Compounds > pentyl gallate
Page last updated: 2024-12-08

pentyl gallate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

pentyl gallate: food and pharmaceutical antioxidant with ability of electron-donating; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID487559
CHEMBL ID494006
SCHEMBL ID505480
MeSH IDM0295602

Synonyms (8)

Synonym
amyl gallate
pentyl gallate
pentyl 3,4,5-trihydroxybenzoate
CHEMBL494006
benzoic acid, 3,4,5-trihydroxy-, pentyl ester
4568-93-8
SCHEMBL505480
DTXSID10333159

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" PG low aqueous solubility represents a major drawback to its incorporation in topical dosage forms."( Pentyl Gallate Nanoemulsions as Potential Topical Treatment of Herpes Labialis.
Colombo, M; Dall Agnol, D; De Araújo Lopes, SC; Kelmann, RG; Koester, LS; Nunes, RJ; Oliveira Simões, CM; Pistore, M; Rigotto, C; Roman, SS; Silva, IT; Teixeira, HF, 2016)		1.88
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (29)

Assay IDTitleYearJournalArticle
AID417965Antimicrobial activity against Aspergillus niger after 48 hrs by broth microdilution technique2009Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6
Relation between lipophilicity of alkyl gallates and antifungal activity against yeasts and filamentous fungi.
AID417960Antifungal activity against Candida tropicalis after 48 hrs by broth microdilution technique2009Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6
Relation between lipophilicity of alkyl gallates and antifungal activity against yeasts and filamentous fungi.
AID1197620Antiviral activity against HIV1 3B infected in human CEM cells assessed as reduction in virus-induced cytopathicity after 4 to 5 days by microscopy based syncytium cell formation assay2015European journal of medicinal chemistry, Mar-06, Volume: 92Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors.
AID1197623Antiviral activity against HCV genotype 1b I389luc-ubi-neo/NS3-3'/5.1 replicons infected in human Huh5-2 HCV subgenomic replicon-containing cells assessed as reduction in virus replication after 3 days by luciferase reporter gene assay2015European journal of medicinal chemistry, Mar-06, Volume: 92Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors.
AID1197649Antiviral activity against chikungunya virus2015European journal of medicinal chemistry, Mar-06, Volume: 92Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors.
AID417968Antimicrobial activity against Trichophyton rubrum after 48 hrs by broth microdilution technique2009Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6
Relation between lipophilicity of alkyl gallates and antifungal activity against yeasts and filamentous fungi.
AID1197637Antiviral activity against vaccinia virus2015European journal of medicinal chemistry, Mar-06, Volume: 92Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors.
AID1197646Antiviral activity against punta toro virus2015European journal of medicinal chemistry, Mar-06, Volume: 92Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors.
AID417969Antimicrobial activity against Trichophyton mentagrophytes after 48 hrs by broth microdilution technique2009Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6
Relation between lipophilicity of alkyl gallates and antifungal activity against yeasts and filamentous fungi.
AID1197645Antiviral activity against influenza A virus (H1N1)2015European journal of medicinal chemistry, Mar-06, Volume: 92Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors.
AID417963Antimicrobial activity against Aspergillus fumigatus after 48 hrs by broth microdilution technique2009Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6
Relation between lipophilicity of alkyl gallates and antifungal activity against yeasts and filamentous fungi.
AID1197643Antiviral activity against sindbis virus2015European journal of medicinal chemistry, Mar-06, Volume: 92Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors.
AID417959Antifungal activity against Candida albicans after 48 hrs by broth microdilution technique2009Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6
Relation between lipophilicity of alkyl gallates and antifungal activity against yeasts and filamentous fungi.
AID1197621Antiviral activity against HIV2 ROD infected in human CEM cells assessed as reduction in virus-induced cytopathicity after 4 to 5 days by microscopy based syncytium cell formation assay2015European journal of medicinal chemistry, Mar-06, Volume: 92Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors.
AID1197647Antiviral activity against feline coronavirus2015European journal of medicinal chemistry, Mar-06, Volume: 92Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors.
AID417964Antimicrobial activity against Aspergillus flavus after 48 hrs by broth microdilution technique2009Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6
Relation between lipophilicity of alkyl gallates and antifungal activity against yeasts and filamentous fungi.
AID1197642Antiviral activity against reovirus2015European journal of medicinal chemistry, Mar-06, Volume: 92Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors.
AID1197648Antiviral activity against feline herpesvirus2015European journal of medicinal chemistry, Mar-06, Volume: 92Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors.
AID1197644Antiviral activity against influenza A virus H3N22015European journal of medicinal chemistry, Mar-06, Volume: 92Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors.
AID1197622Cytotoxicity against human CEM cells assessed as inhibition of cell proliferation2015European journal of medicinal chemistry, Mar-06, Volume: 92Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors.
AID417961Antifungal activity against Saccharomyces cerevisiae after 48 hrs by broth microdilution technique2009Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6
Relation between lipophilicity of alkyl gallates and antifungal activity against yeasts and filamentous fungi.
AID417966Antimicrobial activity against Microsporum gypseum after 48 hrs by broth microdilution technique2009Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6
Relation between lipophilicity of alkyl gallates and antifungal activity against yeasts and filamentous fungi.
AID1197638Antiviral activity against vesicular stomatitis virus2015European journal of medicinal chemistry, Mar-06, Volume: 92Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors.
AID417962Antifungal activity against Cryptococcus neoformans after 48 hrs by broth microdilution technique2009Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6
Relation between lipophilicity of alkyl gallates and antifungal activity against yeasts and filamentous fungi.
AID1197641Antiviral activity against human parainfluenza virus 32015European journal of medicinal chemistry, Mar-06, Volume: 92Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors.
AID1197624Cytotoxicity against human Huh5-2 cells after 72 hrs by MTS assay2015European journal of medicinal chemistry, Mar-06, Volume: 92Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors.
AID417967Antimicrobial activity against Epidermophyton floccosum after 48 hrs by broth microdilution technique2009Bioorganic & medicinal chemistry letters, Mar-15, Volume: 19, Issue:6
Relation between lipophilicity of alkyl gallates and antifungal activity against yeasts and filamentous fungi.
AID1197640Antiviral activity against RSV2015European journal of medicinal chemistry, Mar-06, Volume: 92Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors.
AID1197639Antiviral activity against human coxsackievirus B42015European journal of medicinal chemistry, Mar-06, Volume: 92Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (12.50)18.2507
2000's3 (37.50)29.6817
2010's3 (37.50)24.3611
2020's1 (12.50)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.68

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.68 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.88 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.68)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
gallic acid
gallate : A trihydroxybenzoate that is the conjugate base of gallic acid.		3.5780trihydroxybenzoic acidantineoplastic agent;
antioxidant;
apoptosis inducer;
astringent;
cyclooxygenase 2 inhibitor;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
geroprotector;
human xenobiotic metabolite;
plant metabolite
pyrogallol
benzenetriol : A triol in which three hydroxy groups are substituted onto a benzene ring.		2.0510benzenetriol;
phenolic donor		plant metabolite
ketoconazole
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.		2.0510dichlorobenzene;
dioxolane;
ether;
imidazoles;
N-acylpiperazine;
N-arylpiperazine
propyl gallate
Propyl Gallate: Antioxidant for foods, fats, oils, ethers, emulsions, waxes, and transformer oils.		2.4220trihydroxybenzoic acid
methyl gallate
methyl gallate: has both immunosuppressive and phytogenic antineoplastic activities; isolated from Acer saccharinum. methyl 3,4,5-trihydroxybenzoate : A gallate ester obtained by the formal condensation of gallic acid with methanol. It exhibits anti-oxidant, anti-tumor, anti-microbial and anti-inflammatory properties.		2.5220gallate esteranti-inflammatory agent;
antioxidant;
plant metabolite
3,4,5-trimethoxybenzoic acid
3,4,5-trimethoxybenzoic acid: RN given refers to parent cpd; structure. 3,4,5-trimethoxybenzoic acid : A benzoic acid derivative carrying 3-, 4- and 5-methoxy substituents.		2.0510benzoic acids;
methoxybenzenes		human urinary metabolite;
human xenobiotic metabolite;
plant metabolite
ethyl gallate
ethyl gallate: used with osmium in procedure for mapping neuronal pathways. ethyl gallate : A gallate ester obtained by the formal condensation of gallic acid with ethanol.		2.830gallate esterplant metabolite
n-butyl gallate
[no description available]		2.7330
lauryl gallate
[no description available]		2.4820gallate ester
octyl gallate
[no description available]		2.4820gallate esterfood antioxidant;
hypoglycemic agent;
plant metabolite
glucose, (beta-d)-isomer
beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.		2.3110D-glucopyranoseepitope;
mouse metabolite
corilagin
corilagin: isolated from Geranii herba. corilagin : An ellagitannin with a hexahydroxydiphenoyl group bridging over the 3-O and 6-O of the glucose core.		2.3110ellagitannin;
gallate ester		antihypertensive agent;
antioxidant;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor;
non-steroidal anti-inflammatory drug
nonyl gallate
[no description available]		2.0510
tenofovir
tenofovir (anhydrous) : A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens is replaced by a [(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(isopropyloxycarbonyloxymethyl) ester (disoproxil ester) prodrug is used as the fumaric acid salt in combination therapy for the treatment of HIV infection.		2.1110nucleoside analogue;
phosphonic acids		antiviral drug;
drug metabolite;
HIV-1 reverse transcriptase inhibitor
terbinafine
[no description available]		2.0510acetylenic compound;
allylamine antifungal drug;
enyne;
naphthalenes;
tertiary amine		EC 1.14.13.132 (squalene monooxygenase) inhibitor;
P450 inhibitor;
sterol biosynthesis inhibitor
telaprevir
[no description available]		2.1110cyclopentapyrrole;
cyclopropanes;
oligopeptide;
pyrazines		antiviral drug;
hepatitis C protease inhibitor;
peptidomimetic
amphotericin b
Amphotericin B: Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.. amphotericin B : A macrolide antibiotic used to treat potentially life-threatening fungal infections.		2.0510antibiotic antifungal drug;
macrolide antibiotic;
polyene antibiotic		antiamoebic agent;
antiprotozoal drug;
bacterial metabolite
pradimicin a
pradimicin A: from actinomycete strain No. P157-2; has inhibitory effect against HIV in vitro; structure given in first source. pradimicin A : A member of the class of pradimicins that is isolated from the cultured broth of Actinomadura hibisca No. P157-2 (ATCC 53557).		2.1110aromatic ether;
carboxylic acid;
disaccharide derivative;
L-alanine derivative;
p-quinones;
polyphenol;
pradimicin;
secondary alcohol
ConditionIndicatedRelationship StrengthStudiesTrials
HIV
Human immunodeficiency virus. A non-taxonomic and historical term referring to any of two species, specifically HIV-1 and/or HIV-2. Prior to 1986, this was called human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). From 1986-1990, it was an official species called HIV. Since 1991, HIV was no longer considered an official species name; the two species were designated HIV-1 and HIV-2.		02.1110
Cold Sore
[description not available]		02.1310
Dermatoses
[description not available]		02.1310
Herpes Labialis
Herpes simplex, caused by type 1 virus, primarily spread by oral secretions and usually occurring as a concomitant of fever. It may also develop in the absence of fever or prior illness. It commonly involves the facial region, especially the lips and the nares. (Dorland, 27th ed.)		07.1310
Skin Diseases
Diseases involving the DERMIS or EPIDERMIS.		02.1310