Page last updated: 2024-08-05 13:36:37

tomaymycin

A pyrrolobenzodiazepine that is (11aS)-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine which is substituted at positions 2,5,7,8 and 11R by ethylidene, oxo, methoxy, hydroxy and methoxy groups, respectively. It is a natural product of Streptomyces achromogenes that binds covalently with guanine in the minor groove of DNA. It is an antitumoral compound which is active in ovarian, plasmacytoma, and leukemia cancer cell lines at nanomolar concentrations.

ChEBI ID: 157681

Members (1)

MemberDefinitionRole
tomaymycinThe (Z)-isomer of tomaymycin.(Z)-tomaymycin

Research

Studies (35)

TimeframeStudies, Drugs in This Class (%)All Drugs %
pre-199015 (42.86)18.7374
1990's11 (31.43)18.2507
2000's4 (11.43)29.6817
2010's5 (14.29)24.3611
2020's0 (0.00)2.80

Study Types

Publication TypeStudies, Drugs in This Class (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (2.86%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other34 (97.14%)84.16%