Page last updated: 2024-12-07

4-chlorosalicylic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

4-Chlorosalicylic acid (4-CSA) is an organic compound that finds application in various fields, including pharmaceuticals and materials science. Its synthesis often involves chlorination of salicylic acid. Research into 4-CSA has focused on its potential as a precursor for various pharmaceuticals, including aspirin-like analgesics. 4-CSA has also been investigated for its antimicrobial and anti-inflammatory properties. Its importance lies in its potential to serve as a building block for new therapeutic agents. The study of 4-CSA is driven by its promising biological activity and its potential to contribute to the development of novel drugs.'

Cross-References

ID SourceID
PubMed CID78782
CHEMBL ID2228307
SCHEMBL ID132175
MeSH IDM0458038

Synonyms (48)

Synonym
unii-7i5gi51211
nsc 15816
ai3-34238
7i5gi51211 ,
einecs 225-829-7
nsc15816
benzoic acid, 4-chloro-2-hydroxy-
nsc-15816
2-hydroxy-4-chlorobenzoic acid
5106-98-9
salicylic acid, 4-chloro-
4-chloro-2-hydroxybenzoic acid
4-chlorosalicylic acid
inchi=1/c7h5clo3/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,9h,(h,10,11
4-chlorosalicylic acid, 93%
C1282
AKOS000120613
4-chloro-2-hydroxybenzoic acid;carnitine tararate;4-chlorosalicylic acid
A20210
4-chloro salicylic acid
S3691
FT-0618264
FS-1525
AM20060221
CL8111
4-chloro-salicylic acid
4-chloro-2-hydroxy-benzoic acid
SCHEMBL132175
4-chloro-2-hydroxy benzoic acid
CHEMBL2228307 ,
p-chlorosalicylic acid
W-105919
4-chlorosalicylicacid
STR03450
mfcd00002449
HY-W016867
DTXSID00199064
4-chloro-2-hydroxybenzoic acid, 4-chloro salicylic acid
AC-8709
bdbm50486235
CS-W017583
SY013510
4-chloro-2-hydroxobenzoic acid
EN300-18326
CCG-266376
Q27268333
Z57901799
PD055465
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Polyphenol oxidase 2Agaricus bisporusIC50 (µMol)520.00000.03403.987110.0000AID1082239
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (7)

Assay IDTitleYearJournalArticle
AID1082238Inhibition of Oryctolagus cuniculus (rabbit) AOX in liver cytosol2011Journal of agricultural and food chemistry, May-11, Volume: 59, Issue:9
Neonicotinoid insecticides: oxidative stress in planta and metallo-oxidase inhibition.
AID1082232Inhibition of xanthine oxidase at IC50 concentration2011Journal of agricultural and food chemistry, May-11, Volume: 59, Issue:9
Neonicotinoid insecticides: oxidative stress in planta and metallo-oxidase inhibition.
AID1082231Inhibition of Oryctolagus cuniculus (rabbit) AOX in liver cytosol at IC50 concentration2011Journal of agricultural and food chemistry, May-11, Volume: 59, Issue:9
Neonicotinoid insecticides: oxidative stress in planta and metallo-oxidase inhibition.
AID1397963Inhibition of mouse recombinant glycolate oxidase expressed in Escherichia coli at 25 uM using glycolate as substrate after 1 min by sulfonated DCIP dye-based assay relative to control2018Journal of medicinal chemistry, 08-23, Volume: 61, Issue:16
Salicylic Acid Derivatives Inhibit Oxalate Production in Mouse Hepatocytes with Primary Hyperoxaluria Type 1.
AID1082237Inhibition of xanthine oxidase2011Journal of agricultural and food chemistry, May-11, Volume: 59, Issue:9
Neonicotinoid insecticides: oxidative stress in planta and metallo-oxidase inhibition.
AID1082236Inhibition of Bos taurus (bovine) CAT in liver2011Journal of agricultural and food chemistry, May-11, Volume: 59, Issue:9
Neonicotinoid insecticides: oxidative stress in planta and metallo-oxidase inhibition.
AID1082239Inhibition of Agaricus bisporus (mushroom) tyrosinase2011Journal of agricultural and food chemistry, May-11, Volume: 59, Issue:9
Neonicotinoid insecticides: oxidative stress in planta and metallo-oxidase inhibition.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (50.00)29.6817
2010's4 (50.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 24.57

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index24.57 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.40 (4.65)
Search Engine Demand Index17.79 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (24.57)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]