| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
gamma-aminobutyric acid
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.. gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4. | 2.69 | 3 | 0 | amino acid zwitterion;
gamma-amino acid;
monocarboxylic acid | human metabolite;
neurotransmitter;
Saccharomyces cerevisiae metabolite;
signalling molecule |
sk&f 82958
[no description available] | 2 | 1 | 0 | benzazepine | |
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine: A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine : A tetrahydropyridine that is 1,2,3,6-tetrahydropyridine substituted by a methyl group at position 1 and a phenyl group at position 4. | 2.41 | 2 | 0 | methylpyridines;
phenylpyridine;
tetrahydropyridine | neurotoxin |
2-hydroxysaclofen
2-hydroxysaclofen: structure given in first source | 1.99 | 1 | 0 | organochlorine compound | |
azides
Azides: Organic or inorganic compounds that contain the -N3 group.. azide : Any nitrogen molecular entity containing the group -N3. | 1.99 | 1 | 0 | pseudohalide anion | mitochondrial respiratory-chain inhibitor |
Arbaclofen
[no description available] | 1.99 | 1 | 0 | organonitrogen compound;
organooxygen compound | |
cabergoline
Cabergoline: An ergoline derivative and dopamine D2-agonist that inhibits PROLACTIN secretion. It is used in the management of HYPERPROLACTINEMIA, and to suppress lactation following childbirth for medical reasons. Cabergoline is also used in the management of PARKINSON DISEASE.. cabergoline : An N-acylurea that is (8R)-ergoline-8-carboxamide in which the hydrogen attached to the piperidine nitrogen (position 6) is substituted by an allyl group and the hydrogens attached to the carboxamide nitrogen are substituted by a 3-(dimethylamino)propyl group and an N-ethylcarbamoyl group. A dopamine D2 receptor agonist, cabergoline is used in the management of Parkinson's disease and of disorders associated with hyperprolactinaemia. | 2 | 1 | 0 | N-acylurea | antineoplastic agent;
antiparkinson drug;
dopamine agonist |
cgp 35348
CGP 35348: antagonizes both GABA-A and GABA-B receptors | 1.99 | 1 | 0 | | |
saclofen
saclofen: GABA-A receptor antagonist | 1.99 | 1 | 0 | organochlorine compound | |
rti 121
RTI 121: structure given in first source; selectively binds to dopamine transporters | 2 | 1 | 0 | | |
cgp 54626
CGP 54626: RN given for (S-(R*,R*))-isomer | 2.4 | 2 | 0 | | |
cocaine
Cocaine: An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.. cocaine : A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca. | 2 | 1 | 0 | benzoate ester;
methyl ester;
tertiary amino compound;
tropane alkaloid | adrenergic uptake inhibitor;
central nervous system stimulant;
dopamine uptake inhibitor;
environmental contaminant;
local anaesthetic;
mouse metabolite;
plant metabolite;
serotonin uptake inhibitor;
sodium channel blocker;
sympathomimetic agent;
vasoconstrictor agent;
xenobiotic |
cgp 62349
[no description available] | 1.99 | 1 | 0 | | |
cgp 71872
CGP 71872: structure in first source | 1.99 | 1 | 0 | | |
3-aminopropylphosphinic acid
3-aminopropylphosphinic acid: structure given in first source; selective GABA receptor agonist | 1.99 | 1 | 0 | | |
ergoline
Ergolines: A series of structurally-related alkaloids that contain the ergoline backbone structure.. ergoline : An indole alkaloid whose structural skeleton is found in many naturally occurring and synthetic ergolines which are known to bind to neurotransmitter receptors, such as dopamine, noradrenaline and serotonin receptors and function as unselective agonists or antagonists at these receptors. | 2 | 1 | 0 | diamine;
ergoline alkaloid;
indole alkaloid fundamental parent;
indole alkaloid;
organic heterotetracyclic compound | |
cgp 56999a
CGP 56999A: structure given in first source | 1.99 | 1 | 0 | | |