isoascorbic-acid and Neoplasms

isoascorbic-acid has been researched along with Neoplasms* in 2 studies

Other Studies

2 other study(ies) available for isoascorbic-acid and Neoplasms

Article	Year
Sodium erythorbate is not carcinogenic in F344 rats. Experimental and molecular pathology, 1984, Volume: 41, Issue:1 Carcinogenicity of sodium erythorbate, a widely used antioxidant food additive, was evaluated using a total of 306 eight-week-old male and female F344/DuCrj rats. Test rats were given 1.25 or 2.5% aqueous solution as drinking water for 104 weeks. Controls were given tap water. All the rats were fed commercial pellets. None of the tumors observed was attributable to sodium erythorbate in drinking water. Neither concentration of sodium erythorbate changed the pattern of spontaneous tumor development in both sexes, except for a slight reduction in aggregate tumor incidence in the 2.5% Group females. Additionally, 2.5% solution suppressed body weight gains in both males and females. These results and prior data by others together suggest that weak mutagens may be noncarcinogenic under certain conditions. Topics: Aging; Animals; Antioxidants; Ascorbic Acid; Body Weight; Female; Food Additives; Male; Neoplasms; Rats; Rats, Inbred F344	1984
Effect of erythorbate on N-methyl-N'-nitro-N-nitrosoguanidine-induced stomach carcinogenesis in F344 rats. The science reports of the research institutes, Tohoku University. Ser. C, Medicine. Tohoku Daigaku, 1983, Volume: 30, Issue:1-4 Topics: Adenocarcinoma; Animals; Antioxidants; Ascorbic Acid; Carcinoma, Squamous Cell; Male; Methylnitronitrosoguanidine; Neoplasms; Rats; Rats, Inbred F344; Sarcoma; Stomach Neoplasms	1983

Article

Year

Sodium erythorbate is not carcinogenic in F344 rats.

Experimental and molecular pathology, 1984, Volume: 41, Issue:1

Carcinogenicity of sodium erythorbate, a widely used antioxidant food additive, was evaluated using a total of 306 eight-week-old male and female F344/DuCrj rats. Test rats were given 1.25 or 2.5% aqueous solution as drinking water for 104 weeks. Controls were given tap water. All the rats were fed commercial pellets. None of the tumors observed was attributable to sodium erythorbate in drinking water. Neither concentration of sodium erythorbate changed the pattern of spontaneous tumor development in both sexes, except for a slight reduction in aggregate tumor incidence in the 2.5% Group females. Additionally, 2.5% solution suppressed body weight gains in both males and females. These results and prior data by others together suggest that weak mutagens may be noncarcinogenic under certain conditions.

Topics: Aging; Animals; Antioxidants; Ascorbic Acid; Body Weight; Female; Food Additives; Male; Neoplasms; Rats; Rats, Inbred F344

1984

Effect of erythorbate on N-methyl-N'-nitro-N-nitrosoguanidine-induced stomach carcinogenesis in F344 rats.

The science reports of the research institutes, Tohoku University. Ser. C, Medicine. Tohoku Daigaku, 1983, Volume: 30, Issue:1-4

Topics: Adenocarcinoma; Animals; Antioxidants; Ascorbic Acid; Carcinoma, Squamous Cell; Male; Methylnitronitrosoguanidine; Neoplasms; Rats; Rats, Inbred F344; Sarcoma; Stomach Neoplasms

1983