drummondin C: structure given in first source; isolated from the weed nits-and-lice (Hypericum drummondii); shows activity against some Gram-positive and Gram-negative bacteria [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 164100 |
| CHEMBL ID | 484443 |
| MeSH ID | M0198661 |
| Synonym |
|---|
| 119171-78-7 |
| drummondin c |
| CHEMBL484443 |
| 2-acetyl-4-[(8-acetyl-5,7-dihydroxy-2,2-dimethylchromen-6-yl)methyl]-3,5-dihydroxy-6,6-dimethylcyclohexa-2,4-dien-1-one |
| 2,5-cyclohexadien-1-one, 2-acetyl-6-((8-acetyl-5,7-dihydroxy-2,2-dimethyl-2h-1-benzopyran-6-yl)methyl)-3,5-dihydroxy-4,4-dimethyl- |
| DTXSID10922880 |
| 2-acetyl-4-[(8-acetyl-5,7-dihydroxy-2,2-dimethyl-2h-1-benzopyran-6-yl)methyl]-3,5-dihydroxy-6,6-dimethylcyclohexa-2,4-dien-1-one |
Drummondin C (1) is an antibiotic isolated from a bioassay-directed fractionation of Hypericum drummondii.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Drummondin C (1) is an antibiotic isolated from a bioassay-directed fractionation of Hypericum drummondii (Grev. " | ( Synthesis and the biological evaluation of the structural units of drummondin C. Baker, JK; Clark, AM; Jayasuriya, H; McChesney, JD, 1991) | 1.96 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID355492 | Antimicrobial activity against Staphylococcus aureus ATCC 6538 after 24 hrs by twofold serial dilution method | |||
| AID355501 | Antimicrobial activity against Pseudomonas aeruginosa after 48 hrs by twofold serial dilution method | |||
| AID355500 | Cytotoxicity against human melanoma cells after 72 hrs | |||
| AID355497 | Cytotoxicity against human breast cancer cells after 72 hrs | |||
| AID1525156 | Antibacterial activity against Staphylococcus aureus measured after 24 hrs | 2019 | Journal of natural products, 05-24, Volume: 82, Issue:5 | The Mosaic of Rottlerin: The Sequel. |
| AID355499 | Cytotoxicity against human lung cancer cells after 72 hrs | |||
| AID355493 | Antimicrobial activity against Bacillus subtilis ATCC 6633 after 24 hrs by twofold serial dilution method | |||
| AID355498 | Cytotoxicity against human colon cancer cells after 72 hrs | |||
| AID355496 | Cytotoxicity against human KB cells after 72 hrs | |||
| AID355494 | Antimicrobial activity against Mycobacterium smegmatis ATCC 607 after 48 hrs by twofold serial dilution method | |||
| AID355495 | Cytotoxicity against mouse P388 cells after 48 hrs | |||
| AID355502 | Antimicrobial activity against Escherichia coli after 48 hrs by twofold serial dilution method | |||
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.53) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||