small protein activating enzyme binding

Definition

Target type: molecularfunction

Binding to a small protein activating enzyme, such as ubiquitin-activating enzyme. [GOC:jl]

Small protein activating enzyme binding refers to the interaction of a protein with a specific class of enzymes known as small protein activating enzymes (SPAs). SPAs are a diverse group of enzymes that catalyze the activation of various small proteins, often by removing N-terminal methionine residues or by cleaving propeptides. The binding of a protein to an SPA can serve several important molecular functions, including:

1. **Activation of the target protein:** The binding of an SPA to a target protein can initiate a conformational change in the target, exposing active sites or removing inhibitory domains, thus triggering the protein's activity.

2. **Regulation of protein stability:** The interaction between an SPA and its target can stabilize the target protein, preventing its degradation or aggregation.

3. **Localization of the target protein:** The SPA can act as a chaperone, guiding the target protein to specific cellular compartments where it is needed.

4. **Modulation of protein-protein interactions:** The SPA can influence the interaction of the target protein with other proteins, either by masking or exposing binding sites.

The precise molecular function of SPA binding varies depending on the specific SPA and target protein involved. For example, some SPAs are involved in the activation of signaling proteins, while others are involved in the maturation of structural proteins. The study of SPA binding is essential for understanding the regulation of protein function and for developing new therapeutic strategies that target protein activation.'
"

Proteins (2)

Compounds (4)