Page last updated: 2024-09-03

ly 274614 and u-50488

ly 274614 has been researched along with u-50488 in 3 studies

Compound Research Comparison

Studies (ly 274614)	Trials (ly 274614)	Recent Studies (post-2010) (ly 274614)	Studies (u-50488)	Trials (u-50488)	Recent Studies (post-2010) (u-50488)
96	0	15	1,664	3	209

Protein Interaction Comparison

Protein	Taxonomy	u-50488 (IC50)
Delta-type opioid receptor	Rattus norvegicus (Norway rat)	2.15
Kappa-type opioid receptor	Mus musculus (house mouse)	0.0027
Mu-type opioid receptor	Rattus norvegicus (Norway rat)	2.15
Kappa-type opioid receptor	Rattus norvegicus (Norway rat)	0.7171
Kappa-type opioid receptor	Cavia porcellus (domestic guinea pig)	0.0958
Kappa-type opioid receptor	Homo sapiens (human)	0.0537

Research

Studies (3)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	3 (100.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Elliott, K; Inturrisi, CE; Kolesnikov, YA; Minami, N; Pasternak, GW	1
Elliott, K; Inturrisi, CE; Kao, B; Kest, B; Man, A	1
Bhargava, HN; Thorat, SN	1

Reviews

1 review(s) available for ly 274614 and u-50488

Article	Year
N-methyl-D-aspartate (NMDA) receptors, mu and kappa opioid tolerance, and perspectives on new analgesic drug development. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1995, Volume: 13, Issue:4 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Dextromethorphan; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Isoquinolines; Narcotics; Nitric Oxide Synthase; Opioid-Related Disorders; Pyrrolidines; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa; Receptors, Opioid, mu	1995

Article

Year

N-methyl-D-aspartate (NMDA) receptors, mu and kappa opioid tolerance, and perspectives on new analgesic drug development.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1995, Volume: 13, Issue:4

Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Dextromethorphan; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Isoquinolines; Narcotics; Nitric Oxide Synthase; Opioid-Related Disorders; Pyrrolidines; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa; Receptors, Opioid, mu

1995

Other Studies

2 other study(ies) available for ly 274614 and u-50488

Article	Year
The NMDA receptor antagonists, LY274614 and MK-801, and the nitric oxide synthase inhibitor, NG-nitro-L-arginine, attenuate analgesic tolerance to the mu-opioid morphine but not to kappa opioids. Pain, 1994, Volume: 56, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Oxidoreductases; Analgesics; Animals; Arginine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Tolerance; Injections, Subcutaneous; Isoquinolines; Male; Mice; Morphine; Naloxone; Nitric Oxide Synthase; Nitroarginine; Pyrrolidines; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa; Receptors, Opioid, mu	1994
Differential effects of LY235959, a competitive antagonist of the NMDA receptor on kappa-opioid receptor agonist induced responses in mice and rats. Brain research, 1997, Feb-07, Volume: 747, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Binding, Competitive; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Mice; Pain Measurement; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa	1997

Article

Year

The NMDA receptor antagonists, LY274614 and MK-801, and the nitric oxide synthase inhibitor, NG-nitro-L-arginine, attenuate analgesic tolerance to the mu-opioid morphine but not to kappa opioids.

Pain, 1994, Volume: 56, Issue:1

Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Oxidoreductases; Analgesics; Animals; Arginine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Tolerance; Injections, Subcutaneous; Isoquinolines; Male; Mice; Morphine; Naloxone; Nitric Oxide Synthase; Nitroarginine; Pyrrolidines; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa; Receptors, Opioid, mu

1994

Differential effects of LY235959, a competitive antagonist of the NMDA receptor on kappa-opioid receptor agonist induced responses in mice and rats.

Brain research, 1997, Feb-07, Volume: 747, Issue:2

Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Binding, Competitive; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Mice; Pain Measurement; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa

1997