Page last updated: 2024-12-10

cv 11194

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

CV 11194: structure given in first source; an angiotensin II receptor antagonist [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID3025727
CHEMBL ID48242
SCHEMBL ID905714
SCHEMBL ID12787593
MeSH IDM0217784

Synonyms (19)

Synonym
2-butyl-3-[2''-(1h-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3h-benzoimidazole-4-carboxylic acid(cv11194)
2-butyl-3-[2''-(1h-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3h-benzoimidazole-4-carboxylic acid
bdbm50044402
cv 11194
CHEMBL48242 ,
cv-11194
L005054
2-butyl-3-[[4-[2-(2h-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylic acid
2-butyl-1-((2'-(1h-tetrazol-5-yl)biphenyl-4-yl)methyl)-1h-benzimidazole-7-carboxylic acid
2-butyl-1-((2'-(1h-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-1h-benzimidazole-7-carboxylic acid
136284-47-4
1h-benzimidazole-7-carboxylic acid, 2-butyl-1-((2'-(1h-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-
SCHEMBL905714
SCHEMBL12787593
FLOKGHWIQFCIJW-UHFFFAOYSA-N ,
2-butyl-1-[[2'-(1h-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid
DTXSID70159756
2-butyl-3-[[4-[2-(2h-tetrazol-5-yl)phenyl]phenyl]methyl]benzoimidazole -4-carboxylic acid
2-butyl-3-[[4-[2-(2h-tetrazol-5-yl)phenyl]phenyl]methyl]benzoimidazole-4-carboxylic acid

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
"In order to improve the oral bioavailability (BA) of 2-butyl-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimid azole - 7-carboxylic acid (3: CV-11194) and 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4- yl]methyl]-1H-benzimidazole-7-carboxylic acid (4: CV-11974), novel angiotensin II (AII) receptor antagonists, chemical modification to yield prodrugs has been examined."( Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of potential prodrugs of benzimidazole-7-carboxylic acids.
Furukawa, Y; Inada, Y; Kato, T; Kohara, Y; Kubo, K; Naka, T; Nishikawa, K; Shibouta, Y; Yoshimura, Y, 1993
)
0.29
" This might be ascribed to their improved bioavailability by increased lipophilicity."( Synthesis and angiotensin II receptor antagonistic activities of benzimidazole derivatives bearing acidic heterocycles as novel tetrazole bioisosteres.
Imamiya, E; Inada, Y; Kohara, Y; Kubo, K; Naka, T; Wada, T, 1996
)
0.29
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Type-1 angiotensin II receptorBos taurus (cattle)IC50 (µMol)0.55000.18000.36500.5500AID568921
Type-1 angiotensin II receptorOryctolagus cuniculus (rabbit)IC50 (µMol)0.00010.00010.09130.5000AID568911
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (3)

Processvia Protein(s)Taxonomy
maintenance of blood vessel diameter homeostasis by renin-angiotensinType-1 angiotensin II receptorBos taurus (cattle)
regulation of vasoconstrictionType-1 angiotensin II receptorBos taurus (cattle)
phospholipase C-activating angiotensin-activated signaling pathwayType-1 angiotensin II receptorBos taurus (cattle)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (2)

Processvia Protein(s)Taxonomy
angiotensin type I receptor activityType-1 angiotensin II receptorBos taurus (cattle)
angiotensin type II receptor activityType-1 angiotensin II receptorBos taurus (cattle)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (20)

Assay IDTitleYearJournalArticle
AID181931Percent inhibition of angiotensin II (0.1 ug/kg iv) -induced pressor response 3h after administration of test compounds (1 mg/kg po) in conscious male Sprague-Dawley rats1996Journal of medicinal chemistry, Dec-20, Volume: 39, Issue:26
Synthesis and angiotensin II receptor antagonistic activities of benzimidazole derivatives bearing acidic heterocycles as novel tetrazole bioisosteres.
AID183922Inhibitory activity on AII (100 ng/kg iv)-induced pressor response after administration at 0.1 mg/kg po in conscious male Sprague-Dawley rats at 5 h.1993Journal of medicinal chemistry, Aug-06, Volume: 36, Issue:16
Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of potential prodrugs of benzimidazole-7-carboxylic acids.
AID194464In vivo inhibition of angiotensin II (0.1 ug/kg) induced increase in blood pressure in conscious male rat at 3 mg/kg for 3h/7h.1993Journal of medicinal chemistry, Jun-11, Volume: 36, Issue:12
Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of benzimidazoles.
AID39041In vitro for inhibition of specific binding of [125I]-angiotensin II (0.02 nM) to bovine adrenal cortex1993Journal of medicinal chemistry, Jun-11, Volume: 36, Issue:12
Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of benzimidazoles.
AID183920Inhibitory activity on AII (100 ng/kg iv)-induced pressor response after administration at 0.1 mg/kg po in conscious male Sprague-Dawley rats at 24 h.1993Journal of medicinal chemistry, Aug-06, Volume: 36, Issue:16
Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of potential prodrugs of benzimidazole-7-carboxylic acids.
AID26234Bioavailability determined from the ratio of AUC(plasma) for 0 to infinity after oral dosing of the test compound (10 mg/kg) to intravenous administration of CD-11194 (1 mg/kg) in rats1993Journal of medicinal chemistry, Aug-06, Volume: 36, Issue:16
Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of potential prodrugs of benzimidazole-7-carboxylic acids.
AID220582Percent inhibition of the Angiotensin-II (0.1micro g/kg, iv) induced pressor response after 7 hours of administration (3 mg/kg po) in rats1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of benzimidazolecarboxylic acids.
AID185269Percent inhibition of the Angiotensin-II (0.1ug/kg, iv) induced pressor response after 3 hours of administration (1 mg/kg po) in rats1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of benzimidazolecarboxylic acids.
AID568911Antagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile response2010Bioorganic & medicinal chemistry, Dec-15, Volume: 18, Issue:24
Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists--a perspective.
AID183917Inhibitory activity on AII (100 ng/kg iv) -induced pressor response after administration at 0.1 mg/kg po in Dawley rats at 0.5 h1993Journal of medicinal chemistry, Aug-06, Volume: 36, Issue:16
Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of potential prodrugs of benzimidazole-7-carboxylic acids.
AID181933Percent inhibition of angiotensin II (0.1 ug/kg iv) -induced pressor response 7 hr after administration of test compounds (1 mg/kg po) in conscious male Sprague-Dawley rats1996Journal of medicinal chemistry, Dec-20, Volume: 39, Issue:26
Synthesis and angiotensin II receptor antagonistic activities of benzimidazole derivatives bearing acidic heterocycles as novel tetrazole bioisosteres.
AID39038Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of benzimidazolecarboxylic acids.
AID183923Inhibitory activity on AII (100 ng/kg iv)-induced pressor response after administration at 0.1 mg/kg po in conscious male Sprague-Dawley rats at 7 h.1993Journal of medicinal chemistry, Aug-06, Volume: 36, Issue:16
Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of potential prodrugs of benzimidazole-7-carboxylic acids.
AID568921Displacement of [125I]-angiotensin 2 from angiotensin AT1 receptor in bovine adrenal cortical membranes2010Bioorganic & medicinal chemistry, Dec-15, Volume: 18, Issue:24
Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists--a perspective.
AID183921Inhibitory activity on AII (100 ng/kg iv)-induced pressor response after administration at 0.1 mg/kg po in conscious male Sprague-Dawley rats at 3 h.1993Journal of medicinal chemistry, Aug-06, Volume: 36, Issue:16
Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of potential prodrugs of benzimidazole-7-carboxylic acids.
AID39039Inhibition of specific binding of [125I]angiotensin II (0.2 nM) to angiotensin II receptor in bovine adrenal cortex1996Journal of medicinal chemistry, Dec-20, Volume: 39, Issue:26
Synthesis and angiotensin II receptor antagonistic activities of benzimidazole derivatives bearing acidic heterocycles as novel tetrazole bioisosteres.
AID185393Percent inhibition of the Angiotensin-II (0.1ug/kg, iv) induced pressor response after 7 hours of administration (1 mg/kg po) in rats1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of benzimidazolecarboxylic acids.
AID183918Inhibitory activity on AII (100 ng/kg iv) -induced pressor response after administration at 0.1 mg/kg po in Dawley rats at 1 h1993Journal of medicinal chemistry, Aug-06, Volume: 36, Issue:16
Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of potential prodrugs of benzimidazole-7-carboxylic acids.
AID185270Percent inhibition of the Angiotensin-II (0.1ug/kg, iv) induced pressor response after 3 hours of administration (3 mg/kg po) in rats1993Journal of medicinal chemistry, Jul-23, Volume: 36, Issue:15
Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of benzimidazolecarboxylic acids.
AID183919Inhibitory activity on AII (100 ng/kg iv)-induced pressor response after administration at 0.1 mg/kg po in conscious male Sprague-Dawley rats at 2 h.1993Journal of medicinal chemistry, Aug-06, Volume: 36, Issue:16
Nonpeptide angiotensin II receptor antagonists. Synthesis and biological activity of potential prodrugs of benzimidazole-7-carboxylic acids.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's5 (83.33)18.2507
2000's0 (0.00)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.24

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.24 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.18 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.24)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (33.33%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other4 (66.67%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]