Page last updated: 2024-09-03

ly 274614 and morphine

ly 274614 has been researched along with morphine in 28 studies

Compound Research Comparison

Studies
(ly 274614)
Trials
(ly 274614)
Recent Studies (post-2010)
(ly 274614)
Studies
(morphine)
Trials
(morphine)
Recent Studies (post-2010) (morphine)
9601544,2705,2008,695

Protein Interaction Comparison

ProteinTaxonomyly 274614 (IC50)morphine (IC50)
Delta-type opioid receptorMus musculus (house mouse)0.2939
Delta-type opioid receptorRattus norvegicus (Norway rat)0.2278
Kappa-type opioid receptorMus musculus (house mouse)0.0828
Mu-type opioid receptorRattus norvegicus (Norway rat)0.0385
Kappa-type opioid receptorRattus norvegicus (Norway rat)0.0545
Mu-type opioid receptorHomo sapiens (human)0.122
Delta-type opioid receptorHomo sapiens (human)0.1199
Kappa-type opioid receptorCavia porcellus (domestic guinea pig)0.9308
Kappa-type opioid receptorHomo sapiens (human)0.655
Mu-type opioid receptorMus musculus (house mouse)0.3305
Mu-type opioid receptorCavia porcellus (domestic guinea pig)0.202
Beta-2 adrenergic receptorCavia porcellus (domestic guinea pig)0.25

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's10 (35.71)18.2507
2000's16 (57.14)29.6817
2010's2 (7.14)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fuller, RW; Ornstein, PL; Perry, KW; Rasmussen, K; Stockton, ME; Swinford, RM1
Elliott, K; Inturrisi, CE; Kolesnikov, YA; Minami, N; Pasternak, GW1
Brodsky, M; Inturrisi, CE; Rasmussen, K1
Cheng, J; Inturrisi, CE; Pasternak, GW; Tiseo, PJ1
Inturrisi, CE; Tiseo, PJ1
Bhargava, HN1
Bilsky, EJ; Hruby, VJ; Inturrisi, CE; Porreca, F; Sadée, W1
Bhargava, HN; Bian, JT; Sharma, SS1
Allen, RM; Dykstra, LA4
Besson, JM; Catheline, G; Le Guen, S1
Allen, RM; Dykstra, LA; Granger, AL2
Barr, GA; Du, T; Inturrisi, CE; Jenab, S; Jones, KL; Zhu, H1
Galizio, M; Keith, JR; Mansfield, WJ; Pitts, RC1
Brodsky, M; Gorman, AL; Inturrisi, CE; Zhu, H1
Grisel, JE; Mogil, JS; Nemmani, KVS; Smith-Carliss, R; Stowe, JR1
Craft, RM; Lee, DA1
Carrigan, KA; Dykstra, LA; Fischer, BD1
Dykstra, LA; Fischer, BD1
Mendez, IA; Trujillo, KA1
Dykstra, LA; Fischer, BD; Henry, FE; Miller, LL; Picker, MJ1
Juni, A; Kest, B; Klein, G; Kowalczyk, B; Ragnauth, A1
Gewirtz, JC; Rothwell, PE; Thomas, MJ1
Dykstra, LA; Fischer, BD; Henry, FE; Ward, SJ1
Balter, RE; Dykstra, LA; Fischer, BD; Henry, FE; Miller, LL; Schmidt, KT1

Other Studies

28 other study(ies) available for ly 274614 and morphine

ArticleYear
NMDA receptor antagonists suppress behaviors but not norepinephrine turnover or locus coeruleus unit activity induced by opiate withdrawal.
    European journal of pharmacology, 1991, May-02, Volume: 197, Issue:1

    Topics: Animals; Behavior, Animal; Dizocilpine Maleate; Electrophysiology; Isoquinolines; Locus Coeruleus; Male; Morphine; Naltrexone; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome

1991
The NMDA receptor antagonists, LY274614 and MK-801, and the nitric oxide synthase inhibitor, NG-nitro-L-arginine, attenuate analgesic tolerance to the mu-opioid morphine but not to kappa opioids.
    Pain, 1994, Volume: 56, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Oxidoreductases; Analgesics; Animals; Arginine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Tolerance; Injections, Subcutaneous; Isoquinolines; Male; Mice; Morphine; Naloxone; Nitric Oxide Synthase; Nitroarginine; Pyrrolidines; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa; Receptors, Opioid, mu

1994
NMDA antagonists and clonidine block c-fos expression during morphine withdrawal.
    Synapse (New York, N.Y.), 1995, Volume: 20, Issue:1

    Topics: Animals; Clonidine; Dizocilpine Maleate; Gene Expression; Genes, fos; In Vitro Techniques; Isoquinolines; Male; Morphine; Naltrexone; Neural Pathways; Nucleic Acid Hybridization; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA Probes; RNA, Messenger; Substance Withdrawal Syndrome

1995
Modulation of morphine tolerance by the competitive N-methyl-D-aspartate receptor antagonist LY274614: assessment of opioid receptor changes.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 268, Issue:1

    Topics: Amino Acid Sequence; Animals; Binding, Competitive; Drug Tolerance; Isoquinolines; Male; Molecular Sequence Data; Morphine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid

1994
Attenuation and reversal of morphine tolerance by the competitive N-methyl-D-aspartate receptor antagonist, LY274614.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 264, Issue:3

    Topics: Animals; Dizocilpine Maleate; Drug Tolerance; Isoquinolines; Male; Morphine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate

1993
Enhancement of morphine actions in morphine-naive and morphine-tolerant mice by LY 235959, a competitive antagonist of the NMDA receptor.
    General pharmacology, 1997, Volume: 28, Issue:1

    Topics: Analgesics, Opioid; Animals; Binding, Competitive; Body Temperature; Drug Synergism; Drug Tolerance; Isoquinolines; Male; Mice; Morphine; Pain Measurement; Receptors, N-Methyl-D-Aspartate

1997
Competitive and non-competitive NMDA antagonists block the development of antinociceptive tolerance to morphine, but not to selective mu or delta opioid agonists in mice.
    Pain, 1996, Volume: 68, Issue:2-3

    Topics: Analgesics, Opioid; Animals; Binding, Competitive; Dizocilpine Maleate; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Excitatory Amino Acid Antagonists; Fentanyl; Isoquinolines; Male; Mice; Mice, Inbred ICR; Morphine; Oligopeptides; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta; Receptors, Opioid, mu

1996
Evidence for a role of N-methyl-D-aspartate receptors in L-arginine-induced attenuation of morphine antinociception.
    Brain research, 1998, Jan-26, Volume: 782, Issue:1-2

    Topics: Animals; Arginine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Mice; Morphine; Narcotics; Neuroprotective Agents; Nociceptors; Receptors, N-Methyl-D-Aspartate; Time Factors

1998
The competitive NMDA receptor antagonist LY235959 modulates the progression of morphine tolerance in rats.
    Psychopharmacology, 1999, Volume: 142, Issue:2

    Topics: Analgesics, Opioid; Animals; Drug Tolerance; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Morphine; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate

1999
Effects of NMDA receptor antagonists on morphine tolerance: a c-Fos study in the lumbar spinal cord of the rat.
    European journal of pharmacology, 1999, May-28, Volume: 373, Issue:1

    Topics: Analgesics, Opioid; Animals; Binding Sites; Carrageenan; Dizocilpine Maleate; Drug Tolerance; Excitatory Amino Acid Antagonists; Glycine; Immunohistochemistry; Isoquinolines; Male; Morphine; Neurons; Proto-Oncogene Proteins c-fos; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord

1999
Role of morphine maintenance dose in the development of tolerance and its attenuation by an NMDA receptor antagonist.
    Psychopharmacology, 2000, Volume: 148, Issue:1

    Topics: Animals; Dose-Response Relationship, Drug; Drug Tolerance; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Morphine; Narcotics; Nociceptors; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, N-Methyl-D-Aspartate

2000
Attenuation of mu-opioid tolerance and cross-tolerance by the competitive N-methyl-D-aspartate receptor antagonist LY235959 is related to tolerance and cross-tolerance magnitude.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 295, Issue:3

    Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cycloparaffins; Dose-Response Relationship, Drug; Drug Tolerance; Etorphine; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Morphine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, mu; Tetrahydronaphthalenes

2000
N-methyl-D-aspartate receptor antagonists potentiate the antinociceptive effects of morphine in squirrel monkeys.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 298, Issue:1

    Topics: Analgesics; Analgesics, Opioid; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Morphine; Pain Measurement; Receptors, N-Methyl-D-Aspartate; Saimiri

2001
Dextromethorphan potentiates the antinociceptive effects of morphine and the delta-opioid agonist SNC80 in squirrel monkeys.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 300, Issue:2

    Topics: Analgesics, Opioid; Animals; Antitussive Agents; Benzamides; Conditioning, Operant; Dextromethorphan; Dizocilpine Maleate; Drug Synergism; Electroshock; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Morphine; Pain Measurement; Piperazines; Pyrrolidinones; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta; Saimiri

2002
Attenuation of acute morphine withdrawal in the neonatal rat by the competitive NMDA receptor antagonist LY235959.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2002, Volume: 26, Issue:3

    Topics: Analgesics, Opioid; Animals; Animals, Newborn; Behavior, Animal; Binding, Competitive; Brain; Excitatory Amino Acid Antagonists; Female; Isoquinolines; Male; Morphine; Pregnancy; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Spinal Cord; Substance Withdrawal Syndrome

2002
Repeated spatial acquisition: effects of NMDA antagonists and morphine.
    Experimental and clinical psychopharmacology, 2003, Volume: 11, Issue:1

    Topics: Analgesics, Opioid; Animals; Avoidance Learning; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Morphine; N-Methylaspartate; Naloxone; Narcotic Antagonists; Phencyclidine; Rats; Rats, Sprague-Dawley; Serial Learning; Space Perception

2003
Region-specific changes in NMDA receptor mRNA induced by chronic morphine treatment are prevented by the co-administration of the competitive NMDA receptor antagonist LY274614.
    Brain research. Molecular brain research, 2003, Jun-10, Volume: 114, Issue:2

    Topics: Animals; Binding, Competitive; Central Nervous System; Dizocilpine Maleate; Down-Regulation; Drug Administration Schedule; Drug Interactions; Drug Tolerance; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Morphine; Neurons; Pain; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger

2003
The competitive N-methyl-D-aspartate receptor antagonist (-)-6-phosphonomethyl-deca-hydroisoquinoline-3-carboxylic acid (LY235959) potentiates the antinociceptive effects of opioids that vary in efficacy at the mu-opioid receptor.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 307, Issue:2

    Topics: Animals; Drug Synergism; Isoquinolines; Levorphanol; Male; Morphine; Narcotics; Pain; Reaction Time; Receptors, Opioid, mu; Saimiri

2003
Modulation of morphine analgesia by site-specific N-methyl-D-aspartate receptor antagonists: dependence on sex, site of antagonism, morphine dose, and time.
    Pain, 2004, Volume: 109, Issue:3

    Topics: Animals; Central Nervous System; Dextromethorphan; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Excitatory Amino Acid Antagonists; Female; Isoquinolines; Male; Mice; Morphine; Pain; Phenols; Piperidines; Quinolones; Receptors, N-Methyl-D-Aspartate; Sex Characteristics; Time Factors

2004
NMDA antagonist modulation of morphine antinociception in female vs. male rats.
    Pharmacology, biochemistry, and behavior, 2005, Volume: 80, Issue:4

    Topics: Analgesics, Opioid; Animals; Dextromethorphan; Dizocilpine Maleate; Dose-Response Relationship, Drug; Estrous Cycle; Excitatory Amino Acid Antagonists; Female; Isoquinolines; Male; Morphine; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, N-Methyl-D-Aspartate; Sex Characteristics

2005
Effects of N-methyl-D-aspartate receptor antagonists on acute morphine-induced and l-methadone-induced antinociception in mice.
    The journal of pain, 2005, Volume: 6, Issue:7

    Topics: Analgesia; Analgesics, Opioid; Animals; Central Nervous System; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Methadone; Mice; Mice, Inbred C57BL; Morphine; Nociceptors; Pain; Pain Measurement; Pain Threshold; Piperidines; Pyrrolidinones; Reaction Time; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate

2005
Interactions between an N-methyl-D-aspartate antagonist and low-efficacy opioid receptor agonists in assays of schedule-controlled responding and thermal nociception.
    The Journal of pharmacology and experimental therapeutics, 2006, Volume: 318, Issue:3

    Topics: Analgesics, Opioid; Animals; Buprenorphine; Butorphanol; Conditioning, Psychological; Dose-Response Relationship, Drug; Drug Interactions; Hot Temperature; Isoquinolines; Male; Mice; Mice, Inbred BALB C; Morphine; N-Methylaspartate; Nalbuphine; Receptors, Opioid

2006
NMDA receptor antagonists inhibit opiate antinociceptive tolerance and locomotor sensitization in rats.
    Psychopharmacology, 2008, Volume: 196, Issue:3

    Topics: Animals; Behavior, Animal; Buprenorphine; Dizocilpine Maleate; Drug Tolerance; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Memantine; Methadone; Morphine; Motor Activity; Narcotics; Opioid-Related Disorders; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate

2008
Increased efficacy of micro-opioid agonist-induced antinociception by metabotropic glutamate receptor antagonists in C57BL/6 mice: comparison with (-)-6-phosphonomethyl-deca-hydroisoquinoline-3-carboxylic acid (LY235959).
    Psychopharmacology, 2008, Volume: 198, Issue:2

    Topics: Analgesics, Opioid; Animals; Bridged Bicyclo Compounds, Heterocyclic; Buprenorphine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Hot Temperature; Isoquinolines; Male; Mice; Mice, Inbred C57BL; Morphine; Narcotic Antagonists; Pain Measurement; Receptors, Metabotropic Glutamate; Receptors, Opioid, mu; Tetrahydronaphthalenes

2008
Sex differences in hyperalgesia during morphine infusion: effect of gonadectomy and estrogen treatment.
    Neuropharmacology, 2008, Volume: 54, Issue:8

    Topics: Analgesics, Opioid; Animals; Data Interpretation, Statistical; Dizocilpine Maleate; Dose-Response Relationship, Drug; Estrogens; Excitatory Amino Acid Antagonists; Female; Hyperalgesia; Infusions, Intravenous; Isoquinolines; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Orchiectomy; Ovariectomy; Pain Measurement; Receptors, N-Methyl-D-Aspartate; Sex Characteristics

2008
Distinct profiles of anxiety and dysphoria during spontaneous withdrawal from acute morphine exposure.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2009, Volume: 34, Issue:10

    Topics: Acoustic Stimulation; Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Chlordiazepoxide; Conditioning, Operant; Depression; Disease Models, Animal; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Propranolol; Rats; Rats, Sprague-Dawley; Reflex, Startle; Substance Withdrawal Syndrome; Time Factors

2009
Attenuation of morphine antinociceptive tolerance by a CB(1) receptor agonist and an NMDA receptor antagonist: Interactive effects.
    Neuropharmacology, 2010, Volume: 58, Issue:2

    Topics: Analgesics; Analgesics, Opioid; Animals; Cyclohexanols; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Drug Tolerance; Excitatory Amino Acid Antagonists; Hot Temperature; Isoquinolines; Male; Mice; Mice, Inbred C57BL; Morphine; Pain; Pain Measurement; Receptor, Cannabinoid, CB1; Receptors, N-Methyl-D-Aspartate

2010
Opioid antinociception, tolerance and dependence: interactions with the N-methyl-D-aspartate system in mice.
    Behavioural pharmacology, 2011, Volume: 22, Issue:5-6

    Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Tolerance; Excitatory Amino Acid Antagonists; Gene Knockdown Techniques; Isoquinolines; Male; Mice; Morphine; Morphine Dependence; Pain; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, mu

2011