ly 274614 has been researched along with n-methylaspartate in 10 studies
| Studies (ly 274614) | Trials (ly 274614) | Recent Studies (post-2010) (ly 274614) | Studies (n-methylaspartate) | Trials (n-methylaspartate) | Recent Studies (post-2010) (n-methylaspartate) |
|---|---|---|---|---|---|
| 96 | 0 | 15 | 10,408 | 59 | 1,902 |
| Protein | Taxonomy | ly 274614 (IC50) | n-methylaspartate (IC50) |
|---|---|---|---|
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | 5.175 | |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | 5.175 | |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | 5.175 | |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | 5.175 | |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | 5.175 | |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | 5.175 | |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | 5.175 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (30.00) | 18.2507 |
| 2000's | 6 (60.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Leander, JD; Ornstein, PL; Salhoff, CR; Schoepp, DD | 1 |
| Ellison, G | 1 |
| Fabiano, C; Ientile, R; Macaione, S; Macaione, V; Pedale, S; Picciurro, V | 1 |
| Birk, AV; Cheng, PY; Gershengorn, MC; Szeto, HH | 1 |
| Davis, AM; Inturrisi, CE | 1 |
| Adler, MW; Cowan, A; Geller, EB; Rawls, SM; Tallarida, RJ | 1 |
| Galizio, M; Keith, JR; Mansfield, WJ; Pitts, RC | 1 |
| Allen, RM; Carelli, RM; Dykstra, LA; Everett, CV; Suchey, TL | 1 |
| Dykstra, LA; Fischer, BD | 1 |
| Adami, MB; Almeida, J; Barretto-de-Souza, L; Crestani, CC; Duarte, JO | 1 |
10 other study(ies) available for ly 274614 and n-methylaspartate
| Article | Year |
|---|---|
Neuroprotectant effects of LY274614, a structurally novel systemically active competitive NMDA receptor antagonist.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Binding, Competitive; Brain; Dose-Response Relationship, Drug; Female; Ibotenic Acid; Isoquinolines; Kainic Acid; Male; N-Methylaspartate; Nerve Degeneration; Quisqualic Acid; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
Competitive and non-competitive NMDA antagonists induce similar limbic degeneration.
Topics: Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Isoquinolines; Limbic System; N-Methylaspartate; Nerve Degeneration; Phencyclidine; Rats; Time Factors | 1994 |
Nitric oxide mediates NMDA-evoked [3H]GABA release from chick retina cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Differentiation; Cells, Cultured; Chick Embryo; Cyclic GMP; Dizocilpine Maleate; gamma-Aminobutyric Acid; Isoquinolines; N-Methylaspartate; Nitric Oxide; Nitroarginine; Nitrogen Oxides; Purinones; Receptors, N-Methyl-D-Aspartate; Retina; Spermine; Tritium | 1997 |
Dynorphin stimulates corticotropin release from mouse anterior pituitary AtT-20 cells through nonopioid mechanisms.
Topics: Adrenocorticotropic Hormone; Animals; Cell Line; Corticotropin-Releasing Hormone; Dynorphins; Endorphins; Excitatory Amino Acid Antagonists; Isoquinolines; Mice; N-Methylaspartate; Narcotics; Peptide Fragments; Pituitary Gland, Anterior | 2000 |
Attenuation of hyperalgesia by LY235959, a competitive N-methyl-D-aspartate receptor antagonist.
Topics: Animals; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hot Temperature; Hyperalgesia; Injections, Spinal; Isoquinolines; Male; N-Methylaspartate; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 2001 |
N-methyl-D-aspartate antagonists and WIN 55212-2 [4,5-dihydro-2-methyl-4(4-morpholinylmethyl)-1-(1-naphthalenyl-carbonyl)-6H-pyrrolo[3,2,1-i,j]quinolin-6-one], a cannabinoid agonist, interact to produce synergistic hypothermia.
Topics: Animals; Benzoxazines; Body Temperature; Calcium Channel Blockers; Cannabinoids; Dextromethorphan; Drug Synergism; Excitatory Amino Acid Antagonists; Hypothermia; Isoquinolines; Kinetics; Morpholines; N-Methylaspartate; Naphthalenes; Rats; Receptors, Cannabinoid; Receptors, Drug; Structure-Activity Relationship | 2002 |
Repeated spatial acquisition: effects of NMDA antagonists and morphine.
Topics: Analgesics, Opioid; Animals; Avoidance Learning; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Morphine; N-Methylaspartate; Naloxone; Narcotic Antagonists; Phencyclidine; Rats; Rats, Sprague-Dawley; Serial Learning; Space Perception | 2003 |
Effects of the competitive N-methyl-D-aspartate receptor antagonist, LY235959 [(-)-6-phosphonomethyl-deca-hydroisoquinoline-3-carboxylic acid], on responding for cocaine under both fixed and progressive ratio schedules of reinforcement.
Topics: Animals; Cocaine; Dextromethorphan; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Isoquinolines; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reinforcement Schedule; Self Administration | 2005 |
Interactions between an N-methyl-D-aspartate antagonist and low-efficacy opioid receptor agonists in assays of schedule-controlled responding and thermal nociception.
Topics: Analgesics, Opioid; Animals; Buprenorphine; Butorphanol; Conditioning, Psychological; Dose-Response Relationship, Drug; Drug Interactions; Hot Temperature; Isoquinolines; Male; Mice; Mice, Inbred BALB C; Morphine; N-Methylaspartate; Nalbuphine; Receptors, Opioid | 2006 |
Both N-methyl-D-aspartate and non-N-methyl-D-aspartate glutamate receptors in the bed nucleus of the stria terminalis modulate the cardiovascular responses to acute restraint stress in rats.
Topics: Animals; Blood Pressure; Cardiovascular System; Heart Rate; Isoquinolines; Male; N-Methylaspartate; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Restraint, Physical; Septal Nuclei; Skin Temperature; Stress, Psychological; Synaptic Transmission | 2017 |