Compounds > hexyl salicylate
Page last updated: 2024-12-06

hexyl salicylate

Description

Hexyl salicylate is an organic compound with the formula C13H18O3. It is a colorless liquid with a floral, fruity odor. It is used as a fragrance ingredient in perfumes, cosmetics, and soaps. It is also used as a plasticizer in plastics. Hexyl salicylate is synthesized by reacting hexyl alcohol with salicylic acid. The reaction is typically carried out in the presence of a catalyst, such as sulfuric acid. Hexyl salicylate has been shown to have some pharmacological activity, including anti-inflammatory and analgesic effects. However, it is not used clinically for these purposes. Hexyl salicylate is a relatively safe compound. It is not known to be carcinogenic, mutagenic, or teratogenic. However, it can cause skin irritation in some individuals. Hexyl salicylate is an important ingredient in many consumer products, and it is therefore studied extensively to ensure its safety and efficacy.'

hexyl salicylate: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID22629
CHEMBL ID495972
CHEBI ID88836
SCHEMBL ID113059
MeSH IDM0518360

Synonyms (44)

Synonym
BIDD:ER0589
benzoic acid, 2-hydroxy-, hexyl ester
n-hexyl salicylate
hexyl salicylate
hexyl 2-hydroxybenzoate
einecs 228-408-6
ai3-07842
1-hexyl salicylate
hexyl salicylate, >98%
6259-76-3
hexyl salicylate, >=99.0% (gc)
chebi:88836 ,
CHEMBL495972
A833874
dtxcid601473521
cas-6259-76-3
tox21_301381
dtxsid4038924 ,
NCGC00255567-01
ec 228-408-6
8f78ey72yl ,
salicylic acid, hexyl ester
unii-8f78ey72yl
FT-0627056
hexyl salicylate [inci]
salicyl acid, n-hexyl ester
AKOS015902848
SCHEMBL113059
n-hexyl 2-hydroxybenzoate
hexylsalicylate
DUKPKQFHJQGTGU-UHFFFAOYSA-N
benzoic acid, hydroxy-, hexyl ester
F0001-1680
hexyl salicylate, analytical reference material
hexyl salicylic acid
hexyl 2-hydroxybenzoic acid
Q27160824
hexylsalicylat
F20692
mfcd00036487
BS-17349
salicylic acid-hexyl ester
salicylic acid, hexyl ester (6ci,7ci,8ci); 1-hexyl salicylate; hexyl 2-hydroxybenzoate; hexyl salicylate; n-hexyl salicylate
CS-W014237
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Occurs in Manufacturing (4 Product(s))

Product Categories

Product CategoryProducts
Beauty & Personal Care4

Products

ProductBrandCategoryCompounds Matched from IngredientsDate Retrieved
Attitude Super Leaves Conditioner - Moisture Rich -- 8 fl ozAttitudeBeauty & Personal CareCitric acid, Cetearyl alcohol, Citric acid, Pentadecalactone, Glyceryl stearate, Methyl dihydrojasmonate, Hexyl salicylate, Maltodextrin, Sodium benzoate2024-11-29 10:47:42
Attitude Super Leaves Moisture Rich Conditioner -- 32 fl ozAttitudeBeauty & Personal Carefloral, citric acid, citric acid, triethyl citrate, pentadecalactone, glyceryl stearate, hexyl salicylate, maltodextrin, sodium benzoate, stearyl alcohol2024-11-29 10:47:42
Attitude Super Leaves Nourishing & Strengthening Conditioner -- 32 fl ozAttitudeBeauty & Personal Carefloral, citric acid, citric acid, geranyl acetate, glyceryl stearate, hexyl salicylate, maltodextrin, sodium benzoate, stearyl alcohol2024-11-29 10:47:42
Attitude Super Leaves Shampoo - Moisture Rich -- 16 fl ozAttitudeBeauty & Personal CareGlyceryl oleate, Citric acid, Citric acid, Panthenol, Pentadecalactone, Methyl dihydrojasmonate, Hexyl salicylate, Maltodextrin, Sodium benzoate2024-11-29 10:47:42

Drug Classes (1)

ClassDescription
benzoate esterEsters of benzoic acid or substituted benzoic acids.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (5)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
LuciferasePhotinus pyralis (common eastern firefly)Potency17.82930.007215.758889.3584AID1224835
AR proteinHomo sapiens (human)Potency61.64480.000221.22318,912.5098AID743036
progesterone receptorHomo sapiens (human)Potency52.20380.000417.946075.1148AID1346784; AID1346795
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency19.79640.003041.611522,387.1992AID1159552; AID1159555
thyroid stimulating hormone receptorHomo sapiens (human)Potency43.27710.001628.015177.1139AID1224843
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID348953Antibacterial activity against Escherichia coli ATCC 9637 up to 200 ug/ml after 2 days by twofold broth dilution method2008European journal of medicinal chemistry, Jun, Volume: 43, Issue:6
Design and evaluation of anacardic acid derivatives as anticavity agents.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (33.33)29.6817
2010's3 (50.00)24.3611
2020's1 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 45.52

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index45.52 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.73 (4.65)
Search Engine Demand Index63.36 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (45.52)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (16.67%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (83.33%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
diethyl phthalate
diethyl phthalate: structure. diethyl phthalate : The diethyl ester of benzene-1,2-dicarboxylic acid.		2.2510diester;
ethyl ester;
phthalate ester		neurotoxin;
plasticiser;
teratogenic agent
1-bromohexane
[no description available]		2.2510
n-propyl disulfide
n-propyl disulfide: major flavor component of onions; non-nitrogenous, pungent volatile oil. dipropyl disulfide : An organic disulfide where the alkyl groups specified are propyl. It is a component of the essential oils obtained from Allium.		2.5520organic disulfideplant metabolite
potassium hydroxide
potassium hydroxide: RN given refers to cpd with MF of K-OH		2.2510alkali metal hydroxide
melamine formaldehyde
[no description available]		2.0710
lunularic acid
lunularic acid: structure given in first source		2.0410stilbenoid
anacardic acid
anacardic acid: isolated from Anacardium occidentale; monophenol monooxygenase inhibitor. anacardic acid : A hydroxybenzoic acid that is salicylic acid substituted by a pentadecyl group at position 6. It is a major component of cashew nut shell liquid and exhibits an extensive range of bioactivities.		2.0410hydroxy monocarboxylic acid;
hydroxybenzoic acid		anti-inflammatory agent;
antibacterial agent;
anticoronaviral agent;
apoptosis inducer;
EC 2.3.1.48 (histone acetyltransferase) inhibitor;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor;
neuroprotective agent;
plant metabolite
anethole
anethole: an isomer of estragole; structurally similar to CAPSAICIN; has some neurological and insecticidal and skin absorption effects; RN given refers to unspecified stereoisomer. anethole : A monomethoxybenzene that is methoxybenzene substituted by a prop-1-en-1-yl group at position 4.. trans-anethole : The trans-stereoisomer of anethole.		2.0410anetholeflavouring agent
ginkgolic acid
[no description available]		2.0410hydroxybenzoic acid
2-hydroxy-6-[(8Z,11Z)-pentadeca-8,11,14-trien-1-yl]benzoic acid
[no description available]		2.0410hydroxybenzoic acid
cardanol
cardanol: from pink pepper; phenol with hydrocarbon side chain which can vary in length & unsaturation		2.0410phenols
salicylates
Salicylates: The salts or esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and anti-inflammatory activities by inhibiting prostaglandin synthesis.. hydroxybenzoate : Any benzoate derivative carrying a single carboxylate group and at least one hydroxy substituent.. salicylates : Any salt or ester arising from reaction of the carboxy group of salicylic acid, or any ester resulting from the condensation of the phenolic hydroxy group of salicylic acid with an organic acid.. salicylate : A monohydroxybenzoate that is the conjugate base of salicylic acid.		4.350monohydroxybenzoateplant metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Caries, Dental
[description not available]		02.0410
Dental Caries
Localized destruction of the tooth surface initiated by decalcification of the enamel followed by enzymatic lysis of organic structures and leading to cavity formation. If left unchecked, the cavity may penetrate the enamel and dentin and reach the pulp.		02.0410
Allergic Contact Dermatitis
[description not available]		02.2110
Dermatitis, Allergic Contact
A contact dermatitis due to allergic sensitization to various substances. These substances subsequently produce inflammatory reactions in the skin of those who have acquired hypersensitivity to them as a result of prior exposure.		02.2110
Primary Peritonitis
[description not available]		02.110
Palmoplantaris Pustulosis
[description not available]		02.110
Peritonitis
INFLAMMATION of the PERITONEUM lining the ABDOMINAL CAVITY as the result of infectious, autoimmune, or chemical processes. Primary peritonitis is due to infection of the PERITONEAL CAVITY via hematogenous or lymphatic spread and without intra-abdominal source. Secondary peritonitis arises from the ABDOMINAL CAVITY itself through RUPTURE or ABSCESS of intra-abdominal organs.		02.110
Psoriasis
A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.		02.110
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