psammaplin-a has been researched along with HIV-Infections* in 2 studies
2 other study(ies) available for psammaplin-a and HIV-Infections
| Article | Year |
|---|---|
Identification of Novel HIV-1 Latency-Reversing Agents from a Library of Marine Natural Products.
Natural products originating from marine and plant materials are a rich source of chemical diversity and unique antimicrobials. Using an established Topics: Anti-HIV Agents; Aquatic Organisms; Biological Products; CD4-Positive T-Lymphocytes; Cell Line; Cell Survival; Disulfides; Drug Discovery; High-Throughput Screening Assays; HIV Infections; HIV-1; Humans; Panobinostat; Phorbol Esters; Proviruses; Tyrosine; Virus Activation; Virus Latency | 2018 |
Study of marine natural products including resorcyclic acid lactones from Humicola fuscoatra that reactivate latent HIV-1 expression in an in vitro model of central memory CD4+ T cells.
An extract of Humicola fuscoatra (UCSC strain no. 108111A) was shown to reactivate latent HIV-1 expression in an in vitro model of central memory CD4+ T cells. We report the bioassay-guided isolation and structure determination of several resorcyclic acid lactones, including four known compounds, radicicol (1, aka. monorden) and pochonins B (2), C (3), and N (4), and three new analogues, radicicols B-D (5-7). Compounds 1-3 and 5 showed moderate activities in the memory T cell model of HIV-1 latency. Radicicol (1) displayed lower potency in reactivating latent HIV-1 (EC50 = 9.1 μM) relative to the HDAC inhibitors apicidin (EC50 = 0.3 μM), romidepsin (EC50 = 0.003 μM), and SAHA (EC50 = 0.6 μM); however, it achieved equivalent maximum efficacy relative to the positive control compounds (98% of SAHA and romidepsin). Topics: Ascomycota; Biological Products; CD4-Positive T-Lymphocytes; Histone Deacetylase Inhibitors; HIV Infections; HIV-1; Humans; Lactones; Macrolides; Marine Biology; Models, Biological; Molecular Structure; Virus Latency | 2014 |