarboxylate transporter 10	0	0	0	1
Carbonic anhydrase 15	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Carbonic anhydrase 14	0	0	0	1
Carbonic anhydrase 5B, mitochondrial	0	0	0	1
phosphoglycerate kinase	1	0	0	1
mitogen-activated protein kinase 1	1	0	0	1
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	2	0	2
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Beta-2 adrenergic receptor	0	2	0	2
D(4) dopamine receptor	0	0	1	1
Histamine H2 receptor	0	2	0	2
Histamine H1 receptor	0	2	0	2
PPM1D protein	2	0	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
tyrosine-protein kinase Yes	1	0	0	1
Bone morphogenetic protein receptor type-1B	0	0	1	1
Membrane-associated progesterone receptor component 1	0	0	1	1
Cell division cycle 7-related protein kinase	0	0	1	1
Serine/threonine-protein kinase PLK4	0	0	1	1
ATP-dependent RNA helicase DDX3X	0	0	1	1
Pyridoxal kinase	0	0	1	1
Citron Rho-interacting kinase	0	0	1	1
Serine/threonine-protein kinase Chk1	0	0	1	1
Aurora kinase A	0	0	1	1
Cyclin-G-associated kinase	0	0	1	1
Ephrin type-B receptor 6	0	0	1	1
Peroxisomal acyl-coenzyme A oxidase 3	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 2	0	0	1	1
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	1	1
Dynamin-like 120 kDa protein, mitochondrial	0	0	1	1
Eukaryotic translation initiation factor 5B	0	0	1	1
Rho-associated protein kinase 2	0	0	1	1
Serine/threonine-protein kinase ULK1	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	1	1
Ribosomal protein S6 kinase alpha-5	0	0	1	1
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	1	1
Ribosomal protein S6 kinase alpha-4	0	0	1	1
Serine/threonine-protein kinase 16	0	0	1	1
Cyclin-dependent kinase-like 5	0	0	1	1
Serine/threonine-protein kinase 10	0	0	1	1
Serine/threonine-protein kinase D3	0	0	1	1
Structural maintenance of chromosomes protein 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase 6	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	1	1
Serine/threonine-protein kinase LATS1	0	0	1	1
Serine/threonine-protein kinase PAK 4	0	0	1	1
Tyrosine-protein kinase ABL1	0	1	1	2
RAF proto-oncogene serine/threonine-protein kinase	0	1	0	1
High affinity nerve growth factor receptor	0	0	1	1
Guanine nucleotide-binding protein G(i) subunit alpha-2	0	0	1	1
ADP/ATP translocase 2	0	0	1	1
Protein kinase C beta type	0	0	1	1
Insulin receptor	0	0	1	1
Cyclin-dependent kinase 1	0	0	1	1
Glycogen phosphorylase, liver form	0	0	1	1
Tyrosine-protein kinase Fes/Fps	0	0	1	1
Adenine phosphoribosyltransferase	0	0	1	1
Tyrosine-protein kinase Yes	0	0	1	1
Tyrosine-protein kinase Lyn	0	0	1	1
Proto-oncogene tyrosine-protein kinase receptor Ret	0	0	1	1
Insulin-like growth factor 1 receptor	0	0	1	1
Signal recognition particle receptor subunit alpha	0	0	1	1
Cytochrome c1, heme protein, mitochondrial	0	0	1	1
Hepatocyte growth factor receptor	0	0	1	1
Tyrosine-protein kinase HCK	0	0	1	1
Platelet-derived growth factor receptor beta	0	0	1	1
Tyrosine-protein kinase Fgr	0	0	1	1
Serine/threonine-protein kinase A-Raf	0	0	1	1
Mast/stem cell growth factor receptor Kit	0	1	0	1
Glycogen phosphorylase, brain form	0	0	1	1
Breakpoint cluster region protein	0	0	1	1
Serine/threonine-protein kinase pim-1	0	0	1	1
Fibroblast growth factor receptor 1	0	0	1	1
DNA topoisomerase 2-alpha	0	0	1	1
Cyclin-dependent kinase 4	0	0	1	1
ADP/ATP translocase 3	0	0	1	1
Inosine-5'-monophosphate dehydrogenase 2	0	0	1	1
Proto-oncogene tyrosine-protein kinase Src	0	0	1	1
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	1	1
Serine/threonine-protein kinase B-raf	0	0	1	1
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	1	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	0	1	1
Tyrosine-protein kinase Fer	0	0	1	1
Protein kinase C alpha type	0	0	1	1
cAMP-dependent protein kinase catalytic subunit alpha	0	0	1	1
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	1	1
Casein kinase II subunit alpha'	0	0	1	1
Ras-related protein Rab-6A	0	0	1	1
Ephrin type-A receptor 1	0	0	1	1
Multifunctional protein ADE2	0	0	1	1
cAMP-dependent protein kinase catalytic subunit beta	0	0	1	1
Ferrochelatase, mitochondrial	0	0	1	1
Ribosomal protein S6 kinase beta-1	0	0	1	1
Tyrosine-protein kinase JAK1	0	0	1	1
Cyclin-dependent kinase 2	0	0	1	1
Beta-adrenergic receptor kinase 1	0	0	1	1
Probable ATP-dependent RNA helicase DDX6	0	0	1	1
Mitogen-activated protein kinase 3	0	0	1	1
MAP/microtubule affinity-regulating kinase 3	0	0	1	1
Mitogen-activated protein kinase 1	0	0	1	1
Ephrin type-A receptor 2	0	0	1	1
Ephrin type-B receptor 2	0	0	1	1
Non-receptor tyrosine-protein kinase TYK2	0	0	1	1
Wee1-like protein kinase	0	0	1	1
Heme oxygenase 2	0	0	1	1
S-adenosylmethionine synthase isoform type-2	0	0	1	1
DnaJ homolog subfamily A member 1	0	0	1	1
RAC-alpha serine/threonine-protein kinase	0	0	1	1
RAC-beta serine/threonine-protein kinase	0	0	1	1
Dual specificity protein kinase TTK	0	0	1	1
DNA replication licensing factor MCM4	0	0	1	1
Myosin-10	0	0	1	1
Vascular endothelial growth factor receptor 2	0	1	0	1
Dual specificity mitogen-activated protein kinase kinase 2	0	0	1	1
Receptor-type tyrosine-protein kinase FLT3	0	0	1	1
Bone morphogenetic protein receptor type-1A	0	0	1	1
Activin receptor type-1B	0	0	1	1
TGF-beta receptor type-1	0	0	1	1
TGF-beta receptor type-2	0	0	1	1
Tyrosine-protein kinase CSK	0	0	1	1
Glycine--tRNA ligase	0	0	1	1
Protein kinase C iota type	0	0	1	1
Exosome RNA helicase MTR4	0	0	1	1
Tyrosine-protein kinase Tec	0	0	1	1
Tyrosine-protein kinase ABL2	0	1	1	2
Tyrosine-protein kinase FRK	0	0	1	1
G protein-coupled receptor kinase 6	0	0	1	1
Tyrosine-protein kinase SYK	0	0	1	1
26S proteasome regulatory subunit 6B	0	0	1	1
Mitogen-activated protein kinase 8	0	0	1	1
Mitogen-activated protein kinase 9	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 3	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	1	1
Casein kinase I isoform alpha	0	0	1	1
Casein kinase I isoform delta	0	0	1	1
MAP kinase-activated protein kinase 2	0	0	1	1
Elongation factor Tu, mitochondrial	0	0	1	1
Choline-phosphate cytidylyltransferase A	0	0	1	1
Cysteine--tRNA ligase, cytoplasmic	0	0	1	1
Casein kinase I isoform epsilon	0	0	1	1
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	1	1
Dual specificity protein kinase CLK1	0	0	1	1
Dual specificity protein kinase CLK2	0	0	1	1
Dual specificity protein kinase CLK3	0	0	1	1
Glycogen synthase kinase-3 alpha	0	0	1	1
Glycogen synthase kinase-3 beta	0	0	1	1
Cyclin-dependent kinase 7	0	0	1	1
Cyclin-dependent kinase 9	0	0	1	1
Ras-related protein Rab-27A	0	0	1	1
Interleukin-1 receptor-associated kinase 1	0	0	1	1
Ribosomal protein S6 kinase alpha-3	0	0	1	1
Serine/threonine-protein kinase Nek2	0	0	1	1
Serine/threonine-protein kinase Nek3	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 6	0	0	1	1
Serine/threonine-protein kinase PLK1	0	0	1	1
LIM domain kinase 1	0	0	1	1
LIM domain kinase 2	0	0	1	1
Mitogen-activated protein kinase 10	0	0	1	1
Tyrosine--tRNA ligase, cytoplasmic	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	1	1
Ephrin type-B receptor 3	0	0	1	1
Ephrin type-A receptor 5	0	0	1	1
Ephrin type-B receptor 4	0	0	1	1
Ephrin type-A receptor 4	0	0	1	1
Adenylate kinase 2, mitochondrial	0	0	1	1
Adenosine kinase	0	0	1	1
Ras-related protein Rab-10	0	0	1	1
Actin-related protein 3	0	0	1	1
Actin-related protein 2	0	0	1	1
GTP-binding nuclear protein Ran	0	0	1	1
Casein kinase I isoform gamma-2	0	0	1	1
Cyclin-dependent kinase 3	0	0	1	1
Cyclin-dependent kinase 6	0	0	1	1
Cyclin-dependent-like kinase 5	0	0	1	1
Cyclin-dependent kinase 16	0	0	1	1
Cyclin-dependent kinase 17	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 1	0	0	1	1
DNA topoisomerase 2-beta	0	0	1	1
Protein kinase C theta type	0	0	1	1
Activin receptor type-1	0	0	1	1
Macrophage-stimulating protein receptor	0	0	1	1
Focal adhesion kinase 1	0	0	1	1
Protein kinase C zeta type	0	0	1	1
Protein kinase C delta type	0	0	1	1
Tyrosine-protein kinase BTK	0	0	1	1
Cyclin-dependent kinase 18	0	0	1	1
Activated CDC42 kinase 1	0	0	1	1
Epithelial discoidin domain-containing receptor 1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	1	1
Tyrosine-protein kinase Mer	0	0	1	1
Serine/threonine-protein kinase 4	0	0	1	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 5	0	0	1	1
Mitogen-activated protein kinase 7	0	0	1	1
Serine/threonine-protein kinase 3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 1	0	0	1	1
Integrin-linked protein kinase	0	0	1	1
Rho-associated protein kinase 1	0	0	1	1
Non-receptor tyrosine-protein kinase TNK1	0	0	1	1
Serine/threonine-protein kinase ATR	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	1	1
Activin receptor type-2B	0	0	1	1
Bone morphogenetic protein receptor type-2	0	0	1	1
Protein-tyrosine kinase 6	0	0	1	1
cGMP-dependent protein kinase 1	0	0	1	1
Cyclin-dependent kinase 13	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	1	1
Protein-tyrosine kinase 2-beta	0	0	1	1
Maternal embryonic leucine zipper kinase	0	0	1	1
Structural maintenance of chromosomes protein 1A	0	0	1	1
Chromodomain-helicase-DNA-binding protein 4	0	0	1	1
Peroxisomal acyl-coenzyme A oxidase 1	0	0	1	1
Cyclin-dependent kinase 10	0	0	1	1
Ephrin type-A receptor 7	0	0	1	1
Delta(24)-sterol reductase	0	0	1	1
Ribosomal protein S6 kinase alpha-1	0	0	1	1
Dual specificity testis-specific protein kinase 1	0	0	1	1
Myosin light chain kinase, smooth muscle	0	0	1	1
Mitogen-activated protein kinase 11	0	0	1	1
Serine/threonine-protein kinase STK11	0	0	1	1
Serine/threonine-protein kinase N1	0	0	1	1
Serine/threonine-protein kinase N2	0	0	1	1
Mitogen-activated protein kinase 14	0	0	1	1
Calcium/calmodulin-dependent protein kinase type IV	0	0	1	1
Mitogen-activated protein kinase kinase kinase 11	0	0	1	1
Discoidin domain-containing receptor 2	0	0	1	1
AP2-associated protein kinase 1	0	0	1	1
Myosin light chain kinase 3	0	0	1	1
Uncharacterized aarF domain-containing protein kinase 5	0	0	1	1
Putative heat shock protein HSP 90-beta 2	0	0	1	1
Serine/threonine-protein kinase MRCK alpha	0	0	1	1
Serine/threonine-protein kinase MRCK gamma	0	0	1	1
Acyl-CoA dehydrogenase family member 10	0	0	1	1
Serine/threonine-protein kinase N3	0	0	1	1
Serine/threonine-protein kinase ULK3	0	0	1	1
Uncharacterized protein FLJ45252	0	0	1	1
Acyl-CoA dehydrogenase family member 11	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	1	1
Serine/threonine-protein kinase MARK2	0	0	1	1
ATP-dependent RNA helicase DHX30	0	0	1	1
Serine/threonine-protein kinase TAO1	0	0	1	1
STE20-related kinase adapter protein alpha	0	0	1	1
Myosin-14	0	0	1	1
AarF domain-containing protein kinase 1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	1	1
MAP kinase-activated protein kinase 5	0	0	1	1
Misshapen-like kinase 1	0	0	1	1
Atypical kinase COQ8A, mitochondrial	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	1	1
Mitogen-activated protein kinase 15	0	0	1	1
Serine/threonine-protein kinase Nek9	0	0	1	1
ATP-dependent RNA helicase DDX1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	1	1
Aurora kinase B	0	0	1	1
MAP/microtubule affinity-regulating kinase 4	0	0	1	1
Serine/threonine-protein kinase Nek1	0	0	1	1
PAS domain-containing serine/threonine-protein kinase	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	1	1
EKC/KEOPS complex subunit TP53RK	0	0	1	1
Dual specificity testis-specific protein kinase 2	0	0	1	1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 5	0	0	1	1
Mitogen-activated protein kinase kinase kinase 3	0	0	1	1
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	1	1
Nucleolar GTP-binding protein 1	0	0	1	1
Serine/threonine-protein kinase D2	0	0	1	1
NUAK family SNF1-like kinase 2	0	0	1	1
RNA cytidine acetyltransferase	0	0	1	1
Serine/threonine-protein kinase SIK2	0	0	1	1
STE20-like serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase TAO3	0	0	1	1
dCTP pyrophosphatase 1	0	0	1	1
Dual specificity protein kinase CLK4	0	0	1	1
Casein kinase I isoform gamma-1	0	0	1	1
Serine/threonine-protein kinase PAK 6	0	0	1	1
Phenylalanine--tRNA ligase beta subunit	0	0	1	1
Isoleucine--tRNA ligase, mitochondrial	0	0	1	1
BMP-2-inducible protein kinase	0	0	1	1
Midasin	0	0	1	1
Interleukin-1 receptor-associated kinase 4	0	0	1	1
Mitogen-activated protein kinase kinase kinase 20	0	0	1	1
Cyclin-dependent kinase 12	0	0	1	1
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	0	0	1	1
Serine/threonine-protein kinase pim-2	0	0	1	1
Serine/threonine-protein kinase 26	0	0	1	1
Serine/threonine-protein kinase NLK	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	1	1
Serine/threonine-protein kinase TBK1	0	0	1	1
Septin-9	0	0	1	1
Ribosomal protein S6 kinase alpha-6	0	0	1	1
TRAF2 and NCK-interacting protein kinase	0	0	1	1
Serine/threonine-protein kinase TAO2	0	0	1	1
Long-chain-fatty-acid--CoA ligase 5	0	0	1	1
Serine/threonine-protein kinase ICK	0	0	1	1
RAC-gamma serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase SIK3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 2	0	0	1	1
Thyroid hormone receptor-associated protein 3	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 3	0	0	1	1
Serine/threonine-protein kinase MRCK beta	0	0	1	1
Interleukin-1 receptor-associated kinase 3	0	0	1	1
Casein kinase I isoform gamma-3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 4	0	0	1	1
Vasopressin V1a receptor	0	1	0	1
Vasopressin V1b receptor	0	1	0	1
Oxytocin receptor	0	1	0	1
Oxytocin receptor	0	0	1	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Metallo-beta-lactamase VIM-11	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
streptokinase A precursor	0	0	1	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	1	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase 1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase OXA-10	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Kappa-type opioid receptor	0	0	0	1
Beta-lactamase TEM	0	1	0	2
Beta-lactamase	0	0	0	1
B2 metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Metallo-beta-lactamase VIM-13	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Efflux transporter	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase Toho-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-b-lactamase	0	0	0	1
Beta-lactamase IMP-1	0	0	0	1
BlaVIM-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Beta-lactamase class B VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	1	0	2
Beta-lactamase VIM-1	0	0	0	1
beta-2 adrenergic receptor	1	0	0	1
thioredoxin glutathione reductase	1	0	0	1
heat shock protein 90, putative	0	0	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A2b	0	0	1	1
Adenosine receptor A1	0	3	0	3
Chain A, Activated Factor Xa Heavy Chain	0	1	0	1
Prothrombin	0	1	1	2
Coagulation factor X	0	2	0	2
Coagulation factor XII	0	1	0	1
Suppressor of tumorigenicity 14 protein	0	1	0	1
polyadenylate-binding protein 1	0	1	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Solute carrier organic anion transporter family member 1A4	0	1	0	3
Solute carrier organic anion transporter family member 1A5	0	0	0	2
Transthyretin	0	1	0	3
Thyroid hormone receptor alpha	0	2	3	5
Thyroid hormone receptor beta	0	2	3	5
Proliferating cell nuclear antigen	0	2	0	2
Retinoic acid receptor RXR-alpha	0	0	2	2
UDP-glucuronosyltransferase 1A1	0	1	0	1
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	2
Solute carrier organic anion transporter family member 4C1	0	1	0	2
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Thyroid hormone receptor beta	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	0	1	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Solute carrier organic anion transporter family member 1C1	0	1	0	1
Albumin	0	0	1	1
Cytochrome P450 2C9	0	1	0	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Protease	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(2)

Research Excerpts

Overview

Context

Treatment

Research

Studies (130)

Protein Targets (913)

Apoplexy, Pituitary

Synonyms(2)

Research Excerpts

Overview

Context

Treatment

Research

Studies (130)

Drugs Studied (52)

Protein Targets (913)