Page last updated: 2024-09-27

Hemangioma Thrombocytopenia Syndrome

Rapidly growing vascular lesion along the midline axis of the neck, upper trunk, and extremities that is characterized by CONSUMPTION COAGULOPATHY; THROMBOCYTOPENIA; and HEMOLYTIC ANEMIA. It is often associated with infantile Kaposiform HEMANGIOENDOTHELIOMA and other vascular tumors such as tufted ANGIOMA.

Synonyms(5)

Synonym
Kasabach-Merritt Phenomenon
Kasabach-Merritt Syndrome
Thrombocytopenia-Hemangioma Syndrome
Hemangioma Thrombocytopenia Syndrome
Hemangioma-Thrombocytopenia Syndrome

Research

Studies (105)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's78 (74.29)28.8240
2020's27 (25.71)9.53
DrugIndicatedRelationship StrengthStudiesTrials
salicylic acid0low30
aspirin0medium51
atenolol0low20
propranolol0low200
thalidomide0low10
ticlopidine0medium41
prednisolone0medium111
prednisone0low60
cytarabine0low10
methylprednisolone0low30
betamethasone0low20
methylprednisolone hemisuccinate0low10
paclitaxel0low20
fluorodeoxyglucose f180low20
fibrinogen0low20
methotrexate0low20
tacrolimus0medium21
dactinomycin0low10
polidocanol0low10
mercaptopurine0low10
sirolimus0medium521
everolimus0low50
gadolinium dtpa0low10

Protein Targets (837)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE7007
Chain A, TYROSYL-DNA PHOSPHODIESTERASE6006
Chain A, Phospholipase A2 isoform 30011
Chain A, HADH2 protein5005
Chain B, HADH2 protein5005
Chain A, 2-oxoglutarate Oxygenase5005
GTP-binding protein (rab7)0011
ras protein, partial0011
interleukin 82002
thioredoxin reductase6006
GLS protein1001
AR protein170017
aldehyde dehydrogenase 1 family, member A19009
thyroid stimulating hormone receptor2002
hypothetical protein, conserved1001
cytochrome P450 family 3 subfamily A polypeptide 4100010
EWS/FLI fusion protein7007
glucocorticoid receptor [Homo sapiens]140014
retinoic acid nuclear receptor alpha variant 19009
estrogen-related nuclear receptor alpha100010
estrogen nuclear receptor alpha170017
cytochrome P450 2D66006
glucocerebrosidase1001
peroxisome proliferator-activated receptor delta5005
Rac1 protein0011
IDH17007
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
euchromatic histone-lysine N-methyltransferase 29009
Bloom syndrome protein isoform 15005
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 15005
DNA polymerase iota isoform a (long)5005
DNA polymerase kappa isoform 14004
muscarinic acetylcholine receptor M12002
lethal factor (plasmid)2002
Prostaglandin-H2 D-isomerase0101
ATP-binding cassette sub-family C member 3012012
Multidrug resistance-associated protein 4012013
Solute carrier family 22 member 60202
Prostaglandin G/H synthase 1 0101
Prostaglandin G/H synthase 2 0101
Bile salt export pump017017
Epidermal growth factor receptor0224
Carbonic anhydrase 10404
Carbonic anhydrase 20415
Fatty acid-binding protein, liver0303
Integrin beta-32204
Myeloperoxidase0101
Prostaglandin G/H synthase 10202
Seed linoleate 13S-lipoxygenase-10101
Integrin alpha-IIb2103
Glutathione hydrolase 1 proenzyme0101
Prostaglandin G/H synthase 10404
Adenosine receptor A10101
Adenosine receptor A2a0101
Substance-P receptor0101
Prostaglandin G/H synthase 20404
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0101
Nuclear receptor ROR-gamma3003
Ras-related protein Rab-2A0011
Gamma-aminobutyric acid receptor subunit alpha-13227
Prostaglandin G/H synthase 20202
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0202
Solute carrier family 22 member 200303
Solute carrier family 22 member 60303
Canalicular multispecific organic anion transporter 1012012
Sigma non-opioid intracellular receptor 10415
Sigma non-opioid intracellular receptor 10011
regulator of G-protein signaling 42002
Beta-1 adrenergic receptor 0124
D(1A) dopamine receptor3003
geminin120012
lamin isoform A-delta106006
Gamma-aminobutyric acid receptor subunit pi3126
Urease0101
Beta-2 adrenergic receptor0426
Beta-1 adrenergic receptor0426
Beta-3 adrenergic receptor0224
Gamma-aminobutyric acid receptor subunit beta-13126
Gamma-aminobutyric acid receptor subunit delta3126
Gamma-aminobutyric acid receptor subunit gamma-23126
5-hydroxytryptamine receptor 1A0326
Gamma-aminobutyric acid receptor subunit alpha-53126
Gamma-aminobutyric acid receptor subunit alpha-33126
Gamma-aminobutyric acid receptor subunit gamma-13126
Gamma-aminobutyric acid receptor subunit alpha-23126
Alpha-1D adrenergic receptor0113
Gamma-aminobutyric acid receptor subunit alpha-43126
Gamma-aminobutyric acid receptor subunit gamma-33126
Gamma-aminobutyric acid receptor subunit alpha-63126
Alpha-1A adrenergic receptor0225
Alpha-1B adrenergic receptor0113
Gamma-aminobutyric acid receptor subunit beta-33126
Gamma-aminobutyric acid receptor subunit beta-23126
TAR DNA-binding protein 433003
Beta-2 adrenergic receptor0124
GABA theta subunit3126
Gamma-aminobutyric acid receptor subunit epsilon3126
ATP-dependent phosphofructokinase4004
pregnane X receptor3003
GLI family zinc finger 39009
progesterone receptor100010
farnesoid X nuclear receptor7007
pregnane X nuclear receptor110011
vitamin D (1,25- dihydroxyvitamin D3) receptor7007
aryl hydrocarbon receptor4004
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a9009
nuclear receptor subfamily 1, group I, member 25005
thyroid hormone receptor beta isoform a6006
nuclear factor erythroid 2-related factor 2 isoform 27008
galanin receptor type 30101
nuclear factor erythroid 2-related factor 2 isoform 17007
Voltage-dependent calcium channel gamma-2 subunit8008
Glucocorticoid receptor08215
Glycine receptor subunit alpha-10808
Glutamate receptor 28008
Glycine receptor subunit beta0808
Glycine receptor subunit alpha-20808
Glycine receptor subunit alpha-30808
ORF730011
endonuclease IV1001
glp-1 receptor, partial2002
phosphopantetheinyl transferase5005
RAR-related orphan receptor gamma7007
USP1 protein, partial8008
TDP1 protein150015
nuclear receptor subfamily 1, group I, member 38008
G6006
67.9K protein5005
LMP1 [Human herpesvirus 4]0002
Histone H2A.x5005
chromobox protein homolog 13003
thyroid hormone receptor beta isoform 2100010
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0202
serine/threonine-protein kinase mTOR isoform 11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 13003
transactivating tegument protein VP16 [Human herpesvirus 1]0202
peripheral myelin protein 228008
nuclear receptor coactivator 3 isoform a0202
Thymidine kinase 2, mitochondrial0101
Interferon beta8008
HLA class I histocompatibility antigen, B alpha chain 6006
Thymidine kinase, cytosolic0101
Cellular tumor antigen p53110011
Thymidine kinase0101
Thymidylate synthase0203
Cytochrome P450 3A40404
Thymidine kinase0101
Deoxycytidine kinase0023
Probable deoxycytidylate deaminase0001
Cytidine deaminase0102
D(1A) dopamine receptor1001
E3 ubiquitin-protein ligase Mdm20101
Enoyl-[acyl-carrier-protein] reductase [NADH] 0101
Inositol hexakisphosphate kinase 16006
Ataxin-2110011
Thymidine kinase0101
Deoxynucleoside kinase0101
cytochrome P450 2C9, partial6006
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Chain A, Ferritin light chain5005
Chain A, Cruzipain1001
15-lipoxygenase, partial2002
hypoxia-inducible factor 1 alpha subunit5005
Microtubule-associated protein tau3003
caspase 7, apoptosis-related cysteine protease2002
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)4004
estrogen receptor 2 (ER beta)5005
retinoid X nuclear receptor alpha9009
peroxisome proliferator activated receptor gamma7007
caspase-32002
RAD510101
activating transcription factor 62002
v-jun sarcoma virus 17 oncogene homolog (avian)6006
Caspase-71001
vitamin D3 receptor isoform VDRA4004
caspase-31001
huntingtin isoform 22002
histone-lysine N-methyltransferase 2A isoform 2 precursor2002
nuclear receptor ROR-gamma isoform 17007
survival motor neuron protein isoform d5005
cytochrome P450 3A4 isoform 13003
caspase-1 isoform alpha precursor3003
ATP-dependent translocase ABCB10508
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 10101
Caspase-73003
Spike glycoprotein6006
Growth factor receptor-bound protein 20101
Pantothenate synthetase0101
Discoidin domain-containing receptor 20123
Growth factor receptor-bound protein 2 0101
Reverse transcriptase/RNaseH 0101
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase0011
ATPase family AAA domain-containing protein 59009
Chain A, Breast cancer type 1 susceptibility protein1001
Chain A, Beta-lactamase3003
acid sphingomyelinase2002
acetylcholinesterase3003
RGS121001
90-kda heat shock protein beta HSP90 beta, partial0101
SMAD family member 22002
ATAD5 protein, partial3003
Fumarate hydratase2002
NFKB1 protein, partial1001
SMAD family member 32002
Thrombopoietin1001
Smad32002
DNA polymerase III, partial1001
isocitrate dehydrogenase 1, partial1001
nonstructural protein 12002
LANA0001
NPYLR7B0011
polyprotein2002
bromodomain adjacent to zinc finger domain 2B3003
thyroid stimulating hormone receptor4004
thyrotropin-releasing hormone receptor1001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
serine-protein kinase ATM isoform a1001
cytochrome P450 2D6 isoform 12002
lysosomal alpha-glucosidase preproprotein1001
peripheral myelin protein 22 isoform 11001
cytochrome P450 2C19 precursor2002
cytochrome P450 2C9 precursor1001
potassium voltage-gated channel subfamily H member 2 isoform d3003
heat shock protein beta-13003
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 11001
importin subunit beta-1 isoform 12002
ubiquitin carboxyl-terminal hydrolase 2 isoform a2002
serine/threonine-protein kinase PLK11001
eyes absent homolog 2 isoform a1001
heat shock protein HSP 90-alpha isoform 20101
snurportin-12002
tumor susceptibility gene 101 protein1001
GTP-binding nuclear protein Ran isoform 11001
muscleblind-like protein 1 isoform 13003
histone acetyltransferase KAT2A isoform 14004
DNA dC->dU-editing enzyme APOBEC-3F isoform a1001
kelch-like ECH-associated protein 10002
neuropeptide S receptor isoform A1001
cGMP-dependent 3',5'-cyclic phosphodiesterase0101
Solute carrier family 22 member 20101
Solute carrier family 22 member 1 0202
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Multidrug resistance-associated protein 50101
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta0101
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A0101
cGMP-specific 3',5'-cyclic phosphodiesterase0101
3',5'-cyclic-AMP phosphodiesterase 0101
Rap guanine nucleotide exchange factor 31001
Neuronal acetylcholine receptor subunit alpha-41001
Neuronal acetylcholine receptor subunit beta-21001
Polyunsaturated fatty acid lipoxygenase ALOX150101
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha0101
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0202
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta0101
Histamine H2 receptor1001
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A0101
Disintegrin and metalloproteinase domain-containing protein 172002
Inositol monophosphatase 11001
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0202
cGMP-inhibited 3',5'-cyclic phosphodiesterase B0101
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A0101
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0101
Exopolyphosphatase PRUNE10101
Multidrug and toxin extrusion protein 20101
Rap guanine nucleotide exchange factor 41001
Multidrug and toxin extrusion protein 10101
Equilibrative nucleoside transporter 10202
Single-stranded DNA cytosine deaminase1001
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A0101
cAMP-specific 3',5'-cyclic phosphodiesterase 7B0101
Broad substrate specificity ATP-binding cassette transporter ABCG20304
Phosphodiesterase 0101
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A0101
Bone morphogenetic protein receptor type-1B0022
Cell division cycle 7-related protein kinase0022
Serine/threonine-protein kinase PLK40022
ATP-dependent RNA helicase DDX3X0022
Pyridoxal kinase0022
Citron Rho-interacting kinase0022
Serine/threonine-protein kinase Chk10022
Aurora kinase A0022
Cyclin-G-associated kinase0022
Ephrin type-B receptor 60022
Peroxisomal acyl-coenzyme A oxidase 30022
Receptor-interacting serine/threonine-protein kinase 20022
Mitotic checkpoint serine/threonine-protein kinase BUB10022
Dynamin-like 120 kDa protein, mitochondrial0022
Eukaryotic translation initiation factor 5B0022
Rho-associated protein kinase 20022
Serine/threonine-protein kinase ULK10022
Serine/threonine-protein kinase/endoribonuclease IRE10022
Ribosomal protein S6 kinase alpha-50022
U5 small nuclear ribonucleoprotein 200 kDa helicase0022
Ribosomal protein S6 kinase alpha-40022
Serine/threonine-protein kinase 160022
Serine/threonine-protein kinase 100022
Serine/threonine-protein kinase D30022
Structural maintenance of chromosomes protein 20022
Mitogen-activated protein kinase kinase kinase 60022
Mitogen-activated protein kinase kinase kinase kinase 40022
Serine/threonine-protein kinase LATS10022
Serine/threonine-protein kinase PAK 40022
Tyrosine-protein kinase ABL10134
High affinity nerve growth factor receptor0022
Guanine nucleotide-binding protein G(i) subunit alpha-20011
ADP/ATP translocase 20022
Protein kinase C beta type0022
Insulin receptor0022
Tyrosine-protein kinase Lck0022
Tyrosine-protein kinase Fyn0123
Cyclin-dependent kinase 10022
Glycogen phosphorylase, liver form0022
Tyrosine-protein kinase Fes/Fps0022
Adenine phosphoribosyltransferase0022
Tyrosine-protein kinase Yes0022
Tyrosine-protein kinase Lyn0022
Proto-oncogene tyrosine-protein kinase receptor Ret0022
Insulin-like growth factor 1 receptor0022
Signal recognition particle receptor subunit alpha0022
Cytochrome c1, heme protein, mitochondrial0022
Hepatocyte growth factor receptor0022
Tyrosine-protein kinase HCK0022
Platelet-derived growth factor receptor beta0022
Tyrosine-protein kinase Fgr0022
Serine/threonine-protein kinase A-Raf0022
Glycogen phosphorylase, brain form0022
Breakpoint cluster region protein0022
Serine/threonine-protein kinase pim-10022
Fibroblast growth factor receptor 10123
DNA topoisomerase 2-alpha0022
Cyclin-dependent kinase 40022
ADP/ATP translocase 30022
Inosine-5'-monophosphate dehydrogenase 20022
Proto-oncogene tyrosine-protein kinase Src0123
cAMP-dependent protein kinase type II-alpha regulatory subunit0022
Serine/threonine-protein kinase B-raf0022
Potassium voltage-gated channel subfamily E member 10101
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform0022
Ribosyldihydronicotinamide dehydrogenase [quinone]0022
Tyrosine-protein kinase Fer0022
Protein kinase C alpha type0022
cAMP-dependent protein kinase catalytic subunit alpha0022
General transcription and DNA repair factor IIH helicase subunit XPD0022
Casein kinase II subunit alpha'0022
Ras-related protein Rab-6A0022
Ephrin type-A receptor 10022
Multifunctional protein ADE20022
cAMP-dependent protein kinase catalytic subunit gamma0011
cAMP-dependent protein kinase catalytic subunit beta0022
Ferrochelatase, mitochondrial0022
Ribosomal protein S6 kinase beta-10022
Tyrosine-protein kinase JAK10022
Cyclin-dependent kinase 20033
Beta-adrenergic receptor kinase 10022
Probable ATP-dependent RNA helicase DDX60022
Mitogen-activated protein kinase 3 0022
MAP/microtubule affinity-regulating kinase 30022
Mitogen-activated protein kinase 10022
Ephrin type-A receptor 20022
Ephrin type-B receptor 20022
Non-receptor tyrosine-protein kinase TYK20022
UMP-CMP kinase 0022
Phosphatidylethanolamine-binding protein 10022
Wee1-like protein kinase0022
Heme oxygenase 20022
S-adenosylmethionine synthase isoform type-20022
DnaJ homolog subfamily A member 10022
RAC-alpha serine/threonine-protein kinase0022
RAC-beta serine/threonine-protein kinase0022
Dual specificity protein kinase TTK0022
DNA replication licensing factor MCM40022
Myosin-100022
Dual specificity mitogen-activated protein kinase kinase 20022
Receptor-type tyrosine-protein kinase FLT30022
Bone morphogenetic protein receptor type-1A0022
Activin receptor type-1B0022
TGF-beta receptor type-10022
TGF-beta receptor type-20022
Electron transfer flavoprotein subunit beta0022
Tyrosine-protein kinase CSK0022
Glycine--tRNA ligase0022
Protein kinase C iota type0022
Exosome RNA helicase MTR40022
Serine/threonine-protein kinase mTOR0325
Tyrosine-protein kinase Tec0022
Tyrosine-protein kinase ABL20022
Tyrosine-protein kinase FRK0022
G protein-coupled receptor kinase 60022
Tyrosine-protein kinase SYK0022
26S proteasome regulatory subunit 6B0022
Mitogen-activated protein kinase 80022
Mitogen-activated protein kinase 90022
Dual specificity mitogen-activated protein kinase kinase 30022
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha0022
Casein kinase I isoform alpha0022
Casein kinase I isoform delta0022
MAP kinase-activated protein kinase 20022
Elongation factor Tu, mitochondrial0022
Choline-phosphate cytidylyltransferase A0022
Cysteine--tRNA ligase, cytoplasmic0022
Casein kinase I isoform epsilon0022
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial0022
Dual specificity protein kinase CLK10022
Dual specificity protein kinase CLK20022
Dual specificity protein kinase CLK30022
Glycogen synthase kinase-3 alpha0022
Glycogen synthase kinase-3 beta0022
Cyclin-dependent kinase 70022
Cyclin-dependent kinase 90022
Ras-related protein Rab-27A0022
Interleukin-1 receptor-associated kinase 10022
Potassium voltage-gated channel subfamily KQT member 10101
Ribosomal protein S6 kinase alpha-30022
Serine/threonine-protein kinase Nek20022
Serine/threonine-protein kinase Nek30022
Dual specificity mitogen-activated protein kinase kinase 60022
Serine/threonine-protein kinase PLK10022
LIM domain kinase 10022
LIM domain kinase 20022
Mitogen-activated protein kinase 100022
Tyrosine--tRNA ligase, cytoplasmic0022
5'-AMP-activated protein kinase subunit gamma-10023
Ephrin type-B receptor 30022
Ephrin type-A receptor 50022
Ephrin type-B receptor 40022
Ephrin type-A receptor 40022
Adenylate kinase 2, mitochondrial0022
Adenosine kinase0022
Ras-related protein Rab-100022
Actin-related protein 30022
Actin-related protein 20022
GTP-binding nuclear protein Ran0022
Casein kinase I isoform gamma-20022
Cyclin-dependent kinase 30011
Cyclin-dependent kinase 60022
Cyclin-dependent-like kinase 5 0022
Cyclin-dependent kinase 160022
Cyclin-dependent kinase 170022
ATP-dependent 6-phosphofructokinase, platelet type0022
Dual specificity mitogen-activated protein kinase kinase 10022
DNA topoisomerase 2-beta0022
Protein kinase C theta type0022
Activin receptor type-10022
Macrophage-stimulating protein receptor0022
Focal adhesion kinase 10022
Protein kinase C delta type0022
Tyrosine-protein kinase BTK0022
Activated CDC42 kinase 10022
Epithelial discoidin domain-containing receptor 10022
Potassium voltage-gated channel subfamily H member 20202
Mitogen-activated protein kinase kinase kinase kinase 20022
Serine/threonine-protein kinase 40022
5'-AMP-activated protein kinase catalytic subunit alpha-10023
Dual specificity mitogen-activated protein kinase kinase 50022
Mitogen-activated protein kinase 70022
Serine/threonine-protein kinase PAK 20022
Serine/threonine-protein kinase 30022
Mitogen-activated protein kinase kinase kinase 10022
Integrin-linked protein kinase0022
Rho-associated protein kinase 10022
Non-receptor tyrosine-protein kinase TNK10022
Calcium/calmodulin-dependent protein kinase type II subunit gamma0022
Calcium/calmodulin-dependent protein kinase type II subunit delta0022
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0022
Activin receptor type-2B0022
Bone morphogenetic protein receptor type-20022
Protein-tyrosine kinase 60022
cGMP-dependent protein kinase 1 0022
Cyclin-dependent kinase 130022
Inhibitor of nuclear factor kappa-B kinase subunit epsilon0022
Protein-tyrosine kinase 2-beta0022
Sodium channel protein type 5 subunit alpha0202
Maternal embryonic leucine zipper kinase0022
Structural maintenance of chromosomes protein 1A0022
Chromodomain-helicase-DNA-binding protein 40022
Peroxisomal acyl-coenzyme A oxidase 10022
Ephrin type-A receptor 70011
Delta(24)-sterol reductase0022
Ribosomal protein S6 kinase alpha-10022
Dual specificity testis-specific protein kinase 10022
Myosin light chain kinase, smooth muscle0022
Mitogen-activated protein kinase 110022
Serine/threonine-protein kinase STK110022
Serine/threonine-protein kinase N10022
Serine/threonine-protein kinase N20022
Mitogen-activated protein kinase 140022
Calcium/calmodulin-dependent protein kinase type IV0022
Mitogen-activated protein kinase kinase kinase 110022
AP2-associated protein kinase 10022
Myosin light chain kinase 30022
Putative heat shock protein HSP 90-beta 20022
Serine/threonine-protein kinase MRCK alpha0022
Serine/threonine-protein kinase MRCK gamma0022
Acyl-CoA dehydrogenase family member 100022
Serine/threonine-protein kinase N30022
Serine/threonine-protein kinase ULK30022
Uncharacterized protein FLJ452520022
Acyl-CoA dehydrogenase family member 110022
Serine/threonine-protein kinase/endoribonuclease IRE20022
Serine/threonine-protein kinase MARK20022
ATP-dependent RNA helicase DHX300022
Serine/threonine-protein kinase TAO10022
STE20-related kinase adapter protein alpha0022
Myosin-140022
AarF domain-containing protein kinase 10022
ATP-dependent RNA helicase DDX420011
Mitogen-activated protein kinase kinase kinase kinase 30022
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B0011
Regulatory-associated protein of mTOR0202
Atypical kinase COQ8A, mitochondrial0022
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma0022
Mitogen-activated protein kinase 150022
Serine/threonine-protein kinase Nek90022
Serine/threonine-protein kinase Nek70011
ATP-dependent RNA helicase DDX10022
Mitogen-activated protein kinase kinase kinase kinase 10022
Aurora kinase B0022
MAP/microtubule affinity-regulating kinase 40022
Serine/threonine-protein kinase Nek10022
PAS domain-containing serine/threonine-protein kinase0022
Calcium/calmodulin-dependent protein kinase kinase 20022
EKC/KEOPS complex subunit TP53RK0022
Dual specificity testis-specific protein kinase 20022
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase0022
Mitogen-activated protein kinase kinase kinase 50022
Mitogen-activated protein kinase kinase kinase 30022
Eukaryotic translation initiation factor 2-alpha kinase 10022
Target of rapamycin complex subunit LST80202
Nucleolar GTP-binding protein 10022
Serine/threonine-protein kinase D20022
NUAK family SNF1-like kinase 20011
RNA cytidine acetyltransferase0022
Serine/threonine-protein kinase SIK20022
STE20-like serine/threonine-protein kinase 0022
Serine/threonine-protein kinase TAO30022
dCTP pyrophosphatase 10022
Dual specificity protein kinase CLK40022
Casein kinase I isoform gamma-10022
Phenylalanine--tRNA ligase beta subunit0022
BMP-2-inducible protein kinase0022
Obg-like ATPase 10022
Midasin0022
Interleukin-1 receptor-associated kinase 40022
Mitogen-activated protein kinase kinase kinase 200022
Cyclin-dependent kinase 120022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 130011
Serine/threonine-protein kinase 260022
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial0022
Serine/threonine-protein kinase NLK0022
5'-AMP-activated protein kinase subunit gamma-20023
Serine/threonine-protein kinase TBK10022
Septin-90022
Potassium voltage-gated channel subfamily D member 30101
Ribosomal protein S6 kinase alpha-60022
TRAF2 and NCK-interacting protein kinase0022
Serine/threonine-protein kinase TAO20022
Long-chain-fatty-acid--CoA ligase 50011
RAC-gamma serine/threonine-protein kinase0022
Serine/threonine-protein kinase SIK30022
Mitogen-activated protein kinase kinase kinase 20022
Thyroid hormone receptor-associated protein 30022
Mitogen-activated protein kinase kinase kinase kinase 50022
Receptor-interacting serine/threonine-protein kinase 30022
Serine/threonine-protein kinase MRCK beta0022
Interleukin-1 receptor-associated kinase 30022
Casein kinase I isoform gamma-30022
Mitogen-activated protein kinase kinase kinase 40022
Chain A, JmjC domain-containing histone demethylation protein 3A2002
thioredoxin glutathione reductase2002
apical membrane antigen 1, AMA11001
hemoglobin subunit beta1001
cellular tumor antigen p53 isoform a2002
transcriptional regulator ERG isoform 32002
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
UDP-glucose 6-dehydrogenase0101
Solute carrier family 22 member 80001
Hypoxanthine-guanine phosphoribosyltransferase0001
UDP-glucose 6-dehydrogenase0101
Purine nucleoside phosphorylase0011
UDP-glucuronosyltransferase 1A1 0101
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
dopamine D1 receptor1001
ClpP1001
Thymidylate synthase 0101
alpha-galactosidase1001
Thymidylate synthase 0101
polyunsaturated fatty acid lipoxygenase ALOX121001
DNA polymerase beta1001
flap endonuclease 11001
DNA polymerase eta isoform 11001
M-phase phosphoprotein 81001
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
Bile salt export pump0404
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0203
Dihydrofolate reductase0203
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Thymidylate synthase0202
Bifunctional dihydrofolate reductase-thymidylate synthase0101
5-hydroxytryptamine receptor 2C0102
High mobility group protein B10022
Dihydrofolate reductase0101
Thymidylate synthase0101
Dihydrofolate reductase0224
Glucose-6-phosphate 1-dehydrogenase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
5-hydroxytryptamine receptor 2A0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Dihydrofolate reductase0202
Histidine decarboxylase0101
Trifunctional purine biosynthetic protein adenosine-30101
Bifunctional purine biosynthesis protein ATIC0202
Multidrug resistance-associated protein 1 0001
Delta-type opioid receptor0101
Mu-type opioid receptor0101
Kappa-type opioid receptor0101
Reduced folate transporter0202
Folylpolyglutamate synthase, mitochondrial0103
6-phosphogluconate dehydrogenase, decarboxylating0101
Solute carrier organic anion transporter family member 1A30001
Dihydrofolate reductase0101
Pteridine reductase 10101
Folylpolyglutamate synthase, mitochondrial0103
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Solute carrier family 22 member 60102
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Dihydrofolate reductase 0101
Solute carrier family 22 member 80102
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Multidrug resistance associated protein0102
Solute carrier organic anion transporter family member 1B30203
Solute carrier family 22 member 110001
Protein-arginine deiminase type-40101
PPM1D protein1001
Nuclear receptor subfamily 1 group I member 20033
Androgen receptor0303
Nuclear receptor subfamily 1 group I member 20011
Luciferase3003
Genome polyprotein 0101
NPC intracellular cholesterol transporter 1 precursor1001
Tubulin alpha-1A chain0012
Tubulin beta chain0011
Tubulin beta-4A chain0113
Receptor tyrosine-protein kinase erbB-20101
Integrin alpha-V 0101
Tubulin beta chain0113
60 kDa chaperonin0101
Tubulin alpha-3C chain0113
Botulinum neurotoxin type A 0101
Apoptosis regulator Bcl-20101
60 kDa heat shock protein, mitochondrial0101
UDP-glucuronosyltransferase 2B70102
UDP-glucuronosyltransferase 1-60101
ATP-dependent translocase ABCB10101
Substance-K receptor0202
UDP-glucuronosyltransferase 1A1 0101
UDP-glucuronosyltransferase 1A40102
Serum paraoxonase/arylesterase 10101
Cholecystokinin receptor type A0314
Melanocortin receptor 50202
UDP-glucuronosyltransferase 2B10 0101
Delta-type opioid receptor0314
10 kDa heat shock protein, mitochondrial0101
Tubulin alpha-1B chain0113
Tubulin alpha-4A chain0113
Tubulin beta-4B chain0113
Bcl-2-like protein 10101
Tyrosine-protein kinase Mer0112
Tubulin beta-3 chain0214
Tubulin beta-2A chain0113
Thiosulfate sulfurtransferase0101
Beta-tubulin 0101
Tubulin beta-8 chain0113
60 kDa chaperonin 0101
Tubulin beta-2B chain0013
Tubulin alpha-3E chain0113
Tubulin alpha-1A chain0113
10 kDa chaperonin 0101
Similar to alpha-tubulin isoform 1 0013
Similar to alpha-tubulin isoform 1 0002
Tubulin alpha-1C chain0113
Tubulin beta-6 chain0113
Tubulin beta-2B chain0113
Tubulin beta-1 chain0113
Nucleotide-binding oligomerization domain-containing protein 20101
Solute carrier organic anion transporter family member 1B10404
luciferase0001
Estrogen receptor0202
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Androgen receptor0202
Cytochrome P450 2C9 0404
Glutamine synthetase0011
Histamine H1 receptor0011
Nociceptin receptor0011
Cytochrome P450 2J20303
Estrogen receptor beta0202
arylsulfatase A2002
Voltage-dependent L-type calcium channel subunit alpha-1C0101
5-hydroxytryptamine receptor 40202
Albumin0112
Cytochrome P450 1A20101
Muscarinic acetylcholine receptor M20112
5-hydroxytryptamine receptor 1A0101
Alpha-2A adrenergic receptor0326
Adenosine receptor A30112
Beta-2 adrenergic receptor0203
Cytochrome P450 2C80202
Cytochrome P450 2D60202
Muscarinic acetylcholine receptor M10112
D(2) dopamine receptor0112
Alpha-1B adrenergic receptor0112
Alpha-2B adrenergic receptor0214
Beta-1 adrenergic receptor0214
Alpha-2C adrenergic receptor0326
D(3) dopamine receptor0101
Alpha-2B adrenergic receptor0011
Muscarinic acetylcholine receptor M30112
D(1A) dopamine receptor0112
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Alpha-2C adrenergic receptor0011
Alpha-2A adrenergic receptor0011
Alpha-1D adrenergic receptor0112
Endothelin-1 receptor0112
Beta-3 adrenergic receptor0202
5-hydroxytryptamine receptor 1B0213
5-hydroxytryptamine receptor 2A0213
5-hydroxytryptamine receptor 2C0213
5-hydroxytryptamine receptor 1B0202
Adenosine receptor A2a0112
Neuromedin-K receptor0011
Type-1 angiotensin II receptor0112
Sodium-dependent serotonin transporter0202
Cytochrome P450 2C190404
5-hydroxytryptamine receptor 70112
Beta-1 adrenergic receptor0101
Mu-type opioid receptor0112
Vasopressin V1a receptor0112
Kappa-type opioid receptor0112
5-hydroxytryptamine receptor 2B0213
Alpha-1A adrenergic receptor0112
5-hydroxytryptamine receptor 60213
5-hydroxytryptamine receptor 70101
Beta-2 adrenergic receptor0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Sodium/bile acid cotransporter0101
Nuclear receptor subfamily 2 group E member 10022
chaperonin-containing TCP-1 beta subunit homolog1001
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
Polyphenol oxidase 20102
Carbonic anhydrase 120101
5'-AMP-activated protein kinase subunit beta-20001
Polymerase acidic protein0011
Carbonic anhydrase 30101
Stromelysin-10011
Tyrosine-protein phosphatase YopH0101
Aldo-keto reductase family 1 member B10101
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Acetylcholinesterase0101
Carbonic anhydrase 40101
Carbonic anhydrase 60101
Cystathionine gamma-lyase0101
Carbonic anhydrase 5A, mitochondrial0101
Carbonic anhydrase 70101
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
Carbonic anhydrase 90101
Carbonic anhydrase0101
Solute carrier family 22 member 70001
Ubiquitin-like domain-containing CTD phosphatase 10101
Carbonic anhydrase 150101
Carbonic anhydrase 130101
5'-AMP-activated protein kinase subunit gamma-30001
Carbonic anhydrase 140101
Carbonic anhydrase 5B, mitochondrial0101
5'-AMP-activated protein kinase subunit beta-10001
Tyrosine-protein kinase JAK20011
Cyclin-dependent kinase-like 50011
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
Eukaryotic translation initiation factor 4E0011
Peptidyl-prolyl cis-trans isomerase FKBP1A0101
Serine/threonine-protein kinase receptor R30011
Alpha-synuclein1001
Peptidyl-prolyl cis-trans isomerase FKBP1A0426
Peptidyl-prolyl cis-trans isomerase FKBP1B0022
Protein kinase C zeta type0011
Cyclin-dependent kinase 180011
Peptidyl-prolyl cis-trans isomerase FKBP50202
Uncharacterized aarF domain-containing protein kinase 50011
Programmed cell death protein 40011
MAP kinase-activated protein kinase 50011
Misshapen-like kinase 10011
Calcium/calmodulin-dependent protein kinase type 1G0011
Serine/threonine-protein kinase mTOR 0101
Isoleucine--tRNA ligase, mitochondrial0011
Serine/threonine-protein kinase ICK0011
Dual specificity tyrosine-phosphorylation-regulated kinase 1B0011
Serine/threonine-protein kinase 240011
Cytochrome P450 3A50101
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0101
Splicing factor 3B subunit 30101
Cereblon isoform 40202
DNA-binding protein Ikaros0001
DNA damage-binding protein 10112
Protein cereblon0214
Cytochrome P450 2B60202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]