Compounds > scoparianoside b
Page last updated: 2024-11-08

scoparianoside b

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

scoparianoside B: isolated from the fruit of Japanese Kochia scoparia; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
Kochiagenus[no description available]AmaranthaceaeA family of flowering plants in the order Caryophyllales, with about 60 genera and more than 800 species of plants, with a few shrubs, trees, and vines. The leaves usually have nonindented edges.[MeSH]

Cross-References

ID SourceID
PubMed CID176596
CHEMBL ID470172
CHEBI ID183931
SCHEMBL ID16556181
MeSH IDM0282094

Synonyms (23)

Synonym
momordin ic
scoparianoside b
CHEMBL470172 ,
CHEBI:183931
96990-18-0
(2s,3s,4s,5r,6r)-6-[[(3s,4ar,6ar,6bs,8as,12as,14ar,14br)-8a-carboxy-4,4,6a,6b,11,11,14b-heptamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-3,5-dihydroxy-4-[(2s,3r,4s,5r)-3,4,5-trihydroxyoxan-2-yl]oxyoxane-2-carboxylic acid
195971-47-2
beta-d-glucopyranosiduronic acid, (3beta)-17-carboxy-28-norolean-18-en-3-yl 3-o-betad-xylopyranosyl-
S9159
AKOS015897153
AC-34122
Q-100908
momordin-ic
momordinic
momordin 1c
SCHEMBL16556181
28-hydroxy-28-oxoolean-12-en-3-yl 3-o-pentopyranosylhexopyranosiduronic acid
DTXSID00914234
HY-N0330
CCG-270448
CS-0008892
A858653
bdbm50591762

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
" The bioavailability of 29 was significantly improved in comparison with its aglycon."( Synthesis and anti-inflammatory activity of saponin derivatives of δ-oleanolic acid.
Chen, C; Cheng, K; Dai, L; Hu, K; Li, H; Liu, L; Sun, H; Wen, X; Xu, Q; Yuan, H, 2021)		0.62
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
triterpenoid saponinA terpene glycoside in which the terpene moiety is a triterpenoid.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Sentrin-specific protease 1Homo sapiens (human)IC50 (µMol)15.38000.00642.64466.1000AID1859337; AID1868248; AID1888105
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (7)

Processvia Protein(s)Taxonomy
positive regulation of transcription by RNA polymerase IISentrin-specific protease 1Homo sapiens (human)
proteolysisSentrin-specific protease 1Homo sapiens (human)
activation of cysteine-type endopeptidase activity involved in apoptotic processSentrin-specific protease 1Homo sapiens (human)
protein sumoylationSentrin-specific protease 1Homo sapiens (human)
protein desumoylationSentrin-specific protease 1Homo sapiens (human)
regulation of mRNA stabilitySentrin-specific protease 1Homo sapiens (human)
apoptotic signaling pathwaySentrin-specific protease 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (4)

Processvia Protein(s)Taxonomy
endopeptidase activitySentrin-specific protease 1Homo sapiens (human)
protein bindingSentrin-specific protease 1Homo sapiens (human)
deSUMOylase activitySentrin-specific protease 1Homo sapiens (human)
SUMO-specific endopeptidase activitySentrin-specific protease 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (5)

Processvia Protein(s)Taxonomy
nucleoplasmSentrin-specific protease 1Homo sapiens (human)
cytoplasmSentrin-specific protease 1Homo sapiens (human)
focal adhesionSentrin-specific protease 1Homo sapiens (human)
nuclear membraneSentrin-specific protease 1Homo sapiens (human)
nucleusSentrin-specific protease 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (4)

Assay IDTitleYearJournalArticle
AID1859337Inhibition of SENP1 (unknown origin)2022European journal of medicinal chemistry, Apr-05, Volume: 233Small-molecule inhibitors targeting small ubiquitin-like modifier pathway for the treatment of cancers and other diseases.
AID1728066Activation of AMPK in human Huh-7 cells assessed as increase in AMPK phosphorylation at Thr172 residue at 10 uM measured after 12 hrs by Western blot analysis2021European journal of medicinal chemistry, Jan-01, Volume: 209Synthesis and anti-inflammatory activity of saponin derivatives of δ-oleanolic acid.
AID1888105Inhibition of recombinant human SENP1 catalytic domain using RanGAP1 as substrate preincubated for 10 mins followed by substrate addition and measured after 30 mins by Western blot analysis2022European journal of medicinal chemistry, Jan-05, Volume: 227Discovery and radiosensitization research of ursolic acid derivatives as SENP1 inhibitors.
AID1868248Inhibition of SENP1 (unknown origin)2022Journal of natural products, 05-27, Volume: 85, Issue:5
Discovery of Natural Ursane-type SENP1 Inhibitors and the Platinum Resistance Reversal Activity Against Human Ovarian Cancer Cells: A Structure-Activity Relationship Study.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (20.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's4 (80.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.66

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.66 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.66)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (40.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other3 (60.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
ketanserin
Ketanserin: A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.. ketanserin : A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group.		2.3110aromatic ketone;
organofluorine compound;
piperidines;
quinazolines		alpha-adrenergic antagonist;
antihypertensive agent;
cardiovascular drug;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
serotonergic antagonist
streptonigrin
[no description available]		4.4320pyridines;
quinolone		antimicrobial agent;
antineoplastic agent
glycyrrhetinic acid
[no description available]		2.3110cyclic terpene ketone;
hydroxy monocarboxylic acid;
pentacyclic triterpenoid		immunomodulator;
plant metabolite
oleanolic acid
[no description available]		2.4520hydroxy monocarboxylic acid;
pentacyclic triterpenoid		plant metabolite
glycyrrhizic acid
glycyrrhizinic acid : A triterpenoid saponin that is the glucosiduronide derivative of 3beta-hydroxy-11-oxoolean-12-en-30-oic acid.		2.3110enone;
glucosiduronic acid;
pentacyclic triterpenoid;
tricarboxylic acid;
triterpenoid saponin		EC 3.4.21.5 (thrombin) inhibitor;
plant metabolite
2,2'-biphenol
biphenyl-2,2'-diol : A member of the class of hydroxybiphenyls carrying hydroxy groups at positions 2 and 2'.		3.5110hydroxybiphenyls
ursolic acid
[no description available]		4.9140hydroxy monocarboxylic acid;
pentacyclic triterpenoid		geroprotector;
plant metabolite
betulinic acid
[no description available]		2.3110hydroxy monocarboxylic acid;
pentacyclic triterpenoid		anti-HIV agent;
anti-inflammatory agent;
antimalarial;
antineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
plant metabolite
Tormentic acid
tormentic acid: aglycone of Rosamultin		3.5110triterpenoidmetabolite
hederagenin
[no description available]		2.3110dihydroxy monocarboxylic acid;
pentacyclic triterpenoid;
sapogenin		plant metabolite
echinocystic acid
[no description available]		3.5110triterpenoid
madecassic acid
[no description available]		2.3110monocarboxylic acid;
pentacyclic triterpenoid;
tetrol		antioxidant;
plant metabolite
maslinic acid
(2Alpha,3beta)-2,3-dihydroxyolean-12-en-28-oic acid: from Luehea divaricata and Agrimonia eupatoria		2.3110dihydroxy monocarboxylic acid;
pentacyclic triterpenoid		anti-inflammatory agent;
antineoplastic agent;
antioxidant;
plant metabolite
uvaol
uvaol: from Vauquelinia corymbosa (Rosaceae)		3.5110triterpenoidmetabolite
triptolide
[no description available]		3.5110diterpenoid;
epoxide;
gamma-lactam;
organic heteroheptacyclic compound		antispermatogenic agent;
plant metabolite
asiatic acid
[no description available]		3.8620monocarboxylic acid;
pentacyclic triterpenoid;
triol		angiogenesis modulating agent;
metabolite
anacardic acid
anacardic acid: isolated from Anacardium occidentale; monophenol monooxygenase inhibitor. anacardic acid : A hydroxybenzoic acid that is salicylic acid substituted by a pentadecyl group at position 6. It is a major component of cashew nut shell liquid and exhibits an extensive range of bioactivities.		3.5110hydroxy monocarboxylic acid;
hydroxybenzoic acid		anti-inflammatory agent;
antibacterial agent;
anticoronaviral agent;
apoptosis inducer;
EC 2.3.1.48 (histone acetyltransferase) inhibitor;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor;
neuroprotective agent;
plant metabolite
boswellic acid
boswellic acid: ursane type; RN given refers to (3alpha,4beta)-isomer; active principle of salai guggal; see also record for salai guggal		3.5110triterpenoid
oleanolic acid 3-o-monoglucuronide
oleanolic acid 3-O-monoglucuronide: structure given in first source		2.3110beta-D-glucosiduronic acid
pomolic acid
pomolic acid: from Rosa woodsii & Hyptis capitata; structure in first source		3.5110triterpenoidmetabolite
kerriamycin b
kerriamycin B: from a streptomycete; structure given in first source		3.5110angucycline antibioticantineoplastic agent
euscaphic acid
euscaphic acid: isolated from medicinal plant, Euscaphis japonica Pax.; structure; RN given refers to 2alpha,3alpha-isomer. euscaphic acid : A pentacyclic triterpenoid that is urs-12-en-28-oic acid substituted by hydroxy groups at positions 2, 3 and 19 respectively (the 2alpha,3alpha-stereoisomer). It has been isolated from the leaves of Rosa laevigata.		3.5110hydroxy monocarboxylic acid;
pentacyclic triterpenoid;
triol		plant metabolite
methyl ursolate
methyl ursolate: structure in first source		2.4110
ginkgolic acid
[no description available]		3.5110hydroxybenzoic acid
3 beta-o-acetylursolic acid
[no description available]		2.4110triterpenoid
beta-escin
[no description available]		1.9910
corosolic acid
[no description available]		3.8620triterpenoidmetabolite
11-keto-boswellic acid
[no description available]		3.5110
kalopanax saponin b
kalopanax saponin B: isolated from Kalopanax septemlobus; structure given in first source. kalopanaxsaponin B : A triterpenoid saponin with hederagenin as the aglycone part. It has been isolated from the stem bark of Kalopanax pictus.		2.3110carboxylic ester;
pentacyclic triterpenoid;
triterpenoid saponin		anti-inflammatory agent;
plant metabolite
ginsenoside ro
ginsenoside Ro: from ginseng; RN given refers to ginsenoside Ro, (all-D)-isomer		2.3110triterpenoid saponinmetabolite
roburic acid
roburic acid : A tetracyclic triterpenoid with formula C30H40O2 that is isolated from the roots of Gentiana dahurica and Gentiana macrophylla.		3.5110monocarboxylic acid;
olefinic compound;
tetracyclic triterpenoid		plant metabolite
2',3',4'-trihydroxyflavone
2',3',4'-trihydroxyflavone: inhibitor of protein sumoylation; structure in first source		3.5110
madecassoside
[no description available]		2.3110carboxylic ester;
pentacyclic triterpenoid;
trisaccharide derivative;
triterpenoid saponin		anti-inflammatory agent;
antioxidant;
antirheumatic drug;
plant metabolite;
vulnerary
ziyuglycoside i
ziyuglycoside I: isolated from the leaves of Hex pupurea; structure in first source		2.3110
ziyuglycoside ii
ziyuglycoside II: isolated from Sanguisorba officinalis; structure in first source		2.3110
ConditionIndicatedRelationship StrengthStudiesTrials
Benign Neoplasms
[description not available]		03.3310
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		03.3310
Epithelial Ovarian Cancer
[description not available]		03.3310
Cancer of Ovary
[description not available]		03.3310
Carcinoma, Ovarian Epithelial
A malignant neoplasm that originates in cells on the surface EPITHELIUM of the ovary and is the most common form of ovarian cancer. There are five histologic subtypes: papillary serous, endometrioid, mucinous, clear cell, and transitional cell. Mutations in BRCA1, OPCML, PRKN, PIK3CA, AKT1, CTNNB1, RRAS2, and CDH1 genes are associated with this cancer.		03.3310
Ovarian Neoplasms
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.		03.3310