hamigeran b

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

hamigeran B: has antiviral activity; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	9976066
CHEMBL ID	380587
MeSH ID	M0464667

Synonyms (3)

Synonym
hamigeran b
CHEMBL380587
(1r,3ar,9br)-7-bromo-6-hydroxy-3a,8-dimethyl-1-propan-2-yl-1,2,3,9b-tetrahydrocyclopenta[a]naphthalene-4,5-dione

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (6)

Assay ID	Title	Year	Journal	Article
AID255785	In vitro cytotoxicity against leukemia P-388 tumor cells	2005	Journal of medicinal chemistry, Sep-08, Volume: 48, Issue:18	Joys of molecules. 2. Endeavors in chemical biology and medicinal chemistry.
AID378904	Cytotoxicity against mouse P388 cells	2000	Journal of natural products, Jan, Volume: 63, Issue:1	Chemistry of sponges. 19. Novel bioactive metabolites from Hamigera tarangaensis.
AID378913	Antiviral activity against Poliovirus	2000	Journal of natural products, Jan, Volume: 63, Issue:1	Chemistry of sponges. 19. Novel bioactive metabolites from Hamigera tarangaensis.
AID378905	Antibacterial activity against Escherichia coli	2000	Journal of natural products, Jan, Volume: 63, Issue:1	Chemistry of sponges. 19. Novel bioactive metabolites from Hamigera tarangaensis.
AID378906	Antifungal activity against Candida albicans	2000	Journal of natural products, Jan, Volume: 63, Issue:1	Chemistry of sponges. 19. Novel bioactive metabolites from Hamigera tarangaensis.
AID378912	Antiviral activity against Herpesvirus	2000	Journal of natural products, Jan, Volume: 63, Issue:1	Chemistry of sponges. 19. Novel bioactive metabolites from Hamigera tarangaensis.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (15)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	9 (60.00)	29.6817
2010's	5 (33.33)	24.3611
2020's	1 (6.67)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 20.17

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	20.17 (24.57)
Research Supply Index	2.77 (2.92)
Research Growth Index	5.32 (4.65)
Search Engine Demand Index	15.26 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (20.17)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	15 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
cyclopentanol [no description available]	2.13	1	cyclopentanols
3-hydroxybutanal [no description available]	2.05	1
cyclopentane Cyclopentanes: A group of alicyclic hydrocarbons with the general formula R-C5H9.. cyclopentanes : Cyclopentane and its derivatives formed by substitution.	2.48	2	cycloalkane; cyclopentanes; volatile organic compound	non-polar solvent
propadiene [no description available]	2.05	1	allenes
iridium Iridium: A metallic element with the atomic symbol Ir, atomic number 77, and atomic weight 192.22.	2.13	1	cobalt group element atom; platinum group metal atom
palladium Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.	2.73	3	metal allergen; nickel group element atom; platinum group metal atom
rhodium Rhodium: A hard and rare metal of the platinum group, atomic number 45, atomic weight 102.905, symbol Rh.. rhodium atom : A cobalt group element atom of atomic number 45.	2.04	1	cobalt group element atom
paclitaxel Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).	2.02	1	taxane diterpenoid; tetracyclic diterpenoid	antineoplastic agent; human metabolite; metabolite; microtubule-stabilising agent
epothilone b [no description available]	2.02	1	epothilone; epoxide	antineoplastic agent; apoptosis inducer; microtubule-stabilising agent
epothilone a Epothilones: A group of 16-member MACROLIDES which stabilize MICROTUBULES in a manner similar to PACLITAXEL. They were originally found in the myxobacterium Sorangium cellulosum, now renamed to Polyangium (MYXOCOCCALES).	2.02	1	epothilone; epoxide	antineoplastic agent; metabolite; microtubule-stabilising agent; tubulin modulator
naphthoquinones Naphthoquinones: Naphthalene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.	3.99	13
sirolimus Sirolimus: A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.. sirolimus : A macrolide lactam isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent.	2.02	1	antibiotic antifungal drug; cyclic acetal; cyclic ketone; ether; macrolide lactam; organic heterotricyclic compound; secondary alcohol	antibacterial drug; anticoronaviral agent; antineoplastic agent; bacterial metabolite; geroprotector; immunosuppressive agent; mTOR inhibitor
ophiocordin azepinostatin: isolated from Fusarium merismoides; structure in first source; RN assigned by CAS - 63590-19-2 (ophiocordin; azepinostatin is not the same as ophiocordin)	2.02	1
fexaramine fexaramine: structure in first source	2.02	1	biphenyls
silicon Silicon: A trace element that constitutes about 27.6% of the earth's crust in the form of SILICON DIOXIDE. It does not occur free in nature. Silicon has the atomic symbol Si, atomic number 14, and atomic weight [28.084; 28.086].	2.42	2	carbon group element atom; metalloid atom; nonmetal atom
sarcodictyin a sarcodictyin A: structure in first source	2.02	1
psammaplin a psammaplin A: isolated from marine sponges Poecillastra and Jaspis; structure in second source	2.02	1
apicularen a apicularen A: isolated from Chondromyces; structure in first source	2.02	1
brevetoxin b brevetoxin B: from dinoflagellate Gymnodinium breve	2.02	1	ciguatoxin
103d5r 103D5R: small-molecule inhibitor of the hypoxia-inducible factor 1 pathway; structure in first source	2.02	1
somatostatin [no description available]	2.02	1	heterodetic cyclic peptide; peptide hormone

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