ly 274614 has been researched along with glutamic acid in 13 studies
| Studies (ly 274614) | Trials (ly 274614) | Recent Studies (post-2010) (ly 274614) | Studies (glutamic acid) | Trials (glutamic acid) | Recent Studies (post-2010) (glutamic acid) |
|---|---|---|---|---|---|
| 96 | 0 | 15 | 41,757 | 452 | 12,876 |
| Protein | Taxonomy | ly 274614 (IC50) | glutamic acid (IC50) |
|---|---|---|---|
| Chain A, GLUTAMATE RECEPTOR SUBUNIT 2 | Rattus norvegicus (Norway rat) | 0.821 | |
| Chain A, Glutamate Receptor Subunit 2 | Rattus norvegicus (Norway rat) | 0.821 | |
| Chain B, Glutamate Receptor Subunit 2 | Rattus norvegicus (Norway rat) | 0.821 | |
| Metabotropic glutamate receptor 8 | Homo sapiens (human) | 0.0057 | |
| Glutamate receptor ionotropic, NMDA 2D | Homo sapiens (human) | 0.07 | |
| Glutamate receptor ionotropic, NMDA 3B | Homo sapiens (human) | 0.07 | |
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | 0.5885 | |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | 0.5885 | |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | 0.5885 | |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | 0.5885 | |
| Glutamate receptor ionotropic, kainate 1 | Rattus norvegicus (Norway rat) | 0.38 | |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | 0.1533 | |
| Glutamate receptor ionotropic, kainate 2 | Rattus norvegicus (Norway rat) | 0.38 | |
| Glutamate receptor 1 | Homo sapiens (human) | 0.613 | |
| Glutamate receptor 2 | Homo sapiens (human) | 0.613 | |
| Glutamate receptor 3 | Homo sapiens (human) | 0.613 | |
| Glutamate receptor ionotropic, kainate 3 | Rattus norvegicus (Norway rat) | 0.38 | |
| Excitatory amino acid transporter 1 | Homo sapiens (human) | 207 | |
| Glutamate receptor 4 | Homo sapiens (human) | 0.613 | |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | 0.1533 | |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | 0.1533 | |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | 0.1533 | |
| Glutamate receptor ionotropic, kainate 4 | Rattus norvegicus (Norway rat) | 0.38 | |
| Glutamate receptor ionotropic, NMDA 1 | Homo sapiens (human) | 0.07 | |
| Glutamate receptor ionotropic, NMDA 2A | Homo sapiens (human) | 0.07 | |
| Glutamate receptor ionotropic, NMDA 2B | Homo sapiens (human) | 0.07 | |
| Glutamate receptor ionotropic, NMDA 2C | Homo sapiens (human) | 0.07 | |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | 0.1533 | |
| Glutamate receptor ionotropic, kainate 5 | Rattus norvegicus (Norway rat) | 0.38 | |
| Glutamate receptor ionotropic, NMDA 3A | Homo sapiens (human) | 0.07 | |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | 0.1533 | |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | 0.1533 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (15.38) | 18.2507 |
| 2000's | 9 (69.23) | 29.6817 |
| 2010's | 2 (15.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Greenamyre, JT; Greene, JG | 1 |
| de Groat, WC; Roppolo, JR; Thor, KB; Yoshiyama, M | 1 |
| Gear, RW; Levine, JD; Tambeli, CH; Young, A | 1 |
| Joyner, PW; McMillen, BA; Parmar, CA; Tyer, WE; Williams, HL | 1 |
| Allen, RM; Carelli, RM; Dykstra, LA | 1 |
| Antunes-Rodrigues, J; Busnardo, C; Corrêa, FM; Tavares, RF | 1 |
| Huang, WT; Kao, CH; Kao, TY; Lin, MT | 1 |
| Corrêa, FM; Resstel, LB; Tavares, RF | 1 |
| Aguiar Corrêa, FM; Deolindo, M; Pelosi, GG; Tavares, RF | 1 |
| Corrêa, FM; Guimarães, FS; Resstel, LB | 1 |
| Alves, FH; Correa, FM; Crestani, CC; Resstel, LB | 1 |
| Alves, FH; Busnardo, C; Correa, FM; Crestani, CC; Resstel, LB | 1 |
| D'Souza, MS; Markou, A | 1 |
13 other study(ies) available for ly 274614 and glutamic acid
| Article | Year |
|---|---|
Characterization of the excitotoxic potential of the reversible succinate dehydrogenase inhibitor malonate.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Body Temperature; Brain Diseases; Cell Death; Corpus Striatum; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glutamic Acid; Glycine; Isoquinolines; Male; Malonates; Neurons; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Succinate Dehydrogenase | 1995 |
Effects of LY274614, a competitive NMDA receptor antagonist, on the micturition reflex in the urethane-anaesthetized rat.
Topics: Acetates; Acetic Acid; Anesthesia; Animals; Decerebrate State; Dizocilpine Maleate; Dose-Response Relationship, Drug; Electromyography; Female; Glutamates; Glutamic Acid; Injections, Spinal; Irritants; Isoquinolines; Pipecolic Acids; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reflex; Spinal Cord; Tetrazoles; Urethane; Urinary Bladder; Urination | 1993 |
Contribution of spinal glutamatergic mechanisms in heterosegmental antinociception induced by noxious stimulation.
Topics: Animals; Benzoates; Capsaicin; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Isoquinolines; Male; Nociceptors; Pyridines; Quinoxalines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Spinal Cord; Stimulation, Chemical; Substance P | 2003 |
Effects of NMDA glutamate receptor antagonist drugs on the volitional consumption of ethanol by a genetic drinking rat.
Topics: Alcohol Drinking; Alcohol-Induced Disorders, Nervous System; Alcoholism; Amino Acids, Cyclic; Animals; Brain; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ethanol; Excitatory Amino Acid Antagonists; Female; Genetic Predisposition to Disease; Glutamic Acid; Isoquinolines; Male; Motor Activity; Pyrrolidinones; Rats; Rats, Inbred Strains; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Volition | 2004 |
Continuous exposure to the competitive N-methyl-D: -aspartate receptor antagonist, LY235959, facilitates escalation of cocaine consumption in Sprague-Dawley rats.
Topics: Analysis of Variance; Animals; Behavior, Addictive; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Administration Schedule; Extinction, Psychological; Glutamic Acid; Isoquinolines; Male; Neurotransmitter Agents; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reinforcement Schedule; Self Administration | 2007 |
Cardiovascular effects of L-glutamate microinjection in the supraoptic nucleus of unanaesthetized rats.
Topics: Animals; Arginine Vasopressin; Blood Pressure; Excitatory Amino Acid Antagonists; Ganglionic Blockers; Glutamic Acid; Heart Rate; Isoquinolines; Male; Microinjections; Pentolinium Tartrate; Quinoxalines; Rats; Rats, Wistar; Supraoptic Nucleus; Vasopressins | 2007 |
Lipopolysaccharide- and glutamate-induced hypothalamic hydroxyl radical elevation and fever can be suppressed by N-methyl-D-aspartate-receptor antagonists.
Topics: Animals; Dinoprostone; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fever; Glutamic Acid; Hydroxybenzoates; Hydroxyl Radical; Hypothalamus; Injections, Intraventricular; Isoquinolines; Lipopolysaccharides; Male; Rabbits; Random Allocation; Receptors, N-Methyl-D-Aspartate | 2007 |
Interaction between glutamatergic and nitrergic mechanisms mediating cardiovascular responses to L-glutamate injection in the diagonal band of Broca in anesthetized rats.
Topics: Anesthesia; Animals; Arginine; Benzoates; Blood Pressure; Diagonal Band of Broca; Dose-Response Relationship, Drug; Glutamic Acid; Heart Rate; Imidazoles; Isoquinolines; Male; Microinjections; Nitrergic Neurons; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Receptors, Glutamate | 2007 |
The ventrolateral periaqueductal gray is involved in the cardiovascular response evoked by l-glutamate microinjection into the lateral hypothalamus of anesthetized rats.
Topics: Anesthesia; Animals; Blood Pressure; Cobalt; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Heart Rate; Hypothalamic Area, Lateral; Isoquinolines; Male; Microinjections; Nerve Block; Periaqueductal Gray; Quinoxalines; Rats; Rats, Wistar | 2008 |
The expression of contextual fear conditioning involves activation of an NMDA receptor-nitric oxide pathway in the medial prefrontal cortex.
Topics: Animals; Arginine; Benzoates; Blood Pressure; Conditioning, Psychological; Excitatory Amino Acid Antagonists; Fear; Freezing Reaction, Cataleptic; Glutamic Acid; Heart Rate; Imidazoles; Isoquinolines; Male; Nitric Oxide; Prefrontal Cortex; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2008 |
N-methyl-D-aspartate receptors in the insular cortex modulate baroreflex in unanesthetized rats.
Topics: Anesthetics; Animals; Antihypertensive Agents; Autonomic Pathways; Baroreflex; Blood Pressure; Bradycardia; Cerebral Cortex; Cobalt; Efferent Pathways; Excitatory Amino Acid Antagonists; Glutamic Acid; Heart Rate; Isoquinolines; Neurons; Nitroprusside; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2009 |
N-methyl-D-aspartate glutamate receptors in the hypothalamic paraventricular nucleus modulate cardiac component of the baroreflex in unanesthetized rats.
Topics: Adrenergic beta-Antagonists; Animals; Baroreflex; Blood Pressure; Bradycardia; Cobalt; Excitatory Amino Acid Antagonists; Glutamic Acid; Heart; Isoquinolines; Male; Microinjections; Parasympathetic Nervous System; Paraventricular Hypothalamic Nucleus; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2010 |
Differential role of N-methyl-D-aspartate receptor-mediated glutamate transmission in the nucleus accumbens shell and core in nicotine seeking in rats.
Topics: Animals; Drug-Seeking Behavior; Excitatory Amino Acid Antagonists; Glutamic Acid; Isoquinolines; Male; Nicotine; Nucleus Accumbens; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Self Administration; Synaptic Transmission | 2014 |