An EC 3.4.22.* (cysteine endopeptidase) inhibitor which interferes with the action of cathepsin L (EC 3.4.22.15).
ChEBI ID: 70821
| Member | Definition | Class |
|---|---|---|
| benzyloxycarbonylphenylalanylphenylalanine diazomethyl ketone | A diazo compound that is L-phenylalanyl-L-phenylalanine in which the amino group is protected by a (benzyloxy)carbonyl group and the carboxy group is substituted by a diazoacetyl group. It is a cathepsin L inhibitor. | Z-Phe-Phe-CHN2 |
| sid 26681509 | A carbohydrazide that is L-tryptophan in which the amino and carboxy groups are substituted by tert-butoxycarbonyl and 2-({[2-(2-ethylanilino)-2-oxoethyl]sulfanyl}carbonyl)hydrazinyl groups, respectively. It is a potent and reversible inhibitor of human cathepsin L (IC50 = 56 nM). | SID 26681509 |
| tln 4601 | diazepinomicin |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 5 (17.24) | 18.7374 |
| 1990's | 5 (17.24) | 18.2507 |
| 2000's | 8 (27.59) | 29.6817 |
| 2010's | 8 (27.59) | 24.3611 |
| 2020's | 3 (10.34) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 1 (3.45%) | 5.53% |
| Reviews | 2 (6.90%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 26 (89.66%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Procathepsin L | Homo sapiens (human) | IC50 | 0.0540 | 3 | 3 |
| procathepsin L isoform 1 preproprotein | Homo sapiens (human) | IC50 | 0.2014 | 1 | 1 |