Compounds > ly 274614
Page last updated: 2024-09-03

ly 274614 and dextromethorphan

ly 274614 has been researched along with dextromethorphan in 7 studies

Compound Research Comparison

Studies
(ly 274614)		Trials
(ly 274614)		Recent Studies (post-2010)
(ly 274614)		Studies
(dextromethorphan)		Trials
(dextromethorphan)		Recent Studies (post-2010) (dextromethorphan)
960152,020342593

Protein Interaction Comparison

ProteinTaxonomyly 274614 (IC50)dextromethorphan (IC50)
Sodium channel protein type 1 subunit alphaRattus norvegicus (Norway rat)1.3
Sodium channel protein type 2 subunit alphaRattus norvegicus (Norway rat)1.3
Sodium channel protein type 3 subunit alphaRattus norvegicus (Norway rat)1.3
Cytochrome P450 2D26Rattus norvegicus (Norway rat)5.6
Cytochrome P450 2D6Homo sapiens (human)2.1768
Sodium-dependent serotonin transporterHomo sapiens (human)0.0027
Sigma non-opioid intracellular receptor 1Cavia porcellus (domestic guinea pig)0.1236

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (14.29)18.2507
2000's6 (85.71)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Elliott, K; Inturrisi, CE; Kao, B; Kest, B; Man, A1
Allen, RM; Dykstra, LA; Granger, AL1
Adler, MW; Cowan, A; Geller, EB; Rawls, SM; Tallarida, RJ1
Constantinou, CE; Tillig, B1
Grisel, JE; Mogil, JS; Nemmani, KVS; Smith-Carliss, R; Stowe, JR1
Craft, RM; Lee, DA1
Allen, RM; Carelli, RM; Dykstra, LA; Everett, CV; Suchey, TL1

Reviews

1 review(s) available for ly 274614 and dextromethorphan

ArticleYear
N-methyl-D-aspartate (NMDA) receptors, mu and kappa opioid tolerance, and perspectives on new analgesic drug development.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1995, Volume: 13, Issue:4

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Dextromethorphan; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Isoquinolines; Narcotics; Nitric Oxide Synthase; Opioid-Related Disorders; Pyrrolidines; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa; Receptors, Opioid, mu

1995

Other Studies

6 other study(ies) available for ly 274614 and dextromethorphan

ArticleYear
Dextromethorphan potentiates the antinociceptive effects of morphine and the delta-opioid agonist SNC80 in squirrel monkeys.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 300, Issue:2

    Topics: Analgesics, Opioid; Animals; Antitussive Agents; Benzamides; Conditioning, Operant; Dextromethorphan; Dizocilpine Maleate; Drug Synergism; Electroshock; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Morphine; Pain Measurement; Piperazines; Pyrrolidinones; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta; Saimiri

2002
N-methyl-D-aspartate antagonists and WIN 55212-2 [4,5-dihydro-2-methyl-4(4-morpholinylmethyl)-1-(1-naphthalenyl-carbonyl)-6H-pyrrolo[3,2,1-i,j]quinolin-6-one], a cannabinoid agonist, interact to produce synergistic hypothermia.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 303, Issue:1

    Topics: Animals; Benzoxazines; Body Temperature; Calcium Channel Blockers; Cannabinoids; Dextromethorphan; Drug Synergism; Excitatory Amino Acid Antagonists; Hypothermia; Isoquinolines; Kinetics; Morpholines; N-Methylaspartate; Naphthalenes; Rats; Receptors, Cannabinoid; Receptors, Drug; Structure-Activity Relationship

2002
Supraspinal N-methyl-D-aspartate receptor inhibition influences the micturition reflex and function of the upper urinary tract of anesthetized and conscious rats.
    Neurourology and urodynamics, 2003, Volume: 22, Issue:2

    Topics: Anesthesia; Animals; Consciousness; Dextromethorphan; Excitatory Amino Acid Antagonists; Female; Injections, Intravenous; Injections, Intraventricular; Isoquinolines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reflex; Ureter; Urination

2003
Modulation of morphine analgesia by site-specific N-methyl-D-aspartate receptor antagonists: dependence on sex, site of antagonism, morphine dose, and time.
    Pain, 2004, Volume: 109, Issue:3

    Topics: Animals; Central Nervous System; Dextromethorphan; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Excitatory Amino Acid Antagonists; Female; Isoquinolines; Male; Mice; Morphine; Pain; Phenols; Piperidines; Quinolones; Receptors, N-Methyl-D-Aspartate; Sex Characteristics; Time Factors

2004
NMDA antagonist modulation of morphine antinociception in female vs. male rats.
    Pharmacology, biochemistry, and behavior, 2005, Volume: 80, Issue:4

    Topics: Analgesics, Opioid; Animals; Dextromethorphan; Dizocilpine Maleate; Dose-Response Relationship, Drug; Estrous Cycle; Excitatory Amino Acid Antagonists; Female; Isoquinolines; Male; Morphine; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, N-Methyl-D-Aspartate; Sex Characteristics

2005
Effects of the competitive N-methyl-D-aspartate receptor antagonist, LY235959 [(-)-6-phosphonomethyl-deca-hydroisoquinoline-3-carboxylic acid], on responding for cocaine under both fixed and progressive ratio schedules of reinforcement.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 315, Issue:1

    Topics: Animals; Cocaine; Dextromethorphan; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Isoquinolines; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reinforcement Schedule; Self Administration

2005