Page last updated: 2024-10-22

albendazole and Loa loa Filariasis

albendazole has been researched along with Loa loa Filariasis in 24 studies

Research Excerpts

ExcerptRelevanceReference
"Because of the life-threatening, post-treatment reactions that have occurred in patients with loiasis treated with ivermectin, evaluation of a short-course albendazole regimen was undertaken in a Loa-endemic region of Cameroon."9.11Human loiasis in a Cameroonian village: a double-blind, placebo-controlled, crossover clinical trial of a three-day albendazole regimen. ( Befidi-Mengue, R; Fogako, J; Folefack, A; Fualem, R; Gwanmesia, P; Horton, J; Leke, R; Nutman, TB; Pensia, E; Quakyi, I; Tabi, TE, 2004)
"To assess the filaricidal activity and clinical safety of albendazole in human loiasis, a double-blind, placebo-controlled study was conducted in an endemic area in Benin, Africa."9.07Albendazole in human loiasis: results of a double-blind, placebo-controlled trial. ( Ahouissou, NL; Ekoué, S; Horton, J; Klion, AD; Lanmasso, T; Massougbodji, A; Nutman, TB, 1993)
"Although diethylcarbamazine is curative in approximately 60% of patients who acquire loiasis as long-term visitors to an endemic area, some individuals continue to have signs and symptoms of infection despite multiple courses of diethylcarbamazine."7.70Albendazole therapy for loiasis refractory to diethylcarbamazine treatment. ( Horton, J; Klion, AD; Nutman, TB, 1999)
"Loiasis is a vector-borne parasitic infection endemic across many areas of Central and West Africa."5.56Encephalopathy in a patient with loiasis treated with albendazole: A case report. ( Biliotti, E; De Angelis, M; Di Bonaventura, C; Franchi, C; Gabrielli, S; Mattiucci, S; Morano, A; Taliani, G; Volpicelli, L, 2020)
"Sixty men and women from a loiasis endemic area in Cameroon were randomized after stratification by screening LLM (≤ 30000, 30001-50000, >50000) to three treatment arms: two doses albendazole followed by 4 doses matching placebo (n = 20), six doses albendazole (n = 20) albendazole or 6 doses matching placebo (n = 20) administered every two months."5.22Effect of Two or Six Doses 800 mg of Albendazole Every Two Months on Loa loa Microfilaraemia: A Double Blind, Randomized, Placebo-Controlled Trial. ( Gounoue, R; Kamgno, J; Kuesel, AC; Nguipdop-Djomo, P; Téjiokem, M, 2016)
"Because of the life-threatening, post-treatment reactions that have occurred in patients with loiasis treated with ivermectin, evaluation of a short-course albendazole regimen was undertaken in a Loa-endemic region of Cameroon."5.11Human loiasis in a Cameroonian village: a double-blind, placebo-controlled, crossover clinical trial of a three-day albendazole regimen. ( Befidi-Mengue, R; Fogako, J; Folefack, A; Fualem, R; Gwanmesia, P; Horton, J; Leke, R; Nutman, TB; Pensia, E; Quakyi, I; Tabi, TE, 2004)
" A trial was therefore conducted to evaluate whether a course of albendazole would bring about a slower decrease in the Loa microfilaraemia, and thus could be used as a mass 'clearing' treatment, before the distribution of ivermectin in areas where onchocerciasis and loiasis are co-endemic."5.10Effects of a 3-day regimen of albendazole (800 mg daily) on Loa loa microfilaraemia. ( Boussinesq, M; Kamgno, J; Moyou-Somo, R; Pion, SD; Tsague-Dongmo, L, 2002)
"To assess the filaricidal activity and clinical safety of albendazole in human loiasis, a double-blind, placebo-controlled study was conducted in an endemic area in Benin, Africa."5.07Albendazole in human loiasis: results of a double-blind, placebo-controlled trial. ( Ahouissou, NL; Ekoué, S; Horton, J; Klion, AD; Lanmasso, T; Massougbodji, A; Nutman, TB, 1993)
"Our findings strongly support WHO's provisional strategy of biannual mass administration of albendazole to eliminate lymphatic filariasis in areas where loiasis is co-endemic and ivermectin cannot be safely mass administered."3.85Effect of 3 years of biannual mass drug administration with albendazole on lymphatic filariasis and soil-transmitted helminth infections: a community-based study in Republic of the Congo. ( Boussinesq, M; Chesnais, CB; Fischer, PU; Missamou, F; Pion, SDS; Weil, GJ, 2017)
"Although diethylcarbamazine is curative in approximately 60% of patients who acquire loiasis as long-term visitors to an endemic area, some individuals continue to have signs and symptoms of infection despite multiple courses of diethylcarbamazine."3.70Albendazole therapy for loiasis refractory to diethylcarbamazine treatment. ( Horton, J; Klion, AD; Nutman, TB, 1999)
"Loiasis has been associated with excess mortality, but clinical studies on its treatment are scant, particularly outside endemic areas, due to the rarity of cases diagnosed."2.87Comparison of different drug regimens for the treatment of loiasis-A TropNet retrospective study. ( Angheben, A; Bisoffi, Z; Bottieau, E; Bouchaud, O; Buonfrate, D; Calleri, G; Clerinx, J; Gobbi, F; Guerriero, M; Herrera-Ávila, JP; Neumayr, A; Rodari, P; Rojo-Marcos, G; Rothe, C; Salvador, F; Treviño, B; Zammarchi, L, 2018)
"Loiasis is a vector-borne parasitic infection endemic across many areas of Central and West Africa."1.56Encephalopathy in a patient with loiasis treated with albendazole: A case report. ( Biliotti, E; De Angelis, M; Di Bonaventura, C; Franchi, C; Gabrielli, S; Mattiucci, S; Morano, A; Taliani, G; Volpicelli, L, 2020)
" When distributing microfilaricides however, considerable care is needed to minimise the risk of severe adverse events (SAEs) in areas that are co-endemic for onchocerciasis or LF and loiasis."1.48Identifying co-endemic areas for major filarial infections in sub-Saharan Africa: seeking synergies and preventing severe adverse events during mass drug administration campaigns. ( Basáñez, MG; Cano, J; O'Hanlon, SJ; Pullan, RL; Rebollo, MP; Tekle, AH; Wanji, S; Zouré, HG, 2018)
"Loiasis was diagnosed by means of positive IgG4 serology against Loa loa."1.32[A patient with loiasis following a trip to Central Africa]. ( Jaspers, CA; Sanders, CJ; van Kortenhof, NM, 2003)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (8.33)18.2507
2000's8 (33.33)29.6817
2010's12 (50.00)24.3611
2020's2 (8.33)2.80

Authors

AuthorsStudies
Zoleko-Manego, R1
Kreuzmair, R1
Veletzky, L1
Ndzebe-Ndoumba, W1
Ekoka Mbassi, D1
Okwu, DG1
Dimessa-Mbadinga-Weyat, LB1
Houtsa-Temgoua, RD1
Mischlinger, J1
McCall, MBB1
Kresmner, PG1
Agnandji, ST1
Lell, B1
Adegnika, AA1
Mombo-Ngoma, G1
Ramharter, M1
Volpicelli, L1
De Angelis, M1
Morano, A1
Biliotti, E1
Franchi, C1
Gabrielli, S1
Mattiucci, S1
Di Bonaventura, C1
Taliani, G1
Pion, SDS1
Chesnais, CB1
Weil, GJ1
Fischer, PU1
Missamou, F1
Boussinesq, M3
Peñafiel-Freire, DM1
Herranz-Aguirre, M1
Cano, J1
Basáñez, MG1
O'Hanlon, SJ1
Tekle, AH1
Wanji, S1
Zouré, HG1
Rebollo, MP1
Pullan, RL1
Gobbi, F2
Bottieau, E1
Bouchaud, O1
Buonfrate, D2
Salvador, F1
Rojo-Marcos, G1
Rodari, P1
Clerinx, J1
Treviño, B1
Herrera-Ávila, JP1
Neumayr, A1
Calleri, G1
Angheben, A2
Rothe, C1
Zammarchi, L1
Guerriero, M1
Bisoffi, Z2
Tamarozzi, F1
Degani, M1
Metzger, WG1
Mordmüller, B1
Bulman, CA1
Bidlow, CM1
Lustigman, S1
Cho-Ngwa, F1
Williams, D1
Rascón, AA1
Tricoche, N1
Samje, M1
Bell, A1
Suzuki, B1
Lim, KC1
Supakorndej, N1
Supakorndej, P1
Wolfe, AR1
Knudsen, GM1
Chen, S1
Wilson, C1
Ang, KH1
Arkin, M1
Gut, J1
Franklin, C1
Marcellino, C1
McKerrow, JH1
Debnath, A1
Sakanari, JA1
Kamgno, J3
Nguipdop-Djomo, P1
Gounoue, R1
Téjiokem, M1
Kuesel, AC1
Moliner, JV1
Valverde, AG1
Sorolla, JM1
Sgrelli, A1
De Socio, GV1
Papili, R1
D'Annibale, ML1
Baldelli, F1
Morrone, A1
Franco, G1
Toma, L1
Tchangmena, OB1
Marangi, M1
Tsague-Dongmo, L1
Pion, SD1
Moyou-Somo, R1
van Kortenhof, NM1
Jaspers, CA1
Sanders, CJ1
Tabi, TE1
Befidi-Mengue, R1
Nutman, TB3
Horton, J3
Folefack, A1
Pensia, E1
Fualem, R1
Fogako, J1
Gwanmesia, P1
Quakyi, I1
Leke, R1
Stemmle, J1
Markwalder, KA1
Zinkernagel, AS1
Wirth, MG1
Grimm, F1
Hirsch-Hoffmann, S1
Thiel, MA1
Franco-Alvarez de Luna, F1
Giménez-Almenara, G1
Vidal, E1
Casal, M1
Klion, AD2
Massougbodji, A1
Ekoué, S1
Lanmasso, T1
Ahouissou, NL1
Blum, J1
Wiestner, A1
Fuhr, P1
Hatz, C1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Host Response to Infection and Treatment in the Filarial Diseases of Humans[NCT00001230]500 participants (Anticipated)Observational1991-03-15Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for albendazole and Loa loa Filariasis

ArticleYear
Loa loa-does it deserve to be neglected?
    The Lancet. Infectious diseases, 2014, Volume: 14, Issue:4

    Topics: Albendazole; Diethylcarbamazine; Filaricides; Humans; Ivermectin; Loiasis

2014
[Loa loa filariasis in Italy: review of the literature with a clinical report].
    Le infezioni in medicina, 2011, Volume: 19, Issue:3

    Topics: Adult; Albendazole; Animals; Antinematodal Agents; Diethylcarbamazine; Diptera; Drug Therapy, Combin

2011

Trials

7 trials available for albendazole and Loa loa Filariasis

ArticleYear
Efficacy, safety, and tolerability of albendazole and ivermectin based regimens for the treatment of microfilaraemic loiasis in adult patients in Gabon: A randomized controlled assessor blinded clinical trial.
    PLoS neglected tropical diseases, 2023, Volume: 17, Issue:8

    Topics: Adult; Albendazole; Animals; Clinical Protocols; Fishes; Gabon; Humans; Ivermectin; Loiasis

2023
Comparison of different drug regimens for the treatment of loiasis-A TropNet retrospective study.
    PLoS neglected tropical diseases, 2018, Volume: 12, Issue:11

    Topics: Adult; Albendazole; Animals; Diethylcarbamazine; Europe; Filaricides; Humans; Ivermectin; Loa; Loias

2018
Effect of Two or Six Doses 800 mg of Albendazole Every Two Months on Loa loa Microfilaraemia: A Double Blind, Randomized, Placebo-Controlled Trial.
    PLoS neglected tropical diseases, 2016, Volume: 10, Issue:3

    Topics: Adolescent; Adult; Aged; Albendazole; Anthelmintics; Cameroon; Double-Blind Method; Female; Humans;

2016
Effects of a 3-day regimen of albendazole (800 mg daily) on Loa loa microfilaraemia.
    Annals of tropical medicine and parasitology, 2002, Volume: 96, Issue:7

    Topics: Adolescent; Adult; Aged; Albendazole; Animals; Cameroon; Child; Drug Administration Schedule; Female

2002
Human loiasis in a Cameroonian village: a double-blind, placebo-controlled, crossover clinical trial of a three-day albendazole regimen.
    The American journal of tropical medicine and hygiene, 2004, Volume: 71, Issue:2

    Topics: Adolescent; Adult; Aged; Albendazole; Animals; Anthelmintics; Cameroon; Cross-Over Studies; Double-B

2004
Albendazole in human loiasis: results of a double-blind, placebo-controlled trial.
    The Journal of infectious diseases, 1993, Volume: 168, Issue:1

    Topics: Adolescent; Adult; Africa, Western; Aged; Albendazole; Double-Blind Method; Female; Humans; Loiasis;

1993
Effect of a single dose (600 mg) of albendazole on Loa loa microfilaraemia.
    Parasite (Paris, France), 2002, Volume: 9, Issue:1

    Topics: Adolescent; Adult; Albendazole; Animals; Child; Dietary Fats; Female; Filaricides; Humans; Loa; Loia

2002

Other Studies

15 other studies available for albendazole and Loa loa Filariasis

ArticleYear
Encephalopathy in a patient with loiasis treated with albendazole: A case report.
    Parasitology international, 2020, Volume: 75

    Topics: Adrenal Cortex Hormones; Adult; Albendazole; Animals; Diagnosis, Differential; Filaricides; Guinea;

2020
Effect of 3 years of biannual mass drug administration with albendazole on lymphatic filariasis and soil-transmitted helminth infections: a community-based study in Republic of the Congo.
    The Lancet. Infectious diseases, 2017, Volume: 17, Issue:7

    Topics: Adolescent; Adult; Albendazole; Animals; Anthelmintics; Antiparasitic Agents; Child; Elephantiasis,

2017
Loiasis, a Subconjunctival Manifestation.
    The Journal of pediatrics, 2017, Volume: 188

    Topics: Albendazole; Animals; Anthelmintics; Child; Conjunctivitis; Drug Therapy, Combination; Eye Infection

2017
Global programme to eliminate lymphatic filariasis: progress report, 2016.
    Releve epidemiologique hebdomadaire, 2017, 10-06, Volume: 92, Issue:40

    Topics: Albendazole; Anthelmintics; Diethylcarbamazine; Disease Eradication; Drug Therapy, Combination; Elep

2017
Identifying co-endemic areas for major filarial infections in sub-Saharan Africa: seeking synergies and preventing severe adverse events during mass drug administration campaigns.
    Parasites & vectors, 2018, 01-31, Volume: 11, Issue:1

    Topics: Africa South of the Sahara; Albendazole; Animals; Diethylcarbamazine; Drug Synergism; Drug Therapy,

2018
Efficacy of High-Dose Albendazole with Ivermectin for Treating Imported Loiasis, Italy.
    Emerging infectious diseases, 2019, Volume: 25, Issue:8

    Topics: Adolescent; Adult; Aged; Albendazole; Antiprotozoal Agents; Biomarkers; Communicable Diseases, Impor

2019
Meeting of the International Task Force for Disease Eradication, January 2014.
    Releve epidemiologique hebdomadaire, 2014, Apr-11, Volume: 89, Issue:15

    Topics: Advisory Committees; Africa; Albendazole; Anthelmintics; Disease Eradication; Elephantiasis, Filaria

2014
Repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasis.
    PLoS neglected tropical diseases, 2015, Volume: 9, Issue:2

    Topics: Adult; Albendazole; Animals; Anthelmintics; Auranofin; Brugia malayi; Cattle; Cell Line; Diethylcarb

2015
[Loa loa meningoencephalitis secondary to treatment with mebendazol].
    Medicina clinica, 2011, Feb-26, Volume: 136, Issue:5

    Topics: Adolescent; Albendazole; Animals; Anthelmintics; Brain Damage, Chronic; Central Nervous System Helmi

2011
A case of loiasis in Rome.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2002, Volume: 16, Issue:3

    Topics: Adult; Albendazole; Anthelmintics; Anti-Inflammatory Agents; Betamethasone; Diagnosis, Differential;

2002
[A patient with loiasis following a trip to Central Africa].
    Nederlands tijdschrift voor geneeskunde, 2003, Jul-05, Volume: 147, Issue:27

    Topics: Albendazole; Animals; Antibodies, Helminth; Cameroon; Diagnosis, Differential; Edema; Eosinophilia;

2003
[Loa loa infection of the eye -- a case series].
    Klinische Monatsblatter fur Augenheilkunde, 2005, Volume: 222, Issue:3

    Topics: Adolescent; Adult; Albendazole; Animals; Cameroon; Combined Modality Therapy; Conjunctiva; Eye Infec

2005
[Patient from the Republic of Congo with intermittent ocular pain].
    Enfermedades infecciosas y microbiologia clinica, 2007, Volume: 25, Issue:3

    Topics: Adult; Albendazole; Animals; Anthelmintics; Congo; Conjunctiva; Conjunctival Diseases; Humans; Loa;

2007
Albendazole therapy for loiasis refractory to diethylcarbamazine treatment.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1999, Volume: 29, Issue:3

    Topics: Adult; Albendazole; Anthelmintics; Diethylcarbamazine; Drug Resistance; Female; Filaricides; Humans;

1999
Encephalopathy following Loa loa treatment with albendazole.
    Acta tropica, 2001, Jan-15, Volume: 78, Issue:1

    Topics: Albendazole; Animals; Anthelmintics; Blood Chemical Analysis; Delirium; Electroencephalography; Ence

2001