ly 274614 has been researched along with naloxone in 4 studies
| Studies (ly 274614) | Trials (ly 274614) | Recent Studies (post-2010) (ly 274614) | Studies (naloxone) | Trials (naloxone) | Recent Studies (post-2010) (naloxone) |
|---|---|---|---|---|---|
| 96 | 0 | 15 | 20,134 | 1,257 | 3,321 |
| Protein | Taxonomy | ly 274614 (IC50) | naloxone (IC50) |
|---|---|---|---|
| Cytochrome P450 2D6 | Homo sapiens (human) | 2 | |
| Delta-type opioid receptor | Mus musculus (house mouse) | 0.043 | |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0219 | |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0019 | |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0019 | |
| Mu-type opioid receptor | Homo sapiens (human) | 0.0397 | |
| Delta-type opioid receptor | Homo sapiens (human) | 0.1896 | |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.05 | |
| Kappa-type opioid receptor | Homo sapiens (human) | 0.0795 | |
| Mu-type opioid receptor | Mus musculus (house mouse) | 0.0154 | |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.0089 | |
| Beta-2 adrenergic receptor | Cavia porcellus (domestic guinea pig) | 0.0055 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Elliott, K; Inturrisi, CE; Kolesnikov, YA; Minami, N; Pasternak, GW | 1 |
| Furuta, S; Hayashi, T; Honma, I; Miyazaki, S; Onodera, K; Sakurada, S; Yonezawa, A | 1 |
| Galizio, M; Keith, JR; Mansfield, WJ; Pitts, RC | 1 |
| Gewirtz, JC; Rothwell, PE; Thomas, MJ | 1 |
4 other study(ies) available for ly 274614 and naloxone
| Article | Year |
|---|---|
The NMDA receptor antagonists, LY274614 and MK-801, and the nitric oxide synthase inhibitor, NG-nitro-L-arginine, attenuate analgesic tolerance to the mu-opioid morphine but not to kappa opioids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Oxidoreductases; Analgesics; Animals; Arginine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Tolerance; Injections, Subcutaneous; Isoquinolines; Male; Mice; Morphine; Naloxone; Nitric Oxide Synthase; Nitroarginine; Pyrrolidines; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1994 |
Age-related differences in forced walking stress-induced analgesia in mice.
Topics: Aging; Analgesia; Animals; Excitatory Amino Acid Antagonists; Formaldehyde; Isoquinolines; Male; Mice; Naloxone; Narcotic Antagonists; Pain Measurement; Receptors, N-Methyl-D-Aspartate; Stress, Psychological; Walking | 2001 |
Repeated spatial acquisition: effects of NMDA antagonists and morphine.
Topics: Analgesics, Opioid; Animals; Avoidance Learning; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Morphine; N-Methylaspartate; Naloxone; Narcotic Antagonists; Phencyclidine; Rats; Rats, Sprague-Dawley; Serial Learning; Space Perception | 2003 |
Distinct profiles of anxiety and dysphoria during spontaneous withdrawal from acute morphine exposure.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Chlordiazepoxide; Conditioning, Operant; Depression; Disease Models, Animal; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Propranolol; Rats; Rats, Sprague-Dawley; Reflex, Startle; Substance Withdrawal Syndrome; Time Factors | 2009 |