diethylcarbamazine has been researched along with Loa loa Filariasis in 88 studies
Diethylcarbamazine: An anthelmintic used primarily as the citrate in the treatment of filariasis, particularly infestations with Wucheria bancrofti or Loa loa.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Diethylcarbamazine citrate (DEC) treatment of loiasis is complicated by adverse reactions that are correlated with the number of circulating microfilariae (mf)." | 9.41 | A Randomized, Placebo-controlled, Double-blind Pilot Study of Single-dose Humanized Anti-IL5 Antibody (Reslizumab) for the Reduction of Eosinophilia Following Diethylcarbamazine Treatment of Loa loa Infection. ( Fay, MP; Herrick, J; Holland-Thomas, N; Klion, AD; Legrand, F; Makiya, M; Nutman, TB; Ramanathan, R; Rampertaap, S; Stoddard, J; Thompson, R; Ware, J, 2021) |
| "Although diethylcarbamazine is curative in approximately 60% of patients who acquire loiasis as long-term visitors to an endemic area, some individuals continue to have signs and symptoms of infection despite multiple courses of diethylcarbamazine." | 7.70 | Albendazole therapy for loiasis refractory to diethylcarbamazine treatment. ( Horton, J; Klion, AD; Nutman, TB, 1999) |
| "Although successful treatment of loiasis with diethylcarbamazine (DEC) has been reported, little is known about the long-term success rate of therapy or the predisposing factors for treatment failure." | 7.69 | Effectiveness of diethylcarbamazine in treating loiasis acquired by expatriate visitors to endemic regions: long-term follow-up. ( Klion, AD; Nutman, TB; Ottesen, EA, 1994) |
| "To prevent the side effects as encephalitis, related with diethylcarbamazine treatment in loiasis, an exchange blood transfusion was proposed." | 7.68 | [Value of filariopheresis in the treatment of Loa loa filariasis]. ( Bisaro, F; Bourée, P; Duedari, N; Norol, F, 1993) |
| "Five cases of encephalitis following treatment with diethylcarbamazine (DEC) were observed in Congolese patients with Loa loa filariasis." | 7.68 | Five cases of encephalitis during treatment of loiasis with diethylcarbamazine. ( Boulesteix, J; Boutes, H; Carme, B; Puruehnce, MF, 1991) |
| "Diethylcarbamazine citrate (DEC) treatment of loiasis is complicated by adverse reactions that are correlated with the number of circulating microfilariae (mf)." | 5.41 | A Randomized, Placebo-controlled, Double-blind Pilot Study of Single-dose Humanized Anti-IL5 Antibody (Reslizumab) for the Reduction of Eosinophilia Following Diethylcarbamazine Treatment of Loa loa Infection. ( Fay, MP; Herrick, J; Holland-Thomas, N; Klion, AD; Legrand, F; Makiya, M; Nutman, TB; Ramanathan, R; Rampertaap, S; Stoddard, J; Thompson, R; Ware, J, 2021) |
| "Loa loa is a filarial parasite that is endemic in West and Central Africa." | 5.29 | Loa loa infection as a cause of migratory angioedema: report of three cases from the Texas Medical Center. ( Kielhofner, MA; Rakita, RM; White, AC, 1993) |
| "In order to reduce the endemicity of loaiasis, mass treatment with ivermectin could be envisaged immediately." | 5.28 | [Current possibilities in the control of Loa Loa filariasis]. ( Noireau, F, 1990) |
| "Severe adverse reactions have been observed in individuals with Loa loa infection treated with either diethylcarbamazine (DEC), the drug of choice for loiasis, or ivermectin (IVM), which is used in mass drug administration programs for control of onchocerciasis and lymphatic filariasis in Africa." | 5.24 | Posttreatment Reactions After Single-Dose Diethylcarbamazine or Ivermectin in Subjects With Loa loa Infection. ( Bopda, J; Fay, MP; Gounoue, R; Herrick, JA; Kamgno, J; Klion, AD; Legrand, F; Makiya, M; Metenou, S; Montavon, C; Nchinda, G; Nguluwe, K; Nutman, TB; Ondigui, BE; Tchana, SM, 2017) |
| "Our results highlight that, by 1 year following treatment, infection-associated immunologic abnormalities had resolved in nearly all patients treated for loiasis, and pretreatment corticosteroids had no influence on the resolution of the immunologic perturbations nor on the efficacy of diethylcarbamazine as a curative agent in loiasis." | 4.02 | Infection-associated Immune Perturbations Resolve 1 Year Following Treatment for Loa loa. ( Herrick, JA; Holland-Thomas, N; Klion, AD; Makiya, MA; Nutman, TB, 2021) |
| "Although diethylcarbamazine is curative in approximately 60% of patients who acquire loiasis as long-term visitors to an endemic area, some individuals continue to have signs and symptoms of infection despite multiple courses of diethylcarbamazine." | 3.70 | Albendazole therapy for loiasis refractory to diethylcarbamazine treatment. ( Horton, J; Klion, AD; Nutman, TB, 1999) |
| "Although successful treatment of loiasis with diethylcarbamazine (DEC) has been reported, little is known about the long-term success rate of therapy or the predisposing factors for treatment failure." | 3.69 | Effectiveness of diethylcarbamazine in treating loiasis acquired by expatriate visitors to endemic regions: long-term follow-up. ( Klion, AD; Nutman, TB; Ottesen, EA, 1994) |
| "In the last ten years ivermectin appeared an efficient and safe alternative to diethylcarbamazine which is known to induce severe adverse reactions in loiasis, including encephalitis." | 3.69 | [Secondary effects of the treatment of hypermicrofilaremic loiasis using ivermectin]. ( Boussinesq, M; Chippaux, JP; Ducorps, M; Gardon, J; Gardon-Wendel, N; Ndong, W; Ranque, S; Schneider, D, 1995) |
| "Diethylcarbamazine (DEC) induced clearance of microfilaraemia in loiasis is associated with severe posttreatment reactions." | 3.69 | Microfilarial clearance in loiasis involves elevation of Th1 and Th2 products and emergence of a specific pattern of T-cell populations. ( Graninger, W; Marberger, M; Paiha, S; Steiner, GE; Winkler, H; Winkler, S, 1996) |
| "To prevent the side effects as encephalitis, related with diethylcarbamazine treatment in loiasis, an exchange blood transfusion was proposed." | 3.68 | [Value of filariopheresis in the treatment of Loa loa filariasis]. ( Bisaro, F; Bourée, P; Duedari, N; Norol, F, 1993) |
| "Five cases of encephalitis following treatment with diethylcarbamazine (DEC) were observed in Congolese patients with Loa loa filariasis." | 3.68 | Five cases of encephalitis during treatment of loiasis with diethylcarbamazine. ( Boulesteix, J; Boutes, H; Carme, B; Puruehnce, MF, 1991) |
| " Although microfilaraemia was not detectable, loiasis was diagnosed, given the clinical manifestations, epidemiological data, history of sub-conjunctival migration of the adult worm (in one case), spectacular recovery (clinical and biological) after treatment with diethylcarbamazine." | 3.67 | [Loa loa filariasis: cause of severe eosinophilia]. ( Carme, B; Nkoua, JL, 1989) |
| " Loa-loa was isolated from the blood and eosinophilia was marked but both were cured by diethylcarbamazine therapy." | 3.66 | Loasis as a possible trigger of African endomyocardial fibrosis: a case report from Nigeria. ( Andy, JJ; Bishara, FF; Odesanmi, WO; Soyinka, OO, 1981) |
| "Two patients with loiasis in whom treatment with diethylcarbamazine had to be interrupted because of serious side effects underwent apheresis to extract microfilarias from the blood." | 3.66 | Usefulness of apheresis to extract microfilarias in management of loiasis. ( Moldenhauer, R; Muylle, L; Peetermans, ME; Taelman, H; Van Brabant, R, 1983) |
| "Recurrent skin edemata due to an infestation with the filaria Loa loa are called Cameroon or Calabar swellings." | 3.66 | [Cameroon swelling; infection by the filaria Loa loa]. ( Gewalt, W; Grüntzig, J, 1979) |
| "Loiasis has been associated with excess mortality, but clinical studies on its treatment are scant, particularly outside endemic areas, due to the rarity of cases diagnosed." | 2.87 | Comparison of different drug regimens for the treatment of loiasis-A TropNet retrospective study. ( Angheben, A; Bisoffi, Z; Bottieau, E; Bouchaud, O; Buonfrate, D; Calleri, G; Clerinx, J; Gobbi, F; Guerriero, M; Herrera-Ávila, JP; Neumayr, A; Rodari, P; Rojo-Marcos, G; Rothe, C; Salvador, F; Treviño, B; Zammarchi, L, 2018) |
| "Imported loiasis is a rare cause of consultation at the return of stay in central Africa, which often poses difficult diagnostic and therapeutic questions to practitioners especially those who are unaccustomed to tropical medicine." | 1.56 | Imported loiasis in France: a retrospective analysis of 167 cases with comparison between sub-Saharan and non sub-Saharan African patients. ( Bouchaud, O; Bourée, P; Cailhol, J; Caumes, E; Dupouy Camet, J; Godineau, N; Loarec, A; Matheron, S; Poilane, I, 2020) |
| " When distributing microfilaricides however, considerable care is needed to minimise the risk of severe adverse events (SAEs) in areas that are co-endemic for onchocerciasis or LF and loiasis." | 1.48 | Identifying co-endemic areas for major filarial infections in sub-Saharan Africa: seeking synergies and preventing severe adverse events during mass drug administration campaigns. ( Basáñez, MG; Cano, J; O'Hanlon, SJ; Pullan, RL; Rebollo, MP; Tekle, AH; Wanji, S; Zouré, HG, 2018) |
| "(1) Lymphatic filariasis is a set of parasitic diseases that are endemic in tropical and subtropical regions and can be disabling in the long term." | 1.35 | Lymphatic filariasis. ( , 2008) |
| "Loa-Loa is a parasitic infection endemic in the tropical rain forests of Western, Central, and Eastern Africa." | 1.32 | [Ocular involvement in systemic Loa-Loa filariasis. Case report and review of the literature]. ( Jaksche, A; Loeffler, KU; Martin, S; Wessels, L, 2004) |
| "Loa loa is a filarial parasite that is endemic in West and Central Africa." | 1.29 | Loa loa infection as a cause of migratory angioedema: report of three cases from the Texas Medical Center. ( Kielhofner, MA; Rakita, RM; White, AC, 1993) |
| "In order to reduce the endemicity of loaiasis, mass treatment with ivermectin could be envisaged immediately." | 1.28 | [Current possibilities in the control of Loa Loa filariasis]. ( Noireau, F, 1990) |
| "This is the first case of Loa loa infection reported from Sri Lanka." | 1.28 | Loa loa in a Sri Lankan expatriate from Nigeria. ( Goonesinghe, SK; Samarasinghe, S; Wickremesinghe, RS, 1989) |
| "Ocular filariasis was observed in an African student living in Missouri." | 1.27 | Loa loa: ocular filariasis in an African student in Missouri. ( Lee, BY; McMillian, R, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 43 (48.86) | 18.7374 |
| 1990's | 19 (21.59) | 18.2507 |
| 2000's | 6 (6.82) | 29.6817 |
| 2010's | 12 (13.64) | 24.3611 |
| 2020's | 8 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Montenegro-Quintana, MA | 1 |
| Pérez-García, MV | 1 |
| Sotomayor-Toribio, M | 1 |
| Cosano-Palma, E | 1 |
| López-Herrero, F | 1 |
| Sánchez-Vicente, JL | 1 |
| Bennuru, S | 1 |
| Kodua, F | 1 |
| Drame, PM | 1 |
| Dahlstrom, E | 1 |
| Nutman, TB | 10 |
| Bouchaud, O | 2 |
| Matheron, S | 1 |
| Loarec, A | 1 |
| Dupouy Camet, J | 1 |
| Bourée, P | 2 |
| Godineau, N | 1 |
| Poilane, I | 1 |
| Cailhol, J | 1 |
| Caumes, E | 1 |
| Herrick, JA | 2 |
| Makiya, MA | 1 |
| Holland-Thomas, N | 2 |
| Klion, AD | 6 |
| Legrand, F | 2 |
| Herrick, J | 1 |
| Makiya, M | 2 |
| Ramanathan, R | 1 |
| Thompson, R | 1 |
| Rampertaap, S | 1 |
| Stoddard, J | 1 |
| Ware, J | 1 |
| Fay, MP | 2 |
| Coyle, C | 1 |
| Weiss, LM | 1 |
| Dunn, CL | 1 |
| Dunn, CP | 1 |
| Ayars, AG | 1 |
| Kalbitz, S | 1 |
| Grünewald, T | 1 |
| Gounoue, R | 1 |
| Nchinda, G | 1 |
| Montavon, C | 1 |
| Bopda, J | 1 |
| Tchana, SM | 1 |
| Ondigui, BE | 1 |
| Nguluwe, K | 1 |
| Metenou, S | 1 |
| Kamgno, J | 1 |
| Nieves-Moreno, M | 1 |
| Bañeros-Rojas, P | 1 |
| Díaz-Valle, D | 1 |
| Gegúndez-Fernández, JA | 1 |
| Baartman, BJ | 1 |
| Nguyen, L | 1 |
| Wiest, P | 1 |
| Steinemann, TL | 1 |
| Cano, J | 1 |
| Basáñez, MG | 1 |
| O'Hanlon, SJ | 1 |
| Tekle, AH | 1 |
| Wanji, S | 1 |
| Zouré, HG | 1 |
| Rebollo, MP | 1 |
| Pullan, RL | 1 |
| Gobbi, F | 1 |
| Bottieau, E | 1 |
| Buonfrate, D | 1 |
| Salvador, F | 1 |
| Rojo-Marcos, G | 1 |
| Rodari, P | 1 |
| Clerinx, J | 1 |
| Treviño, B | 1 |
| Herrera-Ávila, JP | 1 |
| Neumayr, A | 1 |
| Calleri, G | 1 |
| Angheben, A | 1 |
| Rothe, C | 1 |
| Zammarchi, L | 1 |
| Guerriero, M | 1 |
| Bisoffi, Z | 1 |
| Metzger, WG | 1 |
| Mordmüller, B | 1 |
| Bulman, CA | 1 |
| Bidlow, CM | 1 |
| Lustigman, S | 1 |
| Cho-Ngwa, F | 1 |
| Williams, D | 1 |
| Rascón, AA | 1 |
| Tricoche, N | 1 |
| Samje, M | 1 |
| Bell, A | 1 |
| Suzuki, B | 1 |
| Lim, KC | 1 |
| Supakorndej, N | 1 |
| Supakorndej, P | 1 |
| Wolfe, AR | 1 |
| Knudsen, GM | 1 |
| Chen, S | 1 |
| Wilson, C | 1 |
| Ang, KH | 1 |
| Arkin, M | 1 |
| Gut, J | 1 |
| Franklin, C | 1 |
| Marcellino, C | 1 |
| McKerrow, JH | 1 |
| Debnath, A | 1 |
| Sakanari, JA | 1 |
| Saito, M | 1 |
| Armstrong, M | 1 |
| Boadi, S | 1 |
| Lowe, P | 1 |
| Chiodini, PL | 1 |
| Doherty, T | 1 |
| Priest, DH | 1 |
| Moliner, JV | 1 |
| Valverde, AG | 1 |
| Sorolla, JM | 1 |
| Sgrelli, A | 1 |
| De Socio, GV | 1 |
| Papili, R | 1 |
| D'Annibale, ML | 1 |
| Baldelli, F | 1 |
| Uhlig, CE | 1 |
| Dietrich, M | 1 |
| Busse, H | 1 |
| DUKE, BO | 2 |
| BRADY, FJ | 1 |
| EWING, RE | 1 |
| SANGER, S | 1 |
| WOODRUFF, AW | 2 |
| Jaksche, A | 2 |
| Wessels, L | 1 |
| Martin, S | 2 |
| Loeffler, KU | 2 |
| Sbeity, ZH | 1 |
| MURGATROYD, F | 1 |
| SHOOKHOFF, HB | 1 |
| DWORK, KG | 1 |
| Andy, JJ | 1 |
| Bishara, FF | 1 |
| Soyinka, OO | 1 |
| Odesanmi, WO | 1 |
| Vermeer, BJ | 1 |
| van der Kaay, HJ | 1 |
| Sanguigni, S | 1 |
| Sebastiani, A | 1 |
| Marangi, M | 1 |
| Bianchini, C | 1 |
| Aceti, A | 1 |
| Doury, P | 2 |
| Saliou, P | 2 |
| Charmot, G | 2 |
| Muylle, L | 1 |
| Taelman, H | 1 |
| Moldenhauer, R | 1 |
| Van Brabant, R | 1 |
| Peetermans, ME | 1 |
| Gentilini, M | 4 |
| Carme, B | 4 |
| Geldelman, D | 1 |
| Blumberg, R | 1 |
| Sadun, A | 1 |
| Katner, H | 1 |
| Beyt, BE | 1 |
| Krotoski, WA | 1 |
| Lee, BY | 1 |
| McMillian, R | 1 |
| Fleury, P | 1 |
| Liotet, S | 1 |
| Sainte-Laudy, J | 1 |
| Haut, J | 1 |
| Farrer, WE | 1 |
| Wittner, M | 1 |
| Tanowitz, HB | 1 |
| Stanley, SL | 1 |
| Kell, O | 1 |
| Krautheim, H | 1 |
| Wiesinger, EC | 1 |
| Winkler, S | 2 |
| Egger, S | 1 |
| Burgmann, H | 1 |
| Graninger, W | 2 |
| Bordon, LM | 1 |
| Maurice, M | 1 |
| Hulin, C | 1 |
| Rabaud, C | 1 |
| May, T | 1 |
| Neimann, L | 1 |
| Kures, L | 1 |
| Canton, P | 1 |
| Ottesen, EA | 4 |
| Duedari, N | 1 |
| Bisaro, F | 1 |
| Norol, F | 1 |
| Rakita, RM | 1 |
| White, AC | 1 |
| Kielhofner, MA | 1 |
| Ducorps, M | 1 |
| Gardon-Wendel, N | 1 |
| Ranque, S | 1 |
| Ndong, W | 1 |
| Boussinesq, M | 1 |
| Gardon, J | 1 |
| Schneider, D | 1 |
| Chippaux, JP | 1 |
| Low, K | 1 |
| Barker, AJ | 1 |
| Vincent, JM | 1 |
| Paiha, S | 1 |
| Winkler, H | 1 |
| Marberger, M | 1 |
| Steiner, GE | 1 |
| de Viragh, PA | 1 |
| Guggisberg, D | 1 |
| Derighetti, M | 1 |
| van Saanen, M | 1 |
| Panizzon, RG | 1 |
| Horton, J | 1 |
| Goljan, J | 1 |
| Nahorski, W | 1 |
| Tomaszewski, R | 1 |
| Felczak-Korzybska, I | 1 |
| Górski, J | 1 |
| Greenberg, H | 1 |
| Garin, JP | 1 |
| Rougier, J | 1 |
| Mojon, M | 1 |
| Fain, A | 1 |
| Zuidema, PJ | 1 |
| Renard, G | 2 |
| Morand, L | 1 |
| Lacombe, E | 1 |
| Offret, G | 1 |
| Grüntzig, J | 1 |
| Gewalt, W | 1 |
| Georges, P | 1 |
| Houmeau, L | 1 |
| Legall, MA | 1 |
| Badoual, J | 1 |
| Gendrel, D | 1 |
| Eisenstein, EM | 1 |
| Smirniotopoulos, TT | 1 |
| Neumann, MP | 1 |
| Le Guyadec, T | 1 |
| Wolkenstein, P | 1 |
| Ortoli, JC | 1 |
| Ponties-Leroux, B | 1 |
| Beaulieu, P | 1 |
| Millet, P | 1 |
| Paris, L | 1 |
| Datry, A | 3 |
| Durepaire, R | 1 |
| Felix, H | 2 |
| Gaxotte, P | 1 |
| Danis, M | 3 |
| Boulesteix, J | 1 |
| Boutes, H | 1 |
| Puruehnce, MF | 1 |
| Noireau, F | 1 |
| Workman, DM | 1 |
| McNab, AA | 1 |
| Wickremesinghe, RS | 1 |
| Goonesinghe, SK | 1 |
| Samarasinghe, S | 1 |
| Hautekeete, ML | 1 |
| Pailoux, G | 1 |
| Marcellin, P | 1 |
| Girard, PM | 1 |
| Degott, C | 1 |
| Benhamou, JP | 1 |
| Lortholary, O | 2 |
| Jaccard, A | 2 |
| Visser, H | 2 |
| Guillevin, L | 1 |
| Brice, D | 1 |
| Etienne, SD | 1 |
| Le Thi Huong, Du | 1 |
| Wechsler, B | 1 |
| Chandenier, J | 3 |
| Piette, JC | 1 |
| Godeau, P | 1 |
| Nkoua, JL | 1 |
| Van Hoegaerden, M | 1 |
| Flocard, F | 1 |
| Sugiyama, E | 1 |
| Shinonaga, S | 1 |
| Tsukidate, S | 1 |
| Fujita, K | 1 |
| Nawata, H | 1 |
| Sazaki, N | 1 |
| Kamikawadoko, S | 1 |
| Ohtaki, N | 1 |
| Oka, K | 1 |
| Mollereau, M | 1 |
| Fassin, D | 1 |
| Kouchner, G | 1 |
| Fournel, JJ | 1 |
| Miller, KD | 2 |
| Mulligan, M | 2 |
| Reinhardt, GN | 1 |
| Currie, BJ | 1 |
| Steel, C | 1 |
| Toufic, N | 1 |
| Fleck, BW | 1 |
| Macdonald, M | 1 |
| Olness, K | 1 |
| Franciosi, RA | 1 |
| Johnson, MM | 1 |
| Freedman, DO | 1 |
| Pillier-Loriette, C | 1 |
| Rosenheim, M | 1 |
| Nozais, JP | 1 |
| Van Dellen, RG | 1 |
| Gocke, TM | 1 |
| Neafie, RC | 1 |
| Tani, S | 1 |
| Shibuya, T | 1 |
| Beisler, GK | 1 |
| Tanaka, H | 1 |
| Paulisch, FE | 1 |
| Ambroise-Thomas, P | 1 |
| Truong, TK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Host Response to Infection and Treatment in the Filarial Diseases of Humans[NCT00001230] | 500 participants (Anticipated) | Observational | 1991-03-15 | Recruiting | |||
| Comparison Between the Post-Treatment Reactions After Single-dose Ivermectin or DEC in Subjects With Loa Loa Infection[NCT01593722] | Phase 4 | 155 participants (Actual) | Interventional | 2012-04-30 | Completed | ||
| A Randomized, Placebo-controlled, Double-Blind Pilot Study of Single-Dose Humanized Anti-IL5 Antibody (Reslizumab) for the Reduction of Eosinophilia Following Diethylcarbamazine Treatment of Loa Loa Infection[NCT01111305] | Phase 2 | 31 participants (Actual) | Interventional | 2010-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT01593722)
Timeframe: 14 days
| Intervention | participants (Number) |
|---|---|
| Diethylcarbamazine | 3 |
| Ivermectin | 0 |
Symptoms, signs and laboratory abnormalities occurring in the 7 days post-treatment (NCT01593722)
Timeframe: 7 days
| Intervention | events (Number) |
|---|---|
| Diethylcarbamazine | 115 |
| Ivermectin | 103 |
(NCT01593722)
Timeframe: 7 days
| Intervention | percentage of baseline (Geometric Mean) |
|---|---|
| Diethylcarbamazine | 196 |
| Ivermectin | 165 |
Proportion of subjects without signs of infection (NCT01593722)
Timeframe: 6 months
| Intervention | participants (Number) |
|---|---|
| Diethylcarbamazine | 0 |
| Ivermectin | 1 |
Levels of surface marker expression on eosinophils (NCT01593722)
Timeframe: 3 days
| Intervention | % cells expressing CD69 (Geometric Mean) | |
|---|---|---|
| %CD69 expression on eosinophils at peak | %CD69 expression on eosinophils at baseline | |
| Single Dose DEC | 21.5 | 1.7 |
| Single Dose IVM | 21.5 | 1.5 |
Adverse events during the first week of DEC treatment (NCT01111305)
Timeframe: 7 days following initiation of DEC treatment
| Intervention | adverse events (Number) |
|---|---|
| Reslizumab + DEC | 29 |
| Placebo + DEC | 28 |
Peak eosinophil count during the first 7 days of treatment as a percent of the baseline count (NCT01111305)
Timeframe: during the first 7 days of DEC treatment
| Intervention | percent of baseline eosinophil count (Geometric Mean) |
|---|---|
| Reslizumab + DEC | 61 |
| Placebo + DEC | 245.6 |
serum eosinophil granule protein levels on day 7 measured as % baseline (NCT01111305)
Timeframe: one week
| Intervention | % change (Geometric Mean) | |
|---|---|---|
| % day 0 EDN at day 7 | % day 0 EPO at day 7 | |
| Placebo + DEC | 377 | 203 |
| Reslizumab + DEC | 115 | 138 |
(NCT01111305)
Timeframe: 3, 7, and 28 days after initiation of treatment with DEC
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| 3 days | 7 days | 28 days | |
| Placebo | 2 | 4 | 4 |
| Reslizumab | 2 | 4 | 4 |
2 reviews available for diethylcarbamazine and Loa loa Filariasis
| Article | Year |
|---|---|
Loa loa-does it deserve to be neglected?
Topics: Albendazole; Diethylcarbamazine; Filaricides; Humans; Ivermectin; Loiasis | 2014 |
[Loa loa filariasis in Italy: review of the literature with a clinical report].
Topics: Adult; Albendazole; Animals; Antinematodal Agents; Diethylcarbamazine; Diptera; Drug Therapy, Combin | 2011 |
4 trials available for diethylcarbamazine and Loa loa Filariasis
| Article | Year |
|---|---|
A Randomized, Placebo-controlled, Double-blind Pilot Study of Single-dose Humanized Anti-IL5 Antibody (Reslizumab) for the Reduction of Eosinophilia Following Diethylcarbamazine Treatment of Loa loa Infection.
Topics: Adult; Animals; Antibodies, Monoclonal, Humanized; Diethylcarbamazine; Double-Blind Method; Eosinoph | 2021 |
Posttreatment Reactions After Single-Dose Diethylcarbamazine or Ivermectin in Subjects With Loa loa Infection.
Topics: Adult; Aged; Diethylcarbamazine; Drug-Related Side Effects and Adverse Reactions; Female; Filaricide | 2017 |
Comparison of different drug regimens for the treatment of loiasis-A TropNet retrospective study.
Topics: Adult; Albendazole; Animals; Diethylcarbamazine; Europe; Filaricides; Humans; Ivermectin; Loa; Loias | 2018 |
Diethylcarbamazine prophylaxis for human loiasis. Results of a double-blind study.
Topics: Adult; Cameroon; Central African Republic; Diethylcarbamazine; Double-Blind Method; Female; Filarias | 1988 |
82 other studies available for diethylcarbamazine and Loa loa Filariasis
| Article | Year |
|---|---|
Systemic loiasis diagnosed by direct transconjunctival observation.
Topics: Animals; Diethylcarbamazine; Humans; Ivermectin; Loa; Loiasis | 2023 |
A Novel, Highly Sensitive Nucleic Acid Amplification Test Assay for the Diagnosis of Loiasis and its Use for Detection of Circulating Cell-Free DNA.
Topics: Animals; Diethylcarbamazine; DNA; Humans; Loa; Loiasis; Nucleic Acid Amplification Techniques | 2023 |
Imported loiasis in France: a retrospective analysis of 167 cases with comparison between sub-Saharan and non sub-Saharan African patients.
Topics: Adolescent; Adult; Africa, Northern; Animals; Black People; Child; Child, Preschool; Communicable Di | 2020 |
Infection-associated Immune Perturbations Resolve 1 Year Following Treatment for Loa loa.
Topics: Animals; Diethylcarbamazine; Humans; Loa; Loiasis; Microfilariae; Retrospective Studies | 2021 |
Immunomodulatory Therapy for the Management of Loiasis.
Topics: Diethylcarbamazine; Filaricides; Humans; Immunomodulation; Loiasis | 2021 |
When long-standing hives are not chronic spontaneous urticaria.
Topics: Chronic Disease; Dermatitis; Diagnosis, Differential; Diethylcarbamazine; Exanthema; Filaricides; Hu | 2021 |
Loiasis.
Topics: Adult; Animals; Diethylcarbamazine; Eyelids; Female; Filaricides; Humans; Loa; Loiasis | 2021 |
Encephalitis secondary to diethylcarbamazine treatment in a patient with ocular loiasis.
Topics: Adult; Diethylcarbamazine; Encephalitis; Eosinophilia; Eye Infections, Parasitic; Female; Filaricide | 2017 |
Ocular loiasis in Ohio: a case report.
Topics: Adult; Diethylcarbamazine; Eye Infections, Parasitic; Filaricides; Humans; Loiasis; Male; Treatment | 2018 |
Global programme to eliminate lymphatic filariasis: progress report, 2016.
Topics: Albendazole; Anthelmintics; Diethylcarbamazine; Disease Eradication; Drug Therapy, Combination; Elep | 2017 |
Identifying co-endemic areas for major filarial infections in sub-Saharan Africa: seeking synergies and preventing severe adverse events during mass drug administration campaigns.
Topics: Africa South of the Sahara; Albendazole; Animals; Diethylcarbamazine; Drug Synergism; Drug Therapy, | 2018 |
Repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasis.
Topics: Adult; Albendazole; Animals; Anthelmintics; Auranofin; Brugia malayi; Cattle; Cell Line; Diethylcarb | 2015 |
Clinical Features of Imported Loiasis: A Case Series from the Hospital for Tropical Diseases, London.
Topics: Adult; Diethylcarbamazine; Female; Filaricides; Hospitals, Special; Humans; Infectious Disease Incub | 2015 |
Loiasis in US Traveler Returning from Bioko Island, Equatorial Guinea, 2016.
Topics: Adult; Animals; Diethylcarbamazine; Diptera; Equatorial Guinea; Female; Filaricides; Humans; Insect | 2017 |
[Loa loa meningoencephalitis secondary to treatment with mebendazol].
Topics: Adolescent; Albendazole; Animals; Anthelmintics; Brain Damage, Chronic; Central Nervous System Helmi | 2011 |
[Asthenoscopic problems with a subconjunctival worm].
Topics: Adult; Asthenopia; Diethylcarbamazine; Emergencies; Eye Diseases; Filaricides; Humans; Loiasis; Male | 2002 |
Studies on the chemoprophylaxis of loiasis. I. Experiments on monkeys, with special reference to diethylcarbamazine (Banocide).
Topics: Animals; Anthelmintics; Chemoprevention; Diethylcarbamazine; Filariasis; Haplorhini; Humans; Loiasis | 1961 |
Loaiasis: recovery of adult Loa loa.
Topics: Adult; Animals; Biological Phenomena; Diethylcarbamazine; Filariasis; Humans; Loa; Loiasis; Physiolo | 1963 |
Destruction of microfilariae of Loa loa in the liver in loiasis treated with banocide (hetrazan).
Topics: Animals; Diethylcarbamazine; Filariasis; Humans; Liver; Loa; Loiasis; Microfilariae | 1951 |
[Ocular involvement in systemic Loa-Loa filariasis. Case report and review of the literature].
Topics: Adult; Africa, Central; Animals; Combined Modality Therapy; Conjunctival Diseases; Diethylcarbamazin | 2004 |
Loa loa macrofilariasis in the eyelid: case report of the first periocular subcutaneous manifestation in Germany.
Topics: Adult; Africa; Animals; Diethylcarbamazine; Eye Infections, Parasitic; Eyelid Diseases; Female; Fila | 2006 |
Loiasis treated with hetrazan.
Topics: Diethylcarbamazine; Filariasis; Loiasis; Piperazines | 1949 |
Treatment of Loa loa infections with hetrazan.
Topics: Animals; Diethylcarbamazine; Loa; Loiasis; Schistosomiasis | 1949 |
Lymphatic filariasis.
Topics: Adult; Antiparasitic Agents; Child; Diethylcarbamazine; Elephantiasis, Filarial; Female; Humans; Ive | 2008 |
Loasis as a possible trigger of African endomyocardial fibrosis: a case report from Nigeria.
Topics: Child; Diethylcarbamazine; Electrocardiography; Endocardial Fibroelastosis; Eosinophilia; Filariasis | 1981 |
Loiasis: a case report.
Topics: Adult; Diethylcarbamazine; Eyelid Diseases; Female; Filariasis; Humans; Loiasis; Netherlands; Nigeri | 1982 |
[Filariasis: clinico-therapeutic considerations on 24 cases].
Topics: Ascariasis; Diethylcarbamazine; Filariasis; Humans; Levamisole; Loiasis; Mansonelliasis; Onchocercia | 1984 |
[Articular effusions with eosinophils. Apropos of a case report].
Topics: Arthritis, Infectious; Diethylcarbamazine; Eosinophils; Filariasis; Humans; Loiasis; Male; Middle Ag | 1983 |
Usefulness of apheresis to extract microfilarias in management of loiasis.
Topics: Adult; Blood Platelets; Centrifugation; Diethylcarbamazine; Filariasis; Humans; Leukapheresis; Loa; | 1983 |
[Treatment of filariases in a hospital setting. Complications - results].
Topics: Diethylcarbamazine; Dracunculiasis; Eye Diseases; Filariasis; Humans; Loiasis; Lymphatic Diseases | 1981 |
[Eosinophilic articular effusions. Apropos of a case].
Topics: Acute Disease; Arthritis; Diethylcarbamazine; Drug Therapy, Combination; Eosinophilia; Filariasis; H | 1984 |
Ocular Loa Loa with cryoprobe extraction of subconjunctival worm.
Topics: Adolescent; Adult; Africa, Western; Conjunctival Diseases; Cryosurgery; Diethylcarbamazine; Filarias | 1984 |
Loiasis and renal failure.
Topics: Adult; Antigen-Antibody Complex; Diethylcarbamazine; Filariasis; Humans; Kidney Failure, Chronic; Ki | 1984 |
Loa loa: ocular filariasis in an African student in Missouri.
Topics: Adult; Cameroon; Diethylcarbamazine; Eye Diseases; Filariasis; Humans; Loiasis; Male; Missouri | 1984 |
[Ocular loaiasis in a young Caucasian tourist (author's transl)].
Topics: Adult; Conjunctival Diseases; Diethylcarbamazine; Female; Filariasis; Humans; Loiasis | 1980 |
African eye worm (Loa loa) in a tourist.
Topics: Adult; Diethylcarbamazine; Diphenhydramine; Female; Filariasis; Humans; Loa; Loiasis; Travel | 1981 |
Ascending paralysis associated with diethylcarbamazine treatment of M. loa loa infection.
Topics: Adult; Diethylcarbamazine; Filariasis; Humans; Loiasis; Male; Paralysis | 1982 |
[Loaiasis. Clinical aspects and therapy in the field of dermatology].
Topics: Adult; Antiparasitic Agents; Diagnosis, Differential; Diethylcarbamazine; Female; Filariasis; Humans | 1982 |
[African eye worm as initial manifestation of loaiasis].
Topics: Acetaminophen; Adult; Animals; Cameroon; Diazepam; Diethylcarbamazine; Drug Administration Schedule; | 1995 |
Traveller's loiasis in Zimbabwe: a case report.
Topics: Adult; Diethylcarbamazine; Female; Humans; Loiasis; Parasitemia; Travel; Zimbabwe | 1994 |
[Pulmonary involvement with a favorable course during Loa loa filariasis].
Topics: Cameroon; Diethylcarbamazine; Humans; Ivermectin; Loiasis; Lung Diseases, Parasitic; Male; Middle Ag | 1994 |
Effectiveness of diethylcarbamazine in treating loiasis acquired by expatriate visitors to endemic regions: long-term follow-up.
Topics: Diethylcarbamazine; Follow-Up Studies; Humans; Loiasis; Recurrence; Travel | 1994 |
[Value of filariopheresis in the treatment of Loa loa filariasis].
Topics: Adult; Animals; Child; Cytapheresis; Diethylcarbamazine; Female; Hemofiltration; Humans; Loa; Loiasi | 1993 |
Loa loa infection as a cause of migratory angioedema: report of three cases from the Texas Medical Center.
Topics: Adult; Angioedema; Animals; Antibodies, Helminth; Biopsy; Diagnosis, Differential; Diethylcarbamazin | 1993 |
[Secondary effects of the treatment of hypermicrofilaremic loiasis using ivermectin].
Topics: Adult; Aged; Animals; Arthralgia; C-Reactive Protein; Cameroon; Diethylcarbamazine; Female; Fever; F | 1995 |
A thirteen-year-old with a painful, swollen foot and eosinophilia.
Topics: Adolescent; Diethylcarbamazine; Eosinophilia; Female; Filaricides; Humans; Loiasis | 1995 |
Microfilarial clearance in loiasis involves elevation of Th1 and Th2 products and emergence of a specific pattern of T-cell populations.
Topics: Adult; Animals; Cytokines; Diethylcarbamazine; Female; Filaricides; Host-Parasite Interactions; Huma | 1996 |
Monosymptomatic Loa loa infection.
Topics: Adolescent; Animals; Diagnosis, Differential; Diethylcarbamazine; Female; Filaricides; Humans; Loa; | 1998 |
Albendazole therapy for loiasis refractory to diethylcarbamazine treatment.
Topics: Adult; Albendazole; Anthelmintics; Diethylcarbamazine; Drug Resistance; Female; Filaricides; Humans; | 1999 |
Diagnosing and treatment of skin filariases based on own observations.
Topics: Adolescent; Adult; Antiparasitic Agents; Diethylcarbamazine; Female; Filariasis; Filaricides; Humans | 2000 |
Case 1-2002: Loa loa.
Topics: Adult; Diethylcarbamazine; Eye; Filaricides; Humans; Loiasis; Male; Treatment Outcome | 2002 |
[Loaiasis and posterior uveitis. Apropos of a case].
Topics: Adult; Cameroon; Diethylcarbamazine; Filariasis; Humans; Loiasis; Male; Uveitis | 1975 |
[Current problems of loaiasis].
Topics: Africa; Animals; Diethylcarbamazine; Diptera; Disease Reservoirs; Encephalitis; Filariasis; Haplorhi | 1978 |
[Filaria infections from West and Central Africa].
Topics: Adult; Africa, Central; Africa, Western; Blood; Diethylcarbamazine; Dipetalonema; Dipetalonema Infec | 1977 |
[A case of retinal filariasis].
Topics: Child; Diethylcarbamazine; Exchange Transfusion, Whole Blood; Filariasis; Fundus Oculi; Humans; Loia | 1978 |
[Ocular manifestations of loaiasis].
Topics: Diethylcarbamazine; Eye Diseases; Eye Manifestations; Filariasis; Humans; Loiasis; Retinal Diseases; | 1978 |
[Cameroon swelling; infection by the filaria Loa loa].
Topics: Cameroon; Diethylcarbamazine; Edema; Eosinophilia; Eye Diseases; Filariasis; Humans; Insect Vectors; | 1979 |
[Late onset Plasmodium falciparum malaria revealed by corticoid therapy].
Topics: Adolescent; Diethylcarbamazine; Drug Therapy, Combination; Female; France; Gabon; Humans; Loiasis; M | 1992 |
Pulmonary involvement in loiasis.
Topics: Adult; Animals; Diethylcarbamazine; Humans; Loa; Loiasis; Male; Pleural Effusion; Pulmonary Eosinoph | 1992 |
[Foreign body granuloma on calcified loa loa filariasis].
Topics: Adult; Calcinosis; Diethylcarbamazine; Fingers; France; Gabon; Granuloma, Foreign-Body; Humans; Loia | 1992 |
[Value of ivermectin in the initial treatment of loaiasis].
Topics: Diethylcarbamazine; Female; Humans; Ivermectin; Loiasis; Male | 1991 |
Five cases of encephalitis during treatment of loiasis with diethylcarbamazine.
Topics: Adolescent; Adult; Diethylcarbamazine; Encephalitis; Female; Humans; Loiasis; Male | 1991 |
[Current possibilities in the control of Loa Loa filariasis].
Topics: Animals; Diethylcarbamazine; Diptera; Ecology; Humans; Insect Control; Ivermectin; Loa; Loiasis | 1990 |
Effect of diethylcarbamazine on adult Loa in monkeys.
Topics: Animals; Diethylcarbamazine; Female; Loa; Loiasis; Male; Microfilariae; Papio | 1990 |
Loa Loa disease.
Topics: Adult; Animals; Conjunctival Diseases; Diethylcarbamazine; Eye Infections, Parasitic; Humans; Loa; L | 1990 |
Loa loa in a Sri Lankan expatriate from Nigeria.
Topics: Adolescent; Diethylcarbamazine; Female; Filariasis; Humans; Loiasis; Nigeria; Sri Lanka | 1989 |
Presence of Loa loa microfilariae in ascitic fluid.
Topics: Adult; Ampicillin; Animals; Ascitic Fluid; Cefotaxime; Diethylcarbamazine; Drug Therapy, Combination | 1989 |
[Prevention of human Loa loa filariasis].
Topics: Adult; Diethylcarbamazine; Female; Filariasis; Humans; Loiasis | 1989 |
[Loa loa filariasis, encephalitis and treatment with Notézine: an underestimated complication?].
Topics: Adult; Diethylcarbamazine; Encephalitis; Filariasis; Humans; Loiasis; Male | 1989 |
[Loa loa filariasis: cause of severe eosinophilia].
Topics: Adult; Congo; Diethylcarbamazine; Eosinophilia; Filariasis; Humans; Loiasis; Male | 1989 |
Mebendazole treatment of loaiasis.
Topics: Benzimidazoles; Diethylcarbamazine; Filariasis; Humans; Loiasis; Mebendazole | 1985 |
Diethylcarbamazine and human loiasis.
Topics: Diethylcarbamazine; Filariasis; Humans; Loiasis | 1989 |
[A case of loiasis].
Topics: Animals; Democratic Republic of the Congo; Diethylcarbamazine; Filariasis; Humans; Loa; Loiasis; Mal | 1988 |
[Value of cytopheresis in the treatment of loaiasis].
Topics: Cell Separation; Diethylcarbamazine; Female; Filariasis; Humans; Loiasis; Middle Aged | 1985 |
Loa loa infection in temporary residents of endemic regions: recognition of a hyperresponsive syndrome with characteristic clinical manifestations.
Topics: Adult; Africa, Central; Diethylcarbamazine; Female; Filariasis; Humans; Leukocyte Count; Loa; Loiasi | 1986 |
[Loaiasis and its therapeutic difficulties].
Topics: Diethylcarbamazine; Eye Diseases; Filariasis; Humans; Ivermectin; Loiasis | 1986 |
Periocular Loa loa in eastern Scotland: a report of two cases.
Topics: Adult; Diethylcarbamazine; Eye; Female; Filariasis; Humans; Loiasis; Scotland | 1987 |
Loiasis in an expatriate American child: diagnostic and treatment difficulties.
Topics: Cameroon; Child, Preschool; Diethylcarbamazine; Female; Filariasis; Humans; Loiasis; United States | 1987 |
[Value of cytapheresis in the treatment of loaiasis with high blood microfilaria levels. Results in 7 cases].
Topics: Adult; Animals; Blood Component Removal; Diethylcarbamazine; Female; Filariasis; Humans; Loiasis; Ma | 1987 |
Loa loa. An unusual case of chronic urticaria and angioedema in the United States.
Topics: Angioedema; Central African Republic; Chronic Disease; Diethylcarbamazine; Female; Filariasis; Flocc | 1985 |
An imported case of human infection with Loa loa.
Topics: Adult; Africa; Diethylcarbamazine; Diptera; Filariasis; Follow-Up Studies; Germany, West; Humans; In | 1985 |
Application of the indirect fluorescent antibody test on sections of adult filariae to the serodiagnosis, epidemiology and post-therapeutic surveillance of human filariasis.
Topics: Antigens; Central African Republic; Colombia; Cross Reactions; Diethylcarbamazine; Epidemiologic Met | 1974 |