Medically Unexplained Symptoms

Persistent health symptoms which remain unexplained after a complete medical evaluation. A cluster of symptoms that consistently appear together but without a known cause are referred to as a MEDICALLY UNEXPLAINED SYNDROME (MUS).

Synonym
Medically Unexplained Symptoms
Somatic Symptoms

Excerpt	Reference
"Heightened somatic symptoms are reported by a wide range of patients with chronic pain and have been associated with emotional distress and physical dysfunction."	( Belfer, I; Cole, T; Diatchenko, L; Fillingim, RB; Greenspan, JD; Khoury, S; Maixner, W; Neely, GG; Ohrbach, R; Piltonen, MH; Samoshkin, A; Serohijos, AWR; Slade, GD; Smith, SB; Ton, AT, 2019)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	0 (0.00)	18.1394
2010's	19 (44.19)	28.8240
2020's	24 (55.81)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	low	2	0
glycine	low	1	0
3,4-methylenedioxyamphetamine	low	1	0
mianserin	low	1	0
mirtazapine	low	1	0
apnea	low	1	0
risperidone	low	1	0
thyroxine	low	1	0
penicillin g	low	1	0
triiodothyronine	low	1	0
glutamine	low	1	0
tryptophan	low	1	0
diphenhydramine hydrochloride	low	1	0
malondialdehyde	low	1	0
s,n,n'-tripropylthiocarbamate	low	2	0
cetylpyridinium chloride anhydrous	low	1	0
4-methoxyamphetamine	low	1	0
glutamic acid	low	1	0
paroxetine	medium	1	1
itraconazole	low	1	0
venlafaxine hydrochloride	low	1	0
sertraline	low	1	0
nicotine	low	2	0
fibrinogen	low	1	0
cortisone	low	1	0
oxytocin	low	1	0
eicosapentaenoic acid	medium	1	1
cotinine	low	1	0
humulene	low	1	0
naloxone	low	1	0
morphine	low	1	0
pregabalin	low	1	0
n-oleoylglycine	low	1	0
quetiapine fumarate	low	1	0
rome	low	2	0
olanzapine	low	1	0
ego	low	1	0

Protein Targets (696)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
5-hydroxytryptamine receptor 2C	0	10	2	12
5-hydroxytryptamine receptor 2A	0	10	2	12
5-hydroxytryptamine receptor 1A	0	7	2	9
Sodium-dependent noradrenaline transporter	0	12	2	14
Sodium-dependent dopamine transporter	0	5	1	6
5-hydroxytryptamine receptor 1B	0	5	2	7
5-hydroxytryptamine receptor 1D	0	3	2	5
5-hydroxytryptamine receptor 1F	0	3	2	5
5-hydroxytryptamine receptor 2B	0	8	2	10
5-hydroxytryptamine receptor 6	0	1	2	3
Sodium-dependent serotonin transporter	0	13	4	17
Sodium-dependent serotonin transporter	0	8	2	10
5-hydroxytryptamine receptor 7	0	4	2	6
5-hydroxytryptamine receptor 5A	0	1	2	3
5-hydroxytryptamine receptor 5B	0	1	2	3
5-hydroxytryptamine receptor 3A	0	2	2	4
Sodium-dependent dopamine transporter	0	7	2	9
5-hydroxytryptamine receptor 4	0	1	2	3
5-hydroxytryptamine receptor 3B	0	2	2	4
thioredoxin reductase	10	0	0	10
ATAD5 protein, partial	6	0	0	6
TDP1 protein	16	0	0	16
Microtubule-associated protein tau	5	0	0	5
estrogen-related nuclear receptor alpha	12	0	0	12
arylsulfatase A	6	0	0	6
euchromatic histone-lysine N-methyltransferase 2	14	0	0	14
Bloom syndrome protein isoform 1	4	0	0	4
D(1A) dopamine receptor	6	0	0	6
lamin isoform A-delta10	8	0	0	8
neuropeptide S receptor isoform A	4	0	0	4
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	2	0	0	2
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
5-hydroxytryptamine receptor 3E	0	4	0	4
acetylcholinesterase	4	0	0	4
hypoxia-inducible factor 1 alpha subunit	5	0	0	5
RAR-related orphan receptor gamma	9	0	0	9
SMAD family member 2	2	0	0	2
Fumarate hydratase	5	0	0	5
USP1 protein, partial	6	0	0	6
PPM1D protein	2	0	0	2
SMAD family member 3	2	0	0	2
GLI family zinc finger 3	12	0	0	12
AR protein	14	0	0	14
estrogen receptor 2 (ER beta)	6	0	0	6
nuclear receptor subfamily 1, group I, member 3	9	0	0	9
progesterone receptor	7	0	0	7
EWS/FLI fusion protein	7	0	0	7
glucocorticoid receptor [Homo sapiens]	9	0	0	9
retinoic acid nuclear receptor alpha variant 1	8	0	0	8
retinoid X nuclear receptor alpha	7	0	0	7
farnesoid X nuclear receptor	5	0	0	5
pregnane X nuclear receptor	11	0	0	11
estrogen nuclear receptor alpha	17	0	0	17
G	4	0	0	4
cytochrome P450 2D6	6	0	0	6
polyprotein	5	0	0	5
67.9K protein	3	0	0	3
peroxisome proliferator-activated receptor delta	7	0	0	7
peroxisome proliferator activated receptor gamma	8	0	0	8
vitamin D (1,25- dihydroxyvitamin D3) receptor	4	0	0	4
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	4	0	0	4
thyroid stimulating hormone receptor	5	0	0	5
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	7	0	0	7
v-jun sarcoma virus 17 oncogene homolog (avian)	9	0	0	9
lysosomal alpha-glucosidase preproprotein	2	0	0	2
mu-type opioid receptor isoform MOR-1	0	0	1	1
nuclear factor erythroid 2-related factor 2 isoform 2	2	0	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	5	0	0	5
transcriptional regulator ERG isoform 3	3	0	0	3
thyroid hormone receptor beta isoform 2	13	0	0	13
heat shock protein beta-1	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 1	10	0	0	10
nuclear receptor ROR-gamma isoform 1	2	0	0	2
geminin	11	0	0	11
peripheral myelin protein 22	5	0	0	5
histone acetyltransferase KAT2A isoform 1	2	0	0	2
5-hydroxytryptamine receptor 2A	0	0	1	1
Solute carrier family 22 member 2	0	2	0	2
ATP-binding cassette sub-family C member 3	0	8	0	8
Multidrug resistance-associated protein 4	0	8	0	8
5-hydroxytryptamine receptor 3A	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	4	0	0	4
5-hydroxytryptamine receptor 3B	0	4	0	4
Bile salt export pump	0	14	0	14
Interferon beta	6	0	0	6
HLA class I histocompatibility antigen, B alpha chain	4	0	0	4
Cellular tumor antigen p53	11	0	0	11
ATP-dependent translocase ABCB1	0	4	0	6
Cytochrome P450 3A4	0	7	1	8
5-hydroxytryptamine receptor 1A	0	6	7	13
Neuronal acetylcholine receptor subunit alpha-4	1	3	3	8
Neuronal acetylcholine receptor subunit beta-2	1	3	3	8
D(2) dopamine receptor	0	9	1	10
Alpha-1B adrenergic receptor	0	7	1	8
Alpha-2C adrenergic receptor	0	11	0	11
D	0	6	0	6
Glutamate receptor 2	4	2	1	7
Muscarinic acetylcholine receptor M3	0	9	0	9
D(1A) dopamine receptor	0	7	0	7
D(4) dopamine receptor	0	6	0	6
D(1B) dopamine receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	7	1	8
Alpha-1D adrenergic receptor	0	7	0	7
5-hydroxytryptamine receptor 2A	0	11	0	11
5-hydroxytryptamine receptor 2C	0	11	0	11
D(4) dopamine receptor	0	3	0	3
Histamine H1 receptor	0	3	0	3
5-hydroxytryptamine receptor 7	0	6	0	6
Alpha-1A adrenergic receptor	0	7	0	7
Histamine H1 receptor	0	9	1	10
Alpha-1B adrenergic receptor	0	3	0	3
D(3) dopamine receptor	0	8	1	9
5-hydroxytryptamine receptor 2B	0	9	0	9
Alpha-1A adrenergic receptor	0	7	1	8
5-hydroxytryptamine receptor 3A	0	5	0	5
5-hydroxytryptamine receptor 6	0	6	0	7
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	3	0	3
Spike glycoprotein	8	0	0	8
D(2) dopamine receptor	0	9	0	9
Inositol monophosphatase 1	6	0	0	6
Potassium voltage-gated channel subfamily H member 2	0	13	0	13
5-hydroxytryptamine receptor 3D	0	4	0	4
Multidrug and toxin extrusion protein 2	0	2	0	2
5-hydroxytryptamine receptor 3C	0	4	0	4
Inositol hexakisphosphate kinase 1	4	0	0	4
Canalicular multispecific organic anion transporter 1	0	8	0	8
Multidrug and toxin extrusion protein 1	0	3	0	3
Histamine H3 receptor	0	2	0	2
cytochrome P450 2C9, partial	4	0	0	4
Chain A, Ferritin light chain	2	0	0	2
caspase 7, apoptosis-related cysteine protease	2	0	0	2
caspase-3	2	0	0	2
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	5	0	0	5
activating transcription factor 6	3	0	0	3
thyrotropin-releasing hormone receptor	1	0	0	1
vitamin D3 receptor isoform VDRA	5	0	0	5
mitogen-activated protein kinase 1	3	0	0	3
survival motor neuron protein isoform d	4	0	0	4
Caspase-2	0	0	1	1
ATPase family AAA domain-containing protein 5	3	0	0	3
Ataxin-2	5	0	0	5
Chain A, HADH2 protein	1	0	0	1
Chain B, HADH2 protein	1	0	0	1
endonuclease IV	2	0	0	2
dopamine D1 receptor	1	0	0	1
pregnane X receptor	1	0	0	1
GLS protein	9	0	0	9
aldehyde dehydrogenase 1 family, member A1	4	0	0	4
regulator of G-protein signaling 4	8	0	0	8
peripheral myelin protein 22 isoform 1	5	0	0	5
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
chromobox protein homolog 1	7	0	0	7
flap endonuclease 1	4	0	0	4
cytochrome P450 3A4 isoform 1	1	0	0	1
M-phase phosphoprotein 8	3	0	0	3
muscarinic acetylcholine receptor M1	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	1	2	1	4
Glucocorticoid receptor	0	2	0	2
Sex hormone-binding globulin	0	0	1	1
Glycine receptor subunit alpha-1	0	2	0	2
Corticosteroid-binding globulin	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	1	2	1	4
Gamma-aminobutyric acid receptor subunit delta	1	2	1	4
Gamma-aminobutyric acid receptor subunit gamma-2	1	2	2	5
Gamma-aminobutyric acid receptor subunit alpha-5	1	2	1	4
Gamma-aminobutyric acid receptor subunit alpha-3	1	2	1	4
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	1	2	1	4
Gamma-aminobutyric acid receptor subunit alpha-2	1	2	1	4
Glycine receptor subunit alpha-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	1	2	1	4
Gamma-aminobutyric acid receptor subunit gamma-3	1	2	1	4
Gamma-aminobutyric acid receptor subunit alpha-6	1	2	1	4
Gamma-aminobutyric acid receptor subunit alpha-1	1	2	2	5
Gamma-aminobutyric acid receptor subunit beta-3	1	2	1	4
Gamma-aminobutyric acid receptor subunit beta-2	1	2	2	5
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
TAR DNA-binding protein 43	5	0	0	5
GABA theta subunit	1	2	1	4
Gamma-aminobutyric acid receptor subunit epsilon	1	2	1	4
GALC protein	2	0	0	2
Cytochrome P450 1A2	0	3	0	3
Cytochrome P450 2A6	0	3	1	4
Cytochrome P450 2A5	0	2	0	2
Chain A, 2-oxoglutarate Oxygenase	2	0	0	2
thyroid hormone receptor beta isoform a	5	0	0	5
eyes absent homolog 2 isoform a	1	0	0	1
DNA polymerase iota isoform a (long)	2	0	0	2
Alpha-synuclein	2	0	0	2
glp-1 receptor, partial	5	0	0	5
Smad3	4	0	0	4
cytochrome P450 family 3 subfamily A polypeptide 4	7	0	0	7
IDH1	2	0	0	2
aryl hydrocarbon receptor	6	0	0	6
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
Chain A, Protein (peroxisome Proliferator Activated Receptor (ppar-delta))	0	1	0	1
phosphopantetheinyl transferase	5	0	0	5
histone-lysine N-methyltransferase 2A isoform 2 precursor	5	0	0	5
DNA polymerase kappa isoform 1	2	0	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Trypsin	0	1	0	1
Coagulation factor VII	0	1	0	1
Aromatase	0	1	0	1
Tissue factor	0	1	0	1
Retinoic acid receptor RXR-alpha	0	1	2	3
Peroxisome proliferator-activated receptor gamma	0	0	5	5
Prostaglandin G/H synthase 2	0	1	0	1
Oxoeicosanoid receptor 1	0	1	0	1
Gamma-aminobutyric acid	0	0	1	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	1	1
thyroid stimulating hormone receptor	4	0	0	4
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	0	2	0	2
Histone deacetylase 3	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 2	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-6	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit delta	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	1	3
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-2	0	2	1	3
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-1	0	0	1	1
Histone deacetylase 4	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit epsilon	0	2	0	2
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
Histone deacetylase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	1	3
Sterol O-acyltransferase 1	0	0	1	1
Proton-coupled amino acid transporter 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit pi	0	0	1	1
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	0	2
Histone deacetylase 8	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	1	1
Platelet glycoprotein VI	0	0	1	1
Gamma-aminobutyric acid receptor subunit theta	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	0	1	1
Histone deacetylase 6	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 1	0	0	1	1
Histone deacetylase 9	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	2	0	2
Histone deacetylase 5	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
beta-2 adrenergic receptor	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
Metabotropic glutamate receptor 8	0	2	0	2
Metabotropic glutamate receptor 6	0	1	1	3
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Glutathione reductase, mitochondrial	0	2	0	2
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	2	2
Carbonic anhydrase 1	0	0	0	3
Carbonic anhydrase 2	0	0	0	3
Integrin beta-3	0	0	1	1
Integrin alpha-IIb	0	0	1	1
ATP-citrate synthase	0	1	0	1
Glutamate receptor 1	0	2	1	3
Glutamate receptor 3	0	2	1	3
Glutamate receptor 4	0	2	1	3
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, NMDA 1	0	4	2	7
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Excitatory amino acid transporter 1	0	2	0	3
Excitatory amino acid transporter 2	0	2	0	3
Excitatory amino acid transporter 3	0	2	0	3
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	4	2	7
Glutamate receptor ionotropic, NMDA 2B	0	4	2	7
Glutamate receptor ionotropic, NMDA 2C	0	4	2	7
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Metabotropic glutamate receptor 1	0	1	1	3
Metabotropic glutamate receptor 2	0	1	1	3
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	3
Glutamate receptor ionotropic, NMDA 2D	0	4	2	7
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	4	2	7
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	4	2	7
Chain A, Glutamine Binding Protein	0	0	1	1
15-lipoxygenase, partial	1	0	0	1
Neutral amino acid transporter A	0	1	0	1
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Amino acid transporter	0	1	0	1
ATP-dependent phosphofructokinase	4	0	0	4
Glycine receptor subunit alpha-1	0	0	2	2
Sodium- and chloride-dependent glycine transporter 1	0	2	0	2
Large neutral amino acids transporter small subunit 1	0	2	0	2
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Sodium- and chloride-dependent glycine transporter 2	0	2	0	2
Cytochrome P450 144	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
huntingtin isoform 2	1	0	0	1
ras-related protein Rab-9A	3	0	0	3
5-hydroxytryptamine receptor 4	0	8	0	8
Aldo-keto reductase family 1 member B1	0	6	0	6
Muscarinic acetylcholine receptor M2	0	8	0	8
Muscarinic acetylcholine receptor M4	0	9	0	9
Muscarinic acetylcholine receptor M5	0	4	0	4
Muscarinic acetylcholine receptor M5	0	9	0	9
Alpha-2A adrenergic receptor	0	10	1	11
Muscarinic acetylcholine receptor M1	0	8	1	9
Alpha-2B adrenergic receptor	0	9	0	9
D(3) dopamine receptor	0	5	0	5
Alpha-2B adrenergic receptor	0	5	1	6
Endothelin receptor type B	0	1	0	1
Alpha-2C adrenergic receptor	0	5	1	6
Alpha-2A adrenergic receptor	0	5	1	6
5-hydroxytryptamine receptor 3A	0	2	0	2
Endothelin receptor type B	0	1	0	1
Histamine H2 receptor	0	4	0	4
Endothelin-1 receptor	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	1
Histamine H1 receptor	0	1	0	1
Type-2 angiotensin II receptor	0	3	0	3
Histamine H2 receptor	1	1	0	3
Angiotensin-converting enzyme	0	2	0	2
5-hydroxytryptamine receptor 3B	0	2	0	2
G-protein coupled receptor	0	1	0	1
Transporter	0	10	1	12
cytochrome P450 2D6 isoform 1	2	0	0	2
cytochrome P450 2C19 precursor	2	0	0	2
cytochrome P450 2C9 precursor	1	0	0	1
Opioid receptor, delta 1b	0	1	0	1
Solute carrier family 22 member 1	0	1	0	2
Acetylcholinesterase	0	1	0	1
Opioid receptor homologue	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Muscarinic acetylcholine receptor M1	0	3	0	3
Muscarinic acetylcholine receptor M3	0	3	0	3
Muscarinic acetylcholine receptor M4	0	4	0	4
Muscarinic acetylcholine receptor M2	0	3	0	3
Translocator protein	0	1	1	2
Histidine decarboxylase	0	0	2	2
ATP-dependent translocase ABCB1	0	1	0	1
Proteinase-activated receptor 1	0	1	1	2
Delta-type opioid receptor	0	4	1	7
Delta-type opioid receptor	0	5	3	9
Kappa-type opioid receptor	0	3	1	6
Mu-type opioid receptor	0	5	3	11
Kappa-type opioid receptor	0	3	3	7
Mu-type opioid receptor	0	4	2	8
UDP-glucuronosyltransferase 1A3	0	0	0	1
Delta-type opioid receptor	0	4	2	8
Kappa-type opioid receptor	0	4	1	6
Kappa-type opioid receptor	0	4	3	9
Mu-type opioid receptor	0	3	1	7
Nociceptin receptor	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	5	1	6
Beta-2 adrenergic receptor	0	2	0	2
Mas-related G-protein coupled receptor member X2	0	0	1	1
Mu-type opioid receptor	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	6	0	6
Cytochrome P450 2D6	0	5	0	5
Cytochrome P450 2C9	0	2	0	2
Adenosine receptor A1	0	3	0	3
Cytochrome P450 2J2	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	2	1	3
UDP-glucuronosyltransferase 1A8	0	0	0	1
Sigma non-opioid intracellular receptor 1	0	2	0	2
interleukin 8	1	0	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit beta	0	2	1	3
Acetylcholine receptor subunit gamma	0	2	1	3
Acetylcholine receptor subunit delta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-3	0	2	2	5
Acetylcholine receptor subunit gamma	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Acetylcholine receptor subunit beta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-2	0	2	2	5
Neuronal acetylcholine receptor subunit beta-3	0	2	2	5
Neuronal acetylcholine receptor subunit beta-4	0	2	2	5
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-5	0	2	2	5
Acetylcholine receptor subunit beta-like 2	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-5	0	0	1	1
Neuronal acetylcholine receptor subunit beta-4	0	2	1	3
Muscarinic acetylcholine receptor M4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-7	0	2	2	4
Neuronal acetylcholine receptor subunit alpha-6	0	2	2	5
Neuronal acetylcholine receptor subunit alpha-9	0	2	2	5
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Nuclear receptor ROR-gamma	1	0	0	1
Acetylcholine-binding protein	0	1	1	2
Acetylcholine receptor subunit epsilon	0	0	1	1
Neuronal acetylcholine receptor subunit beta-3	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-7	0	2	2	5
Acetylcholine receptor subunit delta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	1	2
Cytochrome P450 2A13	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-5	0	2	0	2
Liver carboxylesterase B-1	0	1	0	1
Solute carrier family 22 member 1	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Neuronal acetylcholine receptor subunit beta-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	2	0	2
Soluble acetylcholine receptor	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-10	0	2	2	5
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	2	0	2
Integrin beta	0	0	1	1
Glycoprotein IIb	0	0	1	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Angiotensin-converting enzyme	0	7	0	7
UDP-glucuronosyltransferase 1A4	0	0	0	1
Adenosine receptor A1	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Transporter	0	2	0	2
Nuclear receptor subfamily 3 group C member 3	0	7	0	7
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	1	0	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Vasopressin V2 receptor	0	1	1	2
Oxytocin receptor	0	2	2	4
Vasopressin V1a receptor	0	1	0	1
Vasopressin V1a receptor	0	2	1	3
Vasopressin V1b receptor	0	1	1	2
Vasopressin V1b receptor	0	1	0	1
Oxytocin receptor	0	1	0	1
Oxytocin receptor	0	0	1	1
Vasopressin V2 receptor	0	1	0	1
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
Sodium-dependent noradrenaline transporter	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
Myeloperoxidase	0	2	0	2
Quinolone resistance protein NorA	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Beta-adrenergic receptor kinase 1	0	1	0	1
Potassium voltage-gated channel subfamily A member 3	0	1	0	1
Beta-adrenergic receptor kinase 1	0	1	1	2
Substance-P receptor	0	1	0	1
Rhodopsin kinase GRK1	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
D(1A) dopamine receptor	2	0	0	2
P2X purinoceptor 4	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Envelope glycoprotein	0	0	2	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Rhodopsin kinase GRK1	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
P2X purinoceptor 4	0	1	0	1
Beta-adrenergic receptor kinase 1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Metallo-beta-lactamase VIM-11	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
streptokinase A precursor	0	0	1	1
Solute carrier family 22 member 6	0	1	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	1	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase 1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase OXA-10	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 1	0	1	0	1
Beta-lactamase TEM	0	1	0	2
Guanine nucleotide-binding protein G	1	0	0	1
Beta-lactamase	0	0	0	1
B2 metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Metallo-beta-lactamase VIM-13	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Efflux transporter	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase Toho-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-b-lactamase	0	0	0	1
Beta-lactamase IMP-1	0	0	0	1
BlaVIM-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	1	0	1
Beta-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Beta-lactamase class B VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	1	0	2
Beta-lactamase VIM-1	0	0	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	2
Voltage-dependent calcium channel subunit alpha-2/delta-2	0	1	0	1
Albumin	0	0	1	1
Beta-1 adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
D(2) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Sphingosine kinase 2	0	2	0	2
Sphingosine kinase 1	0	1	0	1
Chain A, Beta-lactamase	1	0	0	1
nonstructural protein 1	1	0	0	1
Rap guanine nucleotide exchange factor 3	2	0	0	2
Transcriptional activator protein LuxR	0	1	0	1
D(1B) dopamine receptor	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
Melanocortin receptor 5	0	2	0	2
Cytochrome P450 2C19	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
apical membrane antigen 1, AMA1	2	0	0	2
serine/threonine-protein kinase PLK1	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	3
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Solute carrier organic anion transporter family member 1A5	0	0	0	2
Transthyretin	0	1	0	3
Thyroid hormone receptor alpha	0	2	3	5
Thyroid hormone receptor beta	0	2	3	5
Proliferating cell nuclear antigen	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	1	0	1
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	2
Solute carrier organic anion transporter family member 1A3	0	0	0	2
Solute carrier organic anion transporter family member 4C1	0	1	0	2
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Solute carrier organic anion transporter family member 1B1	0	0	0	2
glucocerebrosidase	1	0	0	1
muscleblind-like protein 1 isoform 1	1	0	0	1
Androgen receptor	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Solute carrier organic anion transporter family member 1C1	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	0	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
thioredoxin glutathione reductase	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
Carbonic anhydrase 12	0	0	0	1
Dihydrofolate reductase	0	2	0	2
Plasma kallikrein	0	0	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Carbonic anhydrase 3	0	0	0	1
Stromelysin-1	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Carbonic anhydrase 4	0	0	0	1
Carbonic anhydrase 6	0	0	0	1
Substance-P receptor	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase 7	0	0	0	1
Tryptophan 2,3-dioxygenase	0	1	0	2
Carbonic anhydrase	0	0	0	1
SLC16A10 protein	0	0	0	1
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Carbonic anhydrase 9	0	0	0	1
Carbonic anhydrase	0	0	0	1
Tryprostatin B synthase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Carbonic anhydrase	0	0	0	1
Monocarboxylate transporter 10	0	0	0	1
Carbonic anhydrase 15	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Carbonic anhydrase 14	0	0	0	1
Phospholipase A-2-activating protein	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Medically Unexplained Symptoms

Synonyms(2)

Research Excerpts

Overview

Research

Studies (43)

Protein Targets (696)

Medically Unexplained Symptoms

Synonyms(2)

Research Excerpts

Overview

Research

Studies (43)

Drugs Studied (45)

Protein Targets (696)