Page last updated: 2024-09-03

l 158809 and losartan

l 158809 has been researched along with losartan in 26 studies

Compound Research Comparison

Studies (l 158809)	Trials (l 158809)	Recent Studies (post-2010) (l 158809)	Studies (losartan)	Trials (losartan)	Recent Studies (post-2010) (losartan)
137	0	7	7,231	1,245	2,118

Protein Interaction Comparison

Protein	Taxonomy	losartan (IC50)
Bile salt export pump	Homo sapiens (human)	9.01
Cytochrome P450 2C9	Homo sapiens (human)	2.882
Angiotensin-converting enzyme	Homo sapiens (human)	0.019
Atrial natriuretic peptide receptor 3	Homo sapiens (human)	0.0018
5-hydroxytryptamine receptor 1A	Rattus norvegicus (Norway rat)	0.019
Type-1A angiotensin II receptor	Rattus norvegicus (Norway rat)	0.0247
Type-1B angiotensin II receptor	Rattus norvegicus (Norway rat)	0.0234
Adenosine receptor A2a	Rattus norvegicus (Norway rat)	0.0032
Type-1 angiotensin II receptor	Homo sapiens (human)	0.047
Type-1 angiotensin II receptor	Oryctolagus cuniculus (rabbit)	0.025
Type-2 angiotensin II receptor	Rattus norvegicus (Norway rat)	0.0118
Type-2 angiotensin II receptor	Homo sapiens (human)	0.019
Platelet glycoprotein VI	Homo sapiens (human)	4
Solute carrier organic anion transporter family member 1B3	Homo sapiens (human)	1.1481
Type-1 angiotensin II receptor	Cavia porcellus (domestic guinea pig)	0.018
Solute carrier organic anion transporter family member 1B1	Homo sapiens (human)	0.2884

Research

Studies (26)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	19 (73.08)	18.2507
2000's	5 (19.23)	29.6817
2010's	2 (7.69)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Chakravarty, PK; Chang, RS; Chen, TB; Faust, KA; Lotti, VJ; Mantlo, NB; Ondeyka, DL; Schorn, TW; Siegl, PK; Sweet, CS	1
Chakravarty, PK; Chang, RS; Chen, A; Chen, TB; Faust, KA; Gable, RA; Kivlighn, SD; Lotti, VJ; Naylor, EM; Zingaro, GJ	1
Bagley, SW; Chakravarty, PK; Chang, RS; Chen, TB; Dhanoa, DS; Kivlighn, SD; Lotti, VJ; Patchett, AA; Siegl, PK; Zingaro, GJ	1
Bagley, SW; Chang, RS; Chen, TB; Dhanoa, DS; Greenlee, WJ; Kivlighn, SD; Lotti, VJ; Patchett, AA; Siegl, PK; Zingaro, GJ	2
Altenbach, RJ; Basha, FZ; Boyd, SA; Brune, ME; Buckner, SA; Crowell, D; De, B; Drizin, I; Winn, M; Zydowsky, TM	1
Ashton, WT; Cantone, CL; Chang, LL; Chang, RS; Chen, TB; Faust, KA; Hutchins, SM; Lotti, VJ; MacCoss, M; Strelitz, RA	1
Goldberg, MR; Greenlee, WJ; Irvin, JD; Prendergast, K; Smith, RD; Timmermans, PB; Wexler, RR	1
Anzini, M; Cappelli, A; De Benedetti, PG; Ferrari, F; Gallelli, A; Giorgi, G; Makovec, F; Mennuni, L; Menziani, MC; Pericot Mohr Gl, Gl; Rizzo, M; Vomero, S	1
Berellini, G; Cruciani, G; Mannhold, R	1
Anzini, M; Cappelli, A; Caselli, G; Ferrari, F; Gallelli, A; Giordani, A; Giorgi, G; Giuliani, G; Makovec, F; Mennuni, L; Mohr, Gl; Nannicini, C; Peris, W; Valenti, S; Vomero, S	1
Giridhar, R; Murumkar, P; Naik, P; Yadav, MR	1
Meanwell, NA	1
Chang, RS; Chen, TB; Lotti, VJ	1
Chakravarty, PK; Chang, RS; Clineschmidt, BV; Greenlee, WJ; Lotti, VJ; Mantlo, NB; Patchett, AA; Siegl, PK	1
Chakravarty, PK; Chang, RS; Greenlee, WJ; Lotti, VJ; Mantlo, NB; Ondeyka, DL; Patchett, AA; Siegl, PK; Sweet, CS	1
Caussade, F; Cazes, M; Cloarec, A; Delchambre, C; Versigny, A; Virone-Oddos, A	1
Bauer, JH; Reams, GP	1
Grove, KL; Speth, RC	1
Dagenais, P; Escher, E	1
Diz, DI; Ferrario, CM; Jaiswal, N; Jaiswal, RK; Tallant, EA	1
Cazes, M; Cloarec, A; Provost, D; Versigny, A	1
Almansa, C; Carceller, E; Cavalcanti, FL; de Arriba, AF; Forn, J; García-Rafanell, J; Gómez, LA; Rodríguez, R	1
Jung, YS; Lee, BH; Lee, SH; Shin, HS; Yoo, SE; Yun, SI	1
Bechtold, AG; Scheuer, DA	1
Li, X; Papp, M; Uhal, BD; Wang, R; Zhuang, J	1

Reviews

3 review(s) available for l 158809 and losartan

Article	Year
Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy. Journal of medicinal chemistry, 1996, Feb-02, Volume: 39, Issue:3 Topics: Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Humans; Receptors, Angiotensin; Structure-Activity Relationship	1996
Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists--a perspective. Bioorganic & medicinal chemistry, 2010, Dec-15, Volume: 18, Issue:24 Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Antihypertensive Agents; Humans; Losartan	2010
The angiotensin II type 1 receptor antagonists. A new class of antihypertensive drugs. Archives of internal medicine, 1995, Jul-10, Volume: 155, Issue:13 Topics: Acrylates; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Benzoates; Biphenyl Compounds; Humans; Imidazoles; Irbesartan; Losartan; Pyridines; Quinolines; Telmisartan; Tetrazoles; Thiophenes; Valine; Valsartan	1995

Other Studies

23 other study(ies) available for l 158809 and losartan

Article	Year
Potent, orally active imidazo[4,5-b]pyridine-based angiotensin II receptor antagonists. Journal of medicinal chemistry, 1991, Volume: 34, Issue:9 Topics: Administration, Oral; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Imidazoles; Purines; Rats; Tetrazoles	1991
A highly potent, orally active imidazo[4,5-b]pyridine biphenylacylsulfonamide (MK-996; L-159,282): a new AT1-selective angiotensin II receptor antagonist. Journal of medicinal chemistry, 1994, Nov-25, Volume: 37, Issue:24 Topics: Administration, Oral; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Dogs; Imidazoles; Macaca mulatta; Pyridines; Rats	1994
(Dipropylphenoxy)phenylacetic acids: a new generation of nonpeptide angiotensin II receptor antagonists. Journal of medicinal chemistry, 1993, Nov-12, Volume: 36, Issue:23 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta; Biphenyl Compounds; Blood Pressure; Brain; Imidazoles; Losartan; Phenylacetates; Rabbits; Rats; Receptors, Angiotensin; Tetrazoles	1993
Non-peptide angiotensin II receptor antagonists. 1. Design, synthesis, and biological activity of N-substituted indoles and dihydroindoles. Journal of medicinal chemistry, 1993, Dec-24, Volume: 36, Issue:26 Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Acylation; Alkylation; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta; Benzoates; Blood Pressure; Drug Design; Imidazoles; Indoles; Kinetics; Mesencephalon; Molecular Structure; Pyridines; Rabbits; Rats; Receptors, Angiotensin; Structure-Activity Relationship	1993
Non-peptide angiotensin II receptor antagonists. 2. Design, synthesis, and biological activity of N-substituted (phenylamino)phenylacetic acids and acyl sulfonamides. Journal of medicinal chemistry, 1993, Dec-24, Volume: 36, Issue:26 Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta; Blood Pressure; Drug Design; Imidazoles; Kinetics; Mesencephalon; Molecular Structure; Phenylacetates; Pyridines; Rabbits; Rats; Receptors, Angiotensin; Structure-Activity Relationship; Sulfonamides; Tetrazoles	1993
2-(Alkylamino)nicotinic acid and analogs. Potent angiotensin II antagonists. Journal of medicinal chemistry, 1993, Sep-03, Volume: 36, Issue:18 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta; Biological Availability; Iodine Radioisotopes; Liver; Male; Muscle Contraction; Niacin; Nicotinic Acids; Rabbits; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Receptors, Angiotensin; Tetrazoles	1993
Nonpeptide angiotensin II antagonists derived from 4H-1,2,4-triazoles and 3H-imidazo[1,2-b][1,2,4]triazoles. Journal of medicinal chemistry, 1993, Mar-05, Volume: 36, Issue:5 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta; Binding, Competitive; Blood Pressure; Male; Molecular Structure; Rabbits; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Structure-Activity Relationship; Triazoles	1993
Design, synthesis, structural studies, biological evaluation, and computational simulations of novel potent AT(1) angiotensin II receptor antagonists based on the 4-phenylquinoline structure. Journal of medicinal chemistry, 2004, May-06, Volume: 47, Issue:10 Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Aorta, Thoracic; Binding, Competitive; Computer Simulation; Crystallography, X-Ray; Drug Design; Imidazoles; In Vitro Techniques; Isometric Contraction; Ligands; Liver; Male; Models, Molecular; Molecular Structure; Muscle, Smooth, Vascular; Purines; Pyridines; Quinolines; Rabbits; Radioligand Assay; Rats; Rats, Wistar; Structure-Activity Relationship; Tetrazoles	2004
Pharmacophore, drug metabolism, and pharmacokinetics models on non-peptide AT1, AT2, and AT1/AT2 angiotensin II receptor antagonists. Journal of medicinal chemistry, 2005, Jun-30, Volume: 48, Issue:13 Topics: Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Binding Sites; Biphenyl Compounds; Kinetics; Losartan; Models, Molecular; Molecular Conformation; Oxidation-Reduction; Pharmaceutical Preparations; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Structure-Activity Relationship; Tetrazoles	2005
Design, synthesis, and biological evaluation of AT1 angiotensin II receptor antagonists based on the pyrazolo[3,4-b]pyridine and related heteroaromatic bicyclic systems. Journal of medicinal chemistry, 2008, Apr-10, Volume: 51, Issue:7 Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Aorta, Thoracic; Bridged Bicyclo Compounds, Heterocyclic; Caco-2 Cells; Cell Membrane Permeability; Crystallography, X-Ray; Drug Design; Humans; Intestinal Mucosa; Male; Models, Molecular; Molecular Structure; Pyrazoles; Pyridines; Rabbits; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Stereoisomerism; Structure-Activity Relationship	2008
Synopsis of some recent tactical application of bioisosteres in drug design. Journal of medicinal chemistry, 2011, Apr-28, Volume: 54, Issue:8 Topics: Cytochrome P-450 Enzyme System; Drug Design	2011
Characterization of the binding of [3H]L-158,809: a new potent and selective nonpeptide angiotensin II receptor (AT1) antagonist radioligand. Molecular pharmacology, 1992, Volume: 42, Issue:6 Topics: Adrenal Glands; Angiotensin Receptor Antagonists; Animals; Binding, Competitive; Biphenyl Compounds; Guanylyl Imidodiphosphate; Imidazoles; Kidney; Kinetics; Liver; Losartan; Molecular Structure; Radioligand Assay; Rats; Tetrazoles	1992
In vitro pharmacology of L-158,809, a new highly potent and selective angiotensin II receptor antagonist. The Journal of pharmacology and experimental therapeutics, 1992, Volume: 262, Issue:1 Topics: Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Binding, Competitive; Biphenyl Compounds; Brain; Cell Membrane; Culture Techniques; Humans; Imidazoles; Losartan; Macaca mulatta; Muscle, Smooth, Vascular; Rabbits; Rats; Species Specificity; Tetrazoles	1992
In vivo pharmacology of L-158,809, a new highly potent and selective nonpeptide angiotensin II receptor antagonist. The Journal of pharmacology and experimental therapeutics, 1992, Volume: 262, Issue:1 Topics: Administration, Oral; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Female; Imidazoles; Injections, Intravenous; Losartan; Macaca mulatta; Male; Pressoreceptors; Pyridines; Rats; Rats, Inbred Strains; Tetrazoles	1992
In vitro pharmacological characterization of UP 269-6, a novel nonpeptide angiotensin II receptor antagonist. Fundamental & clinical pharmacology, 1995, Volume: 9, Issue:2 Topics: Adrenal Medulla; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta; Binding, Competitive; Biphenyl Compounds; Dose-Response Relationship, Drug; Imidazoles; In Vitro Techniques; Losartan; Male; Muscle, Smooth, Vascular; Pyrimidines; Radioligand Assay; Rats; Tetrazoles	1995
Angiotensin II and non-angiotensin II displaceable binding sites for [3H]losartan in the rat liver. Biochemical pharmacology, 1993, Nov-02, Volume: 46, Issue:9 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Binding Sites; Binding, Competitive; Biphenyl Compounds; Imidazoles; Liver; Losartan; Male; Rats; Receptors, Angiotensin; Subcellular Fractions; Tetrazoles; Tritium	1993
Anti-angiotensin antibodies cross-reactive with nonpeptide angiotensin antagonists as angiotensin receptor model. Regulatory peptides, 1993, Mar-19, Volume: 44, Issue:2 Topics: Adrenocorticotropic Hormone; Amino Acid Sequence; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antibodies; Biphenyl Compounds; Cross Reactions; Enzyme-Linked Immunosorbent Assay; Imidazoles; Losartan; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Naloxone; Pyridines; Saralasin; Structure-Activity Relationship; Tetrazoles	1993
Differential regulation of prostaglandin synthesis by angiotensin peptides in porcine aortic smooth muscle cells: subtypes of angiotensin receptors involved. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 265, Issue:2 Topics: Angiotensin Receptor Antagonists; Angiotensins; Animals; Aorta; Biphenyl Compounds; Calcium; Cells, Cultured; Imidazoles; Losartan; Muscle, Smooth, Vascular; Oligopeptides; Peptide Fragments; Prostaglandins; Receptors, Angiotensin; Swine; Tetrazoles	1993
In vivo pharmacological characterization of UP 269-6, a novel nonpeptide angiotensin II receptor antagonist. European journal of pharmacology, 1995, Sep-15, Volume: 284, Issue:1-2 Topics: Administration, Oral; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Decerebrate State; Dogs; Dose-Response Relationship, Drug; Heart Rate; Imidazoles; Injections, Intravenous; Losartan; Male; Pyrimidines; Rats; Rats, Sprague-Dawley; Species Specificity; Tetrazoles; Vasoconstrictor Agents	1995
Diphenylpropionic acids as new AT1 selective angiotensin II antagonists. Journal of medicinal chemistry, 1996, May-24, Volume: 39, Issue:11 Topics: Administration, Oral; Adrenal Glands; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta, Thoracic; Biphenyl Compounds; Blood Pressure; Diet, Sodium-Restricted; Furosemide; Imidazoles; In Vitro Techniques; Indicators and Reagents; Kinetics; Liver; Losartan; Male; Models, Molecular; Molecular Structure; Muscle, Smooth, Vascular; Phenylpropionates; Rabbits; Rats; Stereoisomerism; Structure-Activity Relationship; Tetrazoles	1996
Characterization of angiotensin II antagonism displayed by SK-1080, a novel nonpeptide AT1-receptor antagonist. Journal of cardiovascular pharmacology, 1999, Volume: 33, Issue:3 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta, Thoracic; Binding, Competitive; Blood Pressure; Decerebrate State; Diastole; Dose-Response Relationship, Drug; Heart Rate; Imidazoles; In Vitro Techniques; Losartan; Male; Muscle Contraction; Pyridines; Rabbits; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Sensitivity and Specificity; Tetrazoles	1999
Glucocorticoids potentiate central actions of angiotensin to increase arterial pressure. American journal of physiology. Regulatory, integrative and comparative physiology, 2001, Volume: 280, Issue:6 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Brain; Corticosterone; Drug Synergism; Imidazoles; Injections, Intravenous; Injections, Intraventricular; Losartan; Male; Microinjections; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Reference Values; Tetrazoles	2001
Angiotensin receptor subtype AT(1) mediates alveolar epithelial cell apoptosis in response to ANG II. American journal of physiology. Lung cellular and molecular physiology, 2002, Volume: 282, Issue:4 Topics: Adenocarcinoma; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Apoptosis; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Epithelial Cells; Humans; Imidazoles; Losartan; Lung Neoplasms; Pulmonary Alveoli; Pulmonary Fibrosis; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Respiratory Mucosa; Tetrazoles; Tumor Cells, Cultured; Vasoconstrictor Agents	2002