Compounds > ethiprole
Page last updated: 2024-11-12

ethiprole

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID9930667
CHEMBL ID2228921
CHEBI ID81827
SCHEMBL ID27048
MeSH IDM0447118

Synonyms (37)

Synonym
ethiprole
5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-ethylsulfinyl-pyrazole-3-carbonitrile
FT-0653443
kirappu
5527e53jnb ,
rpa 107382
unii-5527e53jnb
ethiprole [iso]
C18552
A812624
181587-01-9
AKOS015914939
1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-5-amino-4-(ethylsulfinyl)-1h-pyrazole-3-carbonitrile
5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-ethylsulfinylpyrazole
SCHEMBL27048
chebi:81827 ,
CHEMBL2228921
5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(ethylsulfinyl)-1h-pyrazole-3-carbonitrile
ethiprole [mi]
5-amino-1-(2,6-dichloro-.alpha.,.alpha.,.alpha.-trifluoro-p-tolyl)-4-ethylsulfinylpyrazole-3-carbonitrile
DTXSID6058003
5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-(ethylsulfinyl)pyrazole-3-carbonitrile
ethiprole, pestanal(r), analytical standard
J-011597
pesticide5_ethiprole_c13h9cl2f3n4os_1h-pyrazole-3-carbonitrile, 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-(ethylsulfinyl)-
5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-ethylsulfinylpyrazole-3-carbonitrile
CS-0077980
mfcd07366662
Q22807466
AS-14739
5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-(ethylsulfinyl)-1h-pyrazole-3-carbonitrile
BCP13106
(r)-2-acetylamino-3-cyclopropylpropionicacid
E79172
HMS3741G13
1h-pyrazole-3-carbonitrile, 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-(ethylsulfinyl)-
1h-pyrazole-3-carbonitrile, 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-(ethylsulfinyl

Research Excerpts

Effects

ExcerptReferenceRelevance
"Ethiprole has been registered to control planthoppers in rice fields for many years in Asia. "( Dissipation, residue distribution, and risk assessment of ethiprole and its metabolites in rice under various open field conditions.
Dong, B; Hu, J, 2023)		2.6

Toxicity

ExcerptReferenceRelevance
" In this study, five metabolites of ethiprole (ethiprole sulfone, ethiprole sulfide, ethiprole amide, desethylsulfinyl ethiprole and ethiprole sulfone amide) were synthesized and their toxic effects on photosynthetic pigment and antioxidase in aquatic plant Chlorella pyrenoidosa (C."( Enantioselective toxic effects and environmental behavior of ethiprole and its metabolites against Chlorella pyrenoidosa.
Gao, J; Jiang, W; Liu, D; Wang, F; Wang, P; Zhang, Z; Zhou, Z, 2019)		1.03
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

ClassDescription
pyrazoles
ring assemblyTwo or more cyclic systems (single rings or fused systems) which are directly joined to each other by double or single bonds are named ring assemblies when the number of such direct ring junctions is one less than the number of cyclic systems involved.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (17)

Assay IDTitleYearJournalArticle
AID1081499Insecticidal activity against Plutella xylostella (diamondback moth) grown on compound pre-treated fresh cabbage leaves assessed as insect mortality at 5 mg/kg measured 3 days post compound treatment by leaf-dip method2010Journal of agricultural and food chemistry, Apr-28, Volume: 58, Issue:8
Design, synthesis and insecticidal activity of novel phenylpyrazoles containing a 2,2,2-trichloro-1-alkoxyethyl moiety.
AID1081510Insecticidal activity against Culex pipiens pallens (mosquito) assessed as insect mortality at 100 ug/kg measured 1 day post compound treatment2010Journal of agricultural and food chemistry, Apr-28, Volume: 58, Issue:8
Design, synthesis and insecticidal activity of novel phenylpyrazoles containing a 2,2,2-trichloro-1-alkoxyethyl moiety.
AID1081503Insecticidal activity against Plutella xylostella (diamondback moth) grown on compound pre-treated fresh cabbage leaves assessed as insect mortality at 100 mg/kg measured 3 days post compound treatment by leaf-dip method2010Journal of agricultural and food chemistry, Apr-28, Volume: 58, Issue:8
Design, synthesis and insecticidal activity of novel phenylpyrazoles containing a 2,2,2-trichloro-1-alkoxyethyl moiety.
AID1081514Insecticidal activity against Aphis craccivora (cowpea aphid) infested tender soybean shoots exposed to 10 mg/kg test compound solution assessed as insect mortality measured 24 hr post compound treatment2010Journal of agricultural and food chemistry, Apr-28, Volume: 58, Issue:8
Design, synthesis and insecticidal activity of novel phenylpyrazoles containing a 2,2,2-trichloro-1-alkoxyethyl moiety.
AID1081497Insecticidal activity against Mythimna separata (Oriental armyworm) grown on compound pre-treated corn leaves assessed as insect mortality at 200 mg/kg measured 3 days post compound treatment by leaf-dip method2010Journal of agricultural and food chemistry, Apr-28, Volume: 58, Issue:8
Design, synthesis and insecticidal activity of novel phenylpyrazoles containing a 2,2,2-trichloro-1-alkoxyethyl moiety.
AID1081511Insecticidal activity against Aphis craccivora (cowpea aphid) infested tender soybean shoots exposed to test compound solution assessed as insect mortality measured 24 hr post compound treatment2010Journal of agricultural and food chemistry, Apr-28, Volume: 58, Issue:8
Design, synthesis and insecticidal activity of novel phenylpyrazoles containing a 2,2,2-trichloro-1-alkoxyethyl moiety.
AID1081504Insecticidal activity against Plutella xylostella (diamondback moth) grown on compound pre-treated fresh cabbage leaves assessed as insect mortality at 200 mg/kg measured 3 days post compound treatment by leaf-dip method2010Journal of agricultural and food chemistry, Apr-28, Volume: 58, Issue:8
Design, synthesis and insecticidal activity of novel phenylpyrazoles containing a 2,2,2-trichloro-1-alkoxyethyl moiety.
AID1081509Insecticidal activity against Culex pipiens pallens (mosquito) assessed as insect mortality at 50 ug/kg measured 1 day post compound treatment2010Journal of agricultural and food chemistry, Apr-28, Volume: 58, Issue:8
Design, synthesis and insecticidal activity of novel phenylpyrazoles containing a 2,2,2-trichloro-1-alkoxyethyl moiety.
AID1081502Insecticidal activity against Plutella xylostella (diamondback moth) grown on compound pre-treated fresh cabbage leaves assessed as insect mortality at 50 mg/kg measured 3 days post compound treatment by leaf-dip method2010Journal of agricultural and food chemistry, Apr-28, Volume: 58, Issue:8
Design, synthesis and insecticidal activity of novel phenylpyrazoles containing a 2,2,2-trichloro-1-alkoxyethyl moiety.
AID1081513Insecticidal activity against Aphis craccivora (cowpea aphid) infested tender soybean shoots exposed to 5 mg/kg test compound solution assessed as insect mortality measured 24 hr post compound treatment2010Journal of agricultural and food chemistry, Apr-28, Volume: 58, Issue:8
Design, synthesis and insecticidal activity of novel phenylpyrazoles containing a 2,2,2-trichloro-1-alkoxyethyl moiety.
AID1081508Insecticidal activity against Culex pipiens pallens (mosquito) assessed as insect mortality at 25 ug/kg measured 1 day post compound treatment2010Journal of agricultural and food chemistry, Apr-28, Volume: 58, Issue:8
Design, synthesis and insecticidal activity of novel phenylpyrazoles containing a 2,2,2-trichloro-1-alkoxyethyl moiety.
AID1081518Insecticidal activity against Aphis craccivora (cowpea aphid) infested tender soybean shoots exposed to 200 mg/kg test compound solution assessed as insect mortality measured 24 hr post compound treatment2010Journal of agricultural and food chemistry, Apr-28, Volume: 58, Issue:8
Design, synthesis and insecticidal activity of novel phenylpyrazoles containing a 2,2,2-trichloro-1-alkoxyethyl moiety.
AID1081516Insecticidal activity against Aphis craccivora (cowpea aphid) infested tender soybean shoots exposed to 50 mg/kg test compound solution assessed as insect mortality measured 24 hr post compound treatment2010Journal of agricultural and food chemistry, Apr-28, Volume: 58, Issue:8
Design, synthesis and insecticidal activity of novel phenylpyrazoles containing a 2,2,2-trichloro-1-alkoxyethyl moiety.
AID1081517Insecticidal activity against Aphis craccivora (cowpea aphid) infested tender soybean shoots exposed to 100 mg/kg test compound solution assessed as insect mortality measured 24 hr post compound treatment2010Journal of agricultural and food chemistry, Apr-28, Volume: 58, Issue:8
Design, synthesis and insecticidal activity of novel phenylpyrazoles containing a 2,2,2-trichloro-1-alkoxyethyl moiety.
AID1081501Insecticidal activity against Plutella xylostella (diamondback moth) grown on compound pre-treated fresh cabbage leaves assessed as insect mortality at 25 mg/kg measured 3 days post compound treatment by leaf-dip method2010Journal of agricultural and food chemistry, Apr-28, Volume: 58, Issue:8
Design, synthesis and insecticidal activity of novel phenylpyrazoles containing a 2,2,2-trichloro-1-alkoxyethyl moiety.
AID1081500Insecticidal activity against Plutella xylostella (diamondback moth) grown on compound pre-treated fresh cabbage leaves assessed as insect mortality at 10 mg/kg measured 3 days post compound treatment by leaf-dip method2010Journal of agricultural and food chemistry, Apr-28, Volume: 58, Issue:8
Design, synthesis and insecticidal activity of novel phenylpyrazoles containing a 2,2,2-trichloro-1-alkoxyethyl moiety.
AID1081515Insecticidal activity against Aphis craccivora (cowpea aphid) infested tender soybean shoots exposed to 25 mg/kg test compound solution assessed as insect mortality measured 24 hr post compound treatment2010Journal of agricultural and food chemistry, Apr-28, Volume: 58, Issue:8
Design, synthesis and insecticidal activity of novel phenylpyrazoles containing a 2,2,2-trichloro-1-alkoxyethyl moiety.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (24)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (12.50)29.6817
2010's15 (62.50)24.3611
2020's6 (25.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 39.11

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index39.11 (24.57)
Research Supply Index3.22 (2.92)
Research Growth Index5.12 (4.65)
Search Engine Demand Index68.44 (26.88)
Search Engine Supply Index2.62 (0.95)

This Compound (39.11)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other24 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
carbamates
[no description available]		2.1310amino-acid anion
lactic acid
Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed). 2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.		2.05102-hydroxy monocarboxylic acidalgal metabolite;
Daphnia magna metabolite
chlorpyrifos
Chlorpyrifos: An organothiophosphate cholinesterase inhibitor that is used as an insecticide and as an acaricide.. chlorpyrifos : An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.		2.1310chloropyridine;
organic thiophosphate		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
environmental contaminant;
insecticide;
xenobiotic
fipronil
fipronil: has low mammalian toxicity; structure given in first source. fipronil : A racemate comprising equimolar amounts of (R)- and (S)-fipronil.. 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile : A member of the class of pyrazoles that is 1H-pyrazole that is substituted at positions 1, 3, 4, and 5 by 2,6-dichloro-4-(trifluoromethyl)phenyl, cyano, (trifluoromethyl)sulfinyl, and amino groups, respectively.		3.4870(trifluoromethyl)benzenes;
dichlorobenzene;
nitrile;
primary amino compound;
pyrazoles;
sulfoxide
2-propanol
2-Propanol: An isomer of 1-PROPANOL. It is a colorless liquid having disinfectant properties. It is used in the manufacture of acetone and its derivatives and as a solvent. Topically, it is used as an antiseptic.. propan-2-ol : A secondary alcohol that is propane in which one of the hydrogens attached to the central carbon is substituted by a hydroxy group.		2.1510secondary alcohol;
secondary fatty alcohol		protic solvent
2-methylpentane
Hexanes: Six-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives. Various polyneuropathies are caused by hexane poisoning.		2.1510alkane
n-hexane
hexane : An unbranched alkane containing six carbon atoms.		2.1510alkane;
volatile organic compound		neurotoxin;
non-polar solvent
thiazoles
[no description available]		2.13101,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
malondialdehyde
Malondialdehyde: The dialdehyde of malonic acid.. malonaldehyde : A dialdehyde that is propane substituted by two oxo groups at the terminal carbon atoms respectively. A biomarker of oxidative damage to lipids caused by smoking, it exists in vivo mainly in the enol form.		2.2110dialdehydebiomarker
isoprocarb
[no description available]		2.1310carbamate esteragrochemical;
carbamate insecticide;
EC 3.1.1.7 (acetylcholinesterase) inhibitor
buprofezin
buprofezin: tradename - Applaud; used for the control of homopterous insect pests; structure given in first source. (E)-buprofezin : A 2-(tert-butylimino)-5-phenyl-3-(propan-2-yl)-1,3,5-thiadiazinan-4-one in which the C=N double bond has E configuration.. buprofezin : A 2-(tert-butylimino)-5-phenyl-3-(propan-2-yl)-1,3,5-thiadiazinan-4-one in which the C=N double bond has Z configuration.		2.1310thiadiazinane;
ureas
ethofenprox
ethofenprox: synthetic pyrethroid for insecticidal efficacy against mosquito larvae & on non-target organisms. etofenprox : An aromatic ether that is the 3-phenoxybenzyl ether of 2-(4-ethoxyphenyl)-2-methylpropan-1-ol.		2.1310aromatic etherpyrethroid ether insecticide
thiamethoxam
Thiamethoxam: A nitro-oxazine and thiazole derivative that is used as a broad spectrum neonicotinoid insecticide.. thiamethoxam : An oxadiazane that is tetrahydro-N-nitro-4H-1,3,5-oxadiazin-4-imine bearing (2-chloro-1,3-thiazol-5-yl)methyl and methyl substituents at positions 3 and 5 respectively.		2.13101,3-thiazoles;
2-nitroguanidine derivative;
organochlorine compound;
oxadiazane		antifeedant;
carcinogenic agent;
environmental contaminant;
neonicotinoid insectide;
xenobiotic
thiacloprid
thiacloprid: structure in first source. (Z)-thiacloprid : The (Z)-stereoisomer of thiacloprid.. thiacloprid : A nitrile that is cyanamide in which the hydrogens are replaced by a 1,3-thiazolidin-2-ylidene group which in turn is substituted by a (6-chloropyridin-3-yl)methyl group at the ring nitrogen.		2.1310monochloropyridine;
nitrile;
thiazolidines		environmental contaminant;
neonicotinoid insectide;
xenobiotic
prizes
acetamiprid: structure in first source. (E)-acetamiprid : The (E)-stereoisomer of acetamiprid.. acetamiprid : A carboxamidine that is acetamidine in which the amino hydrogens are substituted by a (6-chloropyridin-3-yl)methyl and a methyl group while the hydrogen attached to the imino nitrogen is replaced by a cyano group.		2.1310carboxamidine;
monochloropyridine;
nitrile		environmental contaminant;
neonicotinoid insectide;
xenobiotic
delrin
delrin: linear polyoxymethylene type acetal resin made by polymerization of formaldehyde; RN refers to multi-polymer		2.1710
chlorophyll a
Chlorophyll: Porphyrin derivatives containing magnesium that act to convert light energy in photosynthetic organisms.. chlorophyll : A family of magnesium porphyrins, defined by the presence of a fifth ring beyond the four pyrrole-like rings. The rings can have various side chains which usually include a long phytol chain.		2.2110chlorophyll;
methyl ester		cofactor
pyrethrins
[no description available]		2.1310
imidacloprid
imidacloprid: systemic & contact insecticide exhibiting low mammalian toxicity; structure given in first source; it is one of the neonicotinoid insecticides, which acts as an antagonist by binding to postsynaptic nicotinic receptors in the insect central nervous system. imidacloprid : An imidazolidine that is N-nitroimidazolidin-2-imine bearing a (6-chloro-3-pyridinyl)methyl substituent at position 1.		7.5320imidacloprid;
imidazolidines;
monochloropyridine		environmental contaminant;
genotoxin;
neonicotinoid insectide;
nicotinic acetylcholine receptor agonist;
xenobiotic
clothianidin
clothianidin: structure in first source. clothianidin : An N-nitro compound consisting of 2-nitroguanidine having a (2-chloro-1,3-thiazol-5-yl)methyl group at position 1 and a methyl group at position 3.		2.13101,3-thiazoles;
2-nitroguanidine derivative;
clothianidin;
organochlorine compound		environmental contaminant;
neonicotinoid insectide;
nicotinic acetylcholine receptor agonist;
xenobiotic
ConditionIndicatedRelationship StrengthStudiesTrials
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		02.1510
Delayed Effects, Prenatal Exposure
[description not available]		02.1710
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.		02.1710