Mucinoses

Mucoid states characterized by the elevated deposition and accumulation of mucin (mucopolysaccharides) in dermal tissue. The fibroblasts are responsible for the production of acid mucopolysaccharides (GLYCOSAMINOGLYCANS) in the ground substance of the connective tissue system. When fibroblasts produce abnormally large quantities of mucopolysaccharides as hyaluronic acid, chondroitin sulfate, or heparin, they accumulate in large amounts in the dermis.

Synonym
Mucinoses
Mucinosis

Excerpt	Reference
"Pretibial mucinosis is a histological feature associated with morbid obesity and lymphoedematous features of the legs that should be distinguished from true pretibial myxoedema."	( Amantea, A; Donati, P; Ferrara, G; Montinari, M; Parodi, A; Rongioletti, F; Santoro, F, 2009)
"Dermal mucinoses are a heterogeneous group of disorders characterized by abnormal deposition of dermal mucin, an amorphous substance composed of hyaluronic acid and sulfated glycosaminoglycans."	( Berger, T; Pugashetti, R; Rajendran, P; Seiverling, EV; Zedek, DC, 2010)
"Nodular mucinosis is an unusual form of myxedema which mimics tophaceous gout, and should be considered in patients with Graves disease presenting with subcutaneous nodules."	( Chen, DY; Chen, HH; Chen, YM; Lan, JL; Sheu, WH, 2010)

Excerpt	Reference
"Both the erythroderma and generalized mucinosis responded to topical steroid and PUVA therapy."	( Aiba, S; Fujimura, T; Nakagawa, S; Okuyama, R; Terui, T, 2006)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	2 (3.51)	23.3326
1990's	16 (28.07)	12.5806
2000's	15 (26.32)	18.1394
2010's	20 (35.09)	28.8240
2020's	4 (7.02)	9.53

Drug	Relationship Strength	Studies
quinacrine	low	1
salicylic acid	low	2
dalteparin	low	1
acemetacin	low	1
azathioprine	low	1
chloroquine	low	2
hydroxychloroquine	low	8
indomethacin	low	2
khellin	low	1
prednisolone	low	2
prednisone	low	3
methylprednisolone acetate	low	1
penicillin g	low	1
pantothenic acid	low	1
methylprednisolone	low	3
hematoxylin	low	1
eosine yellowish-(ys)	low	1
trolamine salicylate	low	2
triamcinolone	low	1
diflucortolone valerate	low	1
methotrexate	low	1
cortisone	low	1
tacrolimus	low	4
mycophenolic acid	low	2
dermatan sulfate	low	2
isotretinoin	low	1
clobetasol	low	1
diflucortolone	low	2
chondroitin	low	1
heparitin sulfate	low	2
hyaluronoglucosaminidase	low	2
cyclosporine	low	4
chondroitin sulfates	low	3
alcian blue	low	4

Protein Targets (614)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	8	0	0	8
Chain A, Putative fructose-1,6-bisphosphate aldolase	3	0	0	3
Chain A, Cruzipain	4	0	0	4
Luciferase	5	0	0	5
phosphopantetheinyl transferase	5	0	0	5
SMAD family member 2	5	0	0	5
SMAD family member 3	5	0	0	5
AR protein	19	0	0	19
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	7	0	0	7
estrogen nuclear receptor alpha	20	0	0	20
peroxisome proliferator-activated receptor delta	9	0	0	9
peroxisome proliferator activated receptor gamma	11	0	0	11
vitamin D (1,25- dihydroxyvitamin D3) receptor	11	0	0	11
chromobox protein homolog 1	7	0	0	7
pyruvate kinase PKM isoform a	1	0	0	1
Lactoylglutathione lyase	0	2	0	2
TAR DNA-binding protein 43	4	0	0	4
TDP1 protein	19	0	0	19
glucocorticoid receptor [Homo sapiens]	17	0	0	17
ATP-binding cassette sub-family C member 3	0	11	0	11
Multidrug resistance-associated protein 4	0	11	0	13
Bile salt export pump	0	17	0	17
Cellular tumor antigen p53	11	0	0	11
Thromboxane-A synthase	0	2	0	2
Prostaglandin E2 receptor EP3 subtype	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin E2 receptor EP1 subtype	0	2	0	2
Prostacyclin receptor	0	1	1	2
Nuclear receptor subfamily 4 group A member 2	0	0	2	2
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Canalicular multispecific organic anion transporter 1	0	11	0	11
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier organic anion transporter family member 2B1	0	1	0	1
Solute carrier organic anion transporter family member 3A1	0	0	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	4	0	0	4
Chain A, Ferritin light chain	6	0	0	6
interleukin 8	2	0	0	2
acetylcholinesterase	3	0	0	3
thioredoxin reductase	10	0	0	10
RAR-related orphan receptor gamma	10	0	0	10
ATAD5 protein, partial	5	0	0	5
Fumarate hydratase	2	0	0	2
GLI family zinc finger 3	11	0	0	11
Microtubule-associated protein tau	6	0	0	6
thioredoxin glutathione reductase	5	0	0	5
nuclear receptor subfamily 1, group I, member 3	7	0	0	7
EWS/FLI fusion protein	5	0	0	5
retinoic acid nuclear receptor alpha variant 1	6	0	0	6
retinoid X nuclear receptor alpha	10	0	0	10
estrogen-related nuclear receptor alpha	13	0	0	13
farnesoid X nuclear receptor	7	0	0	7
pregnane X nuclear receptor	11	0	0	11
G	7	0	0	7
polyprotein	2	0	0	2
P53	1	0	0	1
arylsulfatase A	3	0	0	3
IDH1	6	0	0	6
euchromatic histone-lysine N-methyltransferase 2	11	0	0	11
aryl hydrocarbon receptor	8	0	0	8
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	13	0	0	13
thyroid stimulating hormone receptor	3	0	0	3
activating transcription factor 6	4	0	0	4
v-jun sarcoma virus 17 oncogene homolog (avian)	4	0	0	4
Histone H2A.x	3	0	0	3
Bloom syndrome protein isoform 1	5	0	0	5
peripheral myelin protein 22 isoform 1	5	0	0	5
hemoglobin subunit beta	1	0	0	1
cellular tumor antigen p53 isoform a	3	0	0	3
thyroid hormone receptor beta isoform 2	9	0	0	9
heat shock protein beta-1	6	0	0	6
nuclear factor erythroid 2-related factor 2 isoform 1	10	0	0	10
DNA polymerase iota isoform a (long)	6	0	0	6
geminin	13	0	0	13
peripheral myelin protein 22	6	0	0	6
survival motor neuron protein isoform d	9	0	0	9
cytochrome P450 3A4 isoform 1	7	0	0	7
M-phase phosphoprotein 8	6	0	0	6
muscleblind-like protein 1 isoform 1	4	0	0	4
muscarinic acetylcholine receptor M1	2	0	0	2
lamin isoform A-delta10	6	0	0	6
Gamma-aminobutyric acid receptor subunit pi	7	0	0	7
Bile salt export pump	0	3	0	3
Voltage-dependent calcium channel gamma-2 subunit	9	0	0	9
Interferon beta	10	0	0	10
HLA class I histocompatibility antigen, B alpha chain	7	0	0	7
Gamma-aminobutyric acid receptor subunit beta-1	7	0	0	7
Gamma-aminobutyric acid receptor subunit delta	7	0	0	7
Gamma-aminobutyric acid receptor subunit gamma-2	7	0	0	7
Glutamate receptor 2	9	1	0	10
Gamma-aminobutyric acid receptor subunit alpha-5	7	0	0	7
Gamma-aminobutyric acid receptor subunit alpha-3	7	0	0	7
Gamma-aminobutyric acid receptor subunit gamma-1	7	0	0	7
Gamma-aminobutyric acid receptor subunit alpha-2	7	0	0	7
Gamma-aminobutyric acid receptor subunit alpha-4	7	0	0	7
Gamma-aminobutyric acid receptor subunit gamma-3	7	0	0	7
Gamma-aminobutyric acid receptor subunit alpha-6	7	0	0	7
Nuclear receptor ROR-gamma	3	1	1	5
Gamma-aminobutyric acid receptor subunit alpha-1	7	0	0	7
Gamma-aminobutyric acid receptor subunit beta-3	7	0	0	7
Gamma-aminobutyric acid receptor subunit beta-2	7	0	0	7
GABA theta subunit	7	0	0	7
Inositol hexakisphosphate kinase 1	7	0	0	7
ATPase family AAA domain-containing protein 5	9	0	0	9
Ataxin-2	11	0	0	11
Gamma-aminobutyric acid receptor subunit epsilon	7	0	0	7
Protein-arginine deiminase type-4	0	2	0	2
cytochrome P450 2C9, partial	7	0	0	7
pregnane X receptor	4	0	0	4
progesterone receptor	11	0	0	11
cytochrome P450 family 3 subfamily A polypeptide 4	8	0	0	8
nuclear receptor subfamily 1, group I, member 2	5	0	0	5
thyroid hormone receptor beta isoform a	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 2	10	0	0	10
galanin receptor type 3	0	1	0	1
Glucocorticoid receptor	0	14	2	21
Glycine receptor subunit alpha-1	0	14	0	14
Glycine receptor subunit beta	0	14	0	14
Glycine receptor subunit alpha-2	0	14	0	14
Glycine receptor subunit alpha-3	0	14	0	14
ORF73	0	0	1	1
PPM1D protein	3	0	0	3
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	2	0	2
Spike glycoprotein	0	1	2	3
Replicase polyprotein 1ab	0	1	2	3
glucose-6-phosphate 1-dehydrogenase isoform b	0	2	0	2
flap endonuclease 1	5	0	0	5
Transmembrane protease serine 2	0	1	2	3
Dihydrofolate reductase	0	2	0	2
DNA ligase	0	1	0	1
Riboflavin-binding protein	0	1	2	3
Major prion protein	0	0	2	2
Amyloid-beta precursor protein	0	2	0	2
Histidine-rich protein PFHRP-II	0	2	0	3
Procathepsin L	0	2	2	4
Muscarinic acetylcholine receptor M2	0	5	0	5
Muscarinic acetylcholine receptor M4	0	4	0	4
Cytochrome P450 3A4	0	3	1	4
Muscarinic acetylcholine receptor M5	0	4	0	4
Alpha-2A adrenergic receptor	0	4	0	4
Replicase polyprotein 1a	0	1	2	3
Replicase polyprotein 1ab	0	1	2	3
Replicase polyprotein 1ab	0	2	2	4
Spike glycoprotein	0	1	0	1
Replicase polyprotein 1ab	0	3	2	5
Muscarinic acetylcholine receptor M1	0	4	0	4
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	1	0	1
Alpha-2B adrenergic receptor	0	6	0	6
Alpha-2C adrenergic receptor	0	4	0	4
DNA ligase 1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	4	0	4
Serine/threonine-protein kinase mTOR	0	2	0	2
Beta-secretase 1	0	1	0	1
Spike glycoprotein	4	1	2	7
Calcium-dependent protein kinase 1	0	0	1	1
MO15-related protein kinase Pfmrk	0	1	0	1
DNA ligase A	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	4	0	4
Sigma intracellular receptor 2	0	2	0	2
Phosphoethanolamine N-methyltransferase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	2	0	2
Angiotensin-converting enzyme 2	0	1	2	3
Cysteine proteinase falcipain 2a	0	1	0	1
Cysteine proteinase falcipain 2a	0	1	0	1
Chain A, HADH2 protein	6	0	0	6
Chain B, HADH2 protein	6	0	0	6
endonuclease IV	1	0	0	1
dopamine D1 receptor	3	0	0	3
GLS protein	2	0	0	2
aldehyde dehydrogenase 1 family, member A1	9	0	0	9
regulator of G-protein signaling 4	5	0	0	5
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	4	0	0	4
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	2	0	2
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
Multidrug and toxin extrusion protein 1	0	2	0	2
cytochrome P450 2D6	2	0	0	2
Chain A, Beta-lactamase	2	0	0	2
nuclear receptor ROR-gamma isoform 1	6	0	0	6
neuropeptide S receptor isoform A	2	0	0	2
Chain E, Fibrin beta chain	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
Chain A, 2-oxoglutarate Oxygenase	6	0	0	6
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
15-lipoxygenase, partial	2	0	0	2
WRN	1	0	0	1
Mcl-1	0	1	0	1
MPI protein	0	1	0	1
USP1 protein, partial	7	0	0	7
Cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0	0	0	1
alkaline phosphatase, intestinal	0	0	1	1
apical membrane antigen 1, AMA1	1	0	0	1
hypothetical protein, conserved	1	0	0	1
67.9K protein	6	0	0	6
glucocerebrosidase	2	0	0	2
luciferase	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	4	0	0	4
pyruvate kinase	1	0	0	1
CDK5	0	0	0	1
serine-protein kinase ATM isoform a	1	0	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
major prion protein preproprotein Prp precursor	0	1	0	1
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein	0	0	1	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	5	0	0	5
vitamin D3 receptor isoform VDRA	6	0	0	6
intestinal alkaline phosphatase precursor	0	0	1	1
DNA polymerase beta	2	0	0	2
mitogen-activated protein kinase 1	2	0	0	2
serine/threonine-protein kinase PLK1	2	0	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	4	0	0	4
DNA polymerase eta isoform 1	3	0	0	3
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
DNA polymerase kappa isoform 1	6	0	0	6
Vif	0	1	0	1
Tat	0	1	0	1
histone acetyltransferase KAT2A isoform 1	6	0	0	6
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	0	1	0	1
alkaline phosphatase, germ cell type preproprotein	0	0	1	1
endoribonuclease toxin MazF	0	0	1	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Integrin beta-3	2	0	0	2
Integrin alpha-IIb	2	0	0	2
Pyruvate kinase PKM	0	1	0	1
Endothelin receptor type B	1	0	0	1
Endothelin-1 receptor	1	0	0	1
Histamine H2 receptor	2	0	0	2
Inositol monophosphatase 1	1	0	0	1
phosphoglycerate kinase	1	0	0	1
hypothetical protein CAALFM_CR05890CA	0	0	0	1
H3 histone acetyltransferase	0	0	0	1
ATP-dependent phosphofructokinase	4	0	0	4
large T antigen	0	1	0	1
Genome polyprotein	0	1	0	1
Alpha-1D adrenergic receptor	0	4	0	4
Cyclic GMP-AMP synthase	0	2	0	2
Toll-like receptor 9	0	1	0	1
Toll-like receptor 7	0	1	0	1
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
hypoxia-inducible factor 1 alpha subunit	5	0	0	5
estrogen receptor 2 (ER beta)	6	0	0	6
Parkin	3	0	0	3
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
cytochrome P450 2D6 isoform 1	2	0	0	2
cytochrome P450 2C9 precursor	1	0	0	1
ras-related protein Rab-9A	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	3	0	0	3
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin E synthase	0	1	0	1
Solute carrier family 22 member 6	0	3	0	3
Prostaglandin G/H synthase 1	0	1	0	2
Prostaglandin G/H synthase 2	0	1	0	2
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Cytochrome c oxidase subunit 2	0	1	0	1
Epidermal growth factor receptor	0	1	0	1
Phospholipase A2, major isoenzyme	0	1	0	1
Albumin	0	2	1	3
Prostaglandin G/H synthase 1	0	2	0	3
ATP-dependent translocase ABCB1	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Interleukin-8	0	1	0	1
Androgen receptor	0	2	1	3
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	2
Aldo-keto reductase family 1 member B1	0	2	0	2
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member C4	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Sodium-dependent dopamine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Adenosine receptor A1	0	1	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Caspase-1	0	0	0	1
Nitric oxide synthase, inducible	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Substance-P receptor	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	2
Bifunctional epoxide hydrolase 2	0	1	0	1
Prostaglandin G/H synthase 2	0	4	1	5
Prostaglandin G/H synthase 2	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	2	2
Aldo-keto reductase family 1 member C3	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
C-X-C chemokine receptor type 3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Guanine nucleotide-binding protein G	2	0	0	2
Prostaglandin D2 receptor	0	2	0	2
Solute carrier organic anion transporter family member 1A3	0	1	0	2
Prostaglandin G/H synthase 2	0	2	0	2
Aldo-keto reductase family 1 member C1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Solute carrier family 22 member 6	0	2	0	3
Solute carrier family 22 member 7	0	0	0	2
Sigma intracellular receptor 2	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Nicotinate phosphoribosyltransferase	0	2	0	2
Solute carrier family 22 member 8	0	3	0	4
Dehydrogenase/reductase SDR family member 9	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	3
Cytosolic phospholipase A2 gamma	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
Solute carrier organic anion transporter family member 1B1	0	3	0	3
Caspase-7	2	0	0	2
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	1	0	0	1
caspase-3	2	0	0	2
Ornithine decarboxylase	0	0	0	2
Adenosine receptor A3	0	4	0	4
Retinoic acid receptor alpha	0	2	2	4
Alpha-1B adrenergic receptor	0	4	0	4
Retinoic acid receptor gamma	0	2	2	4
Retinoic acid receptor beta	0	2	2	4
Cellular retinoic acid-binding protein 2	0	0	2	2
Mitogen-activated protein kinase 1	0	2	0	2
Retinoic acid receptor RXR-alpha	0	2	2	4
Retinoic acid receptor RXR-beta	0	2	2	4
Retinoic acid receptor RXR-gamma	0	2	2	4
Cellular retinoic acid-binding protein 1	0	2	0	3
5-hydroxytryptamine receptor 2B	0	4	0	4
Alpha-1A adrenergic receptor	0	4	0	4
Cellular retinoic acid-binding protein 1	0	0	2	2
Mitogen-activated protein kinase 14	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Olfactory receptor 51E2	0	1	0	1
glp-1 receptor, partial	3	0	0	3
GALC protein	1	0	0	1
cytochrome P450 2C19 precursor	1	0	0	1
importin subunit beta-1 isoform 1	3	0	0	3
snurportin-1	3	0	0	3
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
Cytochrome P450 1A1	0	2	0	2
Cytochrome P450 1A2	0	2	1	3
Cytochrome P450 2D6	0	1	1	2
Cytochrome P450 2C9	0	3	1	4
Cytochrome P450 2C19	0	1	1	2
Cytochrome P450 1B1	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
acid sphingomyelinase	1	0	0	1
ClpP	1	0	0	1
Thymidylate synthase	0	1	0	1
alpha-galactosidase	1	0	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
transcriptional regulator ERG isoform 3	1	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
caspase-1 isoform alpha precursor	1	0	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Carbonic anhydrase 2	0	2	1	3
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
5-hydroxytryptamine receptor 2C	0	1	0	2
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Caspase-7	1	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 6	0	2	0	2
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier family 22 member 11	0	0	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	2
nonstructural protein 1	2	0	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Androgen receptor	0	3	0	3
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
Chain A, Inosine-5'-Monophosphate Dehydrogenase 2	0	1	0	1
lethal factor (plasmid)	1	0	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Inosine-5'-monophosphate dehydrogenase 2	0	2	0	2
Glutamate receptor 1	0	1	0	1
Glutamate receptor 3	0	1	0	1
Glutamate receptor 4	0	1	0	1
Inosine-5'-monophosphate dehydrogenase 1	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	0	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Alpha-synuclein	1	1	0	2
Inosine-5'-monophosphate dehydrogenase	0	1	0	2
UDP-glucuronosyltransferase 1A7	0	0	0	1
UDP-glucuronosyltransferase 1A10	0	0	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Type II pantothenate kinase	0	0	0	1
Type III pantothenate kinase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Metallo-beta-lactamase VIM-11	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
streptokinase A precursor	0	0	1	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	1	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase 1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase OXA-10	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Kappa-type opioid receptor	0	0	0	1
Solute carrier family 15 member 1	0	1	0	1
Beta-lactamase TEM	0	1	0	2
Beta-lactamase	0	0	0	1
B2 metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Metallo-beta-lactamase VIM-13	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Efflux transporter	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase Toho-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-b-lactamase	0	0	0	1
Beta-lactamase IMP-1	0	0	0	1
BlaVIM-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Beta-lactamase class B VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	1	0	2
Beta-lactamase VIM-1	0	0	0	1
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	2	1	3
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Cytochrome P450 2J2	0	2	0	2
Estrogen receptor beta	0	2	0	2
N	0	1	0	1
NPYLR7B	0	0	1	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
cystic fibrosis transmembrane conductance regulator	0	1	0	1
D(1A) dopamine receptor	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
tumor susceptibility gene 101 protein	1	0	0	1
Glutathione reductase, mitochondrial	0	1	0	1
Major prion protein	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
DNA-directed RNA polymerase subunit alpha	0	1	0	1
DNA-directed RNA polymerase subunit omega	0	1	0	1
DNA-directed RNA polymerase subunit beta'	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Phospholipase A2, membrane associated	0	1	0	1
Phospholipase A2, membrane associated	0	1	0	1
Acidic phospholipase A2 2	0	1	0	1
Acetylcholinesterase	0	2	0	2
Sodium-dependent noradrenaline transporter	0	2	0	2
Histamine H2 receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
Trypanothione reductase	0	2	0	2
D(3) dopamine receptor	0	2	0	2
D(1A) dopamine receptor	1	0	0	1
Aldehyde oxidase 1	0	1	0	1
Cholinesterase	0	1	0	1
Aldehyde oxidase	0	1	0	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Polyphenol oxidase 2	0	1	0	2
Carbonic anhydrase 12	0	1	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Carbonic anhydrase 1	0	2	0	2
Polymerase acidic protein	0	0	1	1
Carbonic anhydrase 3	0	1	0	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Carbonic anhydrase 4	0	1	0	1
Carbonic anhydrase 6	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Carbonic anhydrase 7	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase 9	0	1	0	1
Carbonic anhydrase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
Carbonic anhydrase 15	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
Carbonic anhydrase 14	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
UDP-glucuronosyltransferase 2B7	0	0	0	1
Cytochrome P450 3A5	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	0	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
thyrotropin-releasing hormone receptor	1	0	0	1
Ornithine decarboxylase	0	0	0	1
60 kDa chaperonin	0	1	0	1
Retinoic acid receptor alpha	0	2	2	7
60 kDa heat shock protein, mitochondrial	0	1	0	1
Retinoic acid receptor beta	0	2	2	7
Retinoic acid receptor gamma	0	2	2	7
Alpha-1A adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Retinoic acid receptor RXR-alpha	0	2	2	4
Alpha-1D adrenergic receptor	0	1	0	1
Retinoic acid receptor RXR-beta	0	2	2	4
Nuclear receptor ROR-alpha	0	1	0	1
Retinoic acid receptor RXR-gamma	0	2	2	4
10 kDa heat shock protein, mitochondrial	0	1	0	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	2	1	3
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Nuclear receptor ROR-beta	0	1	0	1
NFKB1 protein, partial	1	0	0	1
Smad3	1	0	0	1
procathepsin L isoform 1 preproprotein	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(2)

Research Excerpts

Overview

Treatment

Research

Studies (57)

Protein Targets (614)

Mucinoses

Synonyms(2)

Research Excerpts

Overview

Treatment

Research

Studies (57)

Drugs Studied (40)

Protein Targets (614)