Compounds > bilobol
Page last updated: 2024-12-10

bilobol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

bilobol: structure given in first source; RN given refers to (Z)-isomer; RN for cpd without isomeric designation not avail 6/90 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID5281852
CHEMBL ID461628
CHEBI ID3104
SCHEMBL ID164545
MeSH IDM0176486

Synonyms (34)

Synonym
CHEBI:3104 ,
5-[(8z)-pentadec-8-enyl]resorcinol
bilobol
22910-86-7
5-[(8z)-pentadec-8-en-1-yl]benzene-1,3-diol
5-(8'z-heptadecenyl)resorcinol
5-[(z)-pentadec-8-enyl]benzene-1,3-diol
bdbm50241751
CHEMBL461628 ,
5-[8'(z)-pentadecenyl]resorcinol
5-{8(z),-pentadecenyl}resorcinol
1,3-benzenediol, 5-(8-pentadecenyl)-, (z)-
5-[(z)-pentadec-8-enylo]resorcinol
SCHEMBL164545
trifurcatol a2
cardol monoene
bilobol c15:1
5-(8z-pentadecenyl)resorcinol
1,3-benzenediol, 5-(8z)-8-pentadecenyl-
(z)-5-(pentadec-8-en-1-yl)benzene-1,3-diol
21:1-.omega.7-cardol
TUGAUFMQYWZJAB-FPLPWBNLSA-N
5-[(z)-pentadec-8-enyl]resorcinol
resorcinol, 5-(8-pentadecenyl)-, (z)-
cis-5-n-pentadec-8'-enylresorcino
LMPK15030001
DTXSID90872874
cardol c15:1
Q4913564
PD182474
1,3-benzenediol, 5-[(8z)-8-pentadecen-1-yl]-
5-(8z)-8-pentadecenyl-1,3-benzenediol
cis-5-pentadec-8'-enylresorcinol
AKOS040735273

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" As constituents with potential contact allergenic and toxic properties in crude Ginkgo extracts a group of alkylphenols (e."( Evidence for toxic effects of alkylphenols from Ginkgo biloba in the hen's egg test (HET).
Baron-Ruppert, G; Luepke, NP, 2001)		0.31
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
5-alkenylresorcinolA resorcinol compound having an alkenyl substituent at the 5-position.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1Bos taurus (cattle)IC50 (µMol)30.03005.66005.66005.6600AID401415
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Other Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (7)

Processvia Protein(s)Taxonomy
in utero embryonic development1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1Bos taurus (cattle)
epidermal growth factor receptor signaling pathway1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1Bos taurus (cattle)
phospholipid catabolic process1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1Bos taurus (cattle)
positive regulation of epithelial cell migration1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1Bos taurus (cattle)
cellular response to vascular endothelial growth factor stimulus1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1Bos taurus (cattle)
phosphatidylinositol metabolic process1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1Bos taurus (cattle)
cellular response to epidermal growth factor stimulus1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1Bos taurus (cattle)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (5)

Processvia Protein(s)Taxonomy
phosphatidylinositol phospholipase C activity1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1Bos taurus (cattle)
guanyl-nucleotide exchange factor activity1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1Bos taurus (cattle)
calcium ion binding1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1Bos taurus (cattle)
protein binding1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1Bos taurus (cattle)
calcium-dependent phospholipase C activity1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1Bos taurus (cattle)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (5)

Processvia Protein(s)Taxonomy
plasma membrane1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1Bos taurus (cattle)
ruffle1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1Bos taurus (cattle)
cytoplasm1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1Bos taurus (cattle)
lamellipodium1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1Bos taurus (cattle)
COP9 signalosome1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1Bos taurus (cattle)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (43)

Assay IDTitleYearJournalArticle
AID335795Antibacterial activity against Bacillus circulans at 100 ug/disk after 18 hrs by disk diffusion assay1993Journal of natural products, Oct, Volume: 56, Issue:10
Use of alkenylresorcinols from Ononis speciosa as synthetic precursors of compounds with potential biological activity.
AID335805Antibacterial activity against Pseudomonas fluorescens N5 after 18 hrs by disk diffusion assay1993Journal of natural products, Oct, Volume: 56, Issue:10
Use of alkenylresorcinols from Ononis speciosa as synthetic precursors of compounds with potential biological activity.
AID376624Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 by antimicrobial susceptibility test2006Journal of natural products, Apr, Volume: 69, Issue:4
5-alkylresorcinols from Merulius incarnatus.
AID335810Antifungal activity against Saccharomyces cerevisiae X-3 after 18 hrs by disk diffusion assay1993Journal of natural products, Oct, Volume: 56, Issue:10
Use of alkenylresorcinols from Ononis speciosa as synthetic precursors of compounds with potential biological activity.
AID379522Inhibition of thrombin at 50 uM2006Journal of natural products, Nov, Volume: 69, Issue:11
A nitrogen-containing 3-alkyl-1,4-benzoquinone and a gomphilactone derivative from Embelia ribes.
AID335803Antibacterial activity against Escherichia coli U9 after 18 hrs by disk diffusion assay1993Journal of natural products, Oct, Volume: 56, Issue:10
Use of alkenylresorcinols from Ononis speciosa as synthetic precursors of compounds with potential biological activity.
AID332456Inhibition of mushroom tyrosinase assessed as oxidation of L-DOPA1994Journal of natural products, Apr, Volume: 57, Issue:4
Tyrosinase inhibitors from Anacardium occidentale fruits.
AID335811Antifungal activity against Aspergillus niger ATCC 9142 after 18 hrs by disk diffusion assay1993Journal of natural products, Oct, Volume: 56, Issue:10
Use of alkenylresorcinols from Ononis speciosa as synthetic precursors of compounds with potential biological activity.
AID401419Growth inhibition of human MCF7 cells after 2 days by SRB assay1998Journal of natural products, Jul, Volume: 61, Issue:7
Phospholipase Cgamma1 inhibitory principles from the sarcotestas of Ginkgo biloba.
AID335807Antibacterial activity against Salmonella after 18 hrs by disk diffusion assay1993Journal of natural products, Oct, Volume: 56, Issue:10
Use of alkenylresorcinols from Ononis speciosa as synthetic precursors of compounds with potential biological activity.
AID401422Growth inhibition of human HT1197 cells after 2 days by SRB assay1998Journal of natural products, Jul, Volume: 61, Issue:7
Phospholipase Cgamma1 inhibitory principles from the sarcotestas of Ginkgo biloba.
AID335814Antifungal activity against Gibberella fujikuroi IMI 58289 after 18 hrs by disk diffusion assay1993Journal of natural products, Oct, Volume: 56, Issue:10
Use of alkenylresorcinols from Ononis speciosa as synthetic precursors of compounds with potential biological activity.
AID335809Antifungal activity against Saccharomyces cerevisiae K-2 after 18 hrs by disk diffusion assay1993Journal of natural products, Oct, Volume: 56, Issue:10
Use of alkenylresorcinols from Ononis speciosa as synthetic precursors of compounds with potential biological activity.
AID335794Antibacterial activity against Bacillus circulans at 200 ug/disk after 18 hrs by disk diffusion assay1993Journal of natural products, Oct, Volume: 56, Issue:10
Use of alkenylresorcinols from Ononis speciosa as synthetic precursors of compounds with potential biological activity.
AID401420Growth inhibition of human HCT15 cells after 2 days by SRB assay1998Journal of natural products, Jul, Volume: 61, Issue:7
Phospholipase Cgamma1 inhibitory principles from the sarcotestas of Ginkgo biloba.
AID335815Antifungal activity against Mucor mucedo after 18 hrs by disk diffusion assay1993Journal of natural products, Oct, Volume: 56, Issue:10
Use of alkenylresorcinols from Ononis speciosa as synthetic precursors of compounds with potential biological activity.
AID335797Antibacterial activity against Bacillus licheniformis CECT20 at 100 ug/disk after 18 hrs by disk diffusion assay1993Journal of natural products, Oct, Volume: 56, Issue:10
Use of alkenylresorcinols from Ononis speciosa as synthetic precursors of compounds with potential biological activity.
AID379517Cytotoxicity against human A2780 cells after 96 hrs by MTT assay2006Journal of natural products, Nov, Volume: 69, Issue:11
A nitrogen-containing 3-alkyl-1,4-benzoquinone and a gomphilactone derivative from Embelia ribes.
AID335799Antibacterial activity against Enterococcus faecalis S-86 at 100 ug/disk after 18 hrs by disk diffusion assay1993Journal of natural products, Oct, Volume: 56, Issue:10
Use of alkenylresorcinols from Ononis speciosa as synthetic precursors of compounds with potential biological activity.
AID335800Antibacterial activity against Micrococcus lysodeikticus at 200 ug/disk after 18 hrs by disk diffusion assay1993Journal of natural products, Oct, Volume: 56, Issue:10
Use of alkenylresorcinols from Ononis speciosa as synthetic precursors of compounds with potential biological activity.
AID335812Antifungal activity against Botrytis cinerea CECT 2100 after 18 hrs by disk diffusion assay1993Journal of natural products, Oct, Volume: 56, Issue:10
Use of alkenylresorcinols from Ononis speciosa as synthetic precursors of compounds with potential biological activity.
AID335798Antibacterial activity against Enterococcus faecalis S-86 at 200 ug/disk after 18 hrs by disk diffusion assay1993Journal of natural products, Oct, Volume: 56, Issue:10
Use of alkenylresorcinols from Ononis speciosa as synthetic precursors of compounds with potential biological activity.
AID335802Antibacterial activity against Alcaligenes faecalis after 18 hrs by disk diffusion assay1993Journal of natural products, Oct, Volume: 56, Issue:10
Use of alkenylresorcinols from Ononis speciosa as synthetic precursors of compounds with potential biological activity.
AID379520Cytotoxicity against human HCT8 cells after 96 hrs by MTT assay2006Journal of natural products, Nov, Volume: 69, Issue:11
A nitrogen-containing 3-alkyl-1,4-benzoquinone and a gomphilactone derivative from Embelia ribes.
AID401423Growth inhibition of human CCD-18Co cells after 2 days by SRB assay1998Journal of natural products, Jul, Volume: 61, Issue:7
Phospholipase Cgamma1 inhibitory principles from the sarcotestas of Ginkgo biloba.
AID379521Inhibition of PTP1B at 50 uM2006Journal of natural products, Nov, Volume: 69, Issue:11
A nitrogen-containing 3-alkyl-1,4-benzoquinone and a gomphilactone derivative from Embelia ribes.
AID335792Antibacterial activity against Bacillus subtilis CECT 397 at 200 ug/disk after 18 hrs by disk diffusion assay1993Journal of natural products, Oct, Volume: 56, Issue:10
Use of alkenylresorcinols from Ononis speciosa as synthetic precursors of compounds with potential biological activity.
AID335791Antibacterial activity against Bacillus megaterium at 100 ug/disk after 18 hrs by disk diffusion assay1993Journal of natural products, Oct, Volume: 56, Issue:10
Use of alkenylresorcinols from Ononis speciosa as synthetic precursors of compounds with potential biological activity.
AID379516Cytotoxicity against human A549 cells after 96 hrs by MTT assay2006Journal of natural products, Nov, Volume: 69, Issue:11
A nitrogen-containing 3-alkyl-1,4-benzoquinone and a gomphilactone derivative from Embelia ribes.
AID332455Inhibition of mushroom tyrosinase assessed as oxidation of L-DOPA at 0.8 mM1994Journal of natural products, Apr, Volume: 57, Issue:4
Tyrosinase inhibitors from Anacardium occidentale fruits.
AID335813Antifungal activity against Botrytis cinerea CECT 2850 after 18 hrs by disk diffusion assay1993Journal of natural products, Oct, Volume: 56, Issue:10
Use of alkenylresorcinols from Ononis speciosa as synthetic precursors of compounds with potential biological activity.
AID335804Antibacterial activity against Pseudomonas reptilovora after 18 hrs by disk diffusion assay1993Journal of natural products, Oct, Volume: 56, Issue:10
Use of alkenylresorcinols from Ononis speciosa as synthetic precursors of compounds with potential biological activity.
AID379518Cytotoxicity against human Bel-7402 cells after 96 hrs by MTT assay2006Journal of natural products, Nov, Volume: 69, Issue:11
A nitrogen-containing 3-alkyl-1,4-benzoquinone and a gomphilactone derivative from Embelia ribes.
AID379519Cytotoxicity against human BGC-823 cells after 96 hrs by MTT assay2006Journal of natural products, Nov, Volume: 69, Issue:11
A nitrogen-containing 3-alkyl-1,4-benzoquinone and a gomphilactone derivative from Embelia ribes.
AID335790Antibacterial activity against Bacillus megaterium at 200 ug/disk after 18 hrs by disk diffusion assay1993Journal of natural products, Oct, Volume: 56, Issue:10
Use of alkenylresorcinols from Ononis speciosa as synthetic precursors of compounds with potential biological activity.
AID401418Growth inhibition of human A549 cells after 2 days by SRB assay1998Journal of natural products, Jul, Volume: 61, Issue:7
Phospholipase Cgamma1 inhibitory principles from the sarcotestas of Ginkgo biloba.
AID401415Inhibition of bovine brain PI-PLCgamma11998Journal of natural products, Jul, Volume: 61, Issue:7
Phospholipase Cgamma1 inhibitory principles from the sarcotestas of Ginkgo biloba.
AID335806Antibacterial activity against Proteus after 18 hrs by disk diffusion assay1993Journal of natural products, Oct, Volume: 56, Issue:10
Use of alkenylresorcinols from Ononis speciosa as synthetic precursors of compounds with potential biological activity.
AID335808Antifungal activity against Saccharomyces cerevisiae S1 after 18 hrs by disk diffusion assay1993Journal of natural products, Oct, Volume: 56, Issue:10
Use of alkenylresorcinols from Ononis speciosa as synthetic precursors of compounds with potential biological activity.
AID401421Growth inhibition of human SKOV3 cells after 2 days by SRB assay1998Journal of natural products, Jul, Volume: 61, Issue:7
Phospholipase Cgamma1 inhibitory principles from the sarcotestas of Ginkgo biloba.
AID335796Antibacterial activity against Bacillus licheniformis CECT20 at 200 ug/disk after 18 hrs by disk diffusion assay1993Journal of natural products, Oct, Volume: 56, Issue:10
Use of alkenylresorcinols from Ononis speciosa as synthetic precursors of compounds with potential biological activity.
AID335793Antibacterial activity against Bacillus subtilis CECT 397 at 100 ug/disk after 18 hrs by disk diffusion assay1993Journal of natural products, Oct, Volume: 56, Issue:10
Use of alkenylresorcinols from Ononis speciosa as synthetic precursors of compounds with potential biological activity.
AID335801Antibacterial activity against Staphylococcus aureus ATCC 8 at 200 ug/disk after 18 hrs by disk diffusion assay1993Journal of natural products, Oct, Volume: 56, Issue:10
Use of alkenylresorcinols from Ononis speciosa as synthetic precursors of compounds with potential biological activity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's4 (33.33)18.2507
2000's3 (25.00)29.6817
2010's3 (25.00)24.3611
2020's2 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 22.56

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index22.56 (24.57)
Research Supply Index2.64 (2.92)
Research Growth Index4.68 (4.65)
Search Engine Demand Index31.58 (26.88)
Search Engine Supply Index3.00 (0.95)

This Compound (22.56)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (7.69%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (92.31%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
salicylic acid
Scalp: The outer covering of the calvaria. It is composed of several layers: SKIN; subcutaneous connective tissue; the occipitofrontal muscle which includes the tendinous galea aponeurotica; loose connective tissue; and the pericranium (the PERIOSTEUM of the SKULL).		2.3920monohydroxybenzoic acidalgal metabolite;
antifungal agent;
antiinfective agent;
EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor;
keratolytic drug;
plant hormone;
plant metabolite
3-cresol
3-cresol: RN given refers to parent cpd. m-cresol : A cresol with the methyl substituent at position 3. It is a minor urinary metabolite of toluene.		1.9910cresolhuman xenobiotic metabolite
melatonin
[no description available]		2.4920acetamides;
tryptamines		anticonvulsant;
central nervous system depressant;
geroprotector;
hormone;
human metabolite;
immunological adjuvant;
mouse metabolite;
radical scavenger
ciprofloxacin
Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.. ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.		2.0310aminoquinoline;
cyclopropanes;
fluoroquinolone antibiotic;
N-arylpiperazine;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone;
zwitterion		antibacterial drug;
antiinfective agent;
antimicrobial agent;
DNA synthesis inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
environmental contaminant;
topoisomerase IV inhibitor;
xenobiotic
embelin
embelin: from Embelia fruit (Myrsinaceae). embelin : A member of the class of dihydroxy-1,4-benzoquinones that is 2,5-dihydroxy-1,4-benzoquinone which is substituted by an undecyl group at position 3. Isolated from Lysimachia punctata and Embelia ribes, it exhibits antimicrobial, antineoplastic and inhibitory activity towards hepatitis C protease.		2.0310dihydroxy-1,4-benzoquinonesantimicrobial agent;
antineoplastic agent;
hepatitis C protease inhibitor;
plant metabolite
pentamidine
Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.. pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.		2.0310aromatic ether;
carboxamidine;
diether		anti-inflammatory agent;
antifungal agent;
calmodulin antagonist;
chemokine receptor 5 antagonist;
EC 2.3.1.48 (histone acetyltransferase) inhibitor;
NMDA receptor antagonist;
S100 calcium-binding protein B inhibitor;
trypanocidal drug;
xenobiotic
piracetam
Piracetam: A compound suggested to be both a nootropic and a neuroprotective agent.		2.0810organonitrogen compound;
organooxygen compound
resorcinol
resorcinol: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7951. resorcinol : A benzenediol that is benzene dihydroxylated at positions 1 and 3.		1.9810benzenediol;
phenolic donor;
resorcinols		erythropoietin inhibitor;
sensitiser
9,10-dimethyl-1,2-benzanthracene
9,10-Dimethyl-1,2-benzanthracene: Polycyclic aromatic hydrocarbon found in tobacco smoke that is a potent carcinogen.. 7,12-dimethyltetraphene : A tetraphene having methyl substituents at the 7- and 12-positions. It is a potent carcinogen and is present in tobacco smoke.		1.9710ortho-fused polycyclic arene;
tetraphenes		carcinogenic agent
catechin
Catechin: An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.. catechin : Members of the class of hydroxyflavan that have a flavan-3-ol skeleton and its substituted derivatives.. rac-catechin : A racemate comprising equimolar amounts of (+)- and (-)-catechin. (+)-catechin : The (+)-enantiomer of catechin and a polyphenolic antioxidant plant metabolite.		2.0310catechinantioxidant;
plant metabolite
orcinol
orcinol: used as reagent for pentoses, lignin, beet sugar, saccharoses, arabinose & diastase; RN given refers to parent cpd; structure. orcinol : A 5-alkylresorcinol in which the alkyl group is specified as methyl.		1.99105-alkylresorcinol;
dihydroxytoluene		Aspergillus metabolite
tetradecanoylphorbol acetate
Tetradecanoylphorbol Acetate: A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.. phorbol ester : Esters of phorbol, originally found in croton oil (from Croton tiglium, of the family Euphorbiaceae). A number of phorbol esters possess activity as tumour promoters and activate the mechanisms associated with cell growth. Some of these are used in experiments as activators of protein kinase C.. phorbol 13-acetate 12-myristate : A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.		1.9710acetate ester;
diester;
phorbol ester;
tertiary alpha-hydroxy ketone;
tetradecanoate ester		antineoplastic agent;
apoptosis inducer;
carcinogenic agent;
mitogen;
plant metabolite;
protein kinase C agonist;
reactive oxygen species generator
topotecan
Topotecan: An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA TOPOISOMERASES, TYPE I.. topotecan : A pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks.		2.0310pyranoindolizinoquinolineantineoplastic agent;
EC 5.99.1.2 (DNA topoisomerase) inhibitor
3-pentadecylphenol
3-pentadecylphenol: structure in first source		2.3920phenols
adipostatin a
adipostatin A: allergen from cashew nut shell oil; as adipostatin found as inhibitor of glycerol-3-phosphate dehydrogenase from Streptomyces; Also found in bees; do not confuse with cardol, RN 57486-25-6, MF unknown;. cardol : Resorcinol substituted at position 5 by a pentadecyl chain.		7.93405-alkylresorcinolEC 1.1.5.3 (glycerol-3-phosphate dehydrogenase) inhibitor
rapanone
rapanone: antiparasitic agent from Rapanea; structure similar to embelin		2.0310dihydroxy-1,4-benzoquinones
6-n-tridecylsalicylic acid
6-n-tridecylsalicylic acid: structure given in first source		1.9910hydroxybenzoic acid
5-heptadecylresorcinol
5-heptadecylresorcinol : A 5-alkylresorcinol that is resorcinol which is substituted by a heptadecyl group at position 5. It is found in wheat bran.		2.03105-alkylresorcinolantineoplastic agent;
plant metabolite
sitosterol, (3beta)-isomer
Sobatum: tradename; active fraction of Solanum trilobatum; reduces side-effects of radiation-induced toxicity. sitosterol : A member of the class of phytosterols that is stigmast-5-ene substituted by a beta-hydroxy group at position 3.		2.03103beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
C29-steroid;
phytosterols;
stigmastane sterol		anticholesteremic drug;
antioxidant;
mouse metabolite;
plant metabolite;
sterol methyltransferase inhibitor
arbutin
hydroquinone O-beta-D-glucopyranoside : A monosaccharide derivative that is hydroquinone attached to a beta-D-glucopyranosyl residue at position 4 via a glycosidic linkage.		1.9810beta-D-glucoside;
monosaccharide derivative		Escherichia coli metabolite;
plant metabolite
amphotericin b
Amphotericin B: Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.. amphotericin B : A macrolide antibiotic used to treat potentially life-threatening fungal infections.		2.0310antibiotic antifungal drug;
macrolide antibiotic;
polyene antibiotic		antiamoebic agent;
antiprotozoal drug;
bacterial metabolite
amentoflavone
[no description available]		1.9910biflavonoid;
hydroxyflavone;
ring assembly		angiogenesis inhibitor;
antiviral agent;
cathepsin B inhibitor;
P450 inhibitor;
plant metabolite
ginkgolic acid
[no description available]		2.6930hydroxybenzoic acid
koaburaside
koaburaside: an anti-histamine compound from Aeschynanthus bracteatus; structure in first source		2.0310
vinaxanthone
vinaxanthone: structure given in first source		1.9910
lyoniside
daucosterol : A steroid saponin that is sitosterol attached to a beta-D-glucopyranosyl residue at position 3 via a glycosidic linkage. It has bee isolated from Panax japonicus var. major and Breynia fruticosa.		2.0310beta-D-glucoside;
monosaccharide derivative;
steroid saponin		plant metabolite
2-hydroxy-6-[(8Z,11Z)-pentadeca-8,11,14-trien-1-yl]benzoic acid
[no description available]		1.9810hydroxybenzoic acid
(+)-lyoniresinol-3-alpha-O-beta-D-glucopyranoside
(+)-lyoniresinol-3-alpha-O-beta-D-glucopyranoside : A lignan that is (+)-lyoniresinol substituted by a beta-D-glucopyranosyl moiety at position 3 via a glycosidic linkage. Isolated from the root barks of Stemmadenia minima and Lycium chinense, it exhibits antimicrobial activities.		2.0310beta-D-glucoside;
dimethoxybenzene;
lignan;
monosaccharide derivative;
polyphenol;
primary alcohol;
tetralins		antibacterial agent;
antifungal agent;
metabolite
cardanol
cardanol: from pink pepper; phenol with hydrocarbon side chain which can vary in length & unsaturation		1.9810phenols
5-(pentadeca-8,11,14-trien-1-yl)resorcinol
5-(pentadeca-8,11,14-trien-1-yl)resorcinol : A resorcinol compound having an 8-cis,11-cis-pentadeca-8,11,14-trien-1-yl substituent at the 5-position.		1.98105-alkatrienylresorcinol
salicylates
Salicylates: The salts or esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and anti-inflammatory activities by inhibiting prostaglandin synthesis.. hydroxybenzoate : Any benzoate derivative carrying a single carboxylate group and at least one hydroxy substituent.. salicylates : Any salt or ester arising from reaction of the carboxy group of salicylic acid, or any ester resulting from the condensation of the phenolic hydroxy group of salicylic acid with an organic acid.. salicylate : A monohydroxybenzoate that is the conjugate base of salicylic acid.		210monohydroxybenzoateplant metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Congenital Zika Syndrome
[description not available]		02.3110
Zika Virus Infection
A viral disease transmitted by the bite of AEDES mosquitoes infected with ZIKA VIRUS. Its mild DENGUE-like symptoms include fever, rash, headaches and ARTHRALGIA. The viral infection during pregnancy, in rare cases, is associated with congenital brain and ocular abnormalities, called Congenital Zika Syndrome, including MICROCEPHALY and may also lead to GUILLAIN-BARRE SYNDROME.		02.3110
Cancer of Skin
[description not available]		01.9710
Skin Neoplasms
Tumors or cancer of the SKIN.		01.9710