Page last updated: 2024-10-24

sphingomyelin synthase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phosphocholine + ceramide = 1,2-diacyl-sn-glycerol + sphingomyelin. [EC:2.7.8.27, RHEA:18765]

Sphingomyelin synthase activity refers to the enzymatic activity that catalyzes the synthesis of sphingomyelin, a crucial phospholipid component of cell membranes. The reaction involves the transfer of a phosphocholine head group from phosphatidylcholine to ceramide, a long-chain fatty acid attached to sphingosine. This process is essential for maintaining membrane integrity, regulating cell signaling, and modulating the activity of membrane-associated proteins. Sphingomyelin synthase activity is vital for a diverse range of cellular functions, including cell growth, differentiation, and apoptosis. It plays a key role in the formation of lipid rafts, specialized microdomains within the plasma membrane that concentrate specific proteins and lipids involved in signaling pathways. Additionally, sphingomyelin synthase activity has been implicated in the pathogenesis of various diseases, including cancer, neurodegenerative disorders, and cardiovascular disease.'
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Proteins (4)

ProteinDefinitionTaxonomy
Phosphatidylcholine:ceramide cholinephosphotransferase 2A phosphatidylcholine:ceramide cholinephosphotransferase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHU3]Homo sapiens (human)
Phosphatidylcholine:ceramide cholinephosphotransferase 1 A phosphatidylcholine:ceramide cholinephosphotransferase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86VZ5]Homo sapiens (human)
Phosphatidylcholine:ceramide cholinephosphotransferase 2A phosphatidylcholine:ceramide cholinephosphotransferase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NHU3]Homo sapiens (human)
Phosphatidylcholine:ceramide cholinephosphotransferase 1 A phosphatidylcholine:ceramide cholinephosphotransferase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86VZ5]Homo sapiens (human)

Compounds (6)

CompoundDefinitionClassesRoles
malabaricone cmalabaricone C: from maize (Myristica fragrans); structure given in first sourcebutanonemetabolite
malabaricone bmalabaricone B: from maize (Myristica fragrans); structure given in first source
malabaricone amalabaricone A: from Myristica malabarica (rampatri), has antipromastigote activity; structure in first source
d 609
2-(2-methoxyanilino)-2-(2-phenylmethoxyphenyl)acetonitrilearomatic ether;
substituted aniline
ginkgolic acidhydroxybenzoic acid