Page last updated: 2024-12-10

trichomonacid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

trichomonacid: RN given refers to phosphate (1:3) salt [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID5285740
CHEMBL ID601778
SCHEMBL ID22509233
MeSH IDM0107862

Synonyms (14)

Synonym
7195-14-4
1,4-pentanediamine, n1,n1-diethyl-n4-(6-methoxy-2-(2-(4-nitrophenyl)ethenyl)-4-quinolinyl)-, phosphate (1:3)
STK097088
n~1~,n~1~-diethyl-n~4~-{6-methoxy-2-[(e)-2-(4-nitrophenyl)ethenyl]quinolin-4-yl}pentane-1,4-diamine
trichomonacid
gnf-pf-182 ,
CHEMBL601778
AKOS000538589
1-n,1-n-diethyl-4-n-[6-methoxy-2-[(e)-2-(4-nitrophenyl)ethenyl]quinolin-4-yl]pentane-1,4-diamine
AKOS021983733
trichomonacide
n-[5-(diethylamino)pentan-2-yl]-6-methoxy-2-[(1e)-2-(4-nitrophenyl)ethenyl]quinolin-4-amine
(e)-n1,n1-diethyl-n4-(6-methoxy-2-(4-nitrostyryl)quinolin-4-yl)pentane-1,4-diamine
SCHEMBL22509233

Research Excerpts

Toxicity

ExcerptReferenceRelevance
"Anti-Trichomonal contraceptives with specifically acting synthetic component and clinically-proven safe natural component may define a new concept in empowering women to control their fertility and reproductive health."( Combining a synthetic spermicide with a natural trichomonacide for safe, prophylactic contraception.
Gupta, G; Jain, A; Kumar, L; Kushwaha, B; Maikhuri, JP; Pandey, A; Rawat, T; Sharma, M; Sharma, V; Sharma, VL; Singh, V; Verma, V, 2014
)
0.66

Bioavailability

ExcerptReferenceRelevance
" The orally bioavailable lead imidazolopiperazine confers complete causal prophylactic protection (15 milligrams/kilogram) in rodent models of malaria and shows potent in vivo blood-stage therapeutic activity."( Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery.
Barnes, SW; Bonamy, GM; Bopp, SE; Borboa, R; Bright, AT; Chatterjee, A; Che, J; Cohen, S; Dharia, NV; Diagana, TT; Fidock, DA; Froissard, P; Gagaring, K; Gettayacamin, M; Glynne, RJ; Gordon, P; Groessl, T; Kato, N; Kuhen, KL; Lee, MC; Mazier, D; McNamara, CW; Meister, S; Nagle, A; Nam, TG; Plouffe, DM; Richmond, W; Roland, J; Rottmann, M; Sattabongkot, J; Schultz, PG; Tuntland, T; Walker, JR; Winzeler, EA; Wu, T; Zhou, B; Zhou, Y, 2011
)
0.37
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (16)

Assay IDTitleYearJournalArticle
AID1676921Resistant index, ratio of EC50 for antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 to antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D72020Journal of medicinal chemistry, 10-22, Volume: 63, Issue:20
Synthesis, Structure-Activity Relationship, and Antimalarial Efficacy of 6-Chloro-2-arylvinylquinolines.
AID1676922Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 infected in human erythrocytes assessed as reduction in microbial growth after 72 hrs by SYBR green I staining based fluorescence assay2020Journal of medicinal chemistry, 10-22, Volume: 63, Issue:20
Synthesis, Structure-Activity Relationship, and Antimalarial Efficacy of 6-Chloro-2-arylvinylquinolines.
AID1676929Stability of compound in mouse liver microsomes assessed as parent compound remaining after 60 mins in presence of NADPH by LC-MS analysis2020Journal of medicinal chemistry, 10-22, Volume: 63, Issue:20
Synthesis, Structure-Activity Relationship, and Antimalarial Efficacy of 6-Chloro-2-arylvinylquinolines.
AID449705NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)2008Proceedings of the National Academy of Sciences of the United States of America, Jul-01, Volume: 105, Issue:26
In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen.
AID1676923Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes assessed as reduction in microbial growth after 72 hrs by SYBR green I staining based fluorescence assay2020Journal of medicinal chemistry, 10-22, Volume: 63, Issue:20
Synthesis, Structure-Activity Relationship, and Antimalarial Efficacy of 6-Chloro-2-arylvinylquinolines.
AID449703NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay 2008Proceedings of the National Academy of Sciences of the United States of America, Jul-01, Volume: 105, Issue:26
In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen.
AID1676930Half life in mouse liver microsomes after 60 mins in presence of NADPH by LC-MS analysis2020Journal of medicinal chemistry, 10-22, Volume: 63, Issue:20
Synthesis, Structure-Activity Relationship, and Antimalarial Efficacy of 6-Chloro-2-arylvinylquinolines.
AID1676924Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTS assay2020Journal of medicinal chemistry, 10-22, Volume: 63, Issue:20
Synthesis, Structure-Activity Relationship, and Antimalarial Efficacy of 6-Chloro-2-arylvinylquinolines.
AID449704NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay2008Proceedings of the National Academy of Sciences of the United States of America, Jul-01, Volume: 105, Issue:26
In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen.
AID449706NOVARTIS: Inhibition Frequency Index (IFI) - the number of HTS assays where a compound showed > 50% inhibition/induction, expressed as a percentage of the number of assays in which the compound was tested.2008Proceedings of the National Academy of Sciences of the United States of America, Jul-01, Volume: 105, Issue:26
In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen.
AID1676925Selectivity index, ratio of EC50 for cytotoxicity against human HepG2 cells to antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd22020Journal of medicinal chemistry, 10-22, Volume: 63, Issue:20
Synthesis, Structure-Activity Relationship, and Antimalarial Efficacy of 6-Chloro-2-arylvinylquinolines.
AID1676926Stability of compound in mouse liver microsomes assessed as parent compound remaining at 1 uM after 60 mins in presence of NADPH by LC-MS analysis2020Journal of medicinal chemistry, 10-22, Volume: 63, Issue:20
Synthesis, Structure-Activity Relationship, and Antimalarial Efficacy of 6-Chloro-2-arylvinylquinolines.
AID1676927Half life in mouse liver microsomes at 1 uM after 60 mins in presence of NADPH by LC-MS analysis2020Journal of medicinal chemistry, 10-22, Volume: 63, Issue:20
Synthesis, Structure-Activity Relationship, and Antimalarial Efficacy of 6-Chloro-2-arylvinylquinolines.
AID1676928Intrinsic clearance in mouse liver microsomes assessed as parent compound at 1 uM after 60 mins in presence of NADPH by LC-MS analysis2020Journal of medicinal chemistry, 10-22, Volume: 63, Issue:20
Synthesis, Structure-Activity Relationship, and Antimalarial Efficacy of 6-Chloro-2-arylvinylquinolines.
AID602118NOVARTIS: Antimalarial liver stage activity measured as a greater than 50% reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells at 10uM compound concentration, determined by immuno-fluorescence.2011Science (New York, N.Y.), Dec-09, Volume: 334, Issue:6061
Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery.
AID602156Novartis GNF Liver Stage Dataset: Malariabox Annotation2011Science (New York, N.Y.), Dec-09, Volume: 334, Issue:6061
Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (20.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's2 (40.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 20.49

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index20.49 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.80 (4.65)
Search Engine Demand Index15.26 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (20.49)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]