Page last updated: 2024-09-03

ly 274614 and naltrexone

ly 274614 has been researched along with naltrexone in 3 studies

Compound Research Comparison

Studies
(ly 274614)
Trials
(ly 274614)
Recent Studies (post-2010)
(ly 274614)
Studies
(naltrexone)
Trials
(naltrexone)
Recent Studies (post-2010) (naltrexone)
960158,7451,2282,642

Protein Interaction Comparison

ProteinTaxonomyly 274614 (IC50)naltrexone (IC50)
Cytochrome P450 2D6Homo sapiens (human)1
Delta-type opioid receptorMus musculus (house mouse)0.0051
Delta-type opioid receptorRattus norvegicus (Norway rat)0.0063
Kappa-type opioid receptorMus musculus (house mouse)0.006
Mu-type opioid receptorRattus norvegicus (Norway rat)0.0005
Kappa-type opioid receptorRattus norvegicus (Norway rat)0.0005
Mu-type opioid receptorHomo sapiens (human)0.006
Delta-type opioid receptorHomo sapiens (human)0.0319
Kappa-type opioid receptorCavia porcellus (domestic guinea pig)0.0093
Kappa-type opioid receptorHomo sapiens (human)0.0377
Mu-type opioid receptorMus musculus (house mouse)0.0076
Mu-type opioid receptorCavia porcellus (domestic guinea pig)0.0004

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (66.67)18.2507
2000's1 (33.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fuller, RW; Ornstein, PL; Perry, KW; Rasmussen, K; Stockton, ME; Swinford, RM1
Brodsky, M; Inturrisi, CE; Rasmussen, K1
Juni, A; Kest, B; Klein, G; Kowalczyk, B; Ragnauth, A1

Other Studies

3 other study(ies) available for ly 274614 and naltrexone

ArticleYear
NMDA receptor antagonists suppress behaviors but not norepinephrine turnover or locus coeruleus unit activity induced by opiate withdrawal.
    European journal of pharmacology, 1991, May-02, Volume: 197, Issue:1

    Topics: Animals; Behavior, Animal; Dizocilpine Maleate; Electrophysiology; Isoquinolines; Locus Coeruleus; Male; Morphine; Naltrexone; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome

1991
NMDA antagonists and clonidine block c-fos expression during morphine withdrawal.
    Synapse (New York, N.Y.), 1995, Volume: 20, Issue:1

    Topics: Animals; Clonidine; Dizocilpine Maleate; Gene Expression; Genes, fos; In Vitro Techniques; Isoquinolines; Male; Morphine; Naltrexone; Neural Pathways; Nucleic Acid Hybridization; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA Probes; RNA, Messenger; Substance Withdrawal Syndrome

1995
Sex differences in hyperalgesia during morphine infusion: effect of gonadectomy and estrogen treatment.
    Neuropharmacology, 2008, Volume: 54, Issue:8

    Topics: Analgesics, Opioid; Animals; Data Interpretation, Statistical; Dizocilpine Maleate; Dose-Response Relationship, Drug; Estrogens; Excitatory Amino Acid Antagonists; Female; Hyperalgesia; Infusions, Intravenous; Isoquinolines; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Orchiectomy; Ovariectomy; Pain Measurement; Receptors, N-Methyl-D-Aspartate; Sex Characteristics

2008