Compounds > spinosyn a
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spinosyn a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

spinosyn A: a macrolide ; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

spinosyn A : A spinosyn in which the sugar amino and hydroxy groups are globally methylated. One of the two active ingredients of spinosad. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID443059
CHEMBL ID501411
CHEBI ID9230
SCHEMBL ID465876
MeSH IDM0296061

Synonyms (32)

Synonym
spinosyn-a
hsdb 7006
(-)-spinosyn a
1h-as-indaceno(3,2-d)oxacyclododecin-7,15-dione, 2,3,3a,5a,5b,6,9,10,11,12,13,14,16a,16b-tetradecahydro-2-((6-deoxy-2,3,4-tri-o-methyl-alpha-l-mannopyranosyl)oxy)- 13-((5-dimethylamino)tetrahydro-6-methyl-2h-pyran-2-yl)oxy)-9-ethyl-14-methyl-, (2r-(2r*,3a
131929-60-7
spinosyn a
spinosad factor a
2r,3as,5ar,5bs,9s,13s,14r,16as,16br)-2-(6-deoxy-2,3,4-tri-o-methyl-?-l-mannopyranosyloxy)-13-(4-dimethylamino-2,3,4,6-tetradeoxy-?-d-erythropyranosyloxy)-9-ethyl-2,3,3a,5a,5b,6,7,9,10,11,12,13,14,15,16a,16b-hexadecahydro-14-methyl-1h-as-indaceno[3,2-d]oxa
a 83543a
lepicidin a
CHEBI:9230 ,
(2r,3as,5ar,5bs,9s,13s,14r,16as,16br)-13-{[(2r,5s,6r)-5-(dimethylamino)-6-methyltetrahydro-2h-pyran-2-yl]oxy}-9-ethyl-14-methyl-7,15-dioxo-2,3,3a,5a,5b,6,7,9,10,11,12,13,14,15,16a,16b-hexadecahydro-1h-as-indaceno[3,2-d]oxacyclododecin-2-yl 6-deoxy-2,3,4-t
CHEMBL501411
oy0l59v61n ,
ccris 8937
(2r,3as,5ar,5bs,9s,13s,14r,16as,16br)-2-((6-deoxy-2,3,4-tri-o-methyl-alpha-l-mannopyranosyl)oxy)-13-(((2r,5s,6r)-5-(dimethylamino)tetrahydro-6-methyl-2h-pyran-2-yl)oxy)-9-ethyl-14-methyl-2,3,3a,5a,5b,6,9,10,11,12,13,14,16a,16b-tetradecahydro-1h-as-indacen
1h-as-indaceno(3,2-d)oxacyclododecin-7,15-dione, 2-((6-deoxy-2,3,4-tri-o-methyl-alpha-l-mannopyranosyl)oxy)-13-(((2r,5s,6r)-5-(dimethylamino)tetrahydro-6-methyl-2h-pyran-2-yl)oxy)-9-ethyl-2,3,3a,5a,5b,6,9,10,11,12,13,14,16a,16b-tetradecahydro-14-methyl-,
unii-oy0l59v61n
spinosad factor a [usan]
spinosyns [mi]
spinosad factor a [hsdb]
SCHEMBL465876
DTXSID8037598
AKOS032946512
(1s,2r,5s,7r,9r,10s,14r,15s,19s)-15-[(2r,5s,6r)-5-(dimethylamino)-6-methyloxan-2-yl]oxy-19-ethyl-14-methyl-7-[(2r,3r,4r,5s,6s)-3,4,5-trimethoxy-6-methyloxan-2-yl]oxy-20-oxatetracyclo[10.10.0.02,10.05,9]docosa-3,11-diene-13,21-dione
SRJQTHAZUNRMPR-UYQKXTDMSA-N
Q27108323
(2r,3as,5ar,5bs,9s,13s,14r,16as,16br)-2-[(6-deoxy-2,3,4-tri-o-methyl-alpha-l-mannopyranosyl)oxy]-13-[[(2r,5s,6r)-5-(dimethylamino)tetrahydro-6-methyl-2h-pyran-2-yl]oxy]-9-ethyl-2,3,3a,5a,5b,6,9,10,11,12,13,14,16a,16b-tetradecahydro-14-methyl-1h-as-indacen
benzenesulfinicacidsodiumsalt
CS-0009656
HY-B0767
1ST20443

Research Excerpts

Overview

Spinosyn A is a polyketide-derived macrolide produced by Saccharopolyspora spinosa. It is an active ingredient in several commercial insecticides.

ExcerptReferenceRelevance
"Spinosyn A is a polyketide-derived macrolide produced by Saccharopolyspora spinosa and is an active ingredient in several commercial insecticides. "( Biosynthesis of spinosyn in Saccharopolyspora spinosa: synthesis of permethylated rhamnose and characterization of the functions of SpnH, SpnI, and SpnK.
Isiorho, EA; Kim, HJ; Liu, HW; Ogasawara, Y; Shin, N; White-Phillip, JA, 2010)		1.8

Dosage Studied

ExcerptRelevanceReference
" Dairy cows were dosed for 28 days with spinosad at rates equivalent to 0, 1, 3, and 10 microg/g in the diet."( Residues of spinosad in meat, milk, and eggs.
Dolder, SC; Gardner, RC; Robb, CK; Rutherford, BS; West, SD, 2000)		0.31
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
pediculicideSubstance used to treat lice (genus Pediculus) infestation.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
spinosynA family of macrolide natural products produced by the soil microorganism Saccharopolyspora spinosa.
spinosyn insecticide
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (30)

Assay IDTitleYearJournalArticle
AID379890Insecticidal activity against beet armyworm assessed as mortality per larva after 5 days2006Journal of natural products, Dec, Volume: 69, Issue:12
Engineering of the spinosyn PKS: directing starter unit incorporation.
AID1420891Induction of apoptosis in human NCI-H460 cells assessed as necrotic cells at 64 uM after 48 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 2.11%)2018Bioorganic & medicinal chemistry letters, 11-01, Volume: 28, Issue:20
Synthesis and antiproliferative activities of novel quartenary ammonium spinosyn derivatives.
AID1420889Induction of apoptosis in human NCI-H460 cells assessed as early apoptotic cells at 32 uM after 48 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 2.17%)2018Bioorganic & medicinal chemistry letters, 11-01, Volume: 28, Issue:20
Synthesis and antiproliferative activities of novel quartenary ammonium spinosyn derivatives.
AID1420886Antiproliferative activity against human U87MG cells after 48 hrs by MTT assay2018Bioorganic & medicinal chemistry letters, 11-01, Volume: 28, Issue:20
Synthesis and antiproliferative activities of novel quartenary ammonium spinosyn derivatives.
AID379172Insecticidal activity against beet armyworm eggs assessed as inhibition of insect growth at 28 degC after 6 days by lepidopteran diet assay2006Journal of natural products, Oct, Volume: 69, Issue:10
Discovery, synthesis, and insecticidal activity of cycloaspeptide E.
AID1420894Induction of apoptosis in human NCI-H460 cells assessed as viable cells at 64 uM after 48 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 93.9%)2018Bioorganic & medicinal chemistry letters, 11-01, Volume: 28, Issue:20
Synthesis and antiproliferative activities of novel quartenary ammonium spinosyn derivatives.
AID1420904Inhibition of oxygen consumption rate in human NCI-H460 cells at 32 uM after 1 hr2018Bioorganic & medicinal chemistry letters, 11-01, Volume: 28, Issue:20
Synthesis and antiproliferative activities of novel quartenary ammonium spinosyn derivatives.
AID379886Insecticidal activity against cotton aphid assessed as count of nonwinged stage live aphid after 72 hrs with 24 hrs of photoperiod prior to grading2006Journal of natural products, Dec, Volume: 69, Issue:12
Engineering of the spinosyn PKS: directing starter unit incorporation.
AID1420883Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay2018Bioorganic & medicinal chemistry letters, 11-01, Volume: 28, Issue:20
Synthesis and antiproliferative activities of novel quartenary ammonium spinosyn derivatives.
AID1420893Induction of apoptosis in human NCI-H460 cells assessed as early apoptotic cells at 64 uM after 48 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 2.17%)2018Bioorganic & medicinal chemistry letters, 11-01, Volume: 28, Issue:20
Synthesis and antiproliferative activities of novel quartenary ammonium spinosyn derivatives.
AID1420905Growth inhibition of human NCI-H460 cells at 32 uM after 48 hrs by MTT assay2018Bioorganic & medicinal chemistry letters, 11-01, Volume: 28, Issue:20
Synthesis and antiproliferative activities of novel quartenary ammonium spinosyn derivatives.
AID1420884Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay2018Bioorganic & medicinal chemistry letters, 11-01, Volume: 28, Issue:20
Synthesis and antiproliferative activities of novel quartenary ammonium spinosyn derivatives.
AID1420887Induction of apoptosis in human NCI-H460 cells assessed as necrotic cells at 32 uM after 48 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 2.11%)2018Bioorganic & medicinal chemistry letters, 11-01, Volume: 28, Issue:20
Synthesis and antiproliferative activities of novel quartenary ammonium spinosyn derivatives.
AID379887Insecticidal activity against green peach aphid assessed as count of nonwinged stage live aphid after 72 hrs with 24 hrs of photoperiod prior to grading2006Journal of natural products, Dec, Volume: 69, Issue:12
Engineering of the spinosyn PKS: directing starter unit incorporation.
AID379892Insecticidal activity against two-spotted spinder mites assessed as count of live mites after 4 days with low light condition2006Journal of natural products, Dec, Volume: 69, Issue:12
Engineering of the spinosyn PKS: directing starter unit incorporation.
AID1667599Antiproliferative activity against human U87MG cells incubated for 48 hrs2020Bioorganic & medicinal chemistry letters, 05-01, Volume: 30, Issue:9
Synthesis and anti-OXPHOS, antitumor activities of DLC modified spinosyn derivatives.
AID1420890Induction of apoptosis in human NCI-H460 cells assessed as viable cells at 32 uM after 48 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 93.9%)2018Bioorganic & medicinal chemistry letters, 11-01, Volume: 28, Issue:20
Synthesis and antiproliferative activities of novel quartenary ammonium spinosyn derivatives.
AID1420892Induction of apoptosis in human NCI-H460 cells assessed as late apoptotic cells at 64 uM after 48 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 1.80%)2018Bioorganic & medicinal chemistry letters, 11-01, Volume: 28, Issue:20
Synthesis and antiproliferative activities of novel quartenary ammonium spinosyn derivatives.
AID1667597Antiproliferative activity against human HCT116 cells incubated for 48 hrs2020Bioorganic & medicinal chemistry letters, 05-01, Volume: 30, Issue:9
Synthesis and anti-OXPHOS, antitumor activities of DLC modified spinosyn derivatives.
AID1420888Induction of apoptosis in human NCI-H460 cells assessed as late apoptotic cells at 32 uM after 48 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometric analysis (Rvb = 1.80%)2018Bioorganic & medicinal chemistry letters, 11-01, Volume: 28, Issue:20
Synthesis and antiproliferative activities of novel quartenary ammonium spinosyn derivatives.
AID334207Antilepidopteran activity against tobacco budworm eggs assessed as minimum emergent larvicide concentration after 6 to 7 days2003Journal of natural products, Jan, Volume: 66, Issue:1
Tartrolone C: a novel insecticidal macrodiolide produced by Streptomyces sp. CP1130.
AID334206Antilepidopteran activity against beet armyworm eggs assessed as minimum emergent larvicide concentration after 6 to 7 days2003Journal of natural products, Jan, Volume: 66, Issue:1
Tartrolone C: a novel insecticidal macrodiolide produced by Streptomyces sp. CP1130.
AID1420882Antiproliferative activity against human MCF7 cells at 50 uM after 48 hrs by MTT assay2018Bioorganic & medicinal chemistry letters, 11-01, Volume: 28, Issue:20
Synthesis and antiproliferative activities of novel quartenary ammonium spinosyn derivatives.
AID1667596Antiproliferative activity against human MCF7 cells incubated for 48 hrs2020Bioorganic & medicinal chemistry letters, 05-01, Volume: 30, Issue:9
Synthesis and anti-OXPHOS, antitumor activities of DLC modified spinosyn derivatives.
AID379889Insecticidal activity against tobacco budworm assessed per larva2006Journal of natural products, Dec, Volume: 69, Issue:12
Engineering of the spinosyn PKS: directing starter unit incorporation.
AID1420885Antiproliferative activity against human NCI-H460 cells after 48 hrs by MTT assay2018Bioorganic & medicinal chemistry letters, 11-01, Volume: 28, Issue:20
Synthesis and antiproliferative activities of novel quartenary ammonium spinosyn derivatives.
AID379891Insecticidal activity against cabbage looper assessed as mortality per larva after 5 days2006Journal of natural products, Dec, Volume: 69, Issue:12
Engineering of the spinosyn PKS: directing starter unit incorporation.
AID1420906Induction of apoptosis in human NCI-H460 cells after 48 hrs by Annexin V-FITC/propidium iodide staining-based flow cytometric analysis2018Bioorganic & medicinal chemistry letters, 11-01, Volume: 28, Issue:20
Synthesis and antiproliferative activities of novel quartenary ammonium spinosyn derivatives.
AID379888Insecticidal activity against sweet potato whitefly assessed as larval survival after 13 days2006Journal of natural products, Dec, Volume: 69, Issue:12
Engineering of the spinosyn PKS: directing starter unit incorporation.
AID1667598Antiproliferative activity against human NCI-H460 cells incubated for 48 hrs2020Bioorganic & medicinal chemistry letters, 05-01, Volume: 30, Issue:9
Synthesis and anti-OXPHOS, antitumor activities of DLC modified spinosyn derivatives.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (56)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (3.57)18.2507
2000's26 (46.43)29.6817
2010's22 (39.29)24.3611
2020's6 (10.71)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 40.42

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index40.42 (24.57)
Research Supply Index4.04 (2.92)
Research Growth Index4.95 (4.65)
Search Engine Demand Index50.53 (26.88)
Search Engine Supply Index2.62 (0.95)

This Compound (40.42)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (3.57%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other54 (96.43%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
methane
Methane: The simplest saturated hydrocarbon. It is a colorless, flammable gas, slightly soluble in water. It is one of the chief constituents of natural gas and is formed in the decomposition of organic matter. (Grant & Hackh's Chemical Dictionary, 5th ed). methane : A one-carbon compound in which the carbon is attached by single bonds to four hydrogen atoms. It is a colourless, odourless, non-toxic but flammable gas (b.p. -161degreeC).		2.3110alkane;
gas molecular entity;
mononuclear parent hydride;
one-carbon compound		bacterial metabolite;
fossil fuel;
greenhouse gas
dimethoate
Dimethoate: An organothiophosphorus cholinesterase inhibitor that is used as a systemic and contact insecticide.. dimethoate : A monocarboxylic acid amide that is N-methylacetamide in which one of the hydrogens of the methyl group attached to the carbonyl moiety is replaced by a (dimethoxyphosphorothioyl)sulfanediyl group.		2.2110monocarboxylic acid amide;
organic thiophosphate		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
environmental contaminant;
insecticide;
xenobiotic
malathion
Malathion: A wide spectrum aliphatic organophosphate insecticide widely used for both domestic and commercial agricultural purposes.. malathion : A racemate comprising equimolar amounts of (R) and (S)-malathion. It is a broad spectrum organophosphate proinsecticide used to control a wide range of pests including Coleoptera, Diptera, fruit flies, mosquitos and spider mites.. diethyl 2-[(dimethoxyphosphorothioyl)thio]succinate : A diester that is diethyl succinate in which position 2 is substituted by a (dimethoxyphosphorothioyl)thio group.		210diester;
ethyl ester;
organic thiophosphate
aspartic acid
Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.. aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent. L-aspartic acid : The L-enantiomer of aspartic acid.		2.3110aspartate family amino acid;
aspartic acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
mouse metabolite;
neurotransmitter
thiazoles
[no description available]		2.02101,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
pyrimidine
pyrimidine : The parent compound of the pyrimidines; a diazine having the two nitrogens at the 1- and 3-positions.		2.3110diazine;
pyrimidines		Daphnia magna metabolite
citrulline
citrulline : The parent compound of the citrulline class consisting of ornithine having a carbamoyl group at the N(5)-position.		2.3110amino acid zwitterion;
citrulline		Daphnia magna metabolite;
EC 1.14.13.39 (nitric oxide synthase) inhibitor;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
protective agent;
Saccharomyces cerevisiae metabolite
nereistoxin
nereistoxin: toxin isolated from marine segmented worm, Lumbriconereis heterodopa; RN given refers to parent cpd. nereistoxin : Toxin isolated from marine segmented worm, Lumbriconereis heterodopa. It is also the active insecticide of the proinsecticide thiocyclam.		2.610dithiolanesinsecticide;
toxin
palladium
Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.		7.4420metal allergen;
nickel group element atom;
platinum group metal atom
titanium
Titanium: A dark-gray, metallic element of widespread distribution but occurring in small amounts with atomic number, 22, atomic weight, 47.867 and symbol, Ti; specific gravity, 4.5; used for fixation of fractures.		2.110titanium group element atom
rhamnose
[no description available]		7.9540L-rhamnose
carbamothioic acid, s,s'-(2-(dimethylamino)-1,3-propanediyl) ester
carbamothioic acid, S,S'-(2-(dimethylamino)-1,3-propanediyl) ester: RN given refers to parent cpd; Padan refers to mono-HCl		3.2510nereistoxin analogue insecticide
dihydro-beta-erythroidine
Dihydro-beta-Erythroidine: Dihydro analog of beta-erythroidine, which is isolated from the seeds and other plant parts of Erythrina sp. Leguminosae. It is an alkaloid with curarimimetic properties.. dihydro-beta-erythroidine : An organic heterotetracyclic compound resulting from the partial hydrogenation of the 1,3-diene moiety of beta-erythroidine to give the corresponding 2-ene.		2.0210delta-lactone;
organic heterotetracyclic compound;
tertiary amino compound		nicotinic antagonist
nicotine
(S)-nicotine : A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.		3.25103-(1-methylpyrrolidin-2-yl)pyridineanxiolytic drug;
biomarker;
immunomodulator;
mitogen;
neurotoxin;
nicotinic acetylcholine receptor agonist;
peripheral nervous system drug;
phytogenic insecticide;
plant metabolite;
psychotropic drug;
teratogenic agent;
xenobiotic
methyllycaconitine
methyllycaconitine: natural toxin from seeds of Delphinium brownii; parasympathomimetic and mild nicotine antagonist; antagonist of alpha-conotoxin-MII sensitive presynaptic nicotinic receptors; potent insecticide; RN refers to (1alpha,4(S),6beta,14alpha,16beta)-isomer		2.0210
indoxacarb
indoxacarb: oxadiazine insecticide; structure in first source. insecticide : Strictly, a substance intended to kill members of the class Insecta. In common usage, any substance used for preventing, destroying, repelling or controlling insects.		2.110methyl ester;
organochlorine insecticide		voltage-gated sodium channel blocker
atropine
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate : A tropane alkaloid that is (1R,5)-8-methyl-8-azabicyclo[3.2.1]octane substituted by a (3-hydroxy-2-phenylpropanoyl)oxy group at position 3.		2.0210
spinosyn d
spinosyn D: a macrolide, structure in first source. spinosyn D : A spinosyn in which the sugar amino and hydroxy groups are globally methylated with an additional methyl substituent attached to the tetracyclic skeleton. One of the two active ingredients of spinosad.		5.66240spinosyn insecticide;
spinosyn		pediculicide
forosamine
forosamine: from spiramycin; structure		1.9910hexosamine;
tetradeoxyhexose derivative
glycosides
[no description available]		2.0210
cysteine
Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.		2.3110cysteiniumfundamental metabolite
olivose
olivose: RN given for (D)-isomer		7.0510hexose
cycloaspeptide a
cycloaspeptide A: isolated from the psychrotolerant fungus Penicillium algidum; structure in first source		2.0310
eosine i bluish
Eosine I Bluish: A red fluorescein dye used as a histologic stain. It may be cytotoxic, mutagenic, and inhibit certain mitochondrial functions.		210organic sodium saltfluorescent dye;
histological dye
oligomycin a
[no description available]		2.2510antibiotic antifungal agent;
diketone;
oligomycin;
pentol		antineoplastic agent;
EC 3.6.3.14 (H(+)-transporting two-sector ATPase) inhibitor;
nematicide
spinetoram
spinetoram: a second-generation spinosyn; insecticide		7.5120organic molecular entity
aconitine
Aconitine: A C19 norditerpenoid alkaloid (DITERPENES) from the root of ACONITUM; DELPHINIUM and larkspurs. It activates VOLTAGE-GATED SODIUM CHANNELS. It has been used to induce ARRHYTHMIAS in experimental animals and it has anti-inflammatory and anti-neuralgic properties.. aconitine : A diterpenoid that is 20-ethyl-3alpha,13,15alpha-trihydroxy-1alpha,6alpha,16beta-trimethoxy-4-(methoxymethyl)aconitane-8,14alpha-diol having acetate and benzoate groups at the 8- and 14-positions respectively.		2.0210
imidacloprid
imidacloprid: systemic & contact insecticide exhibiting low mammalian toxicity; structure given in first source; it is one of the neonicotinoid insecticides, which acts as an antagonist by binding to postsynaptic nicotinic receptors in the insect central nervous system. imidacloprid : An imidazolidine that is N-nitroimidazolidin-2-imine bearing a (6-chloro-3-pyridinyl)methyl substituent at position 1.		2.4720imidacloprid;
imidazolidines;
monochloropyridine		environmental contaminant;
genotoxin;
neonicotinoid insectide;
nicotinic acetylcholine receptor agonist;
xenobiotic
clothianidin
clothianidin: structure in first source. clothianidin : An N-nitro compound consisting of 2-nitroguanidine having a (2-chloro-1,3-thiazol-5-yl)methyl group at position 1 and a methyl group at position 3.		2.02101,3-thiazoles;
2-nitroguanidine derivative;
clothianidin;
organochlorine compound		environmental contaminant;
neonicotinoid insectide;
nicotinic acetylcholine receptor agonist;
xenobiotic
pyrimidinones
Pyrimidinones: Heterocyclic compounds known as 2-pyrimidones (or 2-hydroxypyrimidines) and 4-pyrimidones (or 4-hydroxypyrimidines) with the general formula C4H4N2O.		3.2510
ConditionIndicatedRelationship StrengthStudiesTrials
Experimental Neoplasms
[description not available]		02.2510
Colorectal Cancer
[description not available]		07.610
Colorectal Neoplasms
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.		02.610
Argininosuccinate Synthase Deficiency Disease
[description not available]		02.3110
Breast Cancer
[description not available]		02.3110
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.3110
Citrullinemia
A group of diseases related to a deficiency of the enzyme ARGININOSUCCINATE SYNTHASE which causes an elevation of serum levels of CITRULLINE. In neonates, clinical manifestations include lethargy, hypotonia, and SEIZURES. Milder forms also occur. Childhood and adult forms may present with recurrent episodes of intermittent weakness, lethargy, ATAXIA, behavioral changes, and DYSARTHRIA. (From Menkes, Textbook of Child Neurology, 5th ed, p49)		02.3110
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		0210
Ectoparasitic Infestations
Infestations by PARASITES which live on, or burrow into, the surface of their host's EPIDERMIS. Most ectoparasites are ARTHROPODS.		02.9210