Adiposalgia

A rare disease characterized by multiple tumor-like fatty deposits that press on nerves in various sites causing pain and weakness. Often these lipoma-like structures are located on the trunk and limbs but not on the face and hands.

Synonym
Adiposalgia
Dercum's Disease
Dercum Disease
Adiposis Dolorosa
Decum-Vitaut Syndrome
Adipose Tissue Rheumatism
Morbus Dercum
Anders Syndrome
Lipomatosis Dolorosa
Ander's Syndrome

Excerpt	Reference
"Dercum's disease or adiposis dolorosa is a poorly understood disorder with painful fatty deposits in the skin localized to the lower extremities."	( Kastrup, J; Nørgaard, T; Petersen, P; Skagen, K, 1986)
"Dercum's disease (adiposis dolorosa) is associated with very painful subcutaneous fatty deposits normally localized to the lower extremities in which pain treatment is usually unsuccessful."	( Kastrup, J; Petersen, P, 1987)
"Adiposis dolorosa (Dercum's disease) is a syndrome of painful adipose tissue which occurs most often in post-menopausal women and is associated with obesity, asthenia, and emotional disturbances."	( Atkinson, RL, 1982)
"Adiposis dolorosa (Dercum's disease) is a rare fat-tissue malady most frequently presenting in middle-aged women as fatty lumps in the body."	( Pardal Refoyo, JL, 1996)
"Dercum's disease (adiposis dolorosa) is a rare condition characterized by progressively painful fatty deposits, usually, in menopausal women with obesity, asthenia and mental phenomena."	( O'Flynn, P; Reece, PH; Wyatt, M, 1999)
"Dercum's disease (lipomatosis dolorosa) is a relatively unknown illness."	( Heidenreich, F; Schiltz, K; Steiner, J; Weissenborn, K, 2002)
"Dercum's disease is a rare disorder characterized by multiple painful subcutaneous lipomas on the trunk and extremities."	( Desai, MJ; Siriki, R; Wang, D, 2008)
"Dercum's disease (adiposis dolorosa) is characterised by adiposity and chronic pain in the adipose tissue."	( Åberg, M; Brorson, H; Ekman, R; Fagher, B; Hansson, E; Manjer, J; Svensson, H, 2012)
"Dercum disease is a rare disorder of painful subcutaneous adipose tissue masses typically presenting as a constellation of signs and symptoms affecting most organs, including slow lymphatic flow and fatty liver."	( Bilal, J; Ghazala, S; Herbst, KL; Kalb, B; Riaz, IB; Ross, E, 2018)
"Dercum disease is a rare condition characterized by multiple painful fatty tumors distributed throughout the body."	( Al Jalbout, N; Al Saud, AA; Gao, J; Kourosh, AS; Liteplo, A; McFadden, K; Rice, SM; Silence, C, 2023)

Excerpt	Reference
"Two patients with Dercum's disease have been treated repeatedly with intravenous lidocaine for several months each time resulting in immediate pain relief for 8 and 25 days respectively."	( Kastrup, J; Petersen, P, 1987)

Excerpt	Reference
"This is the first reported case of adiposis dolorosa occurring as a complication of corticosteroid treatment."	( Greenbaum, SS; Varga, J, 1991)
"A 60-year-old woman with adiposis dolorosa for 20 years was treated with repeated intravenous infusions of lidocaine."	( Juhlin, L, 1986)
"Dercum's disease (adiposis dolorosa) is associated with very painful subcutaneous fatty deposits normally localized to the lower extremities in which pain treatment is usually unsuccessful."	( Kastrup, J; Petersen, P, 1987)
"A patient with Dercum's disease successfully treated with transdermal lidocaine 5% patches."	( Desai, MJ; Siriki, R; Wang, D, 2008)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	13 (30.95)	23.3326
1990's	8 (19.05)	12.5806
2000's	9 (21.43)	18.1394
2010's	11 (26.19)	28.8240
2020's	1 (2.38)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	low	1	0
salicylic acid	low	1	0
amitriptyline	low	4	0
baclofen	low	1	0
carbamazepine	low	1	0
clonidine	low	1	0
amphetamine	low	1	0
diclofenac	low	1	0
fentanyl	low	1	0
ibuprofen	low	1	0
lidocaine	medium	11	2
isoniazid	low	1	0
mechlorethamine	low	1	0
metformin	low	2	0
mexiletine	medium	4	1
prilocaine	low	1	0
tizanidine	low	1	0
urethane	low	2	0
prednisolone	low	1	0
prednisone	low	2	0
methylprednisolone acetate	low	1	0
methylprednisolone	low	1	0
streptomycin	low	1	0
substance p	low	1	0
xenon radioisotopes	low	1	0
methotrexate	low	1	0
deoxycholic acid	low	2	0
cortisone	low	1	0
pregabalin	low	1	0
psd 502	low	1	0
indocyanine green	medium	1	1
neuropeptide y	low	1	0
vasoactive intestinal peptide	low	1	0

Protein Targets (570)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, HADH2 protein	4	0	0	4
Chain B, HADH2 protein	4	0	0	4
thioredoxin reductase	7	0	0	7
USP1 protein, partial	5	0	0	5
NFKB1 protein, partial	3	0	0	3
GLS protein	5	0	0	5
cytochrome P450 family 3 subfamily A polypeptide 4	4	0	0	4
cytochrome P450 2D6	5	0	0	5
arylsulfatase A	6	0	0	6
cytochrome P450 2D6 isoform 1	3	0	0	3
D(1A) dopamine receptor	4	0	0	4
chromobox protein homolog 1	8	0	0	8
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	7	0	0	7
muscarinic acetylcholine receptor M1	4	0	0	4
Solute carrier family 22 member 1	0	5	0	6
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
ATP-binding cassette sub-family C member 3	0	12	0	12
Multidrug resistance-associated protein 4	0	12	0	13
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
5-hydroxytryptamine receptor 4	0	2	0	2
Bile salt export pump	0	18	0	18
Albumin	0	0	3	3
High affinity nerve growth factor receptor	0	1	2	3
Aldo-keto reductase family 1 member B1	0	2	0	2
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
5-hydroxytryptamine receptor 2C	0	3	1	5
Muscarinic acetylcholine receptor M5	0	1	0	1
Muscarinic acetylcholine receptor M5	0	2	0	2
Alpha-2A adrenergic receptor	0	4	2	6
Muscarinic acetylcholine receptor M2	0	1	0	1
Muscarinic acetylcholine receptor M1	0	2	0	2
Angiotensin-converting enzyme	0	2	0	2
D(2) dopamine receptor	0	3	0	3
5-hydroxytryptamine receptor 2A	0	3	1	4
Alpha-2B adrenergic receptor	0	4	1	5
Alpha-2C adrenergic receptor	0	4	2	6
5-hydroxytryptamine receptor 1A	0	5	1	6
Muscarinic acetylcholine receptor M3	0	2	0	2
D(1A) dopamine receptor	0	2	0	2
D(1B) dopamine receptor	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	2
Sodium-dependent noradrenaline transporter	0	4	0	4
Histamine H2 receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	4	1	5
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
5-hydroxytryptamine receptor 1B	0	5	1	6
5-hydroxytryptamine receptor 1D	0	2	1	3
5-hydroxytryptamine receptor 1F	0	2	1	3
5-hydroxytryptamine receptor 2B	0	2	1	3
5-hydroxytryptamine receptor 6	0	1	1	2
Histamine H1 receptor	0	1	0	1
Sodium-dependent serotonin transporter	0	2	0	2
5-hydroxytryptamine receptor 7	0	1	1	2
5-hydroxytryptamine receptor 5A	0	1	1	2
5-hydroxytryptamine receptor 5B	0	1	1	2
Histamine H1 receptor	0	3	0	3
D(3) dopamine receptor	0	3	0	3
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 4 subunit alpha	0	4	0	5
UDP-glucuronosyltransferase 1A3	0	0	0	3
5-hydroxytryptamine receptor 3A	0	1	1	2
5-hydroxytryptamine receptor 2B	0	4	0	4
Alpha-1A adrenergic receptor	0	2	1	3
Histamine H2 receptor	2	1	0	4
D(1A) dopamine receptor	1	0	0	1
5-hydroxytryptamine receptor 6	0	2	0	2
5-hydroxytryptamine receptor 7	0	2	0	2
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Sodium channel protein type 7 subunit alpha	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Sodium-dependent dopamine transporter	0	2	0	2
Potassium voltage-gated channel subfamily H member 2	0	6	0	6
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Sodium channel protein type 5 subunit alpha	0	3	0	3
Sodium channel protein type 9 subunit alpha	0	6	0	6
Sigma non-opioid intracellular receptor 1	0	3	1	4
5-hydroxytryptamine receptor 4	0	1	1	2
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Canalicular multispecific organic anion transporter 1	0	12	0	12
Sodium channel protein type 2 subunit alpha	0	2	0	2
Ataxin-2	4	0	0	4
Sigma non-opioid intracellular receptor 1	0	4	0	4
5-hydroxytryptamine receptor 3B	0	1	1	2
Sodium channel protein type 3 subunit alpha	0	3	0	3
Sodium channel protein type 11 subunit alpha	0	2	0	2
Sodium channel protein type 8 subunit alpha	0	2	0	2
Histamine H3 receptor	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	2	0	2
Solute carrier family 22 member 3	0	1	0	1
Phenylethanolamine N-methyltransferase	0	2	0	2
Cytochrome P450 2A6	0	2	0	2
Substance-P receptor	0	3	0	3
Cytochrome P450 2A5	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	2	0	2
phosphopantetheinyl transferase	3	0	0	3
ATAD5 protein, partial	4	0	0	4
GLI family zinc finger 3	6	0	0	6
AR protein	14	0	0	14
regulator of G-protein signaling 4	5	0	0	5
67.9K protein	4	0	0	4
euchromatic histone-lysine N-methyltransferase 2	12	0	0	12
activating transcription factor 6	2	0	0	2
Bloom syndrome protein isoform 1	3	0	0	3
cytochrome P450 3A4 isoform 1	4	0	0	4
histone acetyltransferase KAT2A isoform 1	6	0	0	6
lamin isoform A-delta10	9	0	0	9
Gamma-aminobutyric acid receptor subunit pi	4	2	0	6
Gamma-aminobutyric acid type B receptor subunit 2	0	2	2	4
Gamma-aminobutyric acid type B receptor subunit 2	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-1	4	2	0	6
Gamma-aminobutyric acid receptor subunit delta	4	2	0	6
Gamma-aminobutyric acid receptor subunit gamma-2	4	2	2	8
Gamma-aminobutyric acid receptor subunit alpha-5	4	2	0	6
Gamma-aminobutyric acid receptor subunit alpha-3	4	2	0	6
Gamma-aminobutyric acid receptor subunit gamma-1	4	2	0	6
Gamma-aminobutyric acid receptor subunit alpha-2	4	2	0	6
Gamma-aminobutyric acid receptor subunit alpha-4	4	2	0	6
Gamma-aminobutyric acid receptor subunit gamma-3	4	2	0	6
Gamma-aminobutyric acid receptor subunit alpha-6	4	2	0	6
Gamma-aminobutyric acid receptor subunit alpha-1	4	2	2	8
Gamma-aminobutyric acid receptor subunit beta-3	4	2	0	6
Gamma-aminobutyric acid receptor subunit beta-2	4	2	2	8
GABA theta subunit	4	2	0	6
Gamma-aminobutyric acid receptor subunit epsilon	4	2	0	6
Gamma-aminobutyric acid type B receptor subunit 1	0	2	2	4
Gamma-aminobutyric acid type B receptor subunit 1	0	2	0	2
ATP-dependent phosphofructokinase	5	0	0	5
Chain A, Beta-lactamase	2	0	0	2
acetylcholinesterase	3	0	0	3
RAR-related orphan receptor gamma	6	0	0	6
TDP1 protein	10	0	0	10
thyroid stimulating hormone receptor	2	0	0	2
glucocorticoid receptor [Homo sapiens]	8	0	0	8
retinoic acid nuclear receptor alpha variant 1	7	0	0	7
estrogen-related nuclear receptor alpha	6	0	0	6
pregnane X nuclear receptor	6	0	0	6
estrogen nuclear receptor alpha	14	0	0	14
IDH1	6	0	0	6
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	6	0	0	6
thyroid hormone receptor beta isoform a	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 2	7	0	0	7
mitogen-activated protein kinase 1	2	0	0	2
geminin	12	0	0	12
Vpr	1	0	0	1
Bile salt export pump	0	6	0	6
Major prion protein	0	0	1	1
Cellular tumor antigen p53	6	0	0	6
Sodium channel protein type 1 subunit alpha	0	3	0	3
Sodium channel protein type 2 subunit alpha	0	3	0	3
Sodium channel protein type 3 subunit alpha	0	3	0	3
Cytochrome P450 2C9	0	6	0	7
UDP-glucuronosyltransferase 2B7	0	1	0	4
Cytochrome P450 2B6	0	0	1	1
Cytochrome P450 2J2	0	5	0	5
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	1	0	1
Chain A, Ferritin light chain	4	0	0	4
Chain A, Cruzipain	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	3	0	0	3
nuclear receptor subfamily 1, group I, member 3	4	0	0	4
Beta-1 adrenergic receptor	0	0	1	1
Alpha-1B adrenergic receptor	0	0	2	2
cytochrome P450 2C19 precursor	1	0	0	1
cytochrome P450 2C9 precursor	1	0	0	1
Membrane primary amine oxidase	0	1	0	1
5-hydroxytryptamine receptor 3A	0	0	1	1
Solute carrier family 22 member 3	0	2	0	2
5-hydroxytryptamine receptor 1A	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	0	2	2
D	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	2	0	2
Amine oxidase [flavin-containing] A	0	2	0	2
Alpha-2C adrenergic receptor	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	1	0	1
D(1B) dopamine receptor	0	1	0	1
Amine oxidase [flavin-containing] B	0	2	0	2
Adenosine receptor A2b	0	0	1	1
Adenosine receptor A2a	0	1	1	2
Alpha-2B adrenergic receptor	0	0	0	1
D(4) dopamine receptor	0	1	0	1
Delta-type opioid receptor	0	3	0	3
Alpha-1A adrenergic receptor	0	1	1	2
Alpha-1B adrenergic receptor	0	1	1	2
Spike glycoprotein	2	0	0	2
D(2) dopamine receptor	0	1	1	2
Mu-type opioid receptor	0	4	0	4
Inositol monophosphatase 1	1	0	0	1
Alpha-2C adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Nischarin	0	2	0	2
Solute carrier family 22 member 1	0	1	0	2
Multidrug and toxin extrusion protein 1	0	5	0	5
Nischarin	0	2	0	2
endonuclease IV	1	0	0	1
dopamine D1 receptor	2	0	0	2
pregnane X receptor	2	0	0	2
aldehyde dehydrogenase 1 family, member A1	6	0	0	6
progesterone receptor	5	0	0	5
retinoid X nuclear receptor alpha	6	0	0	6
peroxisome proliferator-activated receptor delta	2	0	0	2
peroxisome proliferator activated receptor gamma	3	0	0	3
vitamin D (1,25- dihydroxyvitamin D3) receptor	7	0	0	7
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	2	0	0	2
v-jun sarcoma virus 17 oncogene homolog (avian)	3	0	0	3
peripheral myelin protein 22 isoform 1	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
heat shock protein beta-1	1	0	0	1
flap endonuclease 1	3	0	0	3
survival motor neuron protein isoform d	3	0	0	3
M-phase phosphoprotein 8	2	0	0	2
Glucocorticoid receptor	0	8	2	15
Sex hormone-binding globulin	0	0	1	1
Glycine receptor subunit alpha-1	0	8	0	8
Corticosteroid-binding globulin	0	2	0	2
Glycine receptor subunit beta	0	8	0	8
Glycine receptor subunit alpha-2	0	8	0	8
Glycine receptor subunit alpha-3	0	8	0	8
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
TAR DNA-binding protein 43	5	0	0	5
Chain A, STEROID DELTA-ISOMERASE	0	0	1	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
Steroid Delta-isomerase	0	0	1	1
Vitamin D3 receptor	0	1	1	2
Ileal sodium/bile acid cotransporter	0	1	0	1
G-protein coupled bile acid receptor 1	0	0	1	1
Bile acid receptor	0	0	1	1
Aldo-keto reductase family 1 member B10	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	1	0	2
Prostaglandin G/H synthase 1	0	2	0	2
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Dihydrofolate reductase	0	5	0	6
Cytochrome c oxidase subunit 2	0	1	0	1
Carbonic anhydrase 1	0	3	0	3
Carbonic anhydrase 2	0	3	1	4
Fatty acid-binding protein, liver	0	3	0	3
Transthyretin	0	0	1	3
Albumin	0	3	2	5
Prostaglandin G/H synthase 1	0	3	0	3
Cytochrome P450 3A4	0	2	0	2
Interleukin-8	0	1	0	1
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	1	0	1
Fatty acid-binding protein, intestinal	0	2	0	2
Aldo-keto reductase family 1 member B1	0	2	0	2
UDP-glucuronosyltransferase 1-6	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	2	0	2
Prostaglandin G/H synthase 1	0	3	0	3
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
C-X-C chemokine receptor type 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Prostaglandin G/H synthase 2	0	4	0	4
Prostaglandin G/H synthase 2	0	2	0	3
UDP-glucuronosyltransferase 2B10	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	2	0	2
Prostaglandin G/H synthase 2	0	3	0	3
Prostaglandin G/H synthase 2	0	2	0	2
Carbonic anhydrase 9	0	2	0	2
Solute carrier family 22 member 6	0	3	0	4
Prostaglandin G/H synthase 1	0	2	0	3
Carbonic anhydrase 4	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
UDP-glucuronosyltransferase 1A7	0	1	0	1
UDP-glucuronosyltransferase 1A10	0	1	0	1
Luciferase	4	0	0	4
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
ATP-dependent translocase ABCB1	0	1	0	1
D(4) dopamine receptor	0	1	0	1
Delta-type opioid receptor	0	3	0	3
Mu-type opioid receptor	0	3	1	4
Kappa-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	2	1	3
Delta-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	1	0	1
Gamma-aminobutyric acid	0	0	1	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	1	1
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
transcriptional regulator ERG isoform 3	3	0	0	3
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
peripheral myelin protein 22	3	0	0	3
neuropeptide S receptor isoform A	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Histone deacetylase 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-6	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit delta	0	0	1	1
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-2	0	1	1	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	0	1	1
Histone deacetylase 4	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
Histone deacetylase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Sterol O-acyltransferase 1	0	0	1	1
Proton-coupled amino acid transporter 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	0	1	1
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Histone deacetylase 8	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	1	1
Platelet glycoprotein VI	0	0	1	1
Gamma-aminobutyric acid receptor subunit theta	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	0	1	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 9	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Histone deacetylase 5	0	1	0	1
nonstructural protein 1	2	0	0	2
aryl hydrocarbon receptor	3	0	0	3
thyroid hormone receptor beta isoform 2	4	0	0	4
importin subunit beta-1 isoform 1	3	0	0	3
snurportin-1	3	0	0	3
DNA polymerase kappa isoform 1	3	0	0	3
muscleblind-like protein 1 isoform 1	3	0	0	3
Acid-sensing ion channel 3	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Solute carrier family 22 member 6	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	1
Epidermal growth factor receptor	0	1	0	1
Albumin	0	1	0	1
Cholinesterase	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	2
Acetylcholinesterase	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Adenosine receptor A1	0	1	0	1
Caspase-1	0	1	0	1
Substance-P receptor	0	2	0	2
Aldo-keto reductase family 1 member C3	0	1	0	1
Caspase-3	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Caspase-4	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Caspase-5	0	1	0	1
Caspase-9	0	1	0	1
Acid-sensing ion channel 1	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Solute carrier family 22 member 20	0	3	0	3
Solute carrier family 22 member 8	0	2	0	3
Solute carrier family 22 member 6	0	3	0	3
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	5	0	0	5
Chain A, 2-oxoglutarate Oxygenase	3	0	0	3
EWS/FLI fusion protein	6	0	0	6
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
nuclear receptor ROR-gamma isoform 1	4	0	0	4
N-glycosylase/DNA lyase	0	1	0	1
Polyphenol oxidase 2	0	2	0	3
Myeloperoxidase	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Formamidopyrimidine-DNA glycosylase	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	1
Cytochrome P450 2C8	0	1	0	1
Macrophage migration inhibitory factor	0	1	0	1
Cytochrome P450 2C19	0	1	0	1
Endonuclease III-like protein 1	0	1	0	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	3
Pantothenate synthetase	0	1	0	1
Isocitrate lyase	0	1	0	1
Putative FAD-containing monooxygenase MymA	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Endonuclease 8-like 1	0	1	0	1
Microtubule-associated protein tau	3	0	0	3
Potassium channel subfamily K member 3	0	2	0	2
Potassium channel subfamily K member 2	0	2	0	2
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Fumarate hydratase	1	0	0	1
PPM1D protein	2	0	0	2
polyprotein	1	0	0	1
Interferon beta	3	0	0	3
Solute carrier family 22 member 2	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	2	0	0	2
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
acid sphingomyelinase	1	0	0	1
ClpP	1	0	0	1
15-lipoxygenase, partial	2	0	0	2
estrogen receptor 2 (ER beta)	2	0	0	2
farnesoid X nuclear receptor	1	0	0	1
Thymidylate synthase	0	1	0	1
alpha-galactosidase	1	0	0	1
Thymidylate synthase	0	1	0	1
Histone H2A.x	1	0	0	1
cellular tumor antigen p53 isoform a	1	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	2	0	0	2
vitamin D3 receptor isoform VDRA	3	0	0	3
DNA polymerase beta	1	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
DNA polymerase eta isoform 1	1	0	0	1
DNA polymerase iota isoform a (long)	1	0	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
caspase-1 isoform alpha precursor	1	0	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Voltage-dependent calcium channel gamma-2 subunit	2	0	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Thymidylate synthase	0	2	0	2
Integrin beta-3	1	0	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
Integrin alpha-IIb	1	0	0	1
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Glutamate receptor 2	2	0	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Caspase-7	1	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
ATPase family AAA domain-containing protein 5	3	0	0	3
Solute carrier organic anion transporter family member 1B3	0	0	0	1
Solute carrier family 22 member 11	0	0	0	1
Protein-arginine deiminase type-4	0	3	0	3
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	0	0	1
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
G	1	0	0	1
nuclear receptor subfamily 1, group I, member 2	3	0	0	3
HLA class I histocompatibility antigen, B alpha chain	1	0	0	1
Androgen receptor	0	3	0	3
Inositol hexakisphosphate kinase 1	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
cytochrome P450 2C9, partial	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
Neuropeptide Y receptor type 1	0	2	0	2
Neuropeptide Y receptor type 2	0	2	0	2
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
thioredoxin glutathione reductase	1	0	0	1
Nuclear receptor ROR-gamma	1	0	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	2
Voltage-dependent calcium channel subunit alpha-2/delta-2	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Carbonic anhydrase 12	0	1	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Carbonic anhydrase 3	0	1	0	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Carbonic anhydrase 4	0	1	0	1
Carbonic anhydrase 6	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Carbonic anhydrase 7	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
Carbonic anhydrase 15	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
Carbonic anhydrase 14	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Neuromedin-K receptor	0	0	1	1
Substance-K receptor	0	1	1	2
Substance-K receptor	0	2	0	2
Substance-P receptor	0	2	1	3
Neuromedin-K receptor	0	1	1	2
Substance-K receptor	0	1	0	1
Substance-K receptor	0	1	0	1
Growth hormone secretagogue receptor type 1	0	0	1	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(10)

Research Excerpts

Overview

Context

Treatment

Research

Studies (42)

Protein Targets (570)

Adiposalgia

Synonyms(10)

Research Excerpts

Overview

Context

Treatment

Research

Studies (42)

Drugs Studied (37)

Protein Targets (570)