Page last updated: 2024-09-27

Chronic Paroxysmal Hemicrania

A primary headache disorder that is similar to the CLUSTER HEADACHE with unilateral head pain, but differs by its multiple short severe attacks. It is usually seen in females, and may be responsive to non-steroidal-anti-inflammatory drugs (NSAIDS).

Synonyms(3)

Synonym
Paroxysmal Hemicrania
Episodic Paroxysmal Hemicrania
Chronic Paroxysmal Hemicrania

Research Excerpts

Overview

ExcerptReference
"Paroxysmal hemicrania is a rare syndrome characterized by repeated attacks of strictly unilateral, severe, short-lasting pain occurring with cranial autonomic features."( Cittadini, E; Goadsby, PJ; Matharu, MS, 2008)
"Paroxysmal hemicrania is experienced as headache attacks with pain and accompanying symptoms similar to those of cluster headaches."( Göbel, C; Göbel, H; Heinze, A, 2011)

Context

ExcerptReference
"Paroxysmal hemicrania has not been associated with ipsilateral weakness, loss of sensation and Horner's syndrome."( Koh, YH; Suantio, AM; Tan, BH, 2020)
"Paroxysmal hemicrania has joined the list of stroke chameleons and that it would be one of the differentials in a patient with hemiplegia, hemisensory loss, autonomic signs and severe headache."( Koh, YH; Suantio, AM; Tan, BH, 2020)

Treatment

ExcerptReference
"After 10 months, chronic paroxysmal hemicrania was diagnosed because of the typical symptoms along with a favorable response to indomethacin therapy."( Koch, K; Kolk, A; Talvik, I; Talvik, T, 2006)
"The first patient with chronic paroxysmal hemicrania has been followed for 45 years, and for 33 years with indomethacin treatment."( Sjaastad, O, 2006)

Research

Studies (67)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's24 (35.82)18.1394
2010's35 (52.24)28.8240
2020's8 (11.94)9.53
DrugIndicatedRelationship StrengthStudiesTrials
gamma-aminobutyric acid0low20
salicylic acid0medium21
acetaminophen0low10
amitriptyline0low10
bupivacaine0low10
verapamil0low20
celecoxib0low10
gabapentin0low20
ibuprofen0medium11
lidocaine0low40
indomethacin0medium593
lamotrigine0low30
nitroglycerin0low20
rofecoxib0low20
sumatriptan0low30
prednisolone0low10
methylprednisolone0low10
methysergide0low10
betamethasone0low10
propiconazole0low20
cabergoline0low10
zolmitriptan0low10
oxazolidin-2-one0low10
tadalafil0low10
D-fructopyranose0low40
topiramate0low40
ergoline0low10

Protein Targets (638)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
RAR-related orphan receptor gamma7007
ATAD5 protein, partial2002
GLS protein5005
Microtubule-associated protein tau3003
Smad32002
aldehyde dehydrogenase 1 family, member A16006
thyroid stimulating hormone receptor5005
nuclear receptor subfamily 1, group I, member 36006
progesterone receptor8008
EWS/FLI fusion protein8008
retinoic acid nuclear receptor alpha variant 16006
retinoid X nuclear receptor alpha8008
estrogen-related nuclear receptor alpha110011
estrogen nuclear receptor alpha140014
peroxisome proliferator activated receptor gamma6006
aryl hydrocarbon receptor8008
chromobox protein homolog 18008
thyroid hormone receptor beta isoform 28008
peripheral myelin protein 223003
cytochrome P450 3A4 isoform 13003
Gamma-aminobutyric acid receptor subunit pi3216
ATP-binding cassette sub-family C member 3017017
Multidrug resistance-associated protein 4017017
Solute carrier family 22 member 60404
Carbonic anhydrase 120405
UDP-glucuronosyltransferase 1A90001
Bile salt export pump0505
Voltage-dependent calcium channel gamma-2 subunit6006
Bile salt export pump021021
Cytochrome P450 2B10001
Cytochrome P450 1A10001
Carbonic anhydrase 10708
Carbonic anhydrase 20719
Myoglobin0101
Cytochrome P450 1A10012
Cytochrome P450 1A20001
Prostaglandin G/H synthase 10708
Carbonic anhydrase 30404
Cytochrome P450 3A40404
Cytochrome P450 2D60303
Cytochrome P450 2C9 0808
Polyunsaturated fatty acid lipoxygenase ALOX150101
Gamma-aminobutyric acid receptor subunit beta-13216
Sulfotransferase 1A1 0001
Gamma-aminobutyric acid receptor subunit delta3216
Gamma-aminobutyric acid receptor subunit gamma-23227
UDP-glucuronosyltransferase 1-60001
Glutamate receptor 26006
Gamma-aminobutyric acid receptor subunit alpha-53216
Gamma-aminobutyric acid receptor subunit alpha-33216
Arachidonate 5-lipoxygenase-activating protein0202
UDP-glucuronosyltransferase 1A1 0001
Carbonic anhydrase 40405
Prostaglandin G/H synthase 10607
Carbonic anhydrase 60405
Gamma-aminobutyric acid receptor subunit gamma-13216
Gamma-aminobutyric acid receptor subunit alpha-23216
Gamma-aminobutyric acid receptor subunit alpha-43216
Gamma-aminobutyric acid receptor subunit gamma-33216
Gamma-aminobutyric acid receptor subunit alpha-63216
Carbonic anhydrase 5A, mitochondrial0416
Prostaglandin G/H synthase 208212
Carbonic anhydrase 70405
Nuclear receptor ROR-gamma3003
Cytochrome P450 2J20606
Gamma-aminobutyric acid receptor subunit alpha-13429
Gamma-aminobutyric acid receptor subunit beta-33216
Gamma-aminobutyric acid receptor subunit beta-23227
Carbonic anhydrase 90506
GABA theta subunit3216
Canalicular multispecific organic anion transporter 1017017
Carbonic anhydrase 150404
Carbonic anhydrase 130304
Gamma-aminobutyric acid receptor subunit epsilon3216
Carbonic anhydrase 140405
Carbonic anhydrase 5B, mitochondrial0405
toxin B0001
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
thioredoxin reductase7007
USP1 protein, partial7007
NFKB1 protein, partial2002
cytochrome P450 family 3 subfamily A polypeptide 49009
cytochrome P450 2D66006
arylsulfatase A4004
cytochrome P450 2D6 isoform 13003
D(1A) dopamine receptor4004
atrial natriuretic peptide receptor 2 precursor1001
serine/threonine-protein kinase mTOR isoform 12002
nuclear factor erythroid 2-related factor 2 isoform 16006
muscarinic acetylcholine receptor M14004
Solute carrier family 22 member 1 0304
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
Voltage-dependent L-type calcium channel subunit alpha-1F0213
5-hydroxytryptamine receptor 40606
Albumin0033
High affinity nerve growth factor receptor0123
Aldo-keto reductase family 1 member B10404
Muscarinic acetylcholine receptor M20202
Muscarinic acetylcholine receptor M40202
Muscarinic acetylcholine receptor M10101
Muscarinic acetylcholine receptor M30101
Muscarinic acetylcholine receptor M40101
5-hydroxytryptamine receptor 2C0202
Muscarinic acetylcholine receptor M50101
Muscarinic acetylcholine receptor M50202
Alpha-2A adrenergic receptor0606
Muscarinic acetylcholine receptor M20101
Muscarinic acetylcholine receptor M10202
Angiotensin-converting enzyme0202
D(2) dopamine receptor0505
5-hydroxytryptamine receptor 2A0202
Alpha-2B adrenergic receptor0606
Alpha-2C adrenergic receptor0202
5-hydroxytryptamine receptor 1A010212
Muscarinic acetylcholine receptor M30202
D(1A) dopamine receptor0606
D(1B) dopamine receptor0101
UDP-glucuronosyltransferase 1A40001
Sodium-dependent noradrenaline transporter 0404
Histamine H2 receptor0404
Alpha-1D adrenergic receptor0202
5-hydroxytryptamine receptor 2A0808
5-hydroxytryptamine receptor 2C0707
5-hydroxytryptamine receptor 1B0808
5-hydroxytryptamine receptor 1D0213
5-hydroxytryptamine receptor 1F0101
5-hydroxytryptamine receptor 2B0101
5-hydroxytryptamine receptor 60101
Histamine H1 receptor0101
Sodium-dependent serotonin transporter0606
5-hydroxytryptamine receptor 7 0101
5-hydroxytryptamine receptor 5A0101
5-hydroxytryptamine receptor 5B0101
Histamine H1 receptor0202
D(3) dopamine receptor0606
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 4 subunit alpha0406
UDP-glucuronosyltransferase 1A30002
5-hydroxytryptamine receptor 3A0202
5-hydroxytryptamine receptor 2B0718
Alpha-1A adrenergic receptor0404
Histamine H2 receptor3105
D(1A) dopamine receptor1001
5-hydroxytryptamine receptor 60404
5-hydroxytryptamine receptor 70202
Voltage-dependent N-type calcium channel subunit alpha-1B0101
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0213
Sodium-dependent dopamine transporter 0404
Potassium voltage-gated channel subfamily H member 20808
Voltage-dependent L-type calcium channel subunit alpha-1S0213
Voltage-dependent L-type calcium channel subunit alpha-1C0415
Sodium channel protein type 5 subunit alpha0505
Sodium channel protein type 9 subunit alpha0505
Sigma non-opioid intracellular receptor 10011
5-hydroxytryptamine receptor 4 0101
Nuclear receptor subfamily 3 group C member 3 0202
Sodium channel protein type 2 subunit alpha0202
Ataxin-26006
Sigma non-opioid intracellular receptor 10202
5-hydroxytryptamine receptor 3B0202
Sodium channel protein type 3 subunit alpha0303
Sodium channel protein type 11 subunit alpha0101
Sodium channel protein type 8 subunit alpha0101
Histamine H3 receptor0202
Sodium channel protein type 10 subunit alpha0202
pregnane X receptor3003
GLI family zinc finger 36006
AR protein130013
glucocorticoid receptor [Homo sapiens]100010
farnesoid X nuclear receptor4004
pregnane X nuclear receptor110011
vitamin D (1,25- dihydroxyvitamin D3) receptor5005
IDH16006
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a6006
nuclear receptor subfamily 1, group I, member 23003
thyroid hormone receptor beta isoform a6006
nuclear factor erythroid 2-related factor 2 isoform 26006
galanin receptor type 30101
Glucocorticoid receptor06112
Glycine receptor subunit alpha-10606
Glycine receptor subunit beta0606
Glycine receptor subunit alpha-20606
Glycine receptor subunit alpha-30606
ORF730011
Potassium channel subfamily K member 30202
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 20112
Potassium channel subfamily K member 90101
acetylcholinesterase5005
thyroid stimulating hormone receptor3003
Cellular tumor antigen p537007
Spike glycoprotein6006
Chain A, Beta-lactamase5005
TDP1 protein7007
euchromatic histone-lysine N-methyltransferase 2100010
mitogen-activated protein kinase 14004
geminin9009
Vpr2002
lamin isoform A-delta108008
Major prion protein0011
Sodium channel protein type 1 subunit alpha0303
Sodium channel protein type 2 subunit alpha0404
Sodium channel protein type 3 subunit alpha0303
UDP-glucuronosyltransferase 2B70002
Cytochrome P450 2B60011
Frizzled-80011
P2X purinoceptor 40101
Chain A, Carbonic anhydrase II0101
Chain A, Cruzipain3003
Carbonic anhydrase 0002
Carbonic anhydrase 0202
GTP-binding protein (rab7)0011
ras protein, partial0011
glp-1 receptor, partial3003
hypoxia-inducible factor 1 alpha subunit4004
SMAD family member 23003
PPM1D protein2002
SMAD family member 33003
caspase 7, apoptosis-related cysteine protease1001
estrogen receptor 2 (ER beta)4004
G6006
Carbonic anhydrase 0202
Carbonic anhydrase 0202
67.9K protein3003
peroxisome proliferator-activated receptor delta3003
Carbonic anhydrase0202
Rac1 protein0011
caspase-31001
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
activating transcription factor 62002
thyrotropin-releasing hormone receptor1001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
v-jun sarcoma virus 17 oncogene homolog (avian)3003
Histone H2A.x1001
Caspase-71001
interferon gamma precursor0001
prostaglandin E2 receptor EP2 subtype0001
potassium voltage-gated channel subfamily H member 2 isoform d3003
caspase-31001
heat shock protein beta-12002
Prostaglandin E synthase0202
Histone deacetylase 30202
3-phosphoinositide-dependent protein kinase 10101
Prostaglandin G/H synthase 1 0304
Prostaglandin G/H synthase 2 0405
cGMP-specific 3',5'-cyclic phosphodiesterase0314
Cytochrome c oxidase subunit 10101
Cytochrome c oxidase subunit 20101
Catechol O-methyltransferase0101
Cytochrome c oxidase subunit 20303
Interferon beta7007
HLA class I histocompatibility antigen, B alpha chain 6006
Procathepsin L0202
Seed linoleate 13S-lipoxygenase-10202
Neuronal acetylcholine receptor subunit alpha-40202
Polyunsaturated fatty acid 5-lipoxygenase0303
Quinolone resistance protein NorA0101
Adenosine receptor A30202
Neuronal acetylcholine receptor subunit beta-20202
Beta-3 adrenergic receptor0213
Alpha-1B adrenergic receptor0303
Calpain-2 catalytic subunit0202
Prostaglandin G/H synthase 10404
Adenosine receptor A10303
Cruzipain0101
Sodium/hydrogen exchanger 10101
Indoleamine 2,3-dioxygenase 10202
Sodium-dependent serotonin transporter0011
Delta-type opioid receptor0303
Delta-type opioid receptor0202
Mu-type opioid receptor0303
Bifunctional epoxide hydrolase 20303
Prostaglandin G/H synthase 2 0405
Carbonic anhydrase0202
Urotensin-2 receptor0101
Carbonic anhydrase0202
Histone deacetylase 40202
Ras-related protein Rab-2A0011
D(2) dopamine receptor0404
Prostaglandin G/H synthase 20707
Carbonic anhydrase 0202
Mu-type opioid receptor0505
Beta-carbonic anhydrase 10202
Carbonic anhydrase 20202
Prostaglandin G/H synthase 20405
Histone deacetylase 10202
Mitogen-activated protein kinase 140101
Carbonic anhydrase, alpha family 0202
Carbonic anhydrase 0202
Carbonic anhydrase0202
Carbonic anhydrase0202
Carbonic anhydrase 0202
Sigma intracellular receptor 20202
Delta carbonic anhydrase0202
Prostaglandin G/H synthase 1 0405
Carbonic anhydrase 0202
Prostaglandin G/H synthase 10101
Carbonic anhydrase 130202
Cyclooxygenase-2 0101
Histone deacetylase 70202
Rap guanine nucleotide exchange factor 42002
Inositol hexakisphosphate kinase 16006
Histone deacetylase 20202
Carbonic anhydrase 40404
Polyamine deacetylase HDAC100202
Histone deacetylase 11 0202
ATPase family AAA domain-containing protein 54004
Histone deacetylase 80202
P2Y purinoceptor 120202
Histone deacetylase 60202
Histone deacetylase 90202
Histone deacetylase 50202
cytochrome P450 2C9, partial6006
thioredoxin glutathione reductase1001
regulator of G-protein signaling 44004
Bloom syndrome protein isoform 13003
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
survival motor neuron protein isoform d2002
Voltage-dependent calcium channel subunit alpha-2/delta-10101
ATP-dependent phosphofructokinase2002
Chain A, Ferritin light chain2002
Gamma-aminobutyric acid 0011
Gamma-aminobutyric acid receptor subunit rho-30011
Hsf1 protein0011
bromodomain adjacent to zinc finger domain 2B3003
transcriptional regulator ERG isoform 32002
histone-lysine N-methyltransferase 2A isoform 2 precursor2002
histone acetyltransferase KAT2A isoform 13003
neuropeptide S receptor isoform A2002
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit delta0101
Gamma-aminobutyric acid type B receptor subunit 20011
Gamma-aminobutyric acid type B receptor subunit 20101
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit alpha-60011
Gamma-aminobutyric acid receptor subunit beta-10112
Gamma-aminobutyric acid receptor subunit gamma-20112
Gamma-aminobutyric acid receptor subunit gamma-20011
Gamma-aminobutyric acid receptor subunit delta0011
Sodium- and chloride-dependent GABA transporter 10202
Gamma-aminobutyric acid receptor subunit rho-10022
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit alpha-30011
Gamma-aminobutyric acid receptor subunit gamma-30011
Gamma-aminobutyric acid receptor subunit beta-30112
Gamma-aminobutyric acid receptor subunit rho-20011
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent taurine transporter0101
Gamma-aminobutyric acid receptor subunit alpha-50112
Sodium- and chloride-dependent GABA transporter 20202
Sodium- and chloride-dependent GABA transporter 30202
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-30112
Gamma-aminobutyric acid receptor subunit alpha-20112
Gamma-aminobutyric acid receptor subunit beta-20112
Sodium- and chloride-dependent betaine transporter0202
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-40112
Gamma-aminobutyric acid receptor subunit beta-10011
Gamma-aminobutyric acid receptor subunit alpha-10011
Gamma-aminobutyric acid receptor subunit beta-30011
Gamma-aminobutyric acid receptor subunit epsilon0101
4-aminobutyrate aminotransferase, mitochondrial0001
4-aminobutyrate aminotransferase, mitochondrial0001
TAR DNA-binding protein 433003
Gamma-aminobutyric acid receptor subunit alpha-60112
Sterol O-acyltransferase 10011
Proton-coupled amino acid transporter 10101
Gamma-aminobutyric acid receptor subunit alpha-50011
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit pi0011
Gamma-aminobutyric acid receptor subunit gamma-30101
Gamma-aminobutyric acid receptor subunit alpha-40011
Platelet glycoprotein VI0011
Gamma-aminobutyric acid receptor subunit theta0011
Sodium- and chloride-dependent GABA transporter 20101
Gamma-aminobutyric acid receptor subunit gamma-10011
Gamma-aminobutyric acid type B receptor subunit 10011
Gamma-aminobutyric acid receptor subunit theta0101
Gamma-aminobutyric acid type B receptor subunit 10101
Luciferase2002
nonstructural protein 13003
importin subunit beta-1 isoform 12002
snurportin-12002
DNA polymerase kappa isoform 12002
muscleblind-like protein 1 isoform 12002
Acid-sensing ion channel 30101
Solute carrier organic anion transporter family member 1A40101
Dihydrofolate reductase0101
Epidermal growth factor receptor0202
Fatty acid-binding protein, liver0202
Albumin0336
Albumin0101
Cholinesterase0101
Fatty acid-binding protein, intestinal0101
Polyunsaturated fatty acid 5-lipoxygenase0204
Acetylcholinesterase0202
Caspase-10102
Adenosine receptor A2a0202
Substance-P receptor0202
Aldo-keto reductase family 1 member C30303
Caspase-30101
Solute carrier organic anion transporter family member 1A10101
Caspase-40101
4-aminobutyrate aminotransferase, mitochondrial0101
Caspase-50101
Caspase-90101
Acid-sensing ion channel 10101
Fatty-acid amide hydrolase 10101
Solute carrier family 22 member 60303
Solute carrier family 22 member 200202
Solute carrier family 22 member 80303
Solute carrier family 22 member 60202
Dehydrogenase/reductase SDR family member 90101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE6006
Chain A, membrane-associated prostaglandin E synthase-20101
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, 2-oxoglutarate Oxygenase2002
interleukin 81001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
glucocerebrosidase2002
Parkin1001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)2002
peripheral myelin protein 22 isoform 12002
cytochrome P450 2C9 precursor1001
vitamin D3 receptor isoform VDRA4004
ras-related protein Rab-9A1001
DNA polymerase iota isoform a (long)3003
nuclear receptor ROR-gamma isoform 12002
M-phase phosphoprotein 81001
Prostaglandin-H2 D-isomerase0101
3',5'-cyclic-AMP phosphodiesterase 0101
Solute carrier organic anion transporter family member 2B1 0202
Phospholipase A2, major isoenzyme0101
ATP-dependent translocase ABCB105115
Interleukin-80101
Androgen receptor0213
Aldo-keto reductase family 1 member B10202
Aldo-keto reductase family 1 member B10101
Aldo-keto reductase family 1 member C40101
Sodium-dependent dopamine transporter0101
Thromboxane-A synthase 0101
Serum paraoxonase/arylesterase 10101
Nitric oxide synthase, inducible0101
Prostaglandin E2 receptor EP3 subtype0101
Prostaglandin E2 receptor EP4 subtype0101
Multidrug resistance-associated protein 1 0315
Prostaglandin E2 receptor EP1 subtype0101
Peroxisome proliferator-activated receptor gamma0011
C-X-C chemokine receptor type 30202
Aldo-keto reductase family 1 member C2 0101
Guanine nucleotide-binding protein G2002
Prostaglandin D2 receptor 0202
Solute carrier organic anion transporter family member 1A30101
Lactoylglutathione lyase0101
Aldo-keto reductase family 1 member C10101
Uracil nucleotide/cysteinyl leukotriene receptor0101
Solute carrier family 22 member 70002
Prostaglandin E2 receptor EP2 subtype0101
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0202
Multidrug and toxin extrusion protein 10303
Dehydrogenase/reductase SDR family member 90101
Solute carrier organic anion transporter family member 1B30202
Cytosolic phospholipase A2 gamma0101
Prostaglandin D2 receptor 20112
Solute carrier organic anion transporter family member 1B10404
GALC protein2002
Dihydrofolate reductase0202
Potassium voltage-gated channel subfamily E member 10202
Potassium voltage-gated channel subfamily KQT member 10202
Sigma non-opioid intracellular receptor 10101
flap endonuclease 12002
Potassium voltage-gated channel subfamily A member 50101
Potassium voltage-gated channel subfamily D member 20101
Potassium channel subfamily K member 180101
Nuclear receptor subfamily 1 group I member 20011
Androgen receptor0303
Nuclear receptor subfamily 1 group I member 20011
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
endonuclease IV1001
dopamine D1 receptor1001
DNA polymerase III, partial1001
alpha-galactosidase1001
hexokinase-4 isoform 11001
glucokinase regulatory protein1001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
Beta-1 adrenergic receptor 0011
Beta-2 adrenergic receptor0213
Beta-1 adrenergic receptor0213
Beta-1 adrenergic receptor0112
Beta-1 adrenergic receptor0101
Beta-2 adrenergic receptor0011
luciferase0001
Estrogen receptor0202
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Glutamine synthetase0011
Histamine H1 receptor0011
Nociceptin receptor0011
Estrogen receptor beta0202
phosphopantetheinyl transferase1001
heat shock protein HSP 90-alpha isoform 20001
heat shock protein 90, putative0001
inositol monophosphatase 11001
Prostaglandin G/H synthase 20101
Cytochrome c oxidase subunit 10101
Inositol monophosphatase 11001
Transporter0101
Sodium-dependent serotonin transporter0101
chaperonin-containing TCP-1 beta subunit homolog1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
Polyphenol oxidase 20102
5'-AMP-activated protein kinase subunit beta-20001
Polymerase acidic protein0011
Stromelysin-10011
Tyrosine-protein phosphatase YopH0101
High mobility group protein B10011
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Cystathionine gamma-lyase0101
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Carbonic anhydrase0101
Ubiquitin-like domain-containing CTD phosphatase 10101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
5'-AMP-activated protein kinase subunit beta-10001
5-hydroxytryptamine receptor 3E0101
5-hydroxytryptamine receptor 3B0101
5-hydroxytryptamine receptor 1A0314
Carboxypeptidase M0101
Alpha-1D adrenergic receptor0101
5-hydroxytryptamine receptor 1D0416
5-hydroxytryptamine receptor 1B0426
5-hydroxytryptamine receptor 1E0101
5-hydroxytryptamine receptor 1F0213
5-hydroxytryptamine receptor 70101
Alpha-1A adrenergic receptor0101
5-hydroxytryptamine receptor 3A0101
5-hydroxytryptamine receptor 5A0101
5-hydroxytryptamine receptor 1B0101
5-hydroxytryptamine receptor 1D0101
5-hydroxytryptamine receptor 1A0101
5-hydroxytryptamine receptor 3D0101
5-hydroxytryptamine receptor 3C0101
5-hydroxytryptamine receptor 1B0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
Chain B, cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase0101
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase0101
Phosphodiesterase 0101
GTP-binding nuclear protein Ran isoform 11001
cGMP-dependent 3',5'-cyclic phosphodiesterase0101
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta0101
cGMP-specific 3',5'-cyclic phosphodiesterase0112
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A0101
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A0101
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B0101
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma0101
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha0101
Cystic fibrosis transmembrane conductance regulator0011
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0101
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha0101
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'0101
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma0101
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma0101
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta0101
Acetylcholinesterase0101
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
Synaptic vesicular amine transporter0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase B0101
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A0101
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0101
cGMP-specific 3',5'-cyclic phosphodiesterase0101
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta0101
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A0101
cAMP-specific 3',5'-cyclic phosphodiesterase 7B0101
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A0101
Nuclear receptor subfamily 2 group E member 10011
Chain A, Carbonic anhydrase 10101
Carbonic anhydrase0101
Prolyl endopeptidase0101
Carbonic anhydrase-related protein 110001
Cytochrome P450 2C80202
Carbonic anhydrase 5A, mitochondrial0101
Carbonic anhydrase 20101
Cytochrome P450 2C190101
Glutamate receptor ionotropic, NMDA 2B0101
Neuronal acetylcholine receptor subunit alpha-70101
lysosomal alpha-glucosidase preproprotein1001
huntingtin isoform 21001
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Glycoprotein0101
Muscarinic acetylcholine receptor M20011
ATP-dependent translocase ABCB10101
ATP-dependent translocase ABCB10102
Catechol O-methyltransferase0101
Potassium voltage-gated channel subfamily A member 30101
Kappa-type opioid receptor0101
Chloroquine resistance transporter0101
Broad substrate specificity ATP-binding cassette transporter ABCG20112
Alpha-2B adrenergic receptor0011
Alpha-2C adrenergic receptor0011
Alpha-2A adrenergic receptor0011
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]