ceramide phosphoethanolamine synthase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: an N-acyl-sphingoid base + CDP-ethanolamine = an N-acyl-sphingoid 1-phosphoethanolamine + CMP + H+. [EC:2.7.8.48, PMID:25667419]

Ceramide phosphoethanolamine synthase activity, also known as ceramide phosphotransferase (CPT) activity, is a critical step in the biosynthesis of sphingolipids. This enzyme catalyzes the transfer of the phosphocholine headgroup from phosphatidylethanolamine (PE) to ceramide, producing ceramide phosphoethanolamine (CPE), also known as sphingomyelin. CPE is a crucial component of cell membranes, playing a role in membrane structure, signaling, and cell-cell interactions.

The catalytic mechanism of CPT involves the following steps:

1. **Substrate Binding:** Ceramide and PE bind to the active site of the enzyme.
2. **Phosphoryl Transfer:** The enzyme facilitates the transfer of the phosphoryl group from PE to the primary hydroxyl group of ceramide.
3. **Product Release:** CPE is released from the enzyme, and the enzyme is ready to catalyze another reaction.

The activity of CPT is tightly regulated, and dysregulation of this enzyme is implicated in various pathological conditions, including cancer, neurodegenerative diseases, and cardiovascular diseases. The enzyme's activity is influenced by factors such as substrate availability, pH, and the presence of specific inhibitors.'
"

Proteins (2)

Compounds (6)