Page last updated: 2024-09-27

Smith-Magenis Syndrome

Complex neurobehavioral disorder characterized by distinctive facial features (FACIES), developmental delay and INTELLECTUAL DISABILITY. Behavioral phenotypes include sleep disturbance, maladaptive, self-injurious and attention-seeking behaviors. The sleep disturbance is linked to an abnormal circadian secretion pattern of MELATONIN. The syndrome is associated with de novo deletion or mutation and HAPLOINSUFFICIENCY of the retinoic acid-induced 1 protein on chromosome 17p11.2.

Synonyms(1)

Synonym
Smith-Magenis Syndrome

Research

Studies (51)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's39 (76.47)28.8240
2020's12 (23.53)9.53
DrugIndicatedRelationship StrengthStudiesTrials
adenine0medium111
melatonin0low130
acebutolol0low10
chlorambucil0low20
methylphenidate0medium11
risperidone0low10
thalidomide0low40
prednisone0low10
alanine0low10
levodopa0low10
pyrazines0medium11
vidarabine0medium53
glutamic acid0low10
6-sulfatoxymelatonin0low10
bendamustine hydrochloride0low10
fludalanine0low10
lenalidomide0low20
benzofurans0medium11
bortezomib0medium31
pentostatin0medium11
tretinoin0low50
decitabine0medium11
isomethyleugenol0low10
fludarabine0medium53
freedom0low10
abt-7370low10
nutlin-3a0low10
idelalisib0low20
oligonucleotides0low10
pci 327650medium111
piperidines0medium111
abt-1990low50
warfarin0low10
nitrophenols0low10
allopurinol0low10

Protein Targets (893)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
EWS/FLI fusion protein150015
Apoptosis regulator Bcl-205510
Spike glycoprotein5005
Bcl-2-like protein 10426
Induced myeloid leukemia cell differentiation protein Mcl-10505
Aspartyl/asparaginyl beta-hydroxylase0202
Bcl-2-related protein A10213
Bcl-2-like protein 20303
Bcl2-associated agonist of cell death 0202
Chain A, Apoptosis regulator Bcl-X0101
PPM1D protein4004
Bcl-2-like protein 110101
Interferon beta5005
Beta-casein0101
Alpha-1B adrenergic receptor0404
Alpha-2B adrenergic receptor0202
Alpha-2C adrenergic receptor0202
Alpha-2A adrenergic receptor0202
Adenosine receptor A2a0102
BH3-interacting domain death agonist0202
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog0011
Apoptosis regulator BAX 0101
Bcl-2 homologous antagonist/killer0213
Bcl-2-binding component 3, isoforms 1/20101
Bcl-2-like protein 100101
Solute carrier family 22 member 1 0101
Beta-2 adrenergic receptor0011
Beta-1 adrenergic receptor0213
Beta-3 adrenergic receptor0011
5-hydroxytryptamine receptor 1A0404
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE4004
Chain A, MTA/SAH nucleosidase0101
Chain A, Ribosome-inactivating protein alpha-trichosanthin0011
Chain A, Ricin A chain0011
Chain A, Ribosome-inactivating protein 30011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
RAR-related orphan receptor gamma8008
TDP1 protein130013
AR protein120012
nuclear receptor subfamily 1, group I, member 37007
cytochrome P450 family 3 subfamily A polypeptide 45005
glucocorticoid receptor [Homo sapiens]8008
estrogen-related nuclear receptor alpha120012
pregnane X nuclear receptor7007
estrogen nuclear receptor alpha130013
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a7007
nuclear factor erythroid 2-related factor 2 isoform 25005
heat shock protein beta-13003
importin subunit beta-1 isoform 12002
snurportin-12002
tumor susceptibility gene 101 protein1001
GTP-binding nuclear protein Ran isoform 11001
lamin isoform A-delta105005
Voltage-dependent calcium channel gamma-2 subunit5005
Bile salt export pump013013
Cyclin-dependent kinase 10123
Heat shock protein HSP 90-beta0101
Glutamate receptor 25218
Xanthine dehydrogenase/oxidase0303
TAR DNA-binding protein 432002
Protein mono-ADP-ribosyltransferase PARP150101
Leucine-rich repeat serine/threonine-protein kinase 20202
ATPase family AAA domain-containing protein 55005
Ataxin-25005
Chain A, TYROSYL-DNA PHOSPHODIESTERASE4004
Carbonic anhydrase 10205
Carbonic anhydrase 20205
Alanine racemase, biosynthetic0001
5-hydroxytryptamine receptor 1D0001
Glutamate receptor ionotropic, NMDA 1 0315
Proton-coupled amino acid transporter 10101
Adenosine deaminase0001
Carbonic anhydrase 40001
interleukin 83003
thyroid stimulating hormone receptor3003
estrogen receptor 2 (ER beta)4004
progesterone receptor5005
IDH12002
euchromatic histone-lysine N-methyltransferase 27007
Bloom syndrome protein isoform 16006
transcriptional regulator ERG isoform 32002
thyroid hormone receptor beta isoform 28008
ras-related protein Rab-9A2002
nuclear factor erythroid 2-related factor 2 isoform 17007
geminin9009
survival motor neuron protein isoform d4004
ATP-binding cassette sub-family C member 30909
Multidrug resistance-associated protein 40909
Polyphenol oxidase 20102
Hypoxanthine-guanine phosphoribosyltransferase0001
Cellular tumor antigen p53112013
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase 0101
Adenosine receptor A2a0011
Nuclear receptor ROR-gamma0101
Xanthine dehydrogenase/oxidase0214
Purine nucleoside phosphorylase0011
Canalicular multispecific organic anion transporter 10909
Shiga toxin subunit A0101
Histamine H3 receptor0101
Chain H, Proteasome component PUP10101
Chain I, Proteasome component PUP30101
Chain K, Proteasome component PRE20101
Chain L, Proteasome component C50101
Chain K, Proteasome component PRE20101
Chain L, Proteasome component C50101
Proteasome subunit beta type-110101
Fumarate hydratase3003
caspase 7, apoptosis-related cysteine protease3003
retinoic acid nuclear receptor alpha variant 16006
retinoid X nuclear receptor alpha4004
farnesoid X nuclear receptor4004
polyprotein3003
peroxisome proliferator-activated receptor delta3003
peroxisome proliferator activated receptor gamma3003
vitamin D (1,25- dihydroxyvitamin D3) receptor5005
caspase-33003
nuclear receptor subfamily 1, group I, member 21001
Histone H2A.x2002
Caspase-72002
caspase-32002
26S proteasome non-ATPase regulatory subunit 110101
26S proteasome non-ATPase regulatory subunit 120101
26S proteasome non-ATPase regulatory subunit 140101
Proteasome subunit alpha type-70101
Histone deacetylase 30101
26S proteasome non-ATPase regulatory subunit 30101
Carbonic anhydrase 120203
Prothrombin0112
Chymotrypsinogen A0101
Carbonic anhydrase 30102
Cathepsin B0101
Neutrophil elastase0101
Cathepsin G0202
Lysosomal protective protein0101
Chymotrypsinogen B0101
26S proteasome regulatory subunit 6A0101
Nuclear factor NF-kappa-B p105 subunit0101
Proteasome subunit beta type-10102
Carbonic anhydrase 40102
Carbonic anhydrase 60102
Chymase0101
Proteasome subunit alpha type-10101
Proteasome subunit alpha type-20101
Proteasome subunit alpha type-30101
Proteasome subunit alpha type-40101
Proteasome subunit beta type-80101
Proteasome subunit beta type-80101
Proteasome subunit beta type-90101
Proteasome subunit alpha type-50101
Proteasome subunit beta type-40101
Proteasome subunit beta type-60101
Proteasome subunit beta type-50203
Carbonic anhydrase 5A, mitochondrial0102
26S proteasome regulatory subunit 70101
Lon protease homolog, mitochondrial0101
Proteasome subunit beta type-100101
Carbonic anhydrase 70102
26S proteasome regulatory subunit 6B0123
26S proteasome non-ATPase regulatory subunit 80101
Proteasome subunit beta type-30101
Proteasome subunit beta type-20102
26S proteasome non-ATPase regulatory subunit 70101
26S proteasome non-ATPase regulatory subunit 40101
26S proteasome complex subunit SEM10101
Proteasome subunit alpha type-60101
26S proteasome regulatory subunit 40101
26S proteasome regulatory subunit 80101
26S proteasome regulatory subunit 10B0101
Beta-carbonic anhydrase 10101
Nuclear factor NF-kappa-B p100 subunit 0101
Transcription factor p650101
26S proteasome non-ATPase regulatory subunit 20101
Histone deacetylase 10202
26S proteasome non-ATPase regulatory subunit 60101
Proteasomal ubiquitin receptor ADRM10101
Carbonic anhydrase 90203
ATP-dependent Clp protease proteolytic subunit0112
Carbonic anhydrase 130101
NACHT, LRR and PYD domains-containing protein 3 0101
Proteasome subunit alpha-type 80101
Histone deacetylase 20101
Proteasome subunit beta type-70101
26S proteasome non-ATPase regulatory subunit 10101
Carbonic anhydrase 150102
Histone deacetylase 80101
Histone deacetylase 60101
Carbonic anhydrase 140102
26S proteasome non-ATPase regulatory subunit 130101
Carbonic anhydrase 5B, mitochondrial0102
Luciferase3003
thioredoxin reductase8008
NFKB1 protein, partial1001
GALC protein1001
GLS protein4004
GLI family zinc finger 36006
Microtubule-associated protein tau2002
Thrombopoietin1001
thioredoxin glutathione reductase3003
aldehyde dehydrogenase 1 family, member A16006
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)5005
bromodomain adjacent to zinc finger domain 2B2002
activating transcription factor 63003
v-jun sarcoma virus 17 oncogene homolog (avian)2002
peripheral myelin protein 22 isoform 13003
vitamin D3 receptor isoform VDRA3003
chromobox protein homolog 16006
potassium voltage-gated channel subfamily H member 2 isoform d3003
FAD-linked sulfhydryl oxidase ALR0001
urokinase-type plasminogen activator precursor3003
plasminogen precursor3003
urokinase plasminogen activator surface receptor precursor3003
peripheral myelin protein 224004
muscleblind-like protein 1 isoform 11001
muscarinic acetylcholine receptor M14004
Cytochrome P450 2D60516
Nuclear receptor ROR-gamma3115
Solute carrier organic anion transporter family member 1B30202
ATP-dependent phosphofructokinase4004
Chain A, Beta-lactamase4004
ATAD5 protein, partial2002
67.9K protein4004
exodeoxyribonuclease V subunit RecD0101
exodeoxyribonuclease V subunit RecB0101
exodeoxyribonuclease V subunit RecC0101
DNA (cytosine-5)-methyltransferase 10101
Histone-lysine N-methyltransferase EHMT20101
Smad33003
corticotropin-releasing hormone receptor 20112
corticotropin releasing factor-binding protein0112
glycogen synthase kinase-3 beta isoform 10022
5'-nucleotidase0101
Adenosine receptor A30101
Adenosine deaminase 0103
Chain A, GLUTAMATE RECEPTOR SUBUNIT 20101
Chain A, Glutamate Receptor Subunit 20101
Chain B, Glutamate Receptor Subunit 20101
Chain A, Slr1257 protein0011
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]0101
glp-1 receptor, partial1001
phosphopantetheinyl transferase4004
regulator of G-protein signaling 43003
beta-2 adrenergic receptor1001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
Metabotropic glutamate receptor 80202
Metabotropic glutamate receptor 60113
Glutamate receptor ionotropic, NMDA 2D0101
Excitatory amino acid transporter 40101
Glutamate receptor ionotropic, NMDA 3B0101
Glutathione reductase, mitochondrial0202
Bifunctional aspartokinase/homoserine dehydrogenase 10101
Integrin beta-30011
Integrin alpha-IIb0011
ATP-citrate synthase 0101
Glutamate receptor 10213
Glutamate receptor 30213
Glutamate receptor 40213
Glutamate receptor ionotropic, kainate 10213
Metabotropic glutamate receptor 10213
Metabotropic glutamate receptor 20011
Metabotropic glutamate receptor 30011
Metabotropic glutamate receptor 40112
Metabotropic glutamate receptor 50011
Metabotropic glutamate receptor 60011
Metabotropic glutamate receptor 70011
Glutamate receptor ionotropic, kainate 10112
Metabotropic glutamate receptor 50113
Glutamate receptor ionotropic, kainate 20213
Glutamate receptor 10213
Glutamate receptor 20213
Glutamate receptor 30112
Glutamate receptor ionotropic, kainate 30202
Excitatory amino acid transporter 10203
Excitatory amino acid transporter 20203
Excitatory amino acid transporter 30203
Metabotropic glutamate receptor 80011
Glutamate receptor 40213
Excitatory amino acid transporter 3 0001
Glutamate racemase0001
Metabotropic glutamate receptor 80112
Fatty-acid amide hydrolase 10101
Glutamate receptor ionotropic, NMDA 2A 0214
Glutamate receptor ionotropic, NMDA 2B0214
Glutamate receptor ionotropic, NMDA 2C0214
Glutamate receptor ionotropic, kainate 40202
Glutamate carboxypeptidase 20101
Glutamate receptor ionotropic, NMDA 10101
Glutamate receptor ionotropic, NMDA 2A0101
Glutamate receptor ionotropic, kainate 20112
Glutamate receptor ionotropic, kainate 30101
Glutamate receptor ionotropic, NMDA 2B0101
Metabotropic glutamate receptor 10113
Metabotropic glutamate receptor 20113
Metabotropic glutamate receptor 70113
Metabotropic glutamate receptor 30113
Metabotropic glutamate receptor 40113
Glutamate receptor ionotropic, NMDA 2C0101
Glutamate receptor ionotropic, kainate 50101
Carbonic anhydrase-like protein, putative0002
Glutamate receptor ionotropic, NMDA 2D0214
Glutamate receptor ionotropic, kainate 50202
Glutamate racemase0001
Prolyl 4-hydroxylase0101
Glutamate receptor ionotropic, NMDA 3A0101
Glutamate receptor ionotropic, NMDA 3B0214
Alpha-ketoglutarate-dependent dioxygenase FTO0101
Glutamate receptor ionotropic, NMDA 3A0214
Bone morphogenetic protein receptor type-1B0022
Membrane-associated progesterone receptor component 10011
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform0112
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha0101
Serine/threonine-protein kinase PLK40022
ATP-dependent RNA helicase DDX3X0022
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta0101
Pyridoxal kinase0022
Citron Rho-interacting kinase0022
Serine/threonine-protein kinase Chk10022
Aurora kinase A0022
Cyclin-G-associated kinase0022
Ephrin type-B receptor 60022
Peroxisomal acyl-coenzyme A oxidase 30022
Receptor-interacting serine/threonine-protein kinase 20022
Mitotic checkpoint serine/threonine-protein kinase BUB10022
Dynamin-like 120 kDa protein, mitochondrial0022
Eukaryotic translation initiation factor 5B0011
Rho-associated protein kinase 20022
Serine/threonine-protein kinase ULK10022
Serine/threonine-protein kinase/endoribonuclease IRE10022
Ribosomal protein S6 kinase alpha-50022
U5 small nuclear ribonucleoprotein 200 kDa helicase0022
Ribosomal protein S6 kinase alpha-40022
Serine/threonine-protein kinase 160022
Cyclin-dependent kinase-like 50011
Serine/threonine-protein kinase 100022
Serine/threonine-protein kinase D30022
Structural maintenance of chromosomes protein 20022
Mitogen-activated protein kinase kinase kinase 60022
Mitogen-activated protein kinase kinase kinase kinase 40022
Serine/threonine-protein kinase LATS10022
Serine/threonine-protein kinase PAK 40022
Tyrosine-protein kinase ABL10023
Epidermal growth factor receptor0336
High affinity nerve growth factor receptor0022
Guanine nucleotide-binding protein G(i) subunit alpha-20022
ADP/ATP translocase 20022
Cytochrome P450 1A20314
Protein kinase C beta type0022
Insulin receptor0022
Tyrosine-protein kinase Lck0224
Tyrosine-protein kinase Fyn0224
Glycogen phosphorylase, liver form0022
Tyrosine-protein kinase Fes/Fps0022
Adenine phosphoribosyltransferase0022
Tyrosine-protein kinase Yes0123
Tyrosine-protein kinase Lyn0123
Proto-oncogene tyrosine-protein kinase receptor Ret0123
Insulin-like growth factor 1 receptor0022
Signal recognition particle receptor subunit alpha0022
Cytochrome c1, heme protein, mitochondrial0022
Hepatocyte growth factor receptor0022
Tyrosine-protein kinase HCK0123
Platelet-derived growth factor receptor beta0123
Tyrosine-protein kinase Fgr0112
Serine/threonine-protein kinase A-Raf0022
Glycogen phosphorylase, brain form0022
Breakpoint cluster region protein0023
Serine/threonine-protein kinase pim-10022
Fibroblast growth factor receptor 10022
DNA topoisomerase 2-alpha0022
Cyclin-dependent kinase 40022
ADP/ATP translocase 30022
Inosine-5'-monophosphate dehydrogenase 20022
Proto-oncogene tyrosine-protein kinase Src0123
cAMP-dependent protein kinase type II-alpha regulatory subunit0022
Serine/threonine-protein kinase B-raf0022
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform0022
Ribosyldihydronicotinamide dehydrogenase [quinone]0224
Tyrosine-protein kinase Fer0022
Protein kinase C alpha type0022
cAMP-dependent protein kinase catalytic subunit alpha0022
General transcription and DNA repair factor IIH helicase subunit XPD0022
Casein kinase II subunit alpha'0022
Ras-related protein Rab-6A0022
Ephrin type-A receptor 10022
Multifunctional protein ADE20022
cAMP-dependent protein kinase catalytic subunit gamma0022
cAMP-dependent protein kinase catalytic subunit beta0022
Ferrochelatase, mitochondrial0022
Ribosomal protein S6 kinase beta-10022
Tyrosine-protein kinase JAK10224
Cyclin-dependent kinase 20123
Beta-adrenergic receptor kinase 10022
Probable ATP-dependent RNA helicase DDX60022
Mitogen-activated protein kinase 3 0022
MAP/microtubule affinity-regulating kinase 30022
Deoxycytidine kinase0022
Phosphatidylinositol 3-kinase regulatory subunit alpha0101
Mitogen-activated protein kinase 10123
Ephrin type-A receptor 20123
Ephrin type-B receptor 20022
Non-receptor tyrosine-protein kinase TYK20022
Phosphatidylethanolamine-binding protein 10022
Wee1-like protein kinase0022
Heme oxygenase 20022
S-adenosylmethionine synthase isoform type-20022
DnaJ homolog subfamily A member 10022
RAC-alpha serine/threonine-protein kinase0022
RAC-beta serine/threonine-protein kinase0022
Cytochrome P450 2C190315
DNA replication licensing factor MCM40022
Dual specificity mitogen-activated protein kinase kinase 20123
Receptor-type tyrosine-protein kinase FLT30224
Bone morphogenetic protein receptor type-1A0022
Activin receptor type-1B0022
TGF-beta receptor type-10022
TGF-beta receptor type-20022
Electron transfer flavoprotein subunit beta0011
Tyrosine-protein kinase CSK0123
Glycine--tRNA ligase0022
Protein kinase C iota type0022
Exosome RNA helicase MTR40022
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform0101
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform0101
Serine/threonine-protein kinase mTOR0101
Phosphatidylinositol 4-kinase alpha0101
Tyrosine-protein kinase Tec0123
Tyrosine-protein kinase ABL20022
Tyrosine-protein kinase FRK0123
G protein-coupled receptor kinase 60022
Tyrosine-protein kinase SYK0123
Mitogen-activated protein kinase 80022
Mitogen-activated protein kinase 90022
Dual specificity mitogen-activated protein kinase kinase 40011
Dual specificity mitogen-activated protein kinase kinase 30022
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha0022
Casein kinase I isoform alpha0011
Casein kinase I isoform delta0022
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0101
MAP kinase-activated protein kinase 20022
Elongation factor Tu, mitochondrial0022
Cysteine--tRNA ligase, cytoplasmic0011
Casein kinase I isoform epsilon0022
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial0022
Dual specificity protein kinase CLK10022
Dual specificity protein kinase CLK20022
Glycogen synthase kinase-3 alpha0022
Glycogen synthase kinase-3 beta0022
Cyclin-dependent kinase 70022
Cyclin-dependent kinase 90022
Ras-related protein Rab-27A0022
Interleukin-1 receptor-associated kinase 10022
Ribosomal protein S6 kinase alpha-30022
Serine/threonine-protein kinase Nek20022
Serine/threonine-protein kinase Nek30022
Dual specificity mitogen-activated protein kinase kinase 60022
Serine/threonine-protein kinase PLK10022
LIM domain kinase 10022
LIM domain kinase 20022
Mitogen-activated protein kinase 100022
Tyrosine--tRNA ligase, cytoplasmic0022
5'-AMP-activated protein kinase subunit gamma-10022
Ephrin type-B receptor 30022
Ephrin type-A receptor 50022
Ephrin type-B receptor 40022
Ephrin type-A receptor 40022
Adenylate kinase 2, mitochondrial0022
Adenosine kinase0022
Ras-related protein Rab-100022
Actin-related protein 30022
Actin-related protein 20022
GTP-binding nuclear protein Ran0022
Casein kinase I isoform gamma-20022
DNA-dependent protein kinase catalytic subunit0101
Cyclin-dependent kinase 30022
Cyclin-dependent kinase 60022
Cyclin-dependent-like kinase 5 0022
Cyclin-dependent kinase 160022
Cyclin-dependent kinase 170022
ATP-dependent 6-phosphofructokinase, platelet type0022
Dual specificity mitogen-activated protein kinase kinase 10022
DNA topoisomerase 2-beta0022
Protein kinase C theta type0022
Activin receptor type-10022
Macrophage-stimulating protein receptor0022
Focal adhesion kinase 10022
Protein kinase C delta type0022
Tyrosine-protein kinase BTK0235
Activated CDC42 kinase 10022
Epithelial discoidin domain-containing receptor 10022
Mitogen-activated protein kinase kinase kinase kinase 20022
Serine/threonine-protein kinase 40022
5'-AMP-activated protein kinase catalytic subunit alpha-10022
Dual specificity mitogen-activated protein kinase kinase 50022
Mitogen-activated protein kinase 70022
Serine/threonine-protein kinase PAK 20022
Serine/threonine-protein kinase 30022
Mitogen-activated protein kinase kinase kinase 10022
Integrin-linked protein kinase0022
Rho-associated protein kinase 10022
Non-receptor tyrosine-protein kinase TNK10022
Serine/threonine-protein kinase ATR0011
Calcium/calmodulin-dependent protein kinase type II subunit gamma0022
Calcium/calmodulin-dependent protein kinase type II subunit delta0022
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0022
Activin receptor type-2B0022
Bone morphogenetic protein receptor type-20022
Protein-tyrosine kinase 60123
cGMP-dependent protein kinase 1 0022
Cyclin-dependent kinase 130022
Inhibitor of nuclear factor kappa-B kinase subunit epsilon0022
Protein-tyrosine kinase 2-beta0022
Maternal embryonic leucine zipper kinase0022
Structural maintenance of chromosomes protein 1A0022
Chromodomain-helicase-DNA-binding protein 40022
Peroxisomal acyl-coenzyme A oxidase 10011
Serine/threonine-protein kinase 380022
Ephrin type-A receptor 70022
Delta(24)-sterol reductase0022
Ribosomal protein S6 kinase alpha-10123
Dual specificity testis-specific protein kinase 10011
Myosin light chain kinase, smooth muscle0022
Mitogen-activated protein kinase 110022
Serine/threonine-protein kinase STK110022
Serine/threonine-protein kinase N10022
Serine/threonine-protein kinase N20022
Mitogen-activated protein kinase 140022
Calcium/calmodulin-dependent protein kinase type IV0022
Mitogen-activated protein kinase kinase kinase 110022
MAP kinase-activated protein kinase 30022
Discoidin domain-containing receptor 20022
AP2-associated protein kinase 10022
Myosin light chain kinase 30022
Uncharacterized aarF domain-containing protein kinase 50011
Putative heat shock protein HSP 90-beta 20022
Rab-like protein 30022
Serine/threonine-protein kinase MRCK alpha0022
Serine/threonine-protein kinase MRCK gamma0022
Acyl-CoA dehydrogenase family member 100022
Serine/threonine-protein kinase N30011
Serine/threonine-protein kinase ULK30022
Uncharacterized protein FLJ452520022
Acyl-CoA dehydrogenase family member 110022
Serine/threonine-protein kinase/endoribonuclease IRE20022
Serine/threonine-protein kinase MARK20022
ATP-dependent RNA helicase DHX300022
Serine/threonine-protein kinase TAO10022
STE20-related kinase adapter protein alpha0022
AarF domain-containing protein kinase 10022
ATP-dependent RNA helicase DDX420022
Mitogen-activated protein kinase kinase kinase kinase 30022
MAP kinase-activated protein kinase 50022
Misshapen-like kinase 10022
Phosphatidylinositol 3-kinase catalytic subunit type 30101
Atypical kinase COQ8A, mitochondrial0022
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma0022
Mitogen-activated protein kinase 150022
Serine/threonine-protein kinase Nek90022
ATP-dependent RNA helicase DDX10022
Mitogen-activated protein kinase kinase kinase kinase 10022
Aurora kinase B0022
MAP/microtubule affinity-regulating kinase 40022
Serine/threonine-protein kinase Nek10022
PAS domain-containing serine/threonine-protein kinase0022
Calcium/calmodulin-dependent protein kinase kinase 20022
EKC/KEOPS complex subunit TP53RK0022
Dual specificity testis-specific protein kinase 20011
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase0022
Mitogen-activated protein kinase kinase kinase 50022
Mitogen-activated protein kinase kinase kinase 30022
Eukaryotic translation initiation factor 2-alpha kinase 10022
Nucleolar GTP-binding protein 10022
Serine/threonine-protein kinase D20022
NUAK family SNF1-like kinase 20022
RNA cytidine acetyltransferase0022
Serine/threonine-protein kinase SIK20022
STE20-like serine/threonine-protein kinase 0022
Serine/threonine-protein kinase TAO30022
dCTP pyrophosphatase 10022
Dual specificity protein kinase CLK40022
Casein kinase I isoform gamma-10022
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0101
Serine/threonine-protein kinase PAK 60022
Phenylalanine--tRNA ligase beta subunit0022
BMP-2-inducible protein kinase0022
Midasin0022
Interleukin-1 receptor-associated kinase 40022
Mitogen-activated protein kinase kinase kinase 200022
Cyclin-dependent kinase 120022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 130022
Serine/threonine-protein kinase 260022
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial0022
Serine/threonine-protein kinase NLK0022
Phosphatidylinositol 4-kinase beta0101
5'-AMP-activated protein kinase subunit gamma-20022
Serine/threonine-protein kinase TBK10022
Septin-90022
Ribosomal protein S6 kinase alpha-60022
TRAF2 and NCK-interacting protein kinase0022
Serine/threonine-protein kinase TAO20022
Long-chain-fatty-acid--CoA ligase 50011
Serine/threonine-protein kinase ICK0022
RAC-gamma serine/threonine-protein kinase0022
Serine/threonine-protein kinase 38-like0011
Serine/threonine-protein kinase SIK30022
Mitogen-activated protein kinase kinase kinase 20022
Thyroid hormone receptor-associated protein 30022
Dual specificity tyrosine-phosphorylation-regulated kinase 1B0022
Mitogen-activated protein kinase kinase kinase kinase 50022
Receptor-interacting serine/threonine-protein kinase 30022
Serine/threonine-protein kinase MRCK beta0022
Interleukin-1 receptor-associated kinase 30022
Serine/threonine-protein kinase 240022
Casein kinase I isoform gamma-30022
Mitogen-activated protein kinase kinase kinase 40022
Cereblon isoform 40303
Bromodomain-containing protein 40101
DNA-binding protein Ikaros0014
DNA damage-binding protein 10213
Protein cereblon0429
Zinc finger protein Aiolos0011
Chain A, HADH2 protein4004
Chain B, HADH2 protein4004
Chain A, JmjC domain-containing histone demethylation protein 3A2002
Chain A, 2-oxoglutarate Oxygenase4004
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
dopamine D1 receptor1001
15-lipoxygenase, partial1001
WRN1001
integrase, partial0101
lens epithelium-derived growth factor p750101
apical membrane antigen 1, AMA11001
arylsulfatase A2002
pyruvate kinase1001
hexokinase-4 isoform 11001
atrial natriuretic peptide receptor 1 precursor1001
glucokinase regulatory protein1001
flap endonuclease 11001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
DNA polymerase eta isoform 11001
DNA polymerase iota isoform a (long)1001
DNA polymerase kappa isoform 12002
M-phase phosphoprotein 83003
Plasma kallikrein0001
Polyunsaturated fatty acid lipoxygenase ALOX150101
Tyrosinase0101
Adenosine receptor A10001
Carbonic anhydrase0001
Solute carrier family 15 member 10101
Carbonic anhydrase0001
Large neutral amino acids transporter small subunit 10101
SLC16A10 protein0001
Carbonic anhydrase 0001
Carbonic anhydrase0001
Carbonic anhydrase0001
Carbonic anhydrase 0001
Monocarboxylate transporter 100001
Carbonic anhydrase 130001
phosphoglycerate kinase1001
ClpP1001
aryl hydrocarbon receptor2002
cytochrome P450 2D6 isoform 12002
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
cytochrome P450 3A4 isoform 12002
Gamma-aminobutyric acid receptor subunit pi2002
Cytochrome P450 1A10101
Cytochrome P450 1A2 0101
Myeloperoxidase0101
Cholinesterase0101
Cytochrome P450 2C11 0101
Aromatase0101
Gamma-aminobutyric acid receptor subunit beta-12002
Gamma-aminobutyric acid receptor subunit delta2002
Gamma-aminobutyric acid receptor subunit gamma-22002
Gamma-aminobutyric acid receptor subunit alpha-52002
Gamma-aminobutyric acid receptor subunit alpha-32002
Acetylcholinesterase0101
Gamma-aminobutyric acid receptor subunit gamma-12002
Gamma-aminobutyric acid receptor subunit alpha-22002
Acetylcholinesterase 0101
Gamma-aminobutyric acid receptor subunit alpha-42002
Gamma-aminobutyric acid receptor subunit gamma-32002
Gamma-aminobutyric acid receptor subunit alpha-62002
Mu-type opioid receptor0101
Nociceptin receptor0101
Alpha-1A adrenergic receptor0404
Melatonin receptor type 1A0213
Melatonin receptor type 1C0011
Melatonin receptor type 1A0112
Melatonin receptor type 1B0213
Melatonin receptor type 1C0112
Melatonin receptor type 1B0112
Gamma-aminobutyric acid receptor subunit alpha-12002
Gamma-aminobutyric acid receptor subunit beta-32002
Gamma-aminobutyric acid receptor subunit beta-22002
Nuclear factor erythroid 2-related factor 20001
Cytochrome P450 1B10101
Palmitoleoyl-protein carboxylesterase NOTUM0101
GABA theta subunit2002
Gamma-aminobutyric acid receptor subunit epsilon2002
Carboxylic ester hydrolase 0101
Histamine H3 receptor0202
Sodium-dependent noradrenaline transporter 0202
Sodium-dependent dopamine transporter0202
Sodium-dependent serotonin transporter0303
Sodium-dependent dopamine transporter 0202
cytochrome P450 2D63003
Protein Mdm40202
E3 ubiquitin-protein ligase Mdm20101
Delta-type opioid receptor0011
Death-associated protein kinase 10101
E3 ubiquitin-protein ligase Mdm20101
E3 ubiquitin-protein ligase Mdm21214
Peptidyl-prolyl cis-trans isomerase D0101
Mu-type opioid receptor0011
tyrosine-protein kinase Yes1001
Cell division cycle 7-related protein kinase0011
Testosterone 17-beta-dehydrogenase 30101
Putative nucleoside diphosphate kinase0011
Tyrosine-protein kinase JAK20202
Solute carrier family 22 member 30101
Receptor tyrosine-protein kinase erbB-20112
Macrophage colony-stimulating factor 1 receptor0101
Cytochrome P450 3A40214
Cytochrome P450 2C80102
Cytochrome P450 2C9 0214
Cytochrome P450 2B60102
Receptor tyrosine-protein kinase erbB-30101
Nucleoside diphosphate kinase B0011
G1/S-specific cyclin-E10101
Dual specificity protein kinase TTK0011
Myosin-100011
Tyrosine-protein kinase TXK0112
Choline-phosphate cytidylyltransferase A0011
Tyrosine-protein kinase Blk0112
Cytoplasmic tyrosine-protein kinase BMX0213
cAMP-dependent protein kinase catalytic subunit PRKX0011
Tyrosine-protein kinase JAK30112
Tyrosine-protein kinase ITK/TSK0112
Potassium voltage-gated channel subfamily H member 20404
Tyrosine-protein kinase Mer0011
Receptor tyrosine-protein kinase erbB-40112
Sigma intracellular receptor 20101
Myosin-140011
Serine/threonine-protein kinase Nek70011
Nuclear receptor subfamily 4 group A member 30101
Calcium/calmodulin-dependent protein kinase type 1G0011
Peroxiredoxin-like 2A0101
Platelet glycoprotein VI0101
Obg-like ATPase 10011
Adenosine deaminase0101
Adenosine deaminase 0101
pregnane X receptor2002
nuclear receptor ROR-gamma isoform 12002
Glucocorticoid receptor0213
Glycine receptor subunit alpha-10202
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
acetylcholinesterase1001
thyroid stimulating hormone receptor2002
cytochrome P450 2C19 precursor1001
Solute carrier family 22 member 20101
Voltage-dependent L-type calcium channel subunit alpha-1F0101
5-hydroxytryptamine receptor 40202
Albumin0022
Muscarinic acetylcholine receptor M20101
Muscarinic acetylcholine receptor M40101
ATP-dependent translocase ABCB10001
5-hydroxytryptamine receptor 1A0123
5-hydroxytryptamine receptor 2C0202
Muscarinic acetylcholine receptor M50101
Alpha-2A adrenergic receptor0202
Muscarinic acetylcholine receptor M10101
Angiotensin-converting enzyme0202
D(2) dopamine receptor0202
5-hydroxytryptamine receptor 2A0202
Alpha-2B adrenergic receptor0202
Beta-1 adrenergic receptor0101
Alpha-2C adrenergic receptor0202
D0101
D(3) dopamine receptor0101
Muscarinic acetylcholine receptor M30202
D(1A) dopamine receptor0202
D(4) dopamine receptor0101
Glycine receptor subunit alpha-10011
Alpha-1D adrenergic receptor0202
Histamine H2 receptor0202
Alpha-1D adrenergic receptor0202
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0202
5-hydroxytryptamine receptor 1B0202
5-hydroxytryptamine receptor 2B0202
Histamine H1 receptor0112
5-hydroxytryptamine receptor 7 0101
5-hydroxytryptamine receptor 2C 0101
5-hydroxytryptamine receptor 70101
Alpha-1A adrenergic receptor0202
5-hydroxytryptamine receptor 2A0101
Histamine H1 receptor0202
Alpha-1B adrenergic receptor0101
D(3) dopamine receptor0202
5-hydroxytryptamine receptor 2B0404
5-hydroxytryptamine receptor 60101
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0101
D(2) dopamine receptor0101
D(2) dopamine receptor0202
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
5-hydroxytryptamine receptor 2B0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Sodium channel protein type 5 subunit alpha0101
Transporter0101
5-hydroxytryptamine receptor 1A0101
Nuclear receptor subfamily 3 group C member 3 0202
Multidrug and toxin extrusion protein 20101
Multidrug and toxin extrusion protein 10101
Transporter0101
thyroid hormone receptor beta isoform a3003
Prostaglandin G/H synthase 10101
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Prostaglandin G/H synthase 20101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Chain A, Nuclear Receptor ROR-beta0101
Chain A, Ferritin light chain1001
Chain A, Cruzipain1001
hypoxia-inducible factor 1 alpha subunit1001
USP1 protein, partial1001
nonstructural protein 11001
G1001
Parkin1001
thyrotropin-releasing hormone receptor1001
histone acetyltransferase KAT2A isoform 11001
Ornithine decarboxylase0001
HLA class I histocompatibility antigen, B alpha chain 1001
Amyloid-beta precursor protein0101
Ornithine decarboxylase0001
60 kDa chaperonin0101
Adenosine receptor A30202
Retinoic acid receptor alpha0227
60 kDa heat shock protein, mitochondrial0101
Retinoic acid receptor beta0227
Retinoic acid receptor alpha0123
Retinoic acid receptor gamma 0227
Alpha-1A adrenergic receptor0101
Retinoic acid receptor gamma0123
Retinoic acid receptor RXR-alpha0224
Retinoic acid receptor beta0123
Cellular retinoic acid-binding protein 20011
Retinoic acid receptor RXR-alpha0123
Retinoic acid receptor RXR-beta0224
Retinoic acid receptor RXR-beta0123
Retinoic acid receptor RXR-gamma0123
Indoleamine 2,3-dioxygenase 10101
Nuclear receptor ROR-alpha0101
Alpha-synuclein0101
Cellular retinoic acid-binding protein 10102
Retinoic acid receptor RXR-gamma0224
10 kDa heat shock protein, mitochondrial0101
Cellular retinoic acid-binding protein 10011
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 10213
Thiosulfate sulfurtransferase0101
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Indoleamine 2,3-dioxygenase 20101
Inositol hexakisphosphate kinase 11001
Nuclear receptor ROR-beta0101
cytochrome P450 2C9, partial1001
Thymidine kinase, cytosolic0001
Dipeptidyl peptidase 40101
Adenosylhomocysteinase0101
RNA-directed RNA polymerase 0112
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
Albumin0011
Proprotein convertase subtilisin/kexin type 70101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 10101
Protease 0101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 1 0202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]