Page last updated: 2024-12-10

leptospermone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

leptospermone: a beta-triketone phloroglucinol derivative and constituent of essential oil extracted from Leptospermum scoparium (manuka oil); structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
LeptospermumgenusA plant genus of the family MYRTACEAE. The common name of tea tree is also used for MELALEUCA and KUNZEA.[MeSH]MyrtaceaeThe myrtle plant family of the order Myrtales. It includes several aromatic medicinal plants such as EUCALYPTUS.[MeSH]
Leptospermum scopariumspecies[no description available]MyrtaceaeThe myrtle plant family of the order Myrtales. It includes several aromatic medicinal plants such as EUCALYPTUS.[MeSH]

Cross-References

ID SourceID
PubMed CID3083632
CHEMBL ID4090482
SCHEMBL ID1573209
MeSH IDM0495820

Synonyms (19)

Synonym
567-75-9
2,2,4,4-tetramethyl-6-(3-methylbutanoyl)-1,3,5-cyclohexanetrione
unii-2f8xbe046l
1,3,5-cyclohexanetrione, 6-isovaleryl-2,2,4,4-tetramethyl-
2f8xbe046l ,
leptospermone
2,2,4,4-tetramethyl-6-(3-methylbutanoyl)cyclohexane-1,3,5-trione
leptospermone, (+/-)-
1,3,5-cyclohexanetrione, 2,2,4,4-tetramethyl-6-(3-methyl-1-oxobutyl)-
leptospermone [inci]
(+/-)-leptospermone
SCHEMBL1573209
YDWYMAHAWHBPPT-UHFFFAOYSA-N
DTXSID80205258
2,2,4,4-tetramethyl-6-(3-methyl-1-oxobutyl)-1,3,5-cyclohexanetrione
Q6528372
bdbm50264348
CHEMBL4090482 ,
AKOS040752492

Research Excerpts

Overview

Leptospermone is a natural β-triketone that specifically inhibits the enzyme p-hydrophyphenylpyruvate dioxygenase. It has the same molecular target site as that of the commercial herbicide mesotrione.

ExcerptReferenceRelevance
"Leptospermone is a natural β-triketone that specifically inhibits the enzyme p-hydrophyphenylpyruvate dioxygenase, the same molecular target site as that of the commercial herbicide mesotrione. "( In planta mechanism of action of leptospermone: impact of its physico-chemical properties on uptake, translocation, and metabolism.
Dayan, FE; Nanayakkara, NP; Owens, DK, 2013
)
2.11

Effects

ExcerptReferenceRelevance
"Leptospermone has a half-life of 72 h under simulated solar light irradiations."( Evidence for photolytic and microbial degradation processes in the dissipation of leptospermone, a natural β-triketone herbicide.
Barthelmebs, L; Bertrand, C; Besse-Hoggan, P; Dayan, FE; Devers-Lamrani, M; Jrad, AB; Martin-Laurent, F; Raviglione, D; Romdhane, S; Salvia, MV, 2018
)
1.43
"Leptospermone has a half-life of 72 h under simulated solar light irradiations."( Evidence for photolytic and microbial degradation processes in the dissipation of leptospermone, a natural β-triketone herbicide.
Barthelmebs, L; Bertrand, C; Besse-Hoggan, P; Dayan, FE; Devers-Lamrani, M; Jrad, AB; Martin-Laurent, F; Raviglione, D; Romdhane, S; Salvia, MV, 2018
)
1.43
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
4-hydroxyphenylpyruvate dioxygenaseArabidopsis thaliana (thale cress)IC50 (µMol)11.80000.07000.16000.2500AID1480411
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (1)

Processvia Protein(s)Taxonomy
tyrosine catabolic process4-hydroxyphenylpyruvate dioxygenaseArabidopsis thaliana (thale cress)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (1)

Processvia Protein(s)Taxonomy
4-hydroxyphenylpyruvate dioxygenase activity4-hydroxyphenylpyruvate dioxygenaseArabidopsis thaliana (thale cress)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID1480411Inhibition of Arabidopsis thaliana HPPD expressed in Escherichia coli JM105 using 4-HPP as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by HPLC analysis2017Journal of medicinal chemistry, 05-25, Volume: 60, Issue:10
4-Hydroxyphenylpyruvate Dioxygenase and Its Inhibition in Plants and Animals: Small Molecules as Herbicides and Agents for the Treatment of Human Inherited Diseases.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (10.00)18.7374
1990's0 (0.00)18.2507
2000's2 (20.00)29.6817
2010's7 (70.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 29.68

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index29.68 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.89 (4.65)
Search Engine Demand Index34.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (29.68)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (10.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (90.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]