Compounds > hawkinsin
Page last updated: 2024-09-26

hawkinsin

Description

hawkinsin: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

hawkinsin : A cysteine derivative that is cysteine in which the thiol group is substituted by a [2-(carboxymethyl)-2,5-dihydroxycyclohex-3-en-1-yl]sulfanediyl group. Hawkinsinuria is an inherited disorder which is characterized by the inability to break down the amino acid tyrosine. This results in the finding of certain metabolites in the urine, such as hawkinsin. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID173909
CHEBI ID149584
SCHEMBL ID1660794
MeSH IDM0063197

Synonyms (11)

Synonym
hawkinsin
s-[2-(carboxymethyl)-2,5-dihydroxycyclohex-3-en-1-yl]cysteine
63224-90-8
CHEBI:149584
2-cyclohexene-1-acetic acid, 6-((2-amino-2-carboxyethyl)thio)-1,4-dihydroxy-
(2-l-cystein-s-yl-1,4-dihydroxycyclohex-5-en-1-yl)acetic acid
SCHEMBL1660794
2-amino-3-{[2-(carboxymethyl)-2,5-dihydroxycyclohex-3-en-1-yl]sulfanyl}propanoic acid
Q5685191
DTXSID10866992
2-amino-3-[[2-(carboxymethyl)-2,5-dihydroxy-1-cyclohex-3 enyl]sulfanyl]propanoic acid

Research Excerpts

Overview

ExcerptReference
"Hawkinsinuria is a rarely diagnosed autosomal dominantly transmitted inborn error of tyrosine metabolism with impaired conversion of 4-hydroxyphenylpyruvate to homogentisate. "( Engelke, U; Lehnert, W; Stögmann, W; van den Berg, GB; Wevers, RA, 1999)
"Hawkinsin is a sulfur amino acid identified as (2-l-cystein-S-yl, 4-dihydroxycyclohex-5-en-1-yl)acetic acid."( Awata, H; Boneh, A; Danks, DM; Endo, F; Matsuda, I; Matsuura, T; Milovac, T; Ploechl, E; Scott, CR; Tomoeda, K, 2000)

Roles (2)

RoleDescription
biomarkerA substance used as an indicator of a biological state.
human urinary metaboliteAny metabolite (endogenous or exogenous) found in human urine samples.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (6)

ClassDescription
dicarboxylic acidAny carboxylic acid containing two carboxy groups.
cysteine derivativeAn amino acid derivative resulting from reaction of cysteine at the amino group, carboxy group, or thiol group, or from the replacement of any hydrogen of cysteine by a heteroatom. The definition normally excludes peptides containing cysteine residues.
cycloalkeneAn unsaturated monocyclic hydrocarbon having at least one endocyclic double bond.
diolA compound that contains two hydroxy groups, generally assumed to be, but not necessarily, alcoholic. Aliphatic diols are also called glycols.
tertiary allylic alcoholAn allylic alcohol in which the carbon atom that links the double bond to the hydroxy group is also attached to two other carbons (R4,R5 =/= H).
secondary allylic alcoholAn allylic alcohol in which the carbon atom that links the double bond to the hydroxy group is also attached to one other carbon and one hydrogen.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (1)

hawkinsin is involved in 1 pathway(s), involving a total of 7 unique proteins and 24 unique compounds

PathwayProteinsCompounds
Tyrosine metabolism and related disorders724

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19905 (50.00)18.7374
1990's3 (30.00)18.2507
2000's2 (20.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (10.00%)6.00%
Case Studies5 (50.00%)4.05%
Observational0 (0.00%)0.25%
Other4 (40.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
pyrrolidonecarboxylic acid[no description available]medium205-oxoproline;
L-proline derivative;
non-proteinogenic L-alpha-amino acid		algal metabolite
tyrosine[no description available]medium60amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid;
tyrosine		EC 1.3.1.43 (arogenate dehydrogenase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical
4-hydroxyphenylpyruvic acid[no description available]medium102-oxo monocarboxylic acid;
phenols		human metabolite
butyraldehyde[no description available]low00butanalsbiomarker;
Escherichia coli metabolite;
mouse metabolite
carbon monoxide[no description available]low00carbon oxide;
gas molecular entity;
one-carbon compound		biomarker;
EC 1.9.3.1 (cytochrome c oxidase) inhibitor;
human metabolite;
ligand;
metabolite;
mitochondrial respiratory-chain inhibitor;
mouse metabolite;
neurotoxin;
neurotransmitter;
P450 inhibitor;
probe;
signalling molecule;
vasodilator agent
3-methoxytyramine[no description available]low00monomethoxybenzene;
phenols;
phenylethylamine;
primary amino compound		biomarker;
human blood serum metabolite;
human urinary metabolite
arginine[no description available]low00arginine;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		biomarker;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical
heptanal[no description available]low00medium-chain fatty aldehyde;
n-alkanal;
saturated fatty aldehyde		biomarker
homoarginine[no description available]low00homoarginine;
L-lysine derivative;
non-proteinogenic L-alpha-amino acid		biomarker;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
human metabolite;
rat metabolite;
xenobiotic metabolite
malondialdehyde[no description available]low00dialdehydebiomarker
phenylglyoxylic acid[no description available]low002-oxo monocarboxylic acidbiomarker;
human xenobiotic metabolite
isodesmosine[no description available]low00lysine derivative;
pyridinium ion		biomarker
pristane[no description available]low00long-chain alkane;
norterpene		biomarker;
immunological adjuvant
4-heptanone[no description available]low00dialkyl ketonebiomarker;
human urinary metabolite;
human xenobiotic metabolite;
rat metabolite
rubidium chloride[no description available]low00inorganic chloride;
rubidium molecular entity		antidepressant;
biomarker
n-acetyltyrosine[no description available]low00N-acetyltyrosine;
N-acyl-L-tyrosine		biomarker;
EC 2.1.1.4 (acetylserotonin O-methyltransferase) inhibitor;
human urinary metabolite
1,3,5-trimethoxybenzene[no description available]low00methoxybenzenesbiomarker;
human xenobiotic metabolite
nicotine[no description available]low003-(1-methylpyrrolidin-2-yl)pyridineanxiolytic drug;
biomarker;
immunomodulator;
mitogen;
neurotoxin;
nicotinic acetylcholine receptor agonist;
peripheral nervous system drug;
phytogenic insecticide;
plant metabolite;
psychotropic drug;
teratogenic agent;
xenobiotic
5,6-dihydrouridine[no description available]low00uridinesbiomarker
delta(9)-tetrahydrocannabinolic acid[no description available]low00benzochromene;
diterpenoid;
hydroxy monocarboxylic acid;
phytocannabinoid;
polyketide		anti-inflammatory agent;
biomarker;
metabolite;
neuroprotective agent
4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol[no description available]low00nitrosamine;
pyridines;
secondary alcohol		biomarker;
carcinogenic agent;
human urinary metabolite
dityrosine[no description available]low00biphenyls;
non-proteinogenic alpha-amino acid;
tyrosine derivative		biomarker
3-chloro-L-tyrosine[no description available]low00chloroamino acid;
L-alpha-amino acid zwitterion;
L-tyrosine derivative;
monochlorobenzenes;
non-proteinogenic L-alpha-amino acid		biomarker;
human metabolite
pentosidine[no description available]low00imidazopyridine;
non-proteinogenic L-alpha-amino acid		biomarker;
cross-linking reagent
24-hydroxycholesterol[no description available]low0024-hydroxycholesterolbiomarker;
human blood serum metabolite;
mouse metabolite
3-octanone[no description available]low00dialkyl ketoneantifeedant;
biomarker;
fungal metabolite;
human urinary metabolite;
insect attractant;
plant metabolite;
toxin
isoferulic acid[no description available]low00ferulic acidsantioxidant;
biomarker;
metabolite
cotinine[no description available]low00N-alkylpyrrolidine;
pyridines;
pyrrolidin-2-ones;
pyrrolidine alkaloid		antidepressant;
biomarker;
human xenobiotic metabolite;
plant metabolite
s-phenyl-n-acetylcysteine[no description available]low00aryl sulfide;
S-substituted N-acetyl-L-cysteine		biomarker;
human urinary metabolite
1,6-anhydro-beta-glucopyranose[no description available]low00anhydrohexoseArabidopsis thaliana metabolite;
biomarker;
human metabolite
cryptoxanthins[no description available]low00carotenolantioxidant;
biomarker;
plant metabolite;
provitamin A
brassicasterol[no description available]low003beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
ergostanoid;
phytosterols		algal metabolite;
animal metabolite;
biomarker;
EC 1.3.1.72 (Delta(24)-sterol reductase) inhibitor;
human metabolite;
marine metabolite;
plant metabolite;
sterol biosynthesis inhibitor
8-epi-prostaglandin f2alpha[no description available]low00F2-isoprostanebiomarker;
bronchoconstrictor agent;
vasoconstrictor agent
ubiquinone 8[no description available]low00ubiquinonesbiomarker
muconic acid[no description available]low00muconic acidbiomarker;
human xenobiotic metabolite
dehydroergosterol[no description available]low003beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
ergostanoid;
phytosterols		biomarker;
metabolite
ophthalmic acid[no description available]low00L-glutamine derivativebiomarker;
human metabolite
ubiquinol[no description available]low00polyprenylhydroquinone;
ubiquinol		biomarker;
metabolite
3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine[no description available]low00aminopyridine;
aromatic ether;
dichlorobenzene;
organofluorine compound;
pyrazolylpiperidine;
racemate		antineoplastic agent;
biomarker;
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
crizotinib[no description available]low003-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amineantineoplastic agent;
biomarker;
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
apelin-13 peptide[no description available]low00oligopeptideantihypertensive agent;
autophagy inhibitor;
biomarker;
human metabolite;
neuroprotective agent
guanosine monophosphate[no description available]low00guanosine 5'-phosphate;
purine ribonucleoside 5'-monophosphate		biomarker;
Escherichia coli metabolite;
metabolite;
mouse metabolite
8-hydroxy-2'-deoxyguanosine[no description available]low00guanosinesbiomarker
8-nitroguanosine 3',5'-cyclic monophosphate[no description available]low003',5'-cyclic purine nucleotide;
C-nitro compound		biomarker;
Brassica napus metabolite;
human metabolite;
signalling molecule
apelin-12 peptide[no description available]low00oligopeptidebiomarker;
human blood serum metabolite;
human metabolite;
neuroprotective agent
alpha-ketoadipic acid[no description available]low00oxo dicarboxylic acidhuman urinary metabolite;
mouse metabolite
butyric acid[no description available]low00fatty acid 4:0;
straight-chain saturated fatty acid		human urinary metabolite;
Mycoplasma genitalium metabolite
n(1)-methylnicotinamide[no description available]low00pyridinium ionalgal metabolite;
anti-inflammatory agent;
human urinary metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
niacinamide[no description available]low00pyridine alkaloid;
pyridinecarboxamide;
vitamin B3		anti-inflammatory agent;
antioxidant;
cofactor;
EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor;
EC 3.5.1.98 (histone deacetylase) inhibitor;
Escherichia coli metabolite;
geroprotector;
human urinary metabolite;
metabolite;
mouse metabolite;
neuroprotective agent;
Saccharomyces cerevisiae metabolite;
Sir2 inhibitor
niacin[no description available]low00pyridine alkaloid;
pyridinemonocarboxylic acid;
vitamin B3		antidote;
antilipemic drug;
EC 3.5.1.19 (nicotinamidase) inhibitor;
Escherichia coli metabolite;
human urinary metabolite;
metabolite;
mouse metabolite;
plant metabolite;
vasodilator agent
vitamin k 3[no description available]low001,4-naphthoquinones;
vitamin K		angiogenesis inhibitor;
antineoplastic agent;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor;
human urinary metabolite;
nutraceutical
salicyl alcohol[no description available]low00aromatic primary alcohol;
hydroxybenzyl alcohol		human urinary metabolite
trigonelline[no description available]low00alkaloid;
iminium betaine		food component;
human urinary metabolite;
plant metabolite
androsterone[no description available]low0017-oxo steroid;
3alpha-hydroxy steroid;
androstanoid;
C19-steroid		androgen;
anticonvulsant;
human blood serum metabolite;
human metabolite;
human urinary metabolite;
mouse metabolite;
pheromone
n-hexanal[no description available]low00medium-chain fatty aldehyde;
n-alkanal;
saturated fatty aldehyde		human urinary metabolite
pyridoxic acid[no description available]low00hydroxymethylpyridine;
methylpyridines;
monohydroxypyridine;
vitamin B6		human urinary metabolite;
mouse metabolite
benzohydrol[no description available]low00benzyl alcohols;
secondary alcohol		bacterial xenobiotic metabolite;
human urinary metabolite;
human xenobiotic metabolite;
rat metabolite
(3,4-dimethoxyphenyl)acetic acid[no description available]low00dimethoxybenzene;
phenylacetic acids		human urinary metabolite;
human xenobiotic metabolite
4-cymene[no description available]low00monoterpene;
toluenes		human urinary metabolite;
plant metabolite;
volatile oil component
4-bromophenol[no description available]low00bromophenolhuman urinary metabolite;
human xenobiotic metabolite;
marine metabolite;
mouse metabolite;
persistent organic pollutant;
rat metabolite
3,4,5-trimethoxybenzoic acid[no description available]low00benzoic acids;
methoxybenzenes		human urinary metabolite;
human xenobiotic metabolite;
plant metabolite
2-naphthol[no description available]low00naphtholantinematodal drug;
genotoxin;
human urinary metabolite;
human xenobiotic metabolite;
mouse metabolite;
radical scavenger
2-methylfuran[no description available]low00furans;
volatile organic compound		flavouring agent;
fuel;
hepatotoxic agent;
human urinary metabolite;
plant metabolite
3-methoxybenzoic acid[no description available]low00methoxybenzoic acidflavouring agent;
human urinary metabolite
3-tyramine[no description available]low00primary amino compound;
tyramines		human urinary metabolite;
neurotransmitter
2,5-dimethylfuran[no description available]low00furansantifungal agent;
bacterial metabolite;
fuel;
fumigant;
human urinary metabolite;
Maillard reaction product;
plant metabolite
3-methyladipic acid[no description available]low00alpha,omega-dicarboxylic acid;
dicarboxylic fatty acid		human urinary metabolite
nitrohexane[no description available]low00primary nitroalkanehuman urinary metabolite
5-methoxyindoleacetic acid[no description available]low00aromatic ether;
indole-3-acetic acids		antibacterial agent;
Brassica napus metabolite;
carcinogenic agent;
human urinary metabolite;
marine xenobiotic metabolite;
rat metabolite
2-pentylfuran[no description available]low00furansAspergillus metabolite;
bacterial metabolite;
flavouring agent;
human urinary metabolite;
insect repellent;
plant growth stimulator;
volatile oil component
3,5,6-trichloro-2-pyridinol[no description available]low00chloropyridine;
hydroxypyridine;
pyridone		human urinary metabolite;
human xenobiotic metabolite;
marine xenobiotic metabolite
s-methylcysteine[no description available]low00S-alkyl-L-cysteine zwitterion;
S-alkyl-L-cysteine		human urinary metabolite;
plant metabolite
4-anisaldehyde[no description available]low00benzaldehydesbacterial metabolite;
human urinary metabolite;
insect repellent;
plant metabolite
4-vinylphenol[no description available]low00phenolshuman urinary metabolite;
human xenobiotic metabolite
1,2,4-triazole-3-carboxamide[no description available]low00aromatic amide;
monocarboxylic acid amide;
primary carboxamide;
triazoles		drug metabolite;
human urinary metabolite
estradiol 17-sulfate[no description available]low003-hydroxy steroid;
phenolic steroid;
steroid sulfate		human urinary metabolite
nicotinuric acid[no description available]low00N-acylglycinehuman urinary metabolite
1-methylhypoxanthine[no description available]low00methylhypoxanthinehuman urinary metabolite;
rat metabolite
2,3,4-trihydroxbenzophenone[no description available]low00benzenetriol;
hydroxybenzophenone		drug metabolite;
EC 1.14.18.1 (tyrosinase) inhibitor;
human urinary metabolite;
quorum sensing inhibitor;
rat metabolite
n-myristoylglycine[no description available]low00fatty amide;
N-acylglycine		human blood serum metabolite;
human urinary metabolite
6-hydroxynicotinic acid[no description available]low00monohydroxypyridineArabidopsis thaliana metabolite;
human urinary metabolite;
mouse metabolite
2-(methylamino)isobutyric acid[no description available]low00alanine derivative;
alpha-amino acid zwitterion;
non-proteinogenic alpha-amino acid;
secondary amino compound		human urinary metabolite
5-methoxysalicylic acid[no description available]low00methoxysalicylic acidbacterial metabolite;
human urinary metabolite
2,5-furandicarboxylic acid[no description available]medium00dicarboxylic acid;
furans		human urinary metabolite
1,3,7-trimethylurate[no description available]low00oxopurinehuman blood serum metabolite;
human urinary metabolite;
human xenobiotic metabolite;
mouse metabolite
5-hydroxymethyl-2-furoic acid[no description available]low00aromatic primary alcohol;
furoic acid		bacterial xenobiotic metabolite;
fungal metabolite;
human urinary metabolite;
nematicide
acetaminophen mercapturate[no description available]low00acetamides;
organic sulfide;
phenols;
S-substituted N-acetyl-L-cysteine		drug metabolite;
human urinary metabolite;
rat metabolite
n-butyrylglycine[no description available]low00N-acylglycinehuman urinary metabolite
n-acetyltyrosine, (dl)-isomer[no description available]low00N-acetyl-amino acid;
phenols;
tyrosine derivative		human urinary metabolite
salsolinol[no description available]low001-methyl-1,2,3,4-tetrahydroisoquinoline-6,7-diolhuman urinary metabolite
2,8-dihydroxyadenine[no description available]medium006-aminopurines;
diol;
heteroaryl hydroxy compound;
oxopurine		human urinary metabolite;
mammalian metabolite;
mouse metabolite;
nephrotoxic agent
1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid[no description available]low00alpha-amino acid;
aromatic amino acid;
beta-carboline alkaloid		human urinary metabolite;
human xenobiotic metabolite;
plant metabolite;
rat metabolite
n-acetyldopamine[no description available]low00acetamides;
catechols;
N-(fatty acyl)-dopamine;
secondary carboxamide		human urinary metabolite;
marine metabolite
3 alpha,17 alpha-dihydroxy-5 beta-pregnan-20-one[no description available]low0017alpha-hydroxy steroid;
20-oxo steroid;
3alpha-hydroxy steroid;
C21-steroid;
corticosteroid hormone		human urinary metabolite
3-(3-hydroxyphenyl)-3-hydroxypropanoic acid[no description available]low00dihydroxy monocarboxylic acid;
phenols		human urinary metabolite
arsenocholine[no description available]low00arsonium ion;
organoarsenic compound		human urinary metabolite;
marine metabolite;
xenobiotic
s-benzyl-n-acetyl-l-cysteine[no description available]low00organic sulfide;
S-substituted N-acetyl-L-cysteine		human urinary metabolite;
rat metabolite
1-hydroxymethylmidazolam[no description available]low00aromatic primary alcohol;
imidazobenzodiazepine;
monofluorobenzenes;
organochlorine compound		drug metabolite;
human blood serum metabolite;
human urinary metabolite
gamma-glutamylphenylalanine[no description available]low00dipeptidehuman urinary metabolite
mono(2-ethyl-5-oxohexyl)phthalate[no description available]low00methyl ketone;
phthalic acid monoester		human urinary metabolite;
human xenobiotic metabolite
testosterone-17-sulfate[no description available]low003-oxo-Delta(4) steroid;
androstanoid;
steroid sulfate		human urinary metabolite
dopamine 3-o-sulfate[no description available]low00aryl sulfate;
phenols;
primary amino compound;
zwitterion		human blood serum metabolite;
human urinary metabolite
estriol-16 alpha-glucuronide[no description available]low0017beta-hydroxy steroid;
3-hydroxy steroid;
beta-D-glucosiduronic acid;
phenols;
steroid glucosiduronic acid		human urinary metabolite
ursocholic acid[no description available]low0012alpha-hydroxy steroid;
3alpha-hydroxy steroid;
7beta-hydroxy steroid;
bile acid;
C24-steroid;
trihydroxy-5beta-cholanic acid		EC 1.1.1.159 (7alpha-hydroxysteroid dehydrogenase) inhibitor;
human urinary metabolite
dopamine 4-o-sulfate[no description available]low00aryl sulfate;
phenols;
primary amino compound;
zwitterion		human blood serum metabolite;
human urinary metabolite
3-hydroxymethylantipyrine[no description available]low00pyrazolonedrug metabolite;
human urinary metabolite
4-hydroxymidazolam[no description available]low00imidazobenzodiazepine;
monofluorobenzenes;
organic hydroxy compound;
organochlorine compound		drug metabolite;
human blood serum metabolite;
human urinary metabolite
bay-s 9435[no description available]low00cyclopropanes;
fluoroquinolone antibiotic;
N-arylpiperazine;
organosulfonic acid;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone		drug metabolite;
human urinary metabolite
1-hydroxymethylmidazolam glucuronide[no description available]low00beta-D-glucosiduronic acid;
imidazobenzodiazepine;
monofluorobenzenes;
monosaccharide derivative;
organochlorine compound		drug metabolite;
human blood serum metabolite;
human urinary metabolite
lanthionine ketimine[no description available]medium001,4-thiazine;
dicarboxylic acid;
sulfur-containing amino acid		anti-inflammatory agent;
human urinary metabolite;
neuroprotective agent
cystathionine ketimine[no description available]low001-thia-4-azacyclohepta-3-ene-3,5-dicarboxylic acid;
sulfur-containing amino acid		human urinary metabolite;
mammalian metabolite;
rat metabolite;
reactive oxygen species generator
tyramine o-sulfate[no description available]low00aryl sulfate;
primary amino compound;
zwitterion		human urinary metabolite;
human xenobiotic metabolite
acetyltaurine[no description available]low00acetamides;
organosulfonic acid		human blood serum metabolite;
human urinary metabolite
2-s-cysteinyldopa[no description available]low00amino dicarboxylic acid;
aryl sulfide;
catechols;
diamine;
L-tyrosine derivative;
S-conjugate;
S-organyl-L-cysteine		human urinary metabolite
bradykinin, hydroxy-pro(3)-[no description available]low00oligopeptide;
peptide hormone		bradykinin receptor agonist;
human urinary metabolite
mono(2-ethyl-5-hydroxyhexyl) phthalate[no description available]low00phthalic acid monoesterhuman urinary metabolite;
human xenobiotic metabolite
5-hydroxyhexanoic acid[no description available]low00(omega-1)-hydroxy fatty acid;
medium-chain fatty acid		human urinary metabolite
3-hydroxyglutaric acid[no description available]low003-hydroxy carboxylic acid;
alpha,omega-dicarboxylic acid		human blood serum metabolite;
human urinary metabolite
adrenosterone[no description available]low0011-oxo steroid;
17-oxo steroid;
3-oxo-Delta(4) steroid;
androstanoid		androgen;
EC 1.1.1.146 (11beta-hydroxysteroid dehydrogenase) inhibitor;
human urinary metabolite;
marine metabolite
s-adenosyl-3-methylthiopropylamine[no description available]low00adenosines;
sulfonium compound		Escherichia coli metabolite;
human urinary metabolite;
mouse metabolite;
rat metabolite
riboflavin[no description available]low00flavin;
vitamin B2		anti-inflammatory agent;
antioxidant;
cofactor;
Escherichia coli metabolite;
food colouring;
fundamental metabolite;
human urinary metabolite;
mouse metabolite;
photosensitizing agent;
plant metabolite
n-isovalerylglycine[no description available]low00N-acylglycinehuman urinary metabolite
3-(1H-imidazol-1-yl)propanoic acid[no description available]low00imidazolyl carboxylic acidhuman urinary metabolite
kaempferol[no description available]low007-hydroxyflavonol;
flavonols;
tetrahydroxyflavone		antibacterial agent;
geroprotector;
human blood serum metabolite;
human urinary metabolite;
human xenobiotic metabolite;
plant metabolite
20-carboxyleukotriene b4[no description available]low00alpha,omega-dicarboxylic acid;
hydroxy carboxylic acid;
leukotriene		human blood serum metabolite;
human urinary metabolite
genistein[no description available]low007-hydroxyisoflavonesantineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
human urinary metabolite;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor
n-acetylleukotriene e4[no description available]low00leukotrienehuman urinary metabolite
methyl 2,5-dihydroxycinnamate[no description available]low00cinnamate ester;
hydroquinones;
methyl ester		EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor;
geroprotector;
human urinary metabolite;
plant metabolite
cedrene[no description available]low00bridged compound;
carbotricyclic compound;
polycyclic olefin;
sesquiterpene		human urinary metabolite;
volatile oil component
5,12-dihydroxy-6,8,14-eicosatrienoic acid[no description available]low00dihydroxy monocarboxylic acid;
hydroxy polyunsaturated fatty acid;
leukotriene;
long-chain fatty acid		human urinary metabolite;
human xenobiotic metabolite
yunaconitine[no description available]low00acetate ester;
aromatic ether;
benzoate ester;
bridged compound;
diterpene alkaloid;
organic heteropolycyclic compound;
polyether;
secondary alcohol;
tertiary alcohol;
tertiary amino compound		antifeedant;
human urinary metabolite;
phytotoxin;
plant metabolite;
xenobiotic
4-hydroxyestrone[no description available]low0017-oxo steroid;
3-hydroxy steroid;
4-hydroxy steroid;
catechols;
phenolic steroid		carcinogenic agent;
estrogen;
human urinary metabolite
decanoylcarnitine[no description available]low00decanoate ester;
O-acylcarnitine		human urinary metabolite
n-isobutyrylglycine[no description available]low00N-acylglycinehuman urinary metabolite
prolyl-proline[no description available]low00dipeptidehuman urinary metabolite;
Mycoplasma genitalium metabolite
ethyl glucuronide[no description available]low00beta-D-glucosiduronic acidhuman urinary metabolite
dihydrotestosterone glucuronide[no description available]low003-oxo-5alpha-steroid;
steroid glucosiduronic acid		human urinary metabolite
tartronic acid[no description available]low00dicarboxylic acid;
dicarboxylic fatty acid		plant metabolite
alpha-isopropylmalate[no description available]low002-hydroxy carboxylic acid;
3-hydroxy carboxylic acid;
dicarboxylic acid		metabolite
itaconic acid[no description available]low00dicarboxylic acid;
dicarboxylic fatty acid;
olefinic compound		fungal metabolite;
human metabolite
2-succinylbenzoate[no description available]low00dicarboxylic acid
porphobilinogen[no description available]low00aralkylamino compound;
dicarboxylic acid;
pyrroles		Escherichia coli metabolite;
metabolite;
mouse metabolite
meglutol[no description available]low003-hydroxy carboxylic acid;
dicarboxylic acid;
tertiary alcohol		anticholesteremic drug;
antimetabolite;
EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor;
human metabolite;
plant metabolite
cromolyn[no description available]low00chromones;
dicarboxylic acid		anti-asthmatic drug;
calcium channel blocker
benzylsuccinic acid[no description available]low00dicarboxylic acidbacterial xenobiotic metabolite
diethyl malonate[no description available]low00dicarboxylic acid
lauroyl peroxide[no description available]low00dicarboxylic acid
diglycolic acid[no description available]low00dicarboxylic acid
thiodipropionic acid[no description available]low00dicarboxylic acid
chlorendic acid[no description available]low00bridged compound;
dicarboxylic acid;
organochlorine compound		carcinogenic agent
pamoic acid[no description available]low00dicarboxylic acid
diphenic acid[no description available]low00dicarboxylic acid
kainic acid[no description available]low00dicarboxylic acid;
L-proline derivative;
non-proteinogenic L-alpha-amino acid;
pyrrolidinecarboxylic acid		antinematodal drug;
excitatory amino acid agonist
monomethyl succinate[no description available]low00dicarboxylic acid
2,2-dimethylmalonate[no description available]low00dicarboxylic acidfatty acid synthesis inhibitor
ethylmalonic acid[no description available]low00dicarboxylic acid;
dicarboxylic fatty acid		human metabolite
2,6-naphthalenedicarboxylic acid[no description available]low00dicarboxylic acid
calcium propionate[no description available]low00dicarboxylic acid
olsalazine[no description available]low00azobenzenes;
dicarboxylic acid		non-steroidal anti-inflammatory drug;
prodrug
thiodiacetic acid[no description available]low00dicarboxylic acid
nedocromil[no description available]low00dicarboxylic acid;
organic heterotricyclic compound		anti-allergic agent;
anti-asthmatic drug;
non-steroidal anti-inflammatory drug
perindoprilat[no description available]low00dicarboxylic acid;
dipeptide;
L-alanine derivative;
organic heterobicyclic compound		antihypertensive agent;
drug metabolite;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor
beta-aminoglutaric acid[no description available]low00dicarboxylic acidalgal metabolite;
marine metabolite
bromosuccinic acid[no description available]low002-bromocarboxylic acid;
dicarboxylic acid
gamma-glutamyltyrosine[no description available]low00dicarboxylic acid;
dipeptide;
phenols;
primary amino compound;
secondary carboxamide		human metabolite
alpha-methylene glutarate[no description available]low00dicarboxylic acid;
dicarboxylic fatty acid
dihydrokainate[no description available]low00dicarboxylic acid
quinaprilat[no description available]low00dicarboxylic acid;
isoquinolines;
tertiary carboxamide		antihypertensive agent;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor;
vasodilator agent
n-(2-acetamido)iminodiacetic acid[no description available]low00ADA;
dicarboxylic acid;
tricarboxylic acid amide
3-carboxy-4-methyl-5-propyl-2-furanpropionic acid[no description available]low00dicarboxylic acid;
furoic acid		human metabolite;
uremic toxin
methotrexate[no description available]low00dicarboxylic acid;
monocarboxylic acid amide;
pteridines		abortifacient;
antimetabolite;
antineoplastic agent;
antirheumatic drug;
dermatologic drug;
DNA synthesis inhibitor;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor;
immunosuppressive agent
aminopterin[no description available]low00dicarboxylic acidEC 1.5.1.3 (dihydrofolate reductase) inhibitor;
mutagen
4-aminobenzoylglutamic acid[no description available]low00dicarboxylic acid;
dipeptide;
N-acyl-L-alpha-amino acid;
substituted aniline
2,2'-(3-methylcyclohexane-1,1-diyl)diacetic acid[no description available]low00dicarboxylic acid
formiminoglutamic acid[no description available]low00dicarboxylic acid;
L-glutamic acid derivative
gibberellin a12[no description available]low00C20-gibberellin;
dicarboxylic acid
citraconic acid[no description available]low00dicarboxylic acid;
dicarboxylic fatty acid		human metabolite
3-methylglutaconic acid[no description available]low00dicarboxylic acid
succimer[no description available]low00dicarboxylic acid;
dithiol;
sulfur-containing carboxylic acid		chelator
Diethyl 2-(2-furyl)-4-hydroxy-4-methyl-6-oxo-1,3-cyclohexanedicarboxylate[no description available]low00dicarboxylic acid
spiraprilat[no description available]low00azaspiro compound;
dicarboxylic acid;
dipeptide;
dithioketal;
pyrrolidinecarboxylic acid;
secondary amino compound;
tertiary carboxamide		antihypertensive agent;
drug metabolite;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor
2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylic acid[no description available]low00dicarboxylic acid
bilirubin[no description available]low00biladienes;
dicarboxylic acid		antioxidant;
human metabolite;
mouse metabolite
eprosartan[no description available]low00dicarboxylic acid;
imidazoles;
thiophenes		angiotensin receptor antagonist;
antihypertensive agent;
environmental contaminant;
xenobiotic
betalamic acid[no description available]low00betalain;
dicarboxylic acid
7432 s[no description available]low00cephalosporin;
dicarboxylic acid		antibacterial drug
traumatic acid[no description available]low00dicarboxylic acidplant hormone
bay u9773[no description available]low00benzoic acids;
dicarboxylic acid;
organic sulfide;
polyunsaturated fatty acid;
secondary alcohol		leukotriene antagonist
enalaprilat anhydrous[no description available]low00dicarboxylic acid;
dipeptide		antihypertensive agent;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor
benazeprilat[no description available]low00benzazepine;
dicarboxylic acid;
lactam		EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor
ramiprilat[no description available]low00azabicycloalkane;
cyclopentapyrrole;
dicarboxylic acid;
dipeptide		bradykinin receptor B2 agonist;
cardioprotective agent;
drug metabolite;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor;
matrix metalloproteinase inhibitor
trandolaprilat[no description available]low00dicarboxylic acid;
dipeptide;
organic heterobicyclic compound;
secondary amino compound;
tertiary carboxamide		antihypertensive agent;
drug metabolite;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor;
human xenobiotic metabolite
imidaprilat[no description available]low00dicarboxylic acid;
dipeptide;
imidazolidines;
N-acylurea;
secondary amino compound		antihypertensive agent;
drug metabolite;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor
poricoic acid a[no description available]low00dicarboxylic acid;
secondary alcohol;
tricyclic triterpenoid		fungal metabolite
poricoic acid g[no description available]low00dicarboxylic acid;
secondary alcohol;
tricyclic triterpenoid		fungal metabolite
(6R,7R)-7-[[(2R)-2-carboxy-2-(4-hydroxyphenyl)-1-oxoethyl]amino]-7-methoxy-3-[[(1-methyl-5-tetrazolyl)thio]methyl]-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid[no description available]low00dicarboxylic acid;
secondary carboxamide
ferrous fumarate[no description available]low00dicarboxylic acid
salvianolic acid B[no description available]low001-benzofurans;
catechols;
dicarboxylic acid;
enoate ester;
polyphenol		anti-inflammatory agent;
antidepressant;
antineoplastic agent;
antioxidant;
apoptosis inducer;
autophagy inhibitor;
cardioprotective agent;
hepatoprotective agent;
hypoglycemic agent;
neuroprotective agent;
osteogenesis regulator;
plant metabolite
1,4-thiomorpholine-3,5-dicarboxylic acid[no description available]low00dicarboxylic acid;
sulfur-containing carboxylic acid;
thiomorpholines
bay 58-2667[no description available]low00aromatic ether;
benzoic acids;
dicarboxylic acid;
tertiary amino compound		antihypertensive agent;
soluble guanylate cyclase activator;
vasodilator agent
ly 404039[no description available]low00bridged compound;
dicarboxylic acid;
non-proteinogenic amino acid derivative;
organic heterobicyclic compound;
sulfone		antipsychotic agent;
anxiolytic drug;
dopamine agonist;
metabotropic glutamate receptor agonist
carboxyibuprofen[no description available]low00dicarboxylic aciddrug metabolite
nigranoic acid[no description available]low00dicarboxylic acid;
tetracyclic triterpenoid		antineoplastic agent;
HIV-1 reverse transcriptase inhibitor;
metabolite
fertaric acid[no description available]low00aromatic ether;
cinnamate ester;
dicarboxylic acid;
phenols;
tetraric acid derivative
cysteic acid[no description available]low00alanine derivative;
amino sulfonic acid;
carboxyalkanesulfonic acid;
cysteine derivative;
non-proteinogenic alpha-amino acid		animal metabolite
s-propylcysteine[no description available]low00cysteine derivative;
organic sulfide
cystathionine[no description available]low00cysteine derivative
cyclohexene[no description available]low00cycloalkene
limonene[no description available]low00cycloalkene;
p-menthadiene		human metabolite
cyclopropene[no description available]low00cycloalkene;
cyclopropenes
1-methylcyclopropene[no description available]low00cycloalkene;
cyclopropenes		agrochemical;
plant growth regulator
2,2'-thiodiethanol[no description available]low00aliphatic sulfide;
diol		antineoplastic agent;
antioxidant;
metabolite;
solvent
chloramphenicol[no description available]low00C-nitro compound;
carboxamide;
diol;
organochlorine compound		antibacterial drug;
antimicrobial agent;
Escherichia coli metabolite;
geroprotector;
Mycoplasma genitalium metabolite;
protein synthesis inhibitor
triethylene glycol[no description available]low00diol;
poly(ethylene glycol);
primary alcohol		plasticiser
1-butyrylglycerol[no description available]low001-monoglyceride;
butyrate ester;
diol;
fatty acid ester
hexamethylene glycol[no description available]low00diol;
primary alcohol
1,2-cyclohexanediol[no description available]low00diol
ancitabine[no description available]low00diol;
organic heterotricyclic compound		antimetabolite;
antineoplastic agent;
prodrug
pyoluteorin[no description available]low00aromatic ketone;
beta-hydroxy ketone;
diol;
organochlorine compound;
organochlorine pesticide;
polyketide;
pyrroles;
resorcinols		antibacterial agent;
antifungal agent;
apoptosis inducer;
bacterial metabolite;
marine metabolite
diisopropanolnitrosamine[no description available]low00diol;
nitrosamine;
secondary alcohol		carcinogenic agent
16-hydroxytestosterone[no description available]low0016alpha-hydroxy steroid;
17beta-hydroxy steroid;
3-oxo-Delta(4) steroid;
androstanoid;
C19-steroid;
diol;
secondary alcohol		androgen
nebivolol[no description available]low00chromanes;
diol;
organofluorine compound;
secondary alcohol;
secondary amino compound
oxetanocin a[no description available]low00diol;
nucleoside analogue;
oxetanes;
primary alcohol		anti-HIV agent;
antibacterial agent;
bacterial metabolite
nucleocidin[no description available]low006-aminopurines;
adenosines;
diol;
organofluorine compound;
sulfamate ester		antibacterial agent;
bacterial metabolite;
nucleoside antibiotic;
protein synthesis inhibitor;
trypanocidal drug
betulin[no description available]low00diol;
pentacyclic triterpenoid		analgesic;
anti-inflammatory agent;
antineoplastic agent;
antiviral agent;
metabolite
2,5-bis(hydroxymethyl)furan[no description available]low00diol;
furans
erythrodiol[no description available]low00diol;
pentacyclic triterpenoid;
primary alcohol;
secondary alcohol		plant metabolite
fumitremorgin a[no description available]low00aromatic ether;
diol;
indole alkaloid;
organic heterohexacyclic compound;
organic peroxide		mycotoxin
veratrylglycerol-beta-guaiacyl ether[no description available]low00dimethoxybenzene;
diol
xv 638[no description available]low001,3-thiazoles;
benzamides;
diazepanone;
diol;
secondary alcohol;
secondary carboxamide;
ureas		HIV protease inhibitor
picrotin[no description available]low00diol;
epoxide;
gamma-lactone;
organic heteropentacyclic compound;
picrotoxane sesquiterpenoid;
tertiary alcohol		plant metabolite
colforsin daropate[no description available]low00acetate ester;
carboxylic ester;
cyclic ketone;
diol;
organic heterotricyclic compound;
tertiary amino compound		adenylate cyclase agonist;
antihypertensive agent;
cardiotonic drug;
vasodilator agent
16beta,17-dihydroxy-ent-kaurane-19-oic acid[no description available]low00bridged compound;
diol;
ent-kaurane diterpenoid;
hydroxy monocarboxylic acid;
primary alcohol;
tertiary alcohol		anti-HIV agent;
metabolite
fumonisin b2[no description available]low00diester;
diol;
fumonisin;
primary amino compound		Aspergillus metabolite;
carcinogenic agent
14,15-dihydroxyeicosatrienoic acid[no description available]low00DHET;
diol;
secondary allylic alcohol		mouse metabolite
8-isoprostaglandin e2[no description available]low00cyclic ketone;
diol;
prostanoid;
secondary alcohol		bronchoconstrictor agent;
human metabolite;
rat metabolite;
vasoconstrictor agent
calcifediol[no description available]low00D3 vitamins;
diol;
hydroxycalciol		bone density conservation agent;
human metabolite;
metabolite;
mouse metabolite;
nutraceutical
fortimicin a[no description available]low00amino cyclitol glycoside;
aminoglycoside antibiotic;
diol;
monocarboxylic acid amide;
primary amino compound		antibacterial agent;
metabolite
8-hydroxygeraniol[no description available]low00diol;
monoterpenoid;
prenols
pederin[no description available]low00cyclic ketal;
diol;
oxanes;
polyketide;
secondary alcohol;
secondary carboxamide		antimitotic;
antineoplastic agent;
bacterial metabolite;
vesicant
ro 42-5892[no description available]low00cyclopropanes;
diol;
L-histidine derivative;
secondary carboxamide;
sulfone		antihypertensive agent;
EC 3.4.23.15 (renin) inhibitor;
peptidomimetic;
vasodilator agent
riddelliine n-oxide[no description available]low00diol;
macrocyclic lactone;
olefinic compound;
organic heterotricyclic compound;
primary alcohol;
pyrrolizine alkaloid;
tertiary alcohol;
tertiary amine oxide		carcinogenic agent;
genotoxin;
human xenobiotic metabolite;
Jacobaea metabolite;
mutagen;
rat metabolite
3-hydroxyretinol[no description available]low00diol;
retinoid
hypothemycin[no description available]low00aromatic ether;
diol;
enone;
epoxide;
macrolide;
phenols;
polyketide;
secondary alpha-hydroxy ketone		antifungal agent;
antineoplastic agent;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor;
fungal metabolite
protylonolide[no description available]low00diol;
enone;
macrolide		metabolite
8,5'-cyclo-2'-deoxyadenosine[no description available]low00aromatic amine;
bridged compound;
diol;
N-glycosyl compound;
organic heterotetracyclic compound		Mycoplasma genitalium metabolite
alpha-onocerin[no description available]low00diol;
olefinic compound;
secondary alcohol;
triterpenoid		plant metabolite
neodysiherbaine a[no description available]low00amino dicarboxylic acid;
diol;
furopyran;
hydroxy carboxylic acid		animal metabolite;
excitatory amino acid agonist;
marine metabolite
cortistatin a[no description available]low00cortistatins;
diol;
secondary alcohol
verruculogen[no description available]low00aromatic ether;
diol;
indole alkaloid;
organic heterohexacyclic compound;
organic peroxide		Aspergillus metabolite;
GABA modulator;
mycotoxin;
Penicillium metabolite;
potassium channel blocker
resolvin e2[no description available]low00diol;
hydroxy polyunsaturated fatty acid;
resolvin;
secondary allylic alcohol		anti-inflammatory agent;
human xenobiotic metabolite;
rat metabolite
pamapimod[no description available]low00aromatic amine;
aromatic ether;
difluorobenzene;
diol;
primary alcohol;
pyridopyrimidine;
secondary amino compound		antirheumatic drug;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor
triptotriterpenic acid a[no description available]low00diol;
hydroxy monocarboxylic acid;
pentacyclic triterpenoid		plant metabolite
deoxyaconitine[no description available]low00acetate ester;
benzoate ester;
bridged compound;
diol;
diterpene alkaloid;
organic heteropolycyclic compound;
polyether;
secondary alcohol;
tertiary amino compound		plant metabolite
borrelidin[no description available]low00aliphatic nitrile;
diol;
macrolide;
monocarboxylic acid;
secondary alcohol		antifungal agent;
antimalarial;
antimicrobial agent;
antineoplastic agent;
apoptosis inducer;
bacterial metabolite
asperfuranone[no description available]low002-benzofurans;
cyclic ketone;
diol;
polyketide;
secondary alcohol;
tertiary alcohol;
tertiary alpha-hydroxy ketone		antineoplastic agent;
fungal metabolite
capilliposide b[no description available]low00alpha-L-arabinopyranoside;
bridged compound;
cyclic ether;
diol;
hexacyclic triterpenoid;
hexanoate ester;
lactol;
secondary alcohol;
tetrasaccharide derivative;
triterpenoid saponin		antineoplastic agent;
plant metabolite
lancifodilactone g[no description available]low00cyclic ether;
diol;
enol;
gamma-lactone;
oxaspiro compound;
triterpenoid		anti-HIV agent;
metabolite
8,5'-cyclo-2'-deoxyguanosine[no description available]low00aromatic amine;
bridged compound;
diol;
N-glycosyl compound;
organic heterotetracyclic compound		Mycoplasma genitalium metabolite
steviol[no description available]low00bridged compound;
ent-kaurane diterpenoid;
monocarboxylic acid;
tertiary allylic alcohol;
tetracyclic diterpenoid		antineoplastic agent
16,16-dimethylprostaglandin e2[no description available]low00cyclopentanones;
monocarboxylic acid;
prostanoid;
secondary allylic alcohol		anti-ulcer drug;
gastrointestinal drug;
radiation protective agent
4-hydroxyretinal[no description available]low00enal;
retinoid;
secondary allylic alcohol		marine metabolite
piericidin a[no description available]low00aromatic ether;
methylpyridines;
monohydroxypyridine;
secondary allylic alcohol		antimicrobial agent;
bacterial metabolite;
EC 1.6.5.3 [NADH:ubiquinone reductase (H(+)-translocating)] inhibitor;
mitochondrial respiratory-chain inhibitor
11-hydroxy-9,12-octadecadienoic acid[no description available]low00HODE;
secondary allylic alcohol
4-hydroxyretinoic acid[no description available]low00retinoid;
secondary allylic alcohol		human metabolite
5-oxo-15-hydroxy-6,8,11,13-eicosatetraenoic acid[no description available]low00enone;
hydroxy polyunsaturated fatty acid;
icosanoid;
long-chain fatty acid;
oxo fatty acid;
secondary allylic alcohol		human xenobiotic metabolite
17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid[no description available]low00hydroxydocosahexaenoic acid;
secondary allylic alcohol		human xenobiotic metabolite
fostriecin[no description available]low002-pyranones;
olefinic compound;
phosphate monoester;
polyketide;
primary allylic alcohol;
secondary allylic alcohol;
triol		antineoplastic agent;
apoptosis inhibitor;
bacterial metabolite;
EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor;
topoisomerase II inhibitor
beraprost[no description available]low00enyne;
monocarboxylic acid;
organic heterotricyclic compound;
secondary alcohol;
secondary allylic alcohol		anti-inflammatory agent;
antihypertensive agent;
platelet aggregation inhibitor;
prostaglandin receptor agonist;
vasodilator agent
laulimalide[no description available]low00carboxylic ester;
epoxide;
macrolide;
secondary alcohol;
secondary allylic alcohol		animal metabolite;
antimitotic;
antineoplastic agent;
marine metabolite;
microtubule-stabilising agent
resolvin d2[no description available]low00hydroxy polyunsaturated fatty acid;
resolvin;
secondary allylic alcohol;
triol		anti-inflammatory agent;
anti-obesity agent;
estrogen receptor agonist;
human xenobiotic metabolite;
rat metabolite
protectin d1[no description available]low00dihydroxydocosahexaenoic acid;
protectin;
secondary allylic alcohol		anti-inflammatory agent;
apoptosis inhibitor;
hepatoprotective agent;
human xenobiotic metabolite;
neuroprotective agent;
PPARgamma agonist;
specialised pro-resolving mediator
resolvin D4[no description available]low00hydroxy polyunsaturated fatty acid;
resolvin;
secondary allylic alcohol;
triol		anti-inflammatory agent;
human xenobiotic metabolite
resolvin d3[no description available]low00hydroxy polyunsaturated fatty acid;
resolvin;
secondary allylic alcohol;
triol		anti-inflammatory agent;
human xenobiotic metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
4 Hydroxyphenylpyruvate Dioxygenase Deficiency Disease0low20
4-Hydroxyphenol Pyruvic Acid Oxidase Deficiency Disease0low20
4-Hydroxyphenylpyruvate Dioxygenase Deficiency0low20
4-Hydroxyphenylpyruvic Acid Oxidase Deficiency0low20
Acidosis0low20
Acidosis, Renal Tubular0low10
Acidosis, Renal Tubular, Type I0low10
Acidosis, Renal Tubular, Type II0low10
ALDOB Deficiency0low10
Aldolase B Deficiency0low10
Amino Acid Metabolism Disorders, Inborn0low70
Amino Acid Metabolism, Inborn Error0low70
Amino Acid Metabolism, Inborn Errors0low70
Amino Acid Metabolism, Inherited Disorders0low70
Amino Acidopathies, Congenital0low70
Amino Acidopathies, Inborn0low70
Autosomal Dominant Distal Renal Tubular Acidosis0low10
Classic Distal Renal Tubular Acidosis0low10
Congenital Amino Acidopathies0low70
Deficiency Disease, 4-Hydroxyphenol Pyruvic Acid Oxidase0low20
Deficiency Disease, Fumarylacetoacetase0low20
Deficiency Disease, Tyrosine Transaminase0low20
Distal Renal Tubular Acidosis0low10
Failure to Thrive0low10
Fructose Aldolase B Deficiency0low10
Fructose Intolerance0low10
Fructose Intolerance, Hereditary0low10
Fructose-1-Phosphate Aldolase Deficiency0low10
Fructose-1,6-Biphosphate Aldolase Deficiency0low10
Fructose-1,6-Bisphosphate Aldolase B Deficiency0low10
Fructosemia0low10
Fumarylacetoacetase Deficiency0low20
Fumarylacetoacetase Deficiency Disease0low20
Growth Disorders0low10
Hepatorenal Tyrosinemia0low20
Hereditary Fructose Intolerance0low10
Hereditary Tyrosinemia, Type I0low20
Hereditary Tyrosinemia, Type II0low20
Hereditary Tyrosinemia, Type III0low20
Hereditary Tyrosinemias0low20
Hypertyrosinemia0low20
Hypertyrosinemia, Type I0low20
Inborn Errors, Amino Acid Metabolism0low70
Inherited Errors of Amino Acid Metabolism0low70
Keratosis Palmoplantaris with Corneal Dystrophy0low20
Liver Diseases0low10
Liver Dysfunction0low10
Metabolic Acidosis0low20
Oregon Type Tyrosinemia0low20
Proximal Renal Tubular Acidosis0low10
Renal Tubular Acidosis0low10
Renal Tubular Acidosis 10low10
Renal Tubular Acidosis I0low10
Renal Tubular Acidosis II0low10
Renal Tubular Acidosis, Distal, Autosomal Dominant0low10
Renal Tubular Acidosis, Proximal0low10
Renal Tubular Acidosis, Proximal, with Ocular Abnormalities0low10
Renal Tubular Acidosis, Type I0low10
Renal Tubular Acidosis, Type II0low10
Richner-Hanhart Syndrome0low20
Richner-Hanhart Syndrome, Tyrosinosis, Oculocutaneous Type0low20
RTA, Classic Type0low10
RTA, Distal Type, Autosomal Dominant0low10
RTA, Gradient Type0low10
RTA, Proximal Type0low10
Stunted Growth0low10
Stunting0low10
Tat Deficiency0low20
Type I Renal Tubular Acidosis0low10
Type II Renal Tubular Acidosis0low10
Tyrosine Aminotransferase Deficiency0low20
Tyrosine Transaminase Deficiency0low20
Tyrosine Transaminase Deficiency Disease0low20
Tyrosinemia0low20
Tyrosinemia Type 10low20
Tyrosinemia, Type 20low20
Tyrosinemia, Type I0low20
Tyrosinemia, Type II0low20
Tyrosinemia, Type III0low20
Tyrosinemias0low20
Tyrosinemias, Hereditary0low20
Tyrosinosis, Oculocutaneous Type0low20