Page last updated: 2024-12-10
l 158338
Description
L 158338: structure given in first source; angiotensin receptor antagonist [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 3036053 |
| CHEMBL ID | 296725 |
| SCHEMBL ID | 8565683 |
| MeSH ID | M0221421 |
Synonyms (21)
| Synonym |
|---|
| l 158338 |
| CHEMBL296725 , |
| l-158338 |
| L004396 |
| 7-methyl-2-propyl-3-[[4-[2-(2h-tetrazol-5-yl)phenyl]phenyl]methyl]imidazo[4,5-b]pyridine |
| 7-methyl-2-propyl-3-[2''-(2h-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3h-imidazo[4,5-b]pyridine |
| bdbm50009719 |
| 3h-imidazo(4,5-b)pyridine, 7-methyl-2-propyl-3-((2'-(1h-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)- |
| l 158,338 |
| 133240-38-7 |
| l-158,338 |
| 7-methyl-2-propyl-3-((2'-(1h-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-3h-imidazo(4,5-b)pyridine |
| 2h-imidazo(4,5-b)pyridine, 7-methyl-2-propyl-3-((2'-(1h-tetrazol-5-yl)(1,1'-biphenyl)4-yl)methyl)- |
| CYUMNDVYHILLEX-UHFFFAOYSA-N |
| 7-methyl-2-propyl-3-(2'-(tetrazol-5-yl)biphen-4-yl)methyl-3h-imidazo[4,5-b]pyridine |
| 7-methyl-2-n-propyl-3-[{2'- (1h-tetrazol-5-yl)biphenyl-4-yl}methyl]-3h-imidazo[4,5-b]pyridine |
| 7-methyl-2-n-propyl-3-[{2'-(1h-tetrazol-5-yl)biphenyl-4-yl}methyl]-3h-imidazo[4,5-b]pyridine |
| SCHEMBL8565683 |
| DTXSID50158025 |
| 3h-imidazo[4,5-b]pyridine, 7-methyl-2-propyl-3-[[2'-(2h-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- |
| AKOS040745964 |
Protein Targets (1)
Inhibition Measurements
Bioassays (3)
| Assay ID | Title | Year | Journal | Article |
|---|
| AID39195 | Binding affinity towards Angiotensin receptor from rabbit aorta | 1991 | Journal of medicinal chemistry, Sep, Volume: 34, Issue:9
| Potent, orally active imidazo[4,5-b]pyridine-based angiotensin II receptor antagonists. |
| AID37687 | Binding affinity for rat angiotensin II receptor, type 1 | 2004 | Journal of medicinal chemistry, May-06, Volume: 47, Issue:10
| Design, synthesis, structural studies, biological evaluation, and computational simulations of novel potent AT(1) angiotensin II receptor antagonists based on the 4-phenylquinoline structure. |
| AID39360 | The compound was tested for inhibition of angiotensin II receptor induced pressor response in rat after intravenous administration. | 1991 | Journal of medicinal chemistry, Sep, Volume: 34, Issue:9
| Potent, orally active imidazo[4,5-b]pyridine-based angiotensin II receptor antagonists. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (4)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (75.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 12.42
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 12.42 (24.57) | | Research Supply Index | 1.79 (2.92) | | Research Growth Index | 4.21 (4.65) | | Search Engine Demand Index | 0.00 (26.88) | | Search Engine Supply Index | 0.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |