Compounds > vinaxanthone
Page last updated: 2024-12-11

vinaxanthone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

vinaxanthone: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID5487402
CHEMBL ID510257
SCHEMBL ID9382496
MeSH IDM0229696

Synonyms (15)

Synonym
vinaxanthone
5,7-diacetyl-6-(5-carboxy-6,7-dihydroxy-4-oxochromen-3-yl)-2,3-dihydroxy-9-oxoxanthene-1-carboxylic acid
bdbm50259934
5,7-diacetyl-6-(5-carboxy-6,7-dihydroxy-4-oxo-4h-chromen-3-yl)-2,3-dihydroxy-9-oxo-9h-xanthene-1-carboxylic acid
CHEMBL510257 ,
9h-xanthene-1-carboxylic acid, 5,7-diacetyl-6-(5-carboxy-6,7-dihydroxy-4-oxo-4h-1-benzopyran-3-yl)-2,3-dihydroxy-9-oxo-
sm-345431
vina-xanthone
411f
133293-89-7
SCHEMBL9382496
CS-0181638
DTXSID50928043
5,7-diacetyl-6-(5-carboxy-6,7-dihydroxy-4-oxo-4h-1-benzopyran-3-yl)-2,3-dihydroxy-9-oxo-9h-xanthene-1-carboxylic acid
HY-N9480

Research Excerpts

Overview

Vinaxanthone is a new FabI-directed antibacterial of natural origin. It could have potential for further development as a new anti-MRSA agent.

ExcerptReferenceRelevance
"Vinaxanthone is a new FabI-directed antibacterial of natural origin that could have potential for further development as a new anti-MRSA agent."( Vinaxanthone, a new FabI inhibitor from Penicillium sp.
Kim, WG; Sohn, MJ; Zheng, CJ, 2009)		3.24

Toxicity

ExcerptReferenceRelevance
" This study evaluates the acute toxic and sublethal effects (embryonic development, tadpole body size, tadpole swimming performance) of the mixture of the formulated glyphosate Roundup Active and Cosmo-Flux 411F to anuran embryos and tadpoles of four Colombian species under 96h laboratory standard tests and microcosms, which are more similar to field conditions as they include soil, sand and macrophytes."( Acute toxicity and sublethal effects of the mixture glyphosate (Roundup Active) and Cosmo-Flux 411F to anuran embryos and tadpoles of four Colombian species.
Bernal Bautista, MH; Henao Muñoz, LM; Montes Rojas, CM, 2015)		0.42
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1Rattus norvegicus (Norway rat)IC50 (µMol)5.40005.40005.40005.4000AID401416
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Molecular Functions (1)

Processvia Protein(s)Taxonomy
phosphatidylinositol phospholipase C activity1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1Rattus norvegicus (Norway rat)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (1)

Processvia Protein(s)Taxonomy
plasma membrane1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1Rattus norvegicus (Norway rat)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (10)

Assay IDTitleYearJournalArticle
AID401416Inhibition of rat brain PI-PLCgamma11998Journal of natural products, Jul, Volume: 61, Issue:7
Phospholipase Cgamma1 inhibitory principles from the sarcotestas of Ginkgo biloba.
AID383446Inhibition of sea urchin egg fertilization by sea urchin sperm assessed as inhibition of divided eggs by light microscopy2008Journal of natural products, May, Volume: 71, Issue:5
A biaryl xanthone derivative having axial chirality from Penicillium vinaceum.
AID1682373Antimicrobial activity against Staphylococcus aureus assessed as complete inhibition of growth after 24 hrs by broth microdilution method2020Bioorganic & medicinal chemistry letters, 12-15, Volume: 30, Issue:24
The food-grade antimicrobial xanthorrhizol targets the enoyl-ACP reductase (FabI) in Escherichia coli.
AID1682374Inhibition of Staphylococcus aureus FabI assessed as incorporation of [1-14C]acetate to L-[U-14C]leucine2020Bioorganic & medicinal chemistry letters, 12-15, Volume: 30, Issue:24
The food-grade antimicrobial xanthorrhizol targets the enoyl-ACP reductase (FabI) in Escherichia coli.
AID383445Antifungal activity against Saccharomyces cerevisiae after 18 to 24 hrs by disk diffusion test2008Journal of natural products, May, Volume: 71, Issue:5
A biaryl xanthone derivative having axial chirality from Penicillium vinaceum.
AID383448Antitumor activity against Agrobacterium tumefaciens-induced 100 ppm crown gall tumor in potato tubers at 50 ug/ml after 21 days by crown gall tumor potato disk test2008Journal of natural products, May, Volume: 71, Issue:5
A biaryl xanthone derivative having axial chirality from Penicillium vinaceum.
AID383443Antibacterial activity against Staphylococcus aureus by disk diffusion test2008Journal of natural products, May, Volume: 71, Issue:5
A biaryl xanthone derivative having axial chirality from Penicillium vinaceum.
AID383447Antitumor activity against Agrobacterium tumefaciens-induced 10 ppm crown gall tumor in potato tubers at 50 ug/ml after 21 days by crown gall tumor potato disk test2008Journal of natural products, May, Volume: 71, Issue:5
A biaryl xanthone derivative having axial chirality from Penicillium vinaceum.
AID383442Antibacterial activity against Bacillus subtilis by disk diffusion test2008Journal of natural products, May, Volume: 71, Issue:5
A biaryl xanthone derivative having axial chirality from Penicillium vinaceum.
AID383444Antibacterial activity against Escherichia coli by disk diffusion test2008Journal of natural products, May, Volume: 71, Issue:5
A biaryl xanthone derivative having axial chirality from Penicillium vinaceum.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (16.67)18.2507
2000's2 (16.67)29.6817
2010's6 (50.00)24.3611
2020's2 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 20.10

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index20.10 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index5.03 (4.65)
Search Engine Demand Index15.26 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (20.10)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
salicylic acid
Scalp: The outer covering of the calvaria. It is composed of several layers: SKIN; subcutaneous connective tissue; the occipitofrontal muscle which includes the tendinous galea aponeurotica; loose connective tissue; and the pericranium (the PERIOSTEUM of the SKULL).		1.9910monohydroxybenzoic acidalgal metabolite;
antifungal agent;
antiinfective agent;
EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor;
keratolytic drug;
plant hormone;
plant metabolite
3-cresol
3-cresol: RN given refers to parent cpd. m-cresol : A cresol with the methyl substituent at position 3. It is a minor urinary metabolite of toluene.		1.9910cresolhuman xenobiotic metabolite
glycine
[no description available]		2.1110alpha-amino acid;
amino acid zwitterion;
proteinogenic amino acid;
serine family amino acid		EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor;
fundamental metabolite;
hepatoprotective agent;
micronutrient;
neurotransmitter;
NMDA receptor agonist;
nutraceutical
aurintricarboxylic acid
Aurintricarboxylic Acid: A dye which inhibits protein biosynthesis at the initial stages. The ammonium salt (aluminon) is a reagent for the colorimetric estimation of aluminum in water, foods, and tissues.. aurintricarboxylic acid : A member of the class of quinomethanes that is 3-methylidene-6-oxocyclohexa-1,4-diene-1-carboxylic acid in which the methylidene hydrogens are replaced by 4-carboxy-3-hydroxyphenyl groups. The trisodium salt is the biological stain 'chrome violet CG' while the triammonium salt is 'aluminon'.		1.9810monohydroxybenzoic acid;
quinomethanes;
tricarboxylic acid		fluorochrome;
histological dye;
insulin-like growth factor receptor 1 antagonist
triclosan
[no description available]		2.2510aromatic ether;
dichlorobenzene;
monochlorobenzenes;
phenols		antibacterial agent;
antimalarial;
drug allergen;
EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor;
fungicide;
persistent organic pollutant;
xenobiotic
xanthenes
Xanthenes: Compounds with three aromatic rings in linear arrangement with an OXYGEN in the center ring.		1.9810xanthene
orcinol
orcinol: used as reagent for pentoses, lignin, beet sugar, saccharoses, arabinose & diastase; RN given refers to parent cpd; structure. orcinol : A 5-alkylresorcinol in which the alkyl group is specified as methyl.		1.99105-alkylresorcinol;
dihydroxytoluene		Aspergillus metabolite
citromycetin
citromycetin: structure		1.9810
epigallocatechin gallate
epigallocatechin gallate: a steroid 5alpha-reductase inhibitor and antimutagen in green tea (Camellia sinensis). (-)-epigallocatechin 3-gallate : A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.		2.2510flavans;
gallate ester;
polyphenol		antineoplastic agent;
antioxidant;
apoptosis inducer;
geroprotector;
Hsp90 inhibitor;
neuroprotective agent;
plant metabolite
3-pentadecylphenol
3-pentadecylphenol: structure in first source		1.9910phenols
xanthorrhizol
xanthorrhizol: structure in first source		2.2510sesquiterpenoid
6-n-tridecylsalicylic acid
6-n-tridecylsalicylic acid: structure given in first source		1.9910hydroxybenzoic acid
amentoflavone
[no description available]		1.9910biflavonoid;
hydroxyflavone;
ring assembly		angiogenesis inhibitor;
antiviral agent;
cathepsin B inhibitor;
P450 inhibitor;
plant metabolite
bilobol
bilobol: structure given in first source; RN given refers to (Z)-isomer; RN for cpd without isomeric designation not avail 6/90		1.99105-alkenylresorcinol
ginkgolic acid
[no description available]		1.9910hydroxybenzoic acid
xanthofulvin
xanthofulvin: structure in first source		7.520
anthecotulide
anthecotulide: from Anthemis cotula; structure in first source		2.2510butan-4-olide
ConditionIndicatedRelationship StrengthStudiesTrials
E coli Infections
[description not available]		02.2510
Escherichia coli Infections
Infections with bacteria of the species ESCHERICHIA COLI.		02.2510
Cornea Injuries
[description not available]		02.1510
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.5320
Dry Eye
[description not available]		02.1510
Dry Eye Syndromes
Corneal and conjunctival dryness due to deficient tear production, predominantly in menopausal and post-menopausal women. Filamentary keratitis or erosion of the conjunctival and corneal epithelium may be caused by these disorders. Sensation of the presence of a foreign body in the eye and burning of the eyes may occur.		02.1510
Corneal Injuries
Damage or trauma inflicted to the CORNEA by external means.		02.1510
Injuries, Spinal Cord
[description not available]		02.110
Spinal Cord Injuries
Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).		02.110
Corneal Angiogenesis
[description not available]		02.0710
Corneal Neovascularization
New blood vessels originating from the corneal blood vessels and extending from the limbus into the adjacent CORNEAL STROMA. Neovascularization in the superficial and/or deep corneal stroma is a sequel to numerous inflammatory diseases of the ocular anterior segment, such as TRACHOMA, viral interstitial KERATITIS, microbial KERATOCONJUNCTIVITIS, and the immune response elicited by CORNEAL TRANSPLANTATION.		02.0710