Compounds > pityriacitrin
Page last updated: 2024-11-13

pityriacitrin

Description

pityriacitrin: the yeast Malassezia furfur; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID56649540
CHEMBL ID1910711
SCHEMBL ID21479840
MeSH IDM0445574

Synonyms (6)

Synonym
CHEMBL1910711
SCHEMBL21479840
244295-64-5
(1h-indol-3-yl)(9h-pyrido[3,4-b]indol-1-yl)methanone
pityriacitrin
F75215

Research Excerpts

Overview

Pityriacitrin is a natural marine alkaloid with a typical β-carboline scaffold. It has been demonstrated to exhibit diverse biological functions.

ExcerptReferenceRelevance
"Pityriacitrin is a marine alkaloid with typical β-carboline scaffold, and which has been proven to exhibit diverse biological functions. "( Synthesis and biological evaluation of marine alkaloid-oriented β-carboline analogues.
Ke, S; Shi, L; Wang, K; Xu, T; Yang, Z; Zhang, Y, 2019)		1.96
"Pityriacitrin is a natural marine alkaloid with a typical β-carboline scaffold, and which has been demonstrated to exhibit diverse biological functions. "( Marine Alkaloid Pityriacitrin and Its Analogues: Discovery, Structures, Synthetic Methods and Biological Properties.
Ke, S; Min, Y; Wan, Z; Wang, K; Xu, T; Yang, Z, 2021)		2.41
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (14)

Assay IDTitleYearJournalArticle
AID1593058Cytotoxicity against human HepG2 cells assessed as growth inhibition at 40 ug/mL after 72 hrs by MTT assay2019European journal of medicinal chemistry, Apr-15, Volume: 168Synthesis and biological evaluation of marine alkaloid-oriented β-carboline analogues.
AID1593059Cytotoxicity against African green monkey MARC145 cells assessed as growth inhibition at 40 ug/mL after 72 hrs by MTT assay2019European journal of medicinal chemistry, Apr-15, Volume: 168Synthesis and biological evaluation of marine alkaloid-oriented β-carboline analogues.
AID626074Cytotoxicity against human MCF7 cells after 18 hrs by MTT assay2011European journal of medicinal chemistry, Dec, Volume: 46, Issue:12
Total synthesis and bioactivity of the marine alkaloid pityriacitrin and some of its derivatives.
AID626076Cytotoxicity against human PC3 cells after 18 hrs by MTT assay2011European journal of medicinal chemistry, Dec, Volume: 46, Issue:12
Total synthesis and bioactivity of the marine alkaloid pityriacitrin and some of its derivatives.
AID626075Cytotoxicity against human MDA231 cells after 18 hrs by MTT assay2011European journal of medicinal chemistry, Dec, Volume: 46, Issue:12
Total synthesis and bioactivity of the marine alkaloid pityriacitrin and some of its derivatives.
AID1265389Induction of P-glycoprotein in human LS180 cells assessed as accumulation of intracellular rhodamine-123 at 1 uM after 48 hrs by fluorescence assay relative to control2016European journal of medicinal chemistry, Jan-01, Volume: 107Discovery of a marine-derived bis-indole alkaloid fascaplysin, as a new class of potent P-glycoprotein inducer and establishment of its structure-activity relationship.
AID1593056Cytotoxicity against human SGC7901 cells assessed as growth inhibition at 40 ug/mL after 72 hrs by MTT assay2019European journal of medicinal chemistry, Apr-15, Volume: 168Synthesis and biological evaluation of marine alkaloid-oriented β-carboline analogues.
AID1593062Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by MTT assay2019European journal of medicinal chemistry, Apr-15, Volume: 168Synthesis and biological evaluation of marine alkaloid-oriented β-carboline analogues.
AID1593060Cytotoxicity against human SGC7901 cells assessed as growth inhibition after 72 hrs by MTT assay2019European journal of medicinal chemistry, Apr-15, Volume: 168Synthesis and biological evaluation of marine alkaloid-oriented β-carboline analogues.
AID1700578Cytotoxicity against human A549 cells assessed as reduction in cell viability by MTT assay
AID1593061Cytotoxicity against human A875 cells assessed as growth inhibition after 72 hrs by MTT assay2019European journal of medicinal chemistry, Apr-15, Volume: 168Synthesis and biological evaluation of marine alkaloid-oriented β-carboline analogues.
AID1593063Cytotoxicity against African green monkey MARC145 cells assessed as growth inhibition after 72 hrs by MTT assay2019European journal of medicinal chemistry, Apr-15, Volume: 168Synthesis and biological evaluation of marine alkaloid-oriented β-carboline analogues.
AID1265397Cytotoxicity against human LS180 cells assessed as cell viability at 10 uM after 48 hrs by MTT assay relative to control2016European journal of medicinal chemistry, Jan-01, Volume: 107Discovery of a marine-derived bis-indole alkaloid fascaplysin, as a new class of potent P-glycoprotein inducer and establishment of its structure-activity relationship.
AID1593057Cytotoxicity against human A875 cells assessed as growth inhibition at 40 ug/mL after 72 hrs by MTT assay2019European journal of medicinal chemistry, Apr-15, Volume: 168Synthesis and biological evaluation of marine alkaloid-oriented β-carboline analogues.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (45.45)29.6817
2010's3 (27.27)24.3611
2020's3 (27.27)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 23.78

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index23.78 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index4.63 (4.65)
Search Engine Demand Index23.28 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (23.78)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (9.09%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (90.91%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
tryptamine
[no description available]		2.0210aminoalkylindole;
aralkylamino compound;
indole alkaloid;
tryptamines		human metabolite;
mouse metabolite;
plant metabolite
fluorouracil
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.		2.2110nucleobase analogue;
organofluorine compound		antimetabolite;
antineoplastic agent;
environmental contaminant;
immunosuppressive agent;
radiosensitizing agent;
xenobiotic
tryptophan
Tryptophan: An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.. tryptophan : An alpha-amino acid that is alanine bearing an indol-3-yl substituent at position 3.		2.4320erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
tryptophan zwitterion;
tryptophan		antidepressant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
gramine
gramine : An aminoalkylindole that is indole carrying a dimethylaminomethyl substituent at postion 3.		2.0210aminoalkylindole;
indole alkaloid;
tertiary amino compound		antibacterial agent;
antiviral agent;
plant metabolite;
serotonergic antagonist
paclitaxel
Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).		2.0610taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
fascaplysine
fascaplysine: from tropic sea sponges		2.1310
rifampin
Rifampin: A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)		2.1310cyclic ketal;
hydrazone;
N-iminopiperazine;
N-methylpiperazine;
rifamycins;
semisynthetic derivative;
zwitterion		angiogenesis inhibitor;
antiamoebic agent;
antineoplastic agent;
antitubercular agent;
DNA synthesis inhibitor;
EC 2.7.7.6 (RNA polymerase) inhibitor;
Escherichia coli metabolite;
geroprotector;
leprostatic drug;
neuroprotective agent;
pregnane X receptor agonist;
protein synthesis inhibitor
ConditionIndicatedRelationship StrengthStudiesTrials
Breast Cancer
[description not available]		02.0610
Cancer of Prostate
[description not available]		02.0610
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.0610
Prostatic Neoplasms
Tumors or cancer of the PROSTATE.		02.0610
Malassezia furfur Infection
[description not available]		02.0310
Erythema
Redness of the skin produced by congestion of the capillaries. This condition may result from a variety of disease processes.		02.0310
Tinea Versicolor
A common chronic, noninflammatory and usually symptomless disorder, characterized by the occurrence of multiple macular patches of all sizes and shapes, and varying in pigmentation from fawn-colored to brown. It is seen most frequently in hot, humid, tropical regions and is mostly caused by MALASSEZIA FURFUR (formerly Pityrosporum orbiculare).		02.0310
Sunburn
An injury to the skin causing erythema, tenderness, and sometimes blistering and resulting from excessive exposure to the sun. The reaction is produced by the ultraviolet radiation in sunlight.		02.0110
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