Page last updated: 2024-09-03

ly 274614 and naloxone

ly 274614 has been researched along with naloxone in 4 studies

Compound Research Comparison

Studies
(ly 274614)
Trials
(ly 274614)
Recent Studies (post-2010)
(ly 274614)
Studies
(naloxone)
Trials
(naloxone)
Recent Studies (post-2010) (naloxone)
9601520,1341,2573,321

Protein Interaction Comparison

ProteinTaxonomyly 274614 (IC50)naloxone (IC50)
Cytochrome P450 2D6Homo sapiens (human)2
Delta-type opioid receptorMus musculus (house mouse)0.043
Delta-type opioid receptorRattus norvegicus (Norway rat)0.0219
Mu-type opioid receptorRattus norvegicus (Norway rat)0.0019
Kappa-type opioid receptorRattus norvegicus (Norway rat)0.0019
Mu-type opioid receptorHomo sapiens (human)0.0397
Delta-type opioid receptorHomo sapiens (human)0.1896
Kappa-type opioid receptorCavia porcellus (domestic guinea pig)0.05
Kappa-type opioid receptorHomo sapiens (human)0.0795
Mu-type opioid receptorMus musculus (house mouse)0.0154
Mu-type opioid receptorCavia porcellus (domestic guinea pig)0.0089
Beta-2 adrenergic receptorCavia porcellus (domestic guinea pig)0.0055

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (25.00)18.2507
2000's3 (75.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Elliott, K; Inturrisi, CE; Kolesnikov, YA; Minami, N; Pasternak, GW1
Furuta, S; Hayashi, T; Honma, I; Miyazaki, S; Onodera, K; Sakurada, S; Yonezawa, A1
Galizio, M; Keith, JR; Mansfield, WJ; Pitts, RC1
Gewirtz, JC; Rothwell, PE; Thomas, MJ1

Other Studies

4 other study(ies) available for ly 274614 and naloxone

ArticleYear
The NMDA receptor antagonists, LY274614 and MK-801, and the nitric oxide synthase inhibitor, NG-nitro-L-arginine, attenuate analgesic tolerance to the mu-opioid morphine but not to kappa opioids.
    Pain, 1994, Volume: 56, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Oxidoreductases; Analgesics; Animals; Arginine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Tolerance; Injections, Subcutaneous; Isoquinolines; Male; Mice; Morphine; Naloxone; Nitric Oxide Synthase; Nitroarginine; Pyrrolidines; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa; Receptors, Opioid, mu

1994
Age-related differences in forced walking stress-induced analgesia in mice.
    Drugs under experimental and clinical research, 2001, Volume: 27, Issue:5-6

    Topics: Aging; Analgesia; Animals; Excitatory Amino Acid Antagonists; Formaldehyde; Isoquinolines; Male; Mice; Naloxone; Narcotic Antagonists; Pain Measurement; Receptors, N-Methyl-D-Aspartate; Stress, Psychological; Walking

2001
Repeated spatial acquisition: effects of NMDA antagonists and morphine.
    Experimental and clinical psychopharmacology, 2003, Volume: 11, Issue:1

    Topics: Analgesics, Opioid; Animals; Avoidance Learning; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Morphine; N-Methylaspartate; Naloxone; Narcotic Antagonists; Phencyclidine; Rats; Rats, Sprague-Dawley; Serial Learning; Space Perception

2003
Distinct profiles of anxiety and dysphoria during spontaneous withdrawal from acute morphine exposure.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2009, Volume: 34, Issue:10

    Topics: Acoustic Stimulation; Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Chlordiazepoxide; Conditioning, Operant; Depression; Disease Models, Animal; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Propranolol; Rats; Rats, Sprague-Dawley; Reflex, Startle; Substance Withdrawal Syndrome; Time Factors

2009