Compounds > scorpions
Page last updated: 2024-11-08

scorpions

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID197701
CHEMBL ID2228155
CHEBI ID39183
MeSH IDM0019561

Synonyms (25)

Synonym
CHEBI:39183 ,
hsdb 7465
FT-0667610
2-methyl-1-nitro-3-(oxolan-3-ylmethyl)guanidine
C18509
unii-1w509710wf
scorpion
venom [insecticide]
guanidine, n-methyl-n'-nitro-n''-((tetrahydro-3-furanyl)methyl)-
safari [insecticide]
CHEMBL2228155
CS-5166
HY-B0827
mfcd06795001
dinotefuran, pestanal(r), analytical standard
bdbm50486222
dinotefuran 10 microg/ml in acetonitrile
Q3028468
BCP12994
guanidine, n''-methyl-n-nitro-n'-[(tetrahydro-3-furanyl)methyl]-
1-methyl-3-nitro-2-[(tetrahydrofuran-3-yl)methyl]guanidine
n-methyl-n'-nitro-n''-[(tetrahydro-3-furanyl)methyl]guanidine
n-methyl-n'-nitro-n''-[(oxolan-3-yl)methyl]guanidine
EN300-7399621
D5560
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
neonicotinoid insectideA class of neuro-active insecticides that act at the nicotinic acetylcholine receptor.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
oxolanesAny oxacycle having an oxolane (tetrahydrofuran) skeleton.
dinotefuran
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Polyphenol oxidase 2Agaricus bisporusIC50 (µMol)1,000.00000.03403.987110.0000AID1082239
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (69)

Assay IDTitleYearJournalArticle
AID1111083Insecticidal activity against Anomala orientalis assessed as mortality after 10 days2010Pest management science, Jan, Volume: 66, Issue:1
Variation in the laboratory susceptibility of turf-infesting white grubs (Coleoptera: Scarabaeidae) to biological, biorational and chemical control products.
AID1101019Ratio of IC50 for nicotinic acetylcholine receptor in Myzus persicae to IC50 for nicotinic acetylcholine receptor in Drosophila melanogaster2000Journal of neurochemistry, Sep, Volume: 75, Issue:3
Insect nicotinic acetylcholine receptor: conserved neonicotinoid specificity of [(3)H]imidacloprid binding site.
AID1111949Insecticidal activity against imidacloprid-resistant Aphis gossypii (cotton aphid) in cotton leaves assessed as inhibition of honeydew excretion at LC20 concentration measured after 72 hr by dipping method2011Pest management science, Dec, Volume: 67, Issue:12
Toxicities and sublethal effects of seven neonicotinoid insecticides on survival, growth and reproduction of imidacloprid-resistant cotton aphid, Aphis gossypii.
AID1111076Insecticidal activity against Popillia japonica assessed as mortality after 20 days2010Pest management science, Jan, Volume: 66, Issue:1
Variation in the laboratory susceptibility of turf-infesting white grubs (Coleoptera: Scarabaeidae) to biological, biorational and chemical control products.
AID1081728Insecticidal activity against Lepidoptera (rice borers)2011Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7
Molecular design of dinotefuran with unique insecticidal properties.
AID1081734Insecticidal activity against Pseudococcidae (mealybugs)2011Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7
Molecular design of dinotefuran with unique insecticidal properties.
AID1112903Displacement of [3H]-methyl-SFX from nAChR in Myzus persicae 4106A (green peach aphid) membrane after 70 min2013Pest management science, May, Volume: 69, Issue:5
Investigating the mode of action of sulfoxaflor: a fourth-generation neonicotinoid.
AID1111947Insecticidal activity against imidacloprid-resistant Aphis gossypii (cotton aphid) in cotton leaves assessed as fecundity at LC20 concentration2011Pest management science, Dec, Volume: 67, Issue:12
Toxicities and sublethal effects of seven neonicotinoid insecticides on survival, growth and reproduction of imidacloprid-resistant cotton aphid, Aphis gossypii.
AID1081742Insecticidal activity against Nephotettix cincticeps (green rice leafhopper) assessed as lethality at 0.1 to 1 ppm2011Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7
Molecular design of dinotefuran with unique insecticidal properties.
AID1111078Insecticidal activity against Maladera castanea assessed as mortality after 20 days2010Pest management science, Jan, Volume: 66, Issue:1
Variation in the laboratory susceptibility of turf-infesting white grubs (Coleoptera: Scarabaeidae) to biological, biorational and chemical control products.
AID1081740Binding affinity to Nephotettix cincticeps (green rice leafhopper) nicotinic acetylcholine receptor2011Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7
Molecular design of dinotefuran with unique insecticidal properties.
AID1081720Insecticidal activity against Periplaneta americana (American cockroach)2011Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7
Molecular design of dinotefuran with unique insecticidal properties.
AID1081741Binding affinity to Laodelphax striatella (small brown planthopper) nicotinic acetylcholine receptor2011Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7
Molecular design of dinotefuran with unique insecticidal properties.
AID1111948Insecticidal activity against imidacloprid-resistant Aphis gossypii (cotton aphid) in cotton leaves assessed as longevity at LC20 concentration2011Pest management science, Dec, Volume: 67, Issue:12
Toxicities and sublethal effects of seven neonicotinoid insecticides on survival, growth and reproduction of imidacloprid-resistant cotton aphid, Aphis gossypii.
AID1111079Insecticidal activity against Maladera castanea assessed as mortality after 30 days2010Pest management science, Jan, Volume: 66, Issue:1
Variation in the laboratory susceptibility of turf-infesting white grubs (Coleoptera: Scarabaeidae) to biological, biorational and chemical control products.
AID1081722Insecticidal activity against Diptera (leafminer flies)2011Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7
Molecular design of dinotefuran with unique insecticidal properties.
AID1111080Insecticidal activity against Maladera castanea assessed as mortality after 10 days2010Pest management science, Jan, Volume: 66, Issue:1
Variation in the laboratory susceptibility of turf-infesting white grubs (Coleoptera: Scarabaeidae) to biological, biorational and chemical control products.
AID1080614Displacement of [3H]IMI from nicotinic acetylcholine receptor in Drosophila melanogaster brain2009Journal of agricultural and food chemistry, Mar-25, Volume: 57, Issue:6
Neonicotinoid substituents forming a water bridge at the nicotinic acetylcholine receptor.
AID1112899Insecticidal activity against Myzus persicae 4106A (green peach aphid) fed on compound treated chinese cabbage discs after 72 hr2013Pest management science, May, Volume: 69, Issue:5
Investigating the mode of action of sulfoxaflor: a fourth-generation neonicotinoid.
AID1081738Insecticidal activity against Nephotettix cincticeps (green rice leafhopper)2011Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7
Molecular design of dinotefuran with unique insecticidal properties.
AID1081737Lipophilicity, log P of the compound2011Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7
Molecular design of dinotefuran with unique insecticidal properties.
AID1112902Displacement of [3H]IMD from nAChR in Myzus persicae 4106A (green peach aphid) membrane after 70 min2013Pest management science, May, Volume: 69, Issue:5
Investigating the mode of action of sulfoxaflor: a fourth-generation neonicotinoid.
AID1082232Inhibition of xanthine oxidase at IC50 concentration2011Journal of agricultural and food chemistry, May-11, Volume: 59, Issue:9
Neonicotinoid insecticides: oxidative stress in planta and metallo-oxidase inhibition.
AID1082231Inhibition of Oryctolagus cuniculus (rabbit) AOX in liver cytosol at IC50 concentration2011Journal of agricultural and food chemistry, May-11, Volume: 59, Issue:9
Neonicotinoid insecticides: oxidative stress in planta and metallo-oxidase inhibition.
AID1082239Inhibition of Agaricus bisporus (mushroom) tyrosinase2011Journal of agricultural and food chemistry, May-11, Volume: 59, Issue:9
Neonicotinoid insecticides: oxidative stress in planta and metallo-oxidase inhibition.
AID1111081Insecticidal activity against Anomala orientalis assessed as mortality after 30 days2010Pest management science, Jan, Volume: 66, Issue:1
Variation in the laboratory susceptibility of turf-infesting white grubs (Coleoptera: Scarabaeidae) to biological, biorational and chemical control products.
AID1111075Insecticidal activity against Popillia japonica assessed as mortality after 30 days2010Pest management science, Jan, Volume: 66, Issue:1
Variation in the laboratory susceptibility of turf-infesting white grubs (Coleoptera: Scarabaeidae) to biological, biorational and chemical control products.
AID1111952Insecticidal activity against imidacloprid-resistant Aphis gossypii (cotton aphid) in cotton leaves assessed as mortality measured after 72 hr by dipping method2011Pest management science, Dec, Volume: 67, Issue:12
Toxicities and sublethal effects of seven neonicotinoid insecticides on survival, growth and reproduction of imidacloprid-resistant cotton aphid, Aphis gossypii.
AID1081718Insecticidal activity against Siphonaptera (fleas)2011Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7
Molecular design of dinotefuran with unique insecticidal properties.
AID1082233Inhibition of Agaricus bisporus (mushroom) tyrosinase at IC50 concentration2011Journal of agricultural and food chemistry, May-11, Volume: 59, Issue:9
Neonicotinoid insecticides: oxidative stress in planta and metallo-oxidase inhibition.
AID1111955Insecticidal activity against imidacloprid-resistant Aphis gossypii RF45 (cotton aphid) in cotton leaves assessed as mortality measured after 48 hr by dipping method2011Pest management science, Dec, Volume: 67, Issue:12
Toxicities and sublethal effects of seven neonicotinoid insecticides on survival, growth and reproduction of imidacloprid-resistant cotton aphid, Aphis gossypii.
AID1081727Insecticidal activity against Lepidoptera (peach fruit moth)2011Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7
Molecular design of dinotefuran with unique insecticidal properties.
AID1081733Insecticidal activity against Aphididae (aphids)2011Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7
Molecular design of dinotefuran with unique insecticidal properties.
AID1081747Insecticidal activity against Laodelphax striatella (small brown planthopper) assessed as lethality at 0.1 to 1 ppm2011Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7
Molecular design of dinotefuran with unique insecticidal properties.
AID1081735Insecticidal activity against Aleyrodidae (whiteflies)2011Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7
Molecular design of dinotefuran with unique insecticidal properties.
AID1111077Insecticidal activity against Popillia japonica assessed as mortality after 10 days2010Pest management science, Jan, Volume: 66, Issue:1
Variation in the laboratory susceptibility of turf-infesting white grubs (Coleoptera: Scarabaeidae) to biological, biorational and chemical control products.
AID1111953Insecticidal activity against imidacloprid-resistant Aphis gossypii (cotton aphid) in cotton leaves assessed as reduction in body weight at LC20 concentration measured after 24 hr by dipping method (Rvb = 0.33 +/- 0.0004 mg/aphid)2011Pest management science, Dec, Volume: 67, Issue:12
Toxicities and sublethal effects of seven neonicotinoid insecticides on survival, growth and reproduction of imidacloprid-resistant cotton aphid, Aphis gossypii.
AID1082240Phytotoxicity against Vitis vinifera seedlings assessed as lesions at 50 to 100 ppm after 9 days2011Journal of agricultural and food chemistry, May-11, Volume: 59, Issue:9
Neonicotinoid insecticides: oxidative stress in planta and metallo-oxidase inhibition.
AID1081736Insecticidal activity against Laodelphax striatella (small brown planthopper) 2011Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7
Molecular design of dinotefuran with unique insecticidal properties.
AID1111954Resistance ratio, LC50 for Aphis gossypii RF45 (cotton aphid) to LC50 for Aphis gossypii SS2011Pest management science, Dec, Volume: 67, Issue:12
Toxicities and sublethal effects of seven neonicotinoid insecticides on survival, growth and reproduction of imidacloprid-resistant cotton aphid, Aphis gossypii.
AID1081726Insecticidal activity against Plutella xylostella (diamondback moth) 2011Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7
Molecular design of dinotefuran with unique insecticidal properties.
AID1081732Insecticidal activity against Leptocorisa acuta (rice bugs)2011Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7
Molecular design of dinotefuran with unique insecticidal properties.
AID1111084Insecticidal activity against Amphimallon majalis (European chafer) assessed as mortality after 30 days2010Pest management science, Jan, Volume: 66, Issue:1
Variation in the laboratory susceptibility of turf-infesting white grubs (Coleoptera: Scarabaeidae) to biological, biorational and chemical control products.
AID1082238Inhibition of Oryctolagus cuniculus (rabbit) AOX in liver cytosol2011Journal of agricultural and food chemistry, May-11, Volume: 59, Issue:9
Neonicotinoid insecticides: oxidative stress in planta and metallo-oxidase inhibition.
AID1111956Insecticidal activity against Aphis gossypii SS (cotton aphid) in cotton leaves assessed as mortality measured after 48 hr by dipping method2011Pest management science, Dec, Volume: 67, Issue:12
Toxicities and sublethal effects of seven neonicotinoid insecticides on survival, growth and reproduction of imidacloprid-resistant cotton aphid, Aphis gossypii.
AID1082242Phytotoxicity against Gossypium hirsutum (cotton) seedlings assessed as lesions at 50 to 100 ppm after 9 days2011Journal of agricultural and food chemistry, May-11, Volume: 59, Issue:9
Neonicotinoid insecticides: oxidative stress in planta and metallo-oxidase inhibition.
AID1081739Aqueous solubility of the compound2011Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7
Molecular design of dinotefuran with unique insecticidal properties.
AID1081725Insecticidal activity against Alticini (flea beetles)2011Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7
Molecular design of dinotefuran with unique insecticidal properties.
AID1112900Insecticidal activity against neonicotinoid-resistant Myzus persicae FRC-P (green peach aphid) fed on compound treated chinese cabbage discs after 72 hr2013Pest management science, May, Volume: 69, Issue:5
Investigating the mode of action of sulfoxaflor: a fourth-generation neonicotinoid.
AID1082237Inhibition of xanthine oxidase2011Journal of agricultural and food chemistry, May-11, Volume: 59, Issue:9
Neonicotinoid insecticides: oxidative stress in planta and metallo-oxidase inhibition.
AID1081719Insecticidal activity against Diptera (houseflies)2011Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7
Molecular design of dinotefuran with unique insecticidal properties.
AID1111951Insecticidal activity against imidacloprid-resistant Aphis gossypii (cotton aphid) in cotton leaves assessed as reduction in body weight at LC20 concentration measured after 48 hr by dipping method (Rvb = 0.36 +/- 0.0006 mg/aphid)2011Pest management science, Dec, Volume: 67, Issue:12
Toxicities and sublethal effects of seven neonicotinoid insecticides on survival, growth and reproduction of imidacloprid-resistant cotton aphid, Aphis gossypii.
AID1111086Insecticidal activity against Amphimallon majalis (European chafer) assessed as mortality after 10 days2010Pest management science, Jan, Volume: 66, Issue:1
Variation in the laboratory susceptibility of turf-infesting white grubs (Coleoptera: Scarabaeidae) to biological, biorational and chemical control products.
AID1101020Displacement of [3H]IMI from nicotinic acetylcholine receptor in Drosophila melanogaster head membrane after 90 min by filter binding assay2000Journal of neurochemistry, Sep, Volume: 75, Issue:3
Insect nicotinic acetylcholine receptor: conserved neonicotinoid specificity of [(3)H]imidacloprid binding site.
AID1111085Insecticidal activity against Amphimallon majalis (European chafer) assessed as mortality after 20 days2010Pest management science, Jan, Volume: 66, Issue:1
Variation in the laboratory susceptibility of turf-infesting white grubs (Coleoptera: Scarabaeidae) to biological, biorational and chemical control products.
AID1081731Insecticidal activity against Miridae (plant bugs)2011Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7
Molecular design of dinotefuran with unique insecticidal properties.
AID1081730Insecticidal activity against Lepidoptera (leafminers)2011Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7
Molecular design of dinotefuran with unique insecticidal properties.
AID1082244Phytotoxicity against Glycine max (soybean) seedlings assessed as lesions in unfoliolate leaves at 100 ppm after 9 days2011Journal of agricultural and food chemistry, May-11, Volume: 59, Issue:9
Neonicotinoid insecticides: oxidative stress in planta and metallo-oxidase inhibition.
AID1081723Insecticidal activity against Curculionidae (weevils)2011Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7
Molecular design of dinotefuran with unique insecticidal properties.
AID1081721Insecticidal activity against Chrysomelidae (leaf beetles)2011Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7
Molecular design of dinotefuran with unique insecticidal properties.
AID1081717Insecticidal activity against Caelifera (grasshoppers)2011Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7
Molecular design of dinotefuran with unique insecticidal properties.
AID1111082Insecticidal activity against Anomala orientalis assessed as mortality after 20 days2010Pest management science, Jan, Volume: 66, Issue:1
Variation in the laboratory susceptibility of turf-infesting white grubs (Coleoptera: Scarabaeidae) to biological, biorational and chemical control products.
AID1081729Insecticidal activity against Thysanoptera (thrips)2011Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7
Molecular design of dinotefuran with unique insecticidal properties.
AID1101023Displacement of [3H]IMI from nicotinic acetylcholine receptor in Myzus persicae (green peach aphid) whole body membrane after 90 min by filter binding assay2000Journal of neurochemistry, Sep, Volume: 75, Issue:3
Insect nicotinic acetylcholine receptor: conserved neonicotinoid specificity of [(3)H]imidacloprid binding site.
AID1082241Phytotoxicity against Zea mays (maize) seedlings assessed as lesions at 50 to 100 ppm after 9 days2011Journal of agricultural and food chemistry, May-11, Volume: 59, Issue:9
Neonicotinoid insecticides: oxidative stress in planta and metallo-oxidase inhibition.
AID1111950Insecticidal activity against imidacloprid-resistant Aphis gossypii (cotton aphid) in cotton leaves assessed as reduction in body weight at LC20 concentration measured after 72 hr by dipping method (Rvb = 0.40 +/- 0.0002 mg/aphid)2011Pest management science, Dec, Volume: 67, Issue:12
Toxicities and sublethal effects of seven neonicotinoid insecticides on survival, growth and reproduction of imidacloprid-resistant cotton aphid, Aphis gossypii.
AID1112898Resistance index, ratio of LC50 for neonicotinoid-resistant Myzus persicae FRC-P (green peach aphid) to LC50 for Myzus persicae 4106A2013Pest management science, May, Volume: 69, Issue:5
Investigating the mode of action of sulfoxaflor: a fourth-generation neonicotinoid.
AID1081724Insecticidal activity against Isoptera (termites)2011Journal of agricultural and food chemistry, Apr-13, Volume: 59, Issue:7
Molecular design of dinotefuran with unique insecticidal properties.
AID1080612Insecticidal activity against adult Aphis gossypii (cotton aphid) in cucumber cotyledons assessed as mortality at 500 ppm treated for 5 secs before adult infestation measured after 72 hr2009Journal of agricultural and food chemistry, Mar-25, Volume: 57, Issue:6
Neonicotinoid substituents forming a water bridge at the nicotinic acetylcholine receptor.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (28.57)29.6817
2010's5 (71.43)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 143.82

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index143.82 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.86 (4.65)
Search Engine Demand Index261.29 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (143.82)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
4-hydroxybenzaldehyde
[no description available]		2.0610hydroxybenzaldehydeEC 1.14.17.1 (dopamine beta-monooxygenase) inhibitor;
mouse metabolite;
plant metabolite
benzaldehyde
[no description available]		2.0610benzaldehydesEC 3.1.1.3 (triacylglycerol lipase) inhibitor;
EC 3.5.5.1 (nitrilase) inhibitor;
flavouring agent;
fragrance;
odorant receptor agonist;
plant metabolite
benzoic acid
Benzoic Acid: A fungistatic compound that is widely used as a food preservative. It is conjugated to GLYCINE in the liver and excreted as hippuric acid.. benzoic acid : A compound comprising a benzene ring core carrying a carboxylic acid substituent.. aromatic carboxylic acid : Any carboxylic acid in which the carboxy group is directly bonded to an aromatic ring.		2.0610benzoic acidsalgal metabolite;
antimicrobial food preservative;
drug allergen;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
EC 3.1.1.3 (triacylglycerol lipase) inhibitor;
human xenobiotic metabolite;
plant metabolite
niacin
Niacin: A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties.. vitamin B3 : Any member of a group of vitamers that belong to the chemical structural class called pyridines that exhibit biological activity against vitamin B3 deficiency. Vitamin B3 deficiency causes a condition known as pellagra whose symptoms include depression, dermatitis and diarrhea. The vitamers include nicotinic acid and nicotinamide (and their ionized and salt forms).. nicotinic acid : A pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group.		2.0610pyridine alkaloid;
pyridinemonocarboxylic acid;
vitamin B3		antidote;
antilipemic drug;
EC 3.5.1.19 (nicotinamidase) inhibitor;
Escherichia coli metabolite;
human urinary metabolite;
metabolite;
mouse metabolite;
plant metabolite;
vasodilator agent
pimagedine
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure. aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.		2.0610guanidines;
one-carbon compound		EC 1.14.13.39 (nitric oxide synthase) inhibitor;
EC 1.4.3.4 (monoamine oxidase) inhibitor
chlorpyrifos
Chlorpyrifos: An organothiophosphate cholinesterase inhibitor that is used as an insecticide and as an acaricide.. chlorpyrifos : An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.		2.0510chloropyridine;
organic thiophosphate		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
environmental contaminant;
insecticide;
xenobiotic
fipronil
fipronil: has low mammalian toxicity; structure given in first source. fipronil : A racemate comprising equimolar amounts of (R)- and (S)-fipronil.. 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile : A member of the class of pyrazoles that is 1H-pyrazole that is substituted at positions 1, 3, 4, and 5 by 2,6-dichloro-4-(trifluoromethyl)phenyl, cyano, (trifluoromethyl)sulfinyl, and amino groups, respectively.		2.0810(trifluoromethyl)benzenes;
dichlorobenzene;
nitrile;
primary amino compound;
pyrazoles;
sulfoxide
kojic acid
[no description available]		2.06104-pyranones;
enol;
primary alcohol		Aspergillus metabolite;
EC 1.10.3.1 (catechol oxidase) inhibitor;
EC 1.10.3.2 (laccase) inhibitor;
EC 1.13.11.24 (quercetin 2,3-dioxygenase) inhibitor;
EC 1.14.18.1 (tyrosinase) inhibitor;
EC 1.4.3.3 (D-amino-acid oxidase) inhibitor;
NF-kappaB inhibitor;
skin lightening agent
raloxifene
raloxifene : A member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogens at positions 2, 3, and 6 have been replaced by p-hydroxyphenyl, p-[2-(piperidin-1-yl)ethoxy]benzoyl, and hydroxy groups, respectively.		2.06101-benzothiophenes;
aromatic ketone;
N-oxyethylpiperidine;
phenols		bone density conservation agent;
estrogen antagonist;
estrogen receptor modulator
trichlorfon
Trichlorfon: An organochlorophosphate cholinesterase inhibitor that is used as an insecticide for the control of flies and roaches. It is also used in anthelmintic compositions for animals. (From Merck, 11th ed). trichlorfon : A phosphonic ester that is dimethyl phosphonate in which the hydrogen atom attched to the phosphorous is substituted by a 2,2,2-trichloro-1-hydroxyethyl group.		2.0510organic phosphonate;
organochlorine compound;
phosphonic ester		agrochemical;
anthelminthic drug;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
insecticide
dinoseb
dinoseb: RN given refers to parent cpd; structure. dinoseb : A racemate composed of equimolar amounts of (R)- and (S)-dinoseb.. 2-(butan-2-yl)-4,6-dinitrophenol : A dinitrophenol that is 2,4-dinitrophenol substituted by a butan-2-yl group at position 2.		2.0810dinitrophenol
salicylaldehyde
o-hydroxybenzaldehyde: structure in first source		2.0610hydroxybenzaldehydenematicide;
plant metabolite
furaldehyde
Furaldehyde: A heterocyclic compound consisting of a furan where the hydrogen at position 2 is substituted by a formyl group.. furfural : An aldehyde that is furan with the hydrogen at position 2 substituted by a formyl group.		2.0610aldehyde;
furans		Maillard reaction product;
metabolite
potassium cyanide
[no description available]		2.0610cyanide salt;
one-carbon compound;
potassium salt		EC 1.15.1.1 (superoxide dismutase) inhibitor;
EC 1.9.3.1 (cytochrome c oxidase) inhibitor;
neurotoxin
3-pyridinaldehyde
pyridine-3-carbaldehyde : A pyridinecarbaldehyde that is pyridine substituted by a formyl group at position 3.		2.0610pyridinecarbaldehyde
sodium azide
Sodium Azide: A cytochrome oxidase inhibitor which is a nitridizing agent and an inhibitor of terminal oxidation. (From Merck Index, 12th ed). sodium azide : The sodium salt of hydrogen azide (hydrazoic acid).		2.0610inorganic sodium saltantibacterial agent;
explosive;
mitochondrial respiratory-chain inhibitor;
mutagen
pirimiphos methyl
pirimiphos methyl: structure. pirimiphos-methyl : An organic thiophosphate that is O,O-dimethyl O-pyrimidin-4-yl phosphorothioate substituted by a methyl group at position 6 and a diethylamino group at position 2.		2.0810aminopyrimidine;
organic thiophosphate		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
environmental contaminant;
insecticide
acetamidine
acetamidine: bovine trypsin inhibitor; RN given refers to parent cpd; structure		2.0610carboxamidine
4-chlorosalicylic acid
[no description available]		2.0610
6-chloronicotinic acid
[no description available]		2.0610aromatic carboxylic acid;
pyridines
nicotine
(S)-nicotine : A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.		2.08103-(1-methylpyrrolidin-2-yl)pyridineanxiolytic drug;
biomarker;
immunomodulator;
mitogen;
neurotoxin;
nicotinic acetylcholine receptor agonist;
peripheral nervous system drug;
phytogenic insecticide;
plant metabolite;
psychotropic drug;
teratogenic agent;
xenobiotic
thiacloprid
thiacloprid: structure in first source. (Z)-thiacloprid : The (Z)-stereoisomer of thiacloprid.. thiacloprid : A nitrile that is cyanamide in which the hydrogens are replaced by a 1,3-thiazolidin-2-ylidene group which in turn is substituted by a (6-chloropyridin-3-yl)methyl group at the ring nitrogen.		2.9640monochloropyridine;
nitrile;
thiazolidines		environmental contaminant;
neonicotinoid insectide;
xenobiotic
prizes
acetamiprid: structure in first source. (E)-acetamiprid : The (E)-stereoisomer of acetamiprid.. acetamiprid : A carboxamidine that is acetamidine in which the amino hydrogens are substituted by a (6-chloropyridin-3-yl)methyl and a methyl group while the hydrogen attached to the imino nitrogen is replaced by a cyano group.		2.9640carboxamidine;
monochloropyridine;
nitrile		environmental contaminant;
neonicotinoid insectide;
xenobiotic
2-mercaptonicotinic acid
2-mercaptonicotinic acid: structure given in first source		2.0610
6-mercapto-3-pyridinecarboxylic acid
6-mercapto-3-pyridinecarboxylic acid: structure given in first source		2.0610
nitenpyram
nitenpyram: a nitromethylene neonicotinoid insecticide; structure in first source. (E)-nitenpyram : A nitenpyram in which the double bond has E configuration.. nitenpyram : A C-nitro compound consisting of 2-nitroethene-1,1-diamine where one of the nitrogens bears ethyl and (6-chloro-3-pyridinyl)methyl while the other nitrogen carries a methyl group.		2.9640chloropyridyl insecticide;
nitenpyram
thiamethoxam
[no description available]		2.9840
bifenthrin
bifenthrin: a type I pyrethroid. bifenthrin : A carboxylic ester obtained by formal condensation of cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylic acid and [(2-methyl-1,1'-biphenyl)-3-yl]methanol.. kappa-bifenthrin : A carboxylic ester obtained by formal condensation of the carboxy group of (1R,3R)-3-[(1Z)-2-chloro-3,3,3-trifluoroprop-1-enyl]-2,2-dimethylcyclopropanecarboxylic acid with the hydroxy group of [(2-methyl-1,1'-biphenyl)-3-yl]methanol.		2.0510carboxylic ester;
cyclopropanecarboxylate ester;
cyclopropanes;
organochlorine compound;
organofluorine compound		pyrethroid ester acaricide;
pyrethroid ester insecticide
aldicarb
Aldicarb: Carbamate derivative used as an insecticide, acaricide, and nematocide.. aldicarb : The oxime carbamate resulting from the addition of 2-methyl-2-(methylsulfanyl)propanaldoxime to methyl isocyanate. A member of the class of oxime carbamate insecticides, aldicarb is a mixture of E and Z isomers; it is not known which isomer is more active.		2.0810
mk 936
[no description available]		2.0810
chlorantranilipole
chlorantranilipole: anthranilic diamide insecticide.that disrupts mating in codling moth (Lepidoptera: Tortricidae). chlorantraniliprole : A carboxamide resulting from the formal condensation of the carboxylic acid group of 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid with the primary amino group of 2-amino-5-chloro-N,3-dimethylbenzamide. The first of the anthranilic diamide insecticides, it is a ryanodine receptor activator and is used to protect a wide variety of crops, including corn, cotton, grapes, rice and potatoes.		2.0810monochlorobenzenes;
organobromine compound;
pyrazole insecticide;
pyrazoles;
pyridines;
secondary carboxamide		ryanodine receptor agonist
sulfoxaflor
sulfoxaflor: insecticide targeting sap-feeding pests; structure in first source. sulfoxaflor : A mixture of the four diastereoisomers arising from the two tetrahedral stereocentres of [methyl(oxido){1-[6-(trifluoromethyl)pyridin-3-yl]ethyl}-lambda(6)-sulfanylidene]cyanamide (the sulfur atom and the carbon attached to position 3 of the pyridine ring). [Both E- and Z-isomers involving the S=N double bond and the cyano group exist, but they interconvert rapidly at r.t.]. A nicotinic acetylcholine receptor agonist in insects, sulfoxaflor is used as an insecticide, particularly for the control of aphids.. [methyl(oxido){1-[6-(trifluoromethyl)pyridin-3-yl]ethyl}-lambda(6)-sulfanylidene]cyanamide : A member of the class of pyridines that is 5-ethyl-2-trifluoromethylpyridine in which the ethyl group is substituted at position 1 by an N-cyano-S-methylsulfonimidoyl group. The insecticide sulfoxalor is a mixture of the four possible stereoisomers arising from the two tetrahedral stereocentres.		2.0810nitrile;
organofluorine compound;
pyridines;
sulfoximide
imidacloprid
(E)-imidacloprid : The E-isomer of imidacloprid.		3.4370imidacloprid;
imidazolidines;
monochloropyridine		environmental contaminant;
genotoxin;
neonicotinoid insectide;
nicotinic acetylcholine receptor agonist;
xenobiotic
clothianidin
(E)-clothianidin : A clothiadin that has E configuration at the C=N bond of the nitroguanidine moiety.		3.3601,3-thiazoles;
2-nitroguanidine derivative;
clothianidin;
organochlorine compound		environmental contaminant;
neonicotinoid insectide;
nicotinic acetylcholine receptor agonist;
xenobiotic
allopurinol
Allopurinol: A XANTHINE OXIDASE inhibitor that decreases URIC ACID production. It also acts as an antimetabolite on some simpler organisms.. allopurinol : A bicyclic structure comprising a pyrazole ring fused to a hydroxy-substituted pyrimidine ring.		2.0610nucleobase analogue;
organic heterobicyclic compound		antimetabolite;
EC 1.17.3.2 (xanthine oxidase) inhibitor;
gout suppressant;
radical scavenger
ConditionIndicatedRelationship StrengthStudiesTrials
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		02.0610