gamithromycin and Foot-Rot
gamithromycin has been researched along with Foot-Rot* in 3 studies
Reviews
1 review(s) available for gamithromycin and Foot-Rot
Article | Year |
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Network meta-analysis of the therapeutic effects of various antibiotics on footrot in sheep and cattle.
The present network meta-analysis was performed to compare the effects of antibiotics used in treating footrot in some ruminants and to rank these antibiotics based on their efficacy. Data of 14 eligible studies consisting of 5622 affected animals was included in the analysis. A Bayesian method and Markov Chain Monte Carlo (MCMC) simulations were utilized to analyze data. The estimated results were reported in the form of odds ratios (ORs) with 95% credible intervals (CrI). The Surface Under the Cumulative Ranking Curve (SUCRA) was used to rank antibiotics. Network meta-regressions (NMRs) were conducted to examine the influence of sample sizes, treatment duration, route of administration, and species of animals (sheep and cattle) on the overall outcome. The results indicated that gamithromycin impact on curing footrot was superior to other antibiotics and Lincomycin and oxytetracycline were ranked second and third. The difference between the impact of gamithromycin and amoxicillin (OR = 14.76, CrI: 1.07-193.49) and enrofloxacin (OR = 20.21, CrI: 1.57-229.25) on footrot was significant. There was a significant difference between the effect of oxytetracycline and enrofloxacin (OR = 5.24, CrI: 1.14-23.74) on footrot. The NMR performed based on species of animals fitted data better than network meta-analysis, suggesting erythromycin as the best third antibiotic instead of oxytetracycline. Egger's regression test and the shape of the funnel plot showed no publication bias among included studies. In conclusion, gamithromycin was associated with the highest curing rate benefit when used to treat footrot, followed by lincomycin and oxytetracycline/erythromycin. Among all evaluated antibiotics, enrofloxacin showed the lowest effects on footrot. Topics: Animals; Anti-Bacterial Agents; Bayes Theorem; Cattle; Cattle Diseases; Enrofloxacin; Erythromycin; Foot Rot; Lincomycin; Network Meta-Analysis; Oxytetracycline; Sheep; Sheep Diseases | 2023 |
Trials
1 trial(s) available for gamithromycin and Foot-Rot
Article | Year |
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Targeted antibiotic treatment of lame sheep with footrot using either oxytetracycline or gamithromycin.
A study on parenteral antibiotic treatment in sheep footrot was conducted on 10 farms in southern Germany to obtain information on the efficacy of gamithromycin under practical use conditions compared with a positive control. On each farm, 20 (10 on one farm) lame sheep were clinically evaluated and divided into two groups. On day 1, sheep were treated once according to group with either long-acting oxytetracycline (OTC) at 20 mg/kg bodyweight or gamithromycin at 6 mg/kg; clinical responses were assessed 21 days later. When compared with day 1, both treatments reduced clinical lameness, as reflected in the reduction in the number of footrot-affected feet (OTC: 79.3 per cent; gamithromycin: 93.7 per cent) and in the severity of the lesions. The difference between the two treatments was significant (P<0.01) with an OR of 6.1 in favour of gamithromycin. Of the 33 sheep that were still lame on day 21, nine mildly affected animals were not re-treated and the remaining 24 sheep were re-treated with gamithromycin. On day 42, all but two (on the same farm) of the 33 sheep were cured, giving an overall response rate in this study to one or two parenteral antibiotic treatments of 99 per cent. Topics: Animals; Anti-Bacterial Agents; Foot Rot; Lameness, Animal; Macrolides; Oxytetracycline; Sheep; Sheep Diseases; Treatment Outcome | 2014 |
Other Studies
1 other study(ies) available for gamithromycin and Foot-Rot
Article | Year |
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Field studies on the elimination of footrot in sheep through whole flock treatments with gamithromycin.
Topics: Animals; Anti-Bacterial Agents; Denmark; Disease Eradication; Foot Rot; Germany; Macrolides; Sheep; Sheep Diseases | 2014 |