ly 274614 has been researched along with 2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline in 16 studies
| Studies (ly 274614) | Trials (ly 274614) | Recent Studies (post-2010) (ly 274614) | Studies (2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline) | Trials (2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline) | Recent Studies (post-2010) (2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline) |
|---|---|---|---|---|---|
| 96 | 0 | 15 | 1,216 | 0 | 229 |
| Protein | Taxonomy | ly 274614 (IC50) | 2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline (IC50) |
|---|---|---|---|
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | 0.5781 | |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | 0.5781 | |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | 0.5781 | |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | 0.5781 | |
| Glutamate receptor ionotropic, kainate 1 | Rattus norvegicus (Norway rat) | 2.909 | |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | 0.2 | |
| Glutamate receptor ionotropic, kainate 2 | Rattus norvegicus (Norway rat) | 2.909 | |
| Glutamate receptor 1 | Homo sapiens (human) | 6 | |
| Glutamate receptor 2 | Homo sapiens (human) | 2.5 | |
| Glutamate receptor 3 | Homo sapiens (human) | 1.9 | |
| Glutamate receptor ionotropic, kainate 3 | Rattus norvegicus (Norway rat) | 2.909 | |
| Glutamate receptor 4 | Homo sapiens (human) | 1.1 | |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | 0.2 | |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | 0.2 | |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | 0.2 | |
| Glutamate receptor ionotropic, kainate 4 | Rattus norvegicus (Norway rat) | 2.909 | |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | 0.2 | |
| Glutamate receptor ionotropic, kainate 5 | Rattus norvegicus (Norway rat) | 2.909 | |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | 0.2 | |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | 0.2 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (6.25) | 18.2507 |
| 2000's | 10 (62.50) | 29.6817 |
| 2010's | 5 (31.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Greenamyre, JT; Greene, JG | 1 |
| Gear, RW; Levine, JD; Tambeli, CH; Young, A | 1 |
| Kawano, K; Morinobu, S; Sawada, T; Suenaga, T; Yamawaki, S | 1 |
| Antunes-Rodrigues, J; Busnardo, C; Corrêa, FM; Tavares, RF | 1 |
| Corrêa, FM; Resstel, LB; Tavares, RF | 1 |
| Aguiar Corrêa, FM; Deolindo, M; Pelosi, GG; Tavares, RF | 1 |
| Corrêa, FM; Guimarães, FS; Resstel, LB | 1 |
| Carlezon, WA; Chartoff, E; Kenny, PJ; Markou, A; Roberto, M | 1 |
| Alves, FH; Correa, FM; Crestani, CC; Resstel, LB | 2 |
| Alves, FH; Correa, FM; Crestani, CC; Deolindo, MV; Resstel, LB | 1 |
| Alves, FH; Busnardo, C; Correa, FM; Crestani, CC; Resstel, LB | 1 |
| Alves, FH; Busnardo, C; Correa, FM; Crestani, CC; Resstel, LB; Scopinho, AA | 1 |
| Biagioni, AF; Coimbra, NC; Crippa, JA; de Freitas, RL; Hallak, JE; Medeiros, P; Salgado-Rohner, CJ | 1 |
| Joca, SR; Pereira, VS; Romano, A; Wegener, G | 1 |
| Busnardo, C; Corrêa, FM; Pelosi, GG; Tavares, RF | 1 |
16 other study(ies) available for ly 274614 and 2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline
| Article | Year |
|---|---|
Characterization of the excitotoxic potential of the reversible succinate dehydrogenase inhibitor malonate.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Body Temperature; Brain Diseases; Cell Death; Corpus Striatum; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glutamic Acid; Glycine; Isoquinolines; Male; Malonates; Neurons; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Succinate Dehydrogenase | 1995 |
Contribution of spinal glutamatergic mechanisms in heterosegmental antinociception induced by noxious stimulation.
Topics: Animals; Benzoates; Capsaicin; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Isoquinolines; Male; Nociceptors; Pyridines; Quinoxalines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Spinal Cord; Stimulation, Chemical; Substance P | 2003 |
Influence of immobilization stress on the levels of CaMKII and phospho-CaMKII in the rat hippocampus.
Topics: Animals; Blotting, Western; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Dizocilpine Maleate; DNA Primers; Excitatory Amino Acid Antagonists; Hippocampus; Immunohistochemistry; Isoenzymes; Isoquinolines; Male; Nimodipine; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Restraint, Physical; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Stress, Psychological; Up-Regulation | 2004 |
Cardiovascular effects of L-glutamate microinjection in the supraoptic nucleus of unanaesthetized rats.
Topics: Animals; Arginine Vasopressin; Blood Pressure; Excitatory Amino Acid Antagonists; Ganglionic Blockers; Glutamic Acid; Heart Rate; Isoquinolines; Male; Microinjections; Pentolinium Tartrate; Quinoxalines; Rats; Rats, Wistar; Supraoptic Nucleus; Vasopressins | 2007 |
Interaction between glutamatergic and nitrergic mechanisms mediating cardiovascular responses to L-glutamate injection in the diagonal band of Broca in anesthetized rats.
Topics: Anesthesia; Animals; Arginine; Benzoates; Blood Pressure; Diagonal Band of Broca; Dose-Response Relationship, Drug; Glutamic Acid; Heart Rate; Imidazoles; Isoquinolines; Male; Microinjections; Nitrergic Neurons; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Receptors, Glutamate | 2007 |
The ventrolateral periaqueductal gray is involved in the cardiovascular response evoked by l-glutamate microinjection into the lateral hypothalamus of anesthetized rats.
Topics: Anesthesia; Animals; Blood Pressure; Cobalt; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Heart Rate; Hypothalamic Area, Lateral; Isoquinolines; Male; Microinjections; Nerve Block; Periaqueductal Gray; Quinoxalines; Rats; Rats, Wistar | 2008 |
The expression of contextual fear conditioning involves activation of an NMDA receptor-nitric oxide pathway in the medial prefrontal cortex.
Topics: Animals; Arginine; Benzoates; Blood Pressure; Conditioning, Psychological; Excitatory Amino Acid Antagonists; Fear; Freezing Reaction, Cataleptic; Glutamic Acid; Heart Rate; Imidazoles; Isoquinolines; Male; Nitric Oxide; Prefrontal Cortex; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2008 |
NMDA receptors regulate nicotine-enhanced brain reward function and intravenous nicotine self-administration: role of the ventral tegmental area and central nucleus of the amygdala.
Topics: Amygdala; Animals; Blotting, Western; Catheterization; Electrodes, Implanted; Excitatory Postsynaptic Potentials; Feeding Behavior; Isoquinolines; Male; Nicotine; Nucleus Accumbens; Patch-Clamp Techniques; Prefrontal Cortex; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reward; Self Administration; Ventral Tegmental Area | 2009 |
Bed nucleus of the stria terminalis N-methyl-D-aspartate receptors and nitric oxide modulate the baroreflex cardiac component in unanesthetized rats.
Topics: Animals; Arginine; Baroreflex; Benzoates; Blood Pressure; Cardiac Output; Cholinergic Antagonists; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Free Radical Scavengers; Imidazoles; Isoquinolines; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type I; Nitroprusside; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Septal Nuclei; Tropanes | 2009 |
N-methyl-D-aspartate receptors in the insular cortex modulate baroreflex in unanesthetized rats.
Topics: Anesthetics; Animals; Antihypertensive Agents; Autonomic Pathways; Baroreflex; Blood Pressure; Bradycardia; Cerebral Cortex; Cobalt; Efferent Pathways; Excitatory Amino Acid Antagonists; Glutamic Acid; Heart Rate; Isoquinolines; Neurons; Nitroprusside; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2009 |
Non-N-methyl-d-aspartate glutamate receptors in the lateral hypothalamus modulate cardiac baroreflex responses in conscious rats.
Topics: Animals; Baroreflex; Blood Pressure; Bradycardia; Cobalt; Excitatory Amino Acid Antagonists; Hypothalamic Area, Lateral; Isoquinolines; Male; Microinjections; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Tachycardia | 2009 |
N-methyl-D-aspartate glutamate receptors in the hypothalamic paraventricular nucleus modulate cardiac component of the baroreflex in unanesthetized rats.
Topics: Adrenergic beta-Antagonists; Animals; Baroreflex; Blood Pressure; Bradycardia; Cobalt; Excitatory Amino Acid Antagonists; Glutamic Acid; Heart; Isoquinolines; Male; Microinjections; Parasympathetic Nervous System; Paraventricular Hypothalamic Nucleus; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2010 |
Paraventricular nucleus of the hypothalamus glutamate neurotransmission modulates autonomic, neuroendocrine and behavioral responses to acute restraint stress in rats.
Topics: Animals; Arterial Pressure; Corticosterone; Excitatory Amino Acid Antagonists; Heart Rate; Isoquinolines; Male; Maze Learning; Microinjections; Paraventricular Hypothalamic Nucleus; Quinoxalines; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Restraint, Physical; Skin Temperature; Stress, Psychological; Synaptic Transmission | 2013 |
NMDA and AMPA/kainate glutamatergic receptors in the prelimbic medial prefrontal cortex modulate the elaborated defensive behavior and innate fear-induced antinociception elicited by GABAA receptor blockade in the medial hypothalamus.
Topics: Animals; Behavior, Animal; Bicuculline; Excitatory Amino Acid Antagonists; Fear; GABA-A Receptor Antagonists; Hypothalamus, Middle; Isoquinolines; Male; Nociceptive Pain; Pain Perception; Panic; Prefrontal Cortex; Quinoxalines; Rats, Wistar; Receptors, AMPA; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2014 |
Antidepressant-like effects induced by NMDA receptor blockade and NO synthesis inhibition in the ventral medial prefrontal cortex of rats exposed to the forced swim test.
Topics: Animals; Antidepressive Agents; Depression; Dose-Response Relationship, Drug; Isoquinolines; Male; Nitric Oxide; Nitric Oxide Synthase Type I; Prefrontal Cortex; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Swimming | 2015 |
Involvement of non-NMDA glutamate receptors of the hypothalamic paraventricular nucleus in the cardiovascular response to the microinjection of noradrenaline into the dorsal periaqueductal gray area of rats.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Bradycardia; Catheters, Indwelling; Excitatory Amino Acid Antagonists; Heart Rate; Isoquinolines; Male; Microinjections; Norepinephrine; Paraventricular Hypothalamic Nucleus; Periaqueductal Gray; Quinoxalines; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 2015 |