Compounds > t-muurolol
Page last updated: 2024-12-10

t-muurolol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

T-muurolol: antifungal from Calocedrus formosana leaf; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

(-)-Tau-muurolol : A cadinane sesquiterpenoid that consists of 4-isopropyl-1,6-dimethyl-1,2,3,4,4a,7,8,8a-octahydronaphthalene having a hydroxy substituent at position 1 and (1S,4S,4aR,8aS)-configuration. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

FloraRankFlora DefinitionFamilyFamily Definition
Calocedrusgenus[no description available]CupressaceaeA plant family of the order Pinales, class Pinopsida, division Tracheophyta. They are mainly resinous, aromatic evergreen trees.[MeSH]
Calocedrus formosanaspecies[no description available]CupressaceaeA plant family of the order Pinales, class Pinopsida, division Tracheophyta. They are mainly resinous, aromatic evergreen trees.[MeSH]

Cross-References

ID SourceID
PubMed CID3084331
CHEMBL ID2228956
CHEBI ID132906
SCHEMBL ID5653479
MeSH IDM0483228

Synonyms (21)

Synonym
1-naphthalenol, 1,2,3,4,4a,7,8,8a-octahydro-1,6-dimethyl-4-(1-methylethyl)-, (1s-(1alpha,4alpha,4aalpha,8aalpha))-
epi-alpha-muurolol
(1s,4s,4ar,8as)-4-isopropyl-1,6-dimethyl-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-ol
alpha-epi-muurolol
(-)-tau-muurolol
10-epi-alpha-muurolol
t-muurolol
CHEBI:132906
19912-62-0
(1s,4s,4ar,8as)-1,6-dimethyl-4-propan-2-yl-3,4,4a,7,8,8a-hexahydro-2h-naphthalen-1-ol
CHEMBL2228956
SCHEMBL5653479
.alpha.-epi-muurolol
epi-.alpha.-muurolol
LHYHMMRYTDARSZ-AJNGGQMLSA-N
t-muuroloi
4-isopropyl-1,6-dimethyl-1,2,3,4,4a,7,8,8a-octahydro-1-naphthalenol-, [1s-(1.alpha.,4.alpha.,4a.alpha.,8a.alpha.)]-
(-)-t-muurolol
muurolol t
DTXSID10173698
Q63409422
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (5)

RoleDescription
plant metaboliteAny eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
fungicideA substance used to destroy fungal pests.
volatile oil componentAny plant metabolite that is found naturally as a component of a volatile oil.
marine metaboliteAny metabolite produced during a metabolic reaction in marine macro- and microorganisms.
bacterial metaboliteAny prokaryotic metabolite produced during a metabolic reaction in bacteria.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (4)

ClassDescription
cadinane sesquiterpenoidAny sesquiterpenoid with a cadinane skeleton.
carbobicyclic compoundA bicyclic compound in which all the ring atoms are carbon.
tertiary alcoholA tertiary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has three other carbon atoms attached to it.
octahydronaphthalenesAny carbobycyclic compound that is an octahydronaphthalene or a compound obtained from an octahydronaphthalene by formal substitution of one or more hydrogens.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (4)

Assay IDTitleYearJournalArticle
AID1082713Antifungal activity against Laetiporus sulphureus BCRC 35305 (wood decay fungi) assessed as reduction of fungi mycelium growth at 100 ug/ml2012Journal of agricultural and food chemistry, Jan-11, Volume: 60, Issue:1
Phytochemicals from Cunninghamia konishii Hayata act as antifungal agents.
AID1082714Antifungal activity against Trametes versicolor BCRC 35253 wood decay fungi assessed as reduction of fungi mycelium growth at 100 ug/ml2012Journal of agricultural and food chemistry, Jan-11, Volume: 60, Issue:1
Phytochemicals from Cunninghamia konishii Hayata act as antifungal agents.
AID1082715Antifungal activity against Lenzites betulinus BCRC 35296 assessed as reduction of fungi mycelium growth at 100 ug/ml2012Journal of agricultural and food chemistry, Jan-11, Volume: 60, Issue:1
Phytochemicals from Cunninghamia konishii Hayata act as antifungal agents.
AID1082712Antifungal activity against Gloeophyllum trabeum BCRC 31614 (wood decay fungi) assessed as reduction of fungi mycelium growth at 100 ug/ml2012Journal of agricultural and food chemistry, Jan-11, Volume: 60, Issue:1
Phytochemicals from Cunninghamia konishii Hayata act as antifungal agents.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (14.29)29.6817
2010's6 (85.71)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 24.89

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index24.89 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index5.33 (4.65)
Search Engine Demand Index23.28 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (24.89)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
linalool
linalool: RN given refers to parent cpd without isomeric designation; structure. linalool : A monoterpenoid that is octa-1,6-diene substituted by methyl groups at positions 3 and 7 and a hydroxy group at position 3. It has been isolated from plants like Ocimum canum.		2.0710monoterpenoid;
tertiary alcohol		antimicrobial agent;
fragrance;
plant metabolite;
volatile oil component
alpha-pinene
[no description available]		2.110pineneplant metabolite
sabinene
sabinene: RN given refers to cpd without isomeric designation. sabinene : A thujene that is a bicyclic monoterpene isolated from the essential oils of various plant species.		2.110thujeneplant metabolite
didecyldimethylammonium chloride
[no description available]		2.0710organic molecular entity
cedrol
cedrol: a cyclic terpenoid from cedarwood oil; 8-epicedrol is an epimer		2.0710cedrane sesquiterpenoid;
tertiary alcohol
t-cadinol
T-cadinol: extract of scented myrrh; RN given refers to (1S-(1alpha,4alpha,4aalpha,8abeta)-isomer; RN for cpd without isomeric designation not avail 3/92; structure given in first source. tau-cadinol : A cadinane sesquiterpenoid that is cadin-4-ene carrying a hydroxy substituent at position 10.		2.0710cadinane sesquiterpenoid;
carbobicyclic compound;
octahydronaphthalenes;
tertiary alcohol		plant metabolite;
volatile oil component
farnesyl pyrophosphate
farnesyl pyrophosphate: a sesquiterpene that dimerizes to SQUALENE; RN given refers to cpd without isomeric designation. 2-trans,6-trans-farnesyl diphosphate : The trans,trans-stereoisomer of farnesyl diphosphate.		2.0610farnesyl diphosphateEscherichia coli metabolite;
mouse metabolite
spathulenol
spathulenol: sesquiterpene alcohol isolated from essential oils of Artemisia vulgaris L. & Artemisia dracunculus L.. spathulenol : A tricyclic sesquiterpenoid that is 4-methylidenedecahydro-1H-cyclopropa[e]azulene carrying three methyl substituents at positions 1, 1 and 7 as well as a hydroxy substituent at position 7.		2.0810
sesquiterpenes
[no description available]		3.1850
cadinol
cadinol: from callus cultures of Chamomilla recutita (Asteraceae)		2.4420
gamma-cadinene
gamma-cadinene: metabolite from Aspergillus terreus; RN given for compound with no isomeric designation; structure given. (+)-gamma-cadinene : A member of the cadinene family of sesquiterpenes in which the isopropyl group is cis to the hydrogen at the adjacent bridgehead carbon (the 1S,4aR,8aR enantiomer).		2.0610cadinene;
gamma-cadinene;
octahydronaphthalenes
cadinane
cadinane: structure in first source. cadinane : A sesquiterpene consisting of decalin having two methyl substituents at the 1- and 6-positions, an isopropyl substituent at the 4-position and (1S,4S,4aS,6S,8aS)-configuration.		7.1310sesquiterpene;
terpenoid fundamental parent
viridiflorol
viridiflorol: a strong feeding deterrent for the melaleuca weevil that retards larval development; structure in first source. viridiflorol : A carbotricyclic compound that is (1aS,4aR,7aR,7bR)-decahydro-1H-cyclopropa[e]azulene carrying four methyl substituents at positions 1, 1, 4 and 7 as well as a hydroxy substituent at position 4. It is a sesquiterpenoid isolated from several plant species and is a strong feeding deterrent for the melaleuca weevil that retards larval development.		2.0710carbotricyclic compound;
sesquiterpenoid;
tertiary alcohol		anti-inflammatory agent;
antifeedant;
antimycobacterial drug;
plant metabolite;
volatile oil component
ConditionIndicatedRelationship StrengthStudiesTrials