Page last updated: 2024-12-11
vinaxanthone
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
vinaxanthone: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 5487402 |
| CHEMBL ID | 510257 |
| SCHEMBL ID | 9382496 |
| MeSH ID | M0229696 |
Synonyms (15)
| Synonym |
|---|
| vinaxanthone |
| 5,7-diacetyl-6-(5-carboxy-6,7-dihydroxy-4-oxochromen-3-yl)-2,3-dihydroxy-9-oxoxanthene-1-carboxylic acid |
| bdbm50259934 |
| 5,7-diacetyl-6-(5-carboxy-6,7-dihydroxy-4-oxo-4h-chromen-3-yl)-2,3-dihydroxy-9-oxo-9h-xanthene-1-carboxylic acid |
| CHEMBL510257 , |
| 9h-xanthene-1-carboxylic acid, 5,7-diacetyl-6-(5-carboxy-6,7-dihydroxy-4-oxo-4h-1-benzopyran-3-yl)-2,3-dihydroxy-9-oxo- |
| sm-345431 |
| vina-xanthone |
| 411f |
| 133293-89-7 |
| SCHEMBL9382496 |
| CS-0181638 |
| DTXSID50928043 |
| 5,7-diacetyl-6-(5-carboxy-6,7-dihydroxy-4-oxo-4h-1-benzopyran-3-yl)-2,3-dihydroxy-9-oxo-9h-xanthene-1-carboxylic acid |
| HY-N9480 |
Research Excerpts
Overview
Vinaxanthone is a new FabI-directed antibacterial of natural origin. It could have potential for further development as a new anti-MRSA agent.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Vinaxanthone is a new FabI-directed antibacterial of natural origin that could have potential for further development as a new anti-MRSA agent." | ( Vinaxanthone, a new FabI inhibitor from Penicillium sp. Kim, WG; Sohn, MJ; Zheng, CJ, 2009) | 3.24 |
Toxicity
| Excerpt | Reference | Relevance |
|---|---|---|
| " This study evaluates the acute toxic and sublethal effects (embryonic development, tadpole body size, tadpole swimming performance) of the mixture of the formulated glyphosate Roundup Active and Cosmo-Flux 411F to anuran embryos and tadpoles of four Colombian species under 96h laboratory standard tests and microcosms, which are more similar to field conditions as they include soil, sand and macrophytes." | ( Acute toxicity and sublethal effects of the mixture glyphosate (Roundup Active) and Cosmo-Flux 411F to anuran embryos and tadpoles of four Colombian species. Bernal Bautista, MH; Henao Muñoz, LM; Montes Rojas, CM, 2015) | 0.42 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Protein Targets (1)
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | Rattus norvegicus (Norway rat) | IC50 (µMol) | 5.4000 | 5.4000 | 5.4000 | 5.4000 | AID401416 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
Molecular Functions (1)
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| phosphatidylinositol phospholipase C activity | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | Rattus norvegicus (Norway rat) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
Ceullar Components (1)
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| plasma membrane | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | Rattus norvegicus (Norway rat) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
Bioassays (10)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID401416 | Inhibition of rat brain PI-PLCgamma1 | 1998 | Journal of natural products, Jul, Volume: 61, Issue:7 | Phospholipase Cgamma1 inhibitory principles from the sarcotestas of Ginkgo biloba. |
| AID383446 | Inhibition of sea urchin egg fertilization by sea urchin sperm assessed as inhibition of divided eggs by light microscopy | 2008 | Journal of natural products, May, Volume: 71, Issue:5 | A biaryl xanthone derivative having axial chirality from Penicillium vinaceum. |
| AID1682373 | Antimicrobial activity against Staphylococcus aureus assessed as complete inhibition of growth after 24 hrs by broth microdilution method | 2020 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 30, Issue:24 | The food-grade antimicrobial xanthorrhizol targets the enoyl-ACP reductase (FabI) in Escherichia coli. |
| AID1682374 | Inhibition of Staphylococcus aureus FabI assessed as incorporation of [1-14C]acetate to L-[U-14C]leucine | 2020 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 30, Issue:24 | The food-grade antimicrobial xanthorrhizol targets the enoyl-ACP reductase (FabI) in Escherichia coli. |
| AID383445 | Antifungal activity against Saccharomyces cerevisiae after 18 to 24 hrs by disk diffusion test | 2008 | Journal of natural products, May, Volume: 71, Issue:5 | A biaryl xanthone derivative having axial chirality from Penicillium vinaceum. |
| AID383448 | Antitumor activity against Agrobacterium tumefaciens-induced 100 ppm crown gall tumor in potato tubers at 50 ug/ml after 21 days by crown gall tumor potato disk test | 2008 | Journal of natural products, May, Volume: 71, Issue:5 | A biaryl xanthone derivative having axial chirality from Penicillium vinaceum. |
| AID383443 | Antibacterial activity against Staphylococcus aureus by disk diffusion test | 2008 | Journal of natural products, May, Volume: 71, Issue:5 | A biaryl xanthone derivative having axial chirality from Penicillium vinaceum. |
| AID383447 | Antitumor activity against Agrobacterium tumefaciens-induced 10 ppm crown gall tumor in potato tubers at 50 ug/ml after 21 days by crown gall tumor potato disk test | 2008 | Journal of natural products, May, Volume: 71, Issue:5 | A biaryl xanthone derivative having axial chirality from Penicillium vinaceum. |
| AID383442 | Antibacterial activity against Bacillus subtilis by disk diffusion test | 2008 | Journal of natural products, May, Volume: 71, Issue:5 | A biaryl xanthone derivative having axial chirality from Penicillium vinaceum. |
| AID383444 | Antibacterial activity against Escherichia coli by disk diffusion test | 2008 | Journal of natural products, May, Volume: 71, Issue:5 | A biaryl xanthone derivative having axial chirality from Penicillium vinaceum. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (12)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 6 (50.00) | 24.3611 |
| 2020's | 2 (16.67) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 20.10
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (20.10) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 12 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||