ly 274614 has been researched along with dizocilpine maleate in 37 studies
| Studies (ly 274614) | Trials (ly 274614) | Recent Studies (post-2010) (ly 274614) | Studies (dizocilpine maleate) | Trials (dizocilpine maleate) | Recent Studies (post-2010) (dizocilpine maleate) |
|---|---|---|---|---|---|
| 96 | 0 | 15 | 7,741 | 9 | 1,449 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 24 (64.86) | 18.2507 |
| 2000's | 13 (35.14) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fuller, RW; Hemrick-Luecke, SK; Ornstein, PL | 1 |
| Fuller, RW; Ornstein, PL; Perry, KW; Rasmussen, K; Stockton, ME; Swinford, RM | 1 |
| Azzena, GB; Bagetta, G; Grassi, C; Nisticò, S; Santarelli, R | 1 |
| Elliott, K; Inturrisi, CE; Kolesnikov, YA; Minami, N; Pasternak, GW | 1 |
| Greenamyre, JT; Greene, JG | 1 |
| Brodsky, M; Inturrisi, CE; Rasmussen, K | 1 |
| Ellison, G | 1 |
| Greenamyre, JT; Porter, RH | 1 |
| Beal, MF; Ferrante, RJ; Henshaw, R; Jenkins, BG; Kowall, NW; Rosen, BR; Schulz, JB | 1 |
| de Groat, WC; Roppolo, JR; Thor, KB; Yoshiyama, M | 1 |
| Awere, S; Blackman, A; Leander, JD; Moore, NA | 1 |
| Inturrisi, CE; Tiseo, PJ | 1 |
| Elliott, K; Inturrisi, CE; Kao, B; Kest, B; Man, A | 1 |
| Bhargava, HN; Zhao, GM | 2 |
| Bharagava, HN; Zhao, GM | 1 |
| Bilsky, EJ; Hruby, VJ; Inturrisi, CE; Porreca, F; Sadée, W | 1 |
| Borowicz, K; Czuczwar, SJ; Gasior, M; Kleinrok, Z; Starownik, R | 1 |
| Lashbrook, J; Laughlin, TM; Nichols, ML; Ossipov, M; Porreca, F; Vanderah, TW; Wilcox, GL | 1 |
| Bhargava, HN; Bian, JT; Cao, YJ | 1 |
| Fabiano, C; Ientile, R; Macaione, S; Macaione, V; Pedale, S; Picciurro, V | 1 |
| Bhargava, HN; Bian, JT; Sharma, SS | 1 |
| Besson, JM; Catheline, G; Le Guen, S | 1 |
| Haapalinna, A; Heikkilä, J; Honkanen, A; Korpi, ER; Näkki, R; Sarviharju, M; Vekovischeva, OY | 1 |
| Allen, RM; Dykstra, LA | 1 |
| Allen, RM; Dykstra, LA; Granger, AL | 1 |
| Liu, JS; Zang, MW | 1 |
| Brodsky, M; Gorman, AL; Inturrisi, CE; Zhu, H | 1 |
| Kawano, K; Morinobu, S; Sawada, T; Suenaga, T; Yamawaki, S | 1 |
| Grisel, JE; Mogil, JS; Nemmani, KVS; Smith-Carliss, R; Stowe, JR | 1 |
| Joyner, PW; McMillen, BA; Parmar, CA; Tyer, WE; Williams, HL | 1 |
| Craft, RM; Lee, DA | 1 |
| Allen, RM; Carelli, RM; Dykstra, LA; Everett, CV; Suchey, TL | 1 |
| Chang, CP; Huang, WT; Lin, MT | 1 |
| Huang, WT; Kao, CH; Kao, TY; Lin, MT | 1 |
| Mendez, IA; Trujillo, KA | 1 |
| Juni, A; Kest, B; Klein, G; Kowalczyk, B; Ragnauth, A | 1 |
2 review(s) available for ly 274614 and dizocilpine maleate
| Article | Year |
|---|---|
N-methyl-D-aspartate (NMDA) receptors, mu and kappa opioid tolerance, and perspectives on new analgesic drug development.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Dextromethorphan; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Isoquinolines; Narcotics; Nitric Oxide Synthase; Opioid-Related Disorders; Pyrrolidines; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1995 |
[Blockade of opioid tolerance and dependence by NMDA receptor antagonist].
Topics: Animals; Dizocilpine Maleate; Humans; Isoquinolines; Levulinic Acids; Opioid-Related Disorders; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid | 1999 |
35 other study(ies) available for ly 274614 and dizocilpine maleate
| Article | Year |
|---|---|
Protection against amphetamine-induced neurotoxicity toward striatal dopamine neurons in rodents by LY274614, an excitatory amino acid antagonist.
Topics: Amino Acids; Amphetamine; Animals; Corpus Striatum; Dizocilpine Maleate; Dopamine; Dose-Response Relationship, Drug; Iprindole; Isoquinolines; Male; Methamphetamine; Mice; Nervous System Diseases; Neurons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1992 |
NMDA receptor antagonists suppress behaviors but not norepinephrine turnover or locus coeruleus unit activity induced by opiate withdrawal.
Topics: Animals; Behavior, Animal; Dizocilpine Maleate; Electrophysiology; Isoquinolines; Locus Coeruleus; Male; Morphine; Naltrexone; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome | 1991 |
Possible modulation of auditory middle latency responses by nitric oxide in the inferior colliculus of anaesthetized rats.
Topics: Acoustic Stimulation; Animals; Arginine; Dizocilpine Maleate; Enzyme Inhibitors; Evoked Potentials, Auditory, Brain Stem; Excitatory Amino Acid Antagonists; Inferior Colliculi; Isoquinolines; Male; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar; Reaction Time | 1995 |
The NMDA receptor antagonists, LY274614 and MK-801, and the nitric oxide synthase inhibitor, NG-nitro-L-arginine, attenuate analgesic tolerance to the mu-opioid morphine but not to kappa opioids.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Oxidoreductases; Analgesics; Animals; Arginine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Tolerance; Injections, Subcutaneous; Isoquinolines; Male; Mice; Morphine; Naloxone; Nitric Oxide Synthase; Nitroarginine; Pyrrolidines; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1994 |
Characterization of the excitotoxic potential of the reversible succinate dehydrogenase inhibitor malonate.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Body Temperature; Brain Diseases; Cell Death; Corpus Striatum; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glutamic Acid; Glycine; Isoquinolines; Male; Malonates; Neurons; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Succinate Dehydrogenase | 1995 |
NMDA antagonists and clonidine block c-fos expression during morphine withdrawal.
Topics: Animals; Clonidine; Dizocilpine Maleate; Gene Expression; Genes, fos; In Vitro Techniques; Isoquinolines; Male; Morphine; Naltrexone; Neural Pathways; Nucleic Acid Hybridization; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA Probes; RNA, Messenger; Substance Withdrawal Syndrome | 1995 |
Competitive and non-competitive NMDA antagonists induce similar limbic degeneration.
Topics: Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Isoquinolines; Limbic System; N-Methylaspartate; Nerve Degeneration; Phencyclidine; Rats; Time Factors | 1994 |
Inhibition of autoradiographic MK-801 binding by an endogenous factor.
Topics: Animals; Autoradiography; Brain Chemistry; Dizocilpine Maleate; Isoquinolines; Kynurenic Acid; Ligands; Rats; Receptors, N-Methyl-D-Aspartate | 1994 |
Malonate produces striatal lesions by indirect NMDA receptor activation.
Topics: Animals; Corpus Striatum; Dizocilpine Maleate; Isoquinolines; Magnetic Resonance Imaging; Male; Malonates; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1994 |
Effects of LY274614, a competitive NMDA receptor antagonist, on the micturition reflex in the urethane-anaesthetized rat.
Topics: Acetates; Acetic Acid; Anesthesia; Animals; Decerebrate State; Dizocilpine Maleate; Dose-Response Relationship, Drug; Electromyography; Female; Glutamates; Glutamic Acid; Injections, Spinal; Irritants; Isoquinolines; Pipecolic Acids; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reflex; Spinal Cord; Tetrazoles; Urethane; Urinary Bladder; Urination | 1993 |
NMDA receptor antagonists inhibit catalepsy induced by either dopamine D1 or D2 receptor antagonists.
Topics: Animals; Benzamides; Benzazepines; Catalepsy; Chlordiazepoxide; Dizocilpine Maleate; Dopamine D2 Receptor Antagonists; Haloperidol; Isoquinolines; Male; Rats; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate | 1993 |
Attenuation and reversal of morphine tolerance by the competitive N-methyl-D-aspartate receptor antagonist, LY274614.
Topics: Animals; Dizocilpine Maleate; Drug Tolerance; Isoquinolines; Male; Morphine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1993 |
Effects of N-methyl-D-aspartate receptor antagonists on the analgesia and tolerance to D-Ala2, Glu4 deltorphin II, a delta 2-opioid receptor agonist in mice.
Topics: Analgesics, Opioid; Animals; Dizocilpine Maleate; Drug Interactions; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Mice; Mice, Inbred Strains; Oligopeptides; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta | 1996 |
Effect of antagonism of the NMDA receptor on tolerance to [D-Pen2,D-Pen5]enkephalin, a delta 1-opioid receptor agonist.
Topics: Analgesics; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Isoquinolines; Male; Mice; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta | 1996 |
Effects of competitive and noncompetitive antagonists of the N-methyl-D-aspartate receptor on the analgesic action of delta 1- and delta 2-opioid receptor agonists in mice.
Topics: Analgesics, Opioid; Animals; Antiparkinson Agents; Binding, Competitive; Dizocilpine Maleate; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Excitatory Amino Acid Antagonists; Injections, Intraventricular; Isoquinolines; Male; Membranes; Mice; Oligopeptides; Pain Measurement; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta | 1996 |
Competitive and non-competitive NMDA antagonists block the development of antinociceptive tolerance to morphine, but not to selective mu or delta opioid agonists in mice.
Topics: Analgesics, Opioid; Animals; Binding, Competitive; Dizocilpine Maleate; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Excitatory Amino Acid Antagonists; Fentanyl; Isoquinolines; Male; Mice; Mice, Inbred ICR; Morphine; Oligopeptides; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta; Receptors, Opioid, mu | 1996 |
Anticonvulsant and adverse effects of MK-801, LY 235959, and GYKI 52466 in combination with Ca2+ channel inhibitors in mice.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Avoidance Learning; Benzodiazepines; Calcium Channel Blockers; Dizocilpine Maleate; Drug Interactions; Electroshock; Excitatory Amino Acid Antagonists; Flunarizine; Isoquinolines; Male; Mice; Motor Activity; Nicardipine; Nifedipine; Seizures | 1997 |
Spinally administered dynorphin A produces long-lasting allodynia: involvement of NMDA but not opioid receptors.
Topics: Animals; Dizocilpine Maleate; Dynorphins; Excitatory Amino Acid Antagonists; Injections, Spinal; Isoquinolines; Male; Mice; Mice, Inbred ICR; Narcotic Antagonists; Pain; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid | 1997 |
Effects of NMDA receptor antagonists on delta1- and delta2-opioid receptor agonists-induced changes in the mouse brain [3H]DPDPE binding.
Topics: Animals; Brain; Dizocilpine Maleate; Down-Regulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Membranes; Mice; Oligopeptides; Protein Binding; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta | 1997 |
Nitric oxide mediates NMDA-evoked [3H]GABA release from chick retina cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Differentiation; Cells, Cultured; Chick Embryo; Cyclic GMP; Dizocilpine Maleate; gamma-Aminobutyric Acid; Isoquinolines; N-Methylaspartate; Nitric Oxide; Nitroarginine; Nitrogen Oxides; Purinones; Receptors, N-Methyl-D-Aspartate; Retina; Spermine; Tritium | 1997 |
Evidence for a role of N-methyl-D-aspartate receptors in L-arginine-induced attenuation of morphine antinociception.
Topics: Animals; Arginine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Mice; Morphine; Narcotics; Neuroprotective Agents; Nociceptors; Receptors, N-Methyl-D-Aspartate; Time Factors | 1998 |
Effects of NMDA receptor antagonists on morphine tolerance: a c-Fos study in the lumbar spinal cord of the rat.
Topics: Analgesics, Opioid; Animals; Binding Sites; Carrageenan; Dizocilpine Maleate; Drug Tolerance; Excitatory Amino Acid Antagonists; Glycine; Immunohistochemistry; Isoquinolines; Male; Morphine; Neurons; Proto-Oncogene Proteins c-fos; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1999 |
Enhanced locomotor stimulation by NMDA receptor antagonists in alcohol-sensitive ANT rats.
Topics: Alcohol Drinking; Animals; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Isoquinolines; Ketamine; Male; Motor Activity; Proto-Oncogene Proteins c-fos; Rats; Receptors, N-Methyl-D-Aspartate; Species Specificity | 2000 |
N-methyl-D-aspartate receptor antagonists potentiate the antinociceptive effects of morphine in squirrel monkeys.
Topics: Analgesics; Analgesics, Opioid; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Morphine; Pain Measurement; Receptors, N-Methyl-D-Aspartate; Saimiri | 2001 |
Dextromethorphan potentiates the antinociceptive effects of morphine and the delta-opioid agonist SNC80 in squirrel monkeys.
Topics: Analgesics, Opioid; Animals; Antitussive Agents; Benzamides; Conditioning, Operant; Dextromethorphan; Dizocilpine Maleate; Drug Synergism; Electroshock; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Morphine; Pain Measurement; Piperazines; Pyrrolidinones; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta; Saimiri | 2002 |
Region-specific changes in NMDA receptor mRNA induced by chronic morphine treatment are prevented by the co-administration of the competitive NMDA receptor antagonist LY274614.
Topics: Animals; Binding, Competitive; Central Nervous System; Dizocilpine Maleate; Down-Regulation; Drug Administration Schedule; Drug Interactions; Drug Tolerance; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Morphine; Neurons; Pain; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger | 2003 |
Influence of immobilization stress on the levels of CaMKII and phospho-CaMKII in the rat hippocampus.
Topics: Animals; Blotting, Western; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Dizocilpine Maleate; DNA Primers; Excitatory Amino Acid Antagonists; Hippocampus; Immunohistochemistry; Isoenzymes; Isoquinolines; Male; Nimodipine; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Restraint, Physical; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Stress, Psychological; Up-Regulation | 2004 |
Modulation of morphine analgesia by site-specific N-methyl-D-aspartate receptor antagonists: dependence on sex, site of antagonism, morphine dose, and time.
Topics: Animals; Central Nervous System; Dextromethorphan; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Excitatory Amino Acid Antagonists; Female; Isoquinolines; Male; Mice; Morphine; Pain; Phenols; Piperidines; Quinolones; Receptors, N-Methyl-D-Aspartate; Sex Characteristics; Time Factors | 2004 |
Effects of NMDA glutamate receptor antagonist drugs on the volitional consumption of ethanol by a genetic drinking rat.
Topics: Alcohol Drinking; Alcohol-Induced Disorders, Nervous System; Alcoholism; Amino Acids, Cyclic; Animals; Brain; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ethanol; Excitatory Amino Acid Antagonists; Female; Genetic Predisposition to Disease; Glutamic Acid; Isoquinolines; Male; Motor Activity; Pyrrolidinones; Rats; Rats, Inbred Strains; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Volition | 2004 |
NMDA antagonist modulation of morphine antinociception in female vs. male rats.
Topics: Analgesics, Opioid; Animals; Dextromethorphan; Dizocilpine Maleate; Dose-Response Relationship, Drug; Estrous Cycle; Excitatory Amino Acid Antagonists; Female; Isoquinolines; Male; Morphine; Pain Measurement; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, N-Methyl-D-Aspartate; Sex Characteristics | 2005 |
Effects of the competitive N-methyl-D-aspartate receptor antagonist, LY235959 [(-)-6-phosphonomethyl-deca-hydroisoquinoline-3-carboxylic acid], on responding for cocaine under both fixed and progressive ratio schedules of reinforcement.
Topics: Animals; Cocaine; Dextromethorphan; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Isoquinolines; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reinforcement Schedule; Self Administration | 2005 |
An NMDA receptor-dependent hydroxyl radical pathway in the rabbit hypothalamus may mediate lipopolysaccharide fever.
Topics: Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antioxidants; Body Temperature; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Fever; Hydroxybenzoates; Hydroxyl Radical; Isoquinolines; Lipopolysaccharides; Male; Rabbits; Receptors, N-Methyl-D-Aspartate; Thioctic Acid | 2006 |
Lipopolysaccharide- and glutamate-induced hypothalamic hydroxyl radical elevation and fever can be suppressed by N-methyl-D-aspartate-receptor antagonists.
Topics: Animals; Dinoprostone; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fever; Glutamic Acid; Hydroxybenzoates; Hydroxyl Radical; Hypothalamus; Injections, Intraventricular; Isoquinolines; Lipopolysaccharides; Male; Rabbits; Random Allocation; Receptors, N-Methyl-D-Aspartate | 2007 |
NMDA receptor antagonists inhibit opiate antinociceptive tolerance and locomotor sensitization in rats.
Topics: Animals; Behavior, Animal; Buprenorphine; Dizocilpine Maleate; Drug Tolerance; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Memantine; Methadone; Morphine; Motor Activity; Narcotics; Opioid-Related Disorders; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2008 |
Sex differences in hyperalgesia during morphine infusion: effect of gonadectomy and estrogen treatment.
Topics: Analgesics, Opioid; Animals; Data Interpretation, Statistical; Dizocilpine Maleate; Dose-Response Relationship, Drug; Estrogens; Excitatory Amino Acid Antagonists; Female; Hyperalgesia; Infusions, Intravenous; Isoquinolines; Male; Mice; Morphine; Naltrexone; Narcotic Antagonists; Orchiectomy; Ovariectomy; Pain Measurement; Receptors, N-Methyl-D-Aspartate; Sex Characteristics | 2008 |