ly 274614 has been researched along with morphine in 28 studies
| Studies (ly 274614) | Trials (ly 274614) | Recent Studies (post-2010) (ly 274614) | Studies (morphine) | Trials (morphine) | Recent Studies (post-2010) (morphine) |
|---|---|---|---|---|---|
| 96 | 0 | 15 | 44,270 | 5,200 | 8,695 |
| Protein | Taxonomy | ly 274614 (IC50) | morphine (IC50) |
|---|---|---|---|
| Delta-type opioid receptor | Mus musculus (house mouse) | 0.2939 | |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | 0.2278 | |
| Kappa-type opioid receptor | Mus musculus (house mouse) | 0.0828 | |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0385 | |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0545 | |
| Mu-type opioid receptor | Homo sapiens (human) | 0.122 | |
| Delta-type opioid receptor | Homo sapiens (human) | 0.1199 | |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.9308 | |
| Kappa-type opioid receptor | Homo sapiens (human) | 0.655 | |
| Mu-type opioid receptor | Mus musculus (house mouse) | 0.3305 | |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.202 | |
| Beta-2 adrenergic receptor | Cavia porcellus (domestic guinea pig) | 0.25 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (35.71) | 18.2507 |
| 2000's | 16 (57.14) | 29.6817 |
| 2010's | 2 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fuller, RW; Ornstein, PL; Perry, KW; Rasmussen, K; Stockton, ME; Swinford, RM | 1 |
| Elliott, K; Inturrisi, CE; Kolesnikov, YA; Minami, N; Pasternak, GW | 1 |
| Brodsky, M; Inturrisi, CE; Rasmussen, K | 1 |
| Cheng, J; Inturrisi, CE; Pasternak, GW; Tiseo, PJ | 1 |
| Inturrisi, CE; Tiseo, PJ | 1 |
| Bhargava, HN | 1 |
| Bilsky, EJ; Hruby, VJ; Inturrisi, CE; Porreca, F; Sadée, W | 1 |
| Bhargava, HN; Bian, JT; Sharma, SS | 1 |
| Allen, RM; Dykstra, LA | 4 |
| Besson, JM; Catheline, G; Le Guen, S | 1 |
| Allen, RM; Dykstra, LA; Granger, AL | 2 |
| Barr, GA; Du, T; Inturrisi, CE; Jenab, S; Jones, KL; Zhu, H | 1 |
| Galizio, M; Keith, JR; Mansfield, WJ; Pitts, RC | 1 |
| Brodsky, M; Gorman, AL; Inturrisi, CE; Zhu, H | 1 |
| Grisel, JE; Mogil, JS; Nemmani, KVS; Smith-Carliss, R; Stowe, JR | 1 |
| Craft, RM; Lee, DA | 1 |
| Carrigan, KA; Dykstra, LA; Fischer, BD | 1 |
| Dykstra, LA; Fischer, BD | 1 |
| Mendez, IA; Trujillo, KA | 1 |
| Dykstra, LA; Fischer, BD; Henry, FE; Miller, LL; Picker, MJ | 1 |
| Juni, A; Kest, B; Klein, G; Kowalczyk, B; Ragnauth, A | 1 |
| Gewirtz, JC; Rothwell, PE; Thomas, MJ | 1 |
| Dykstra, LA; Fischer, BD; Henry, FE; Ward, SJ | 1 |
| Balter, RE; Dykstra, LA; Fischer, BD; Henry, FE; Miller, LL; Schmidt, KT | 1 |
28 other study(ies) available for ly 274614 and morphine
| Article | Year |
|---|---|
NMDA receptor antagonists suppress behaviors but not norepinephrine turnover or locus coeruleus unit activity induced by opiate withdrawal.
Topics: Animals; Behavior, Animal; Dizocilpine Maleate; Electrophysiology; Isoquinolines; Locus Coeruleus; Male; Morphine; Naltrexone; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome | 1991 |
The NMDA receptor antagonists, LY274614 and MK-801, and the nitric oxide synthase inhibitor, NG-nitro-L-arginine, attenuate analgesic tolerance to the mu-opioid morphine but not to kappa opioids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Oxidoreductases; Analgesics; Animals; Arginine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Tolerance; Injections, Subcutaneous; Isoquinolines; Male; Mice; Morphine; Naloxone; Nitric Oxide Synthase; Nitroarginine; Pyrrolidines; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1994 |
NMDA antagonists and clonidine block c-fos expression during morphine withdrawal.
Topics: Animals; Clonidine; Dizocilpine Maleate; Gene Expression; Genes, fos; In Vitro Techniques; Isoquinolines; Male; Morphine; Naltrexone; Neural Pathways; Nucleic Acid Hybridization; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA Probes; RNA, Messenger; Substance Withdrawal Syndrome | 1995 |
Modulation of morphine tolerance by the competitive N-methyl-D-aspartate receptor antagonist LY274614: assessment of opioid receptor changes.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Drug Tolerance; Isoquinolines; Male; Molecular Sequence Data; Morphine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid | 1994 |
Attenuation and reversal of morphine tolerance by the competitive N-methyl-D-aspartate receptor antagonist, LY274614.
Topics: Animals; Dizocilpine Maleate; Drug Tolerance; Isoquinolines; Male; Morphine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1993 |
Enhancement of morphine actions in morphine-naive and morphine-tolerant mice by LY 235959, a competitive antagonist of the NMDA receptor.
Topics: Analgesics, Opioid; Animals; Binding, Competitive; Body Temperature; Drug Synergism; Drug Tolerance; Isoquinolines; Male; Mice; Morphine; Pain Measurement; Receptors, N-Methyl-D-Aspartate | 1997 |
Competitive and non-competitive NMDA antagonists block the development of antinociceptive tolerance to morphine, but not to selective mu or delta opioid agonists in mice.
Topics: Analgesics, Opioid; Animals; Binding, Competitive; Dizocilpine Maleate; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Excitatory Amino Acid Antagonists; Fentanyl; Isoquinolines; Male; Mice; Mice, Inbred ICR; Morphine; Oligopeptides; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta; Receptors, Opioid, mu | 1996 |
Evidence for a role of N-methyl-D-aspartate receptors in L-arginine-induced attenuation of morphine antinociception.
Topics: Animals; Arginine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Mice; Morphine; Narcotics; Neuroprotective Agents; Nociceptors; Receptors, N-Methyl-D-Aspartate; Time Factors | 1998 |
The competitive NMDA receptor antagonist LY235959 modulates the progression of morphine tolerance in rats.
Topics: Analgesics, Opioid; Animals; Drug Tolerance; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Morphine; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1999 |
Effects of NMDA receptor antagonists on morphine tolerance: a c-Fos study in the lumbar spinal cord of the rat.
Topics: Analgesics, Opioid; Animals; Binding Sites; Carrageenan; Dizocilpine Maleate; Drug Tolerance; Excitatory Amino Acid Antagonists; Glycine; Immunohistochemistry; Isoquinolines; Male; Morphine; Neurons; Proto-Oncogene Proteins c-fos; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1999 |
Role of morphine maintenance dose in the development of tolerance and its attenuation by an NMDA receptor antagonist.
Topics: Animals; Dose-Response Relationship, Drug; Drug Tolerance; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Morphine; Narcotics; Nociceptors; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, N-Methyl-D-Aspartate | 2000 |
Attenuation of mu-opioid tolerance and cross-tolerance by the competitive N-methyl-D-aspartate receptor antagonist LY235959 is related to tolerance and cross-tolerance magnitude.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cycloparaffins; Dose-Response Relationship, Drug; Drug Tolerance; Etorphine; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Morphine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, mu; Tetrahydronaphthalenes | 2000 |
N-methyl-D-aspartate receptor antagonists potentiate the antinociceptive effects of morphine in squirrel monkeys.
Topics: Analgesics; Analgesics, Opioid; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Morphine; Pain Measurement; Receptors, N-Methyl-D-Aspartate; Saimiri | 2001 |
Dextromethorphan potentiates the antinociceptive effects of morphine and the delta-opioid agonist SNC80 in squirrel monkeys.
Topics: Analgesics, Opioid; Animals; Antitussive Agents; Benzamides; Conditioning, Operant; Dextromethorphan; Dizocilpine Maleate; Drug Synergism; Electroshock; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Morphine; Pain Measurement; Piperazines; Pyrrolidinones; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta; Saimiri | 2002 |
Attenuation of acute morphine withdrawal in the neonatal rat by the competitive NMDA receptor antagonist LY235959.
Topics: Analgesics, Opioid; Animals; Animals, Newborn; Behavior, Animal; Binding, Competitive; Brain; Excitatory Amino Acid Antagonists; Female; Isoquinolines; Male; Morphine; Pregnancy; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Spinal Cord; Substance Withdrawal Syndrome | 2002 |
Repeated spatial acquisition: effects of NMDA antagonists and morphine.
Topics: Analgesics, Opioid; Animals; Avoidance Learning; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Morphine; N-Methylaspartate; Naloxone; Narcotic Antagonists; Phencyclidine; Rats; Rats, Sprague-Dawley; Serial Learning; Space Perception | 2003 |
Region-specific changes in NMDA receptor mRNA induced by chronic morphine treatment are prevented by the co-administration of the competitive NMDA receptor antagonist LY274614.
Topics: Animals; Binding, Competitive; Central Nervous System; Dizocilpine Maleate; Down-Regulation; Drug Administration Schedule; Drug Interactions; Drug Tolerance; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Morphine; Neurons; Pain; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger | 2003 |
The competitive N-methyl-D-aspartate receptor antagonist (-)-6-phosphonomethyl-deca-hydroisoquinoline-3-carboxylic acid (LY235959) potentiates the antinociceptive effects of opioids that vary in efficacy at the mu-opioid receptor.
Topics: Animals; Drug Synergism; Isoquinolines; Levorphanol; Male; Morphine; Narcotics; Pain; Reaction Time; Receptors, Opioid, mu; Saimiri | 2003 |
Modulation of morphine analgesia by site-specific N-methyl-D-aspartate receptor antagonists: dependence on sex, site of antagonism, morphine dose, and time.
Topics: Animals; Central Nervous System; Dextromethorphan; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Excitatory Amino Acid Antagonists; Female; Isoquinolines; Male; Mice; Morphine; Pain; Phenols; Piperidines; Quinolones; Receptors, N-Methyl-D-Aspartate; Sex Characteristics; Time Factors | 2004 |
NMDA antagonist modulation of morphine antinociception in female vs. male rats.
Topics: Analgesics, Opioid; Animals; Dextromethorphan; Dizocilpine Maleate; Dose-Response Relationship, Drug; Estrous Cycle; Excitatory Amino Acid Antagonists; Female; Isoquinolines; Male; Morphine; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, N-Methyl-D-Aspartate; Sex Characteristics | 2005 |
Effects of N-methyl-D-aspartate receptor antagonists on acute morphine-induced and l-methadone-induced antinociception in mice.
Topics: Analgesia; Analgesics, Opioid; Animals; Central Nervous System; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Methadone; Mice; Mice, Inbred C57BL; Morphine; Nociceptors; Pain; Pain Measurement; Pain Threshold; Piperidines; Pyrrolidinones; Reaction Time; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 2005 |
Interactions between an N-methyl-D-aspartate antagonist and low-efficacy opioid receptor agonists in assays of schedule-controlled responding and thermal nociception.
Topics: Analgesics, Opioid; Animals; Buprenorphine; Butorphanol; Conditioning, Psychological; Dose-Response Relationship, Drug; Drug Interactions; Hot Temperature; Isoquinolines; Male; Mice; Mice, Inbred BALB C; Morphine; N-Methylaspartate; Nalbuphine; Receptors, Opioid | 2006 |
NMDA receptor antagonists inhibit opiate antinociceptive tolerance and locomotor sensitization in rats.
Topics: Animals; Behavior, Animal; Buprenorphine; Dizocilpine Maleate; Drug Tolerance; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Memantine; Methadone; Morphine; Motor Activity; Narcotics; Opioid-Related Disorders; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2008 |
Increased efficacy of micro-opioid agonist-induced antinociception by metabotropic glutamate receptor antagonists in C57BL/6 mice: comparison with (-)-6-phosphonomethyl-deca-hydroisoquinoline-3-carboxylic acid (LY235959).
Topics: Analgesics, Opioid; Animals; Bridged Bicyclo Compounds, Heterocyclic; Buprenorphine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Hot Temperature; Isoquinolines; Male; Mice; Mice, Inbred C57BL; Morphine; Narcotic Antagonists; Pain Measurement; Receptors, Metabotropic Glutamate; Receptors, Opioid, mu; Tetrahydronaphthalenes | 2008 |
Sex differences in hyperalgesia during morphine infusion: effect of gonadectomy and estrogen treatment.
Topics: Analgesics, Opioid; Animals; Data Interpretation, Statistical; Dizocilpine Maleate; Dose-Response Relationship, Drug; Estrogens; Excitatory Amino Acid Antagonists; Female; Hyperalgesia; Infusions, Intravenous; Isoquinolines; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Orchiectomy; Ovariectomy; Pain Measurement; Receptors, N-Methyl-D-Aspartate; Sex Characteristics | 2008 |
Distinct profiles of anxiety and dysphoria during spontaneous withdrawal from acute morphine exposure.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Chlordiazepoxide; Conditioning, Operant; Depression; Disease Models, Animal; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Propranolol; Rats; Rats, Sprague-Dawley; Reflex, Startle; Substance Withdrawal Syndrome; Time Factors | 2009 |
Attenuation of morphine antinociceptive tolerance by a CB(1) receptor agonist and an NMDA receptor antagonist: Interactive effects.
Topics: Analgesics; Analgesics, Opioid; Animals; Cyclohexanols; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Drug Tolerance; Excitatory Amino Acid Antagonists; Hot Temperature; Isoquinolines; Male; Mice; Mice, Inbred C57BL; Morphine; Pain; Pain Measurement; Receptor, Cannabinoid, CB1; Receptors, N-Methyl-D-Aspartate | 2010 |
Opioid antinociception, tolerance and dependence: interactions with the N-methyl-D-aspartate system in mice.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Tolerance; Excitatory Amino Acid Antagonists; Gene Knockdown Techniques; Isoquinolines; Male; Mice; Morphine; Morphine Dependence; Pain; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, mu | 2011 |