tacrolimus and Mucinoses

The discrete papular form of lichen myxedematosus (LM) is a rare idiopathic skin disorder. We present a case of this type in an 80-year-old African American woman. She was treated with pimecrolimus cream, which resulted in symptomatic relief. To our knowledge, this is the first report of the discrete papular form of LM occurring in an African American, as well as the first report on the disorder's response to pimecrolimus therapy. We also review the English medical literature on this rare disease and examine and summarize the findings.

Topics: Administration, Topical; Aged; Aged, 80 and over; Biopsy, Needle; Female; Follow-Up Studies; Humans; Immunohistochemistry; Lichenoid Eruptions; Mucinoses; Neck; Severity of Illness Index; Tacrolimus

Topics: Administration, Cutaneous; Administration, Oral; Adult; Biopsy, Needle; Drug Therapy, Combination; Follow-Up Studies; Humans; Immunohistochemistry; Lupus Erythematosus, Cutaneous; Male; Mucinoses; Prednisolone; Rare Diseases; Severity of Illness Index; Tacrolimus; Treatment Outcome

We report on the efficacy of twice daily application of pimecrolimus 1 percent cream in a 48-year-old woman with reticular erythematous mucinosis (REM) syndrome and compare its results with pulsed dye laser (PDL) on the other side of her chest and back. The patient was previously treated by hydroxychloroquine but only a fair response was observed. After application of 5 months of pimecrolimus, the lesions completely resolved and the result was comparable with the other side of her body treated by pulsed dye laser PDL. Topical pimecrolimus and pulsed dye laser appear to be effective and safe treatments for REM.

Topics: Administration, Topical; Biopsy, Needle; Combined Modality Therapy; Erythema; Female; Follow-Up Studies; Humans; Immunohistochemistry; Low-Level Light Therapy; Middle Aged; Mucinoses; Syndrome; Tacrolimus; Treatment Outcome

Topics: Adolescent; Erythema; Humans; Immunosuppressive Agents; Male; Mucinoses; Syndrome; Tacrolimus