BCECTS

An autosomal dominant inherited partial epilepsy syndrome with onset between age 3 and 13 years. Seizures are characterized by PARESTHESIA and tonic or clonic activity of the lower face associated with drooling and DYSARTHRIA. In most cases, affected children are neurologically and developmentally normal. (From Epilepsia 1998 39;Suppl 4:S32-S41)

Synonym
BECTS
BCECTS
Benign Childhood Epilepsy With Centro-Temporal Spikes
Temporal-Central Focal Epilepsy
Rolands Epilepsy
Benign Rolandic Epilepsy
Epilepsy, Centrotemporal
Sylvian Epilepsy
Benign Rolandic Epilepsy of Childhood
Benign Epilepsy With Centrotemporal Spikes
Epilepsy, Rolandic
Centralopathic Epilepsy
Centrotemporal Epilepsy
Benign Epilepsy Of Childhood With Centrotemporal Spikes

Excerpt	Reference
"Benign rolandic epilepsy is the most common epilepsy of childhood."	( Rating, D, 2000)
"Atypical features of rolandic epilepsy are not uncommon, although the long-term prognosis of this condition is not known."	( Chiarelli, F; Cutarella, R; Giannuzzi, R; Latini, G; Morgese, G; Trotta, D; Verrotti, A, 2002)
"BECTS is associated with pervasive cognitive deficits and behavior problems."	( Chen, Q; Cheng, DZ; Ding, N; Liu, WT; Xu, KM; Yan, XX; Zhang, HZ; Zhou, XL, 2020)

Excerpt	Reference
"Ten subjects with benign rolandic epilepsy were evaluated with and without carbamazepine treatment."	( Mitchell, WG; Seidel, WT, 1999)
"Patient 1, a 9-year-old boy with benign Rolandic epilepsy, developed impairment of pitch perception one day after administration of carbamazepine."	( Omura, I; Tateno, A, 2000)
"With a clear correlation of EEG record, benign rolandic epilepsy was diagnosed, so the therapy with valproate was introduced."	( Skrijelj, F; Sokić, D, 2011)
"A changed EEG record in a patient with rolandic epilepsy must not be a predictor of continuation of antiepileptic drugs therapy, after 2-3 years of successful seizures remission."	( Skrijelj, F; Sokić, D, 2011)
"In 18 children with BCECTS, non-parametric statistical analyses using standardized low resolution brain electromagnetic tomography (sLORETA) were performed to compare the current density distribution of four frequency bands (delta, theta, alpha, and beta) between untreated and treated conditions."	( Chung, SY; Eom, TH; Jun, YH; Kim, JM; Kim, YH; Lee, IG, 2019)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	9 (7.14)	12.5806
2000's	57 (45.24)	18.1394
2010's	47 (37.30)	28.8240
2020's	13 (10.32)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	low	1	0
choline	low	1	0
salicylic acid	low	7	0
creatine	low	1	0
inositol	low	1	0
pyridoxine	low	1	0
phenytoin	low	1	0
carbamazepine	medium	32	6
clobazam	medium	1	1
clonazepam	low	4	0
diazepam	low	1	0
valproic acid	medium	26	2
ethosuximide	low	5	0
lamotrigine	low	3	0
methylphenidate	low	1	0
apnea	low	1	0
phenobarbital	low	3	0
piracetam	medium	14	5
propofol	low	1	0
risperidone	low	1	0
sulthiame	medium	15	7
vigabatrin	low	2	0
prednisolone	low	1	0
prednisone	low	2	0
aspartic acid	low	1	0
glutamine	low	1	0
acetylcysteine	low	1	0
d-alpha tocopherol	low	1	0
glutamic acid	low	1	0
oxcarbazepine	medium	9	3
fomesafen	low	1	0
n-acetylaspartic acid	low	1	0
fluorodeoxyglucose f18	low	6	0
lacosamide	low	1	0
inositol 3-phosphate	low	2	0
D-fructopyranose	medium	2	2
bilirubin	low	1	0
levetiracetam	medium	24	5
topiramate	medium	2	2
perampanel	low	1	0
n-acetylcysteinamide	low	1	0
pituitrin	low	1	0
rome	low	1	0

Protein Targets (579)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
Chain A, 2-oxoglutarate Oxygenase	5	0	0	5
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
acetylcholinesterase	4	0	0	4
dopamine D1 receptor	1	0	0	1
15-lipoxygenase, partial	2	0	0	2
pregnane X receptor	3	0	0	3
phosphopantetheinyl transferase	5	0	0	5
RAR-related orphan receptor gamma	3	0	0	3
USP1 protein, partial	7	0	0	7
NFKB1 protein, partial	1	0	0	1
Microtubule-associated protein tau	6	0	0	6
Thrombopoietin	1	0	0	1
AR protein	12	0	0	12
regulator of G-protein signaling 4	4	0	0	4
glucocorticoid receptor [Homo sapiens]	6	0	0	6
retinoic acid nuclear receptor alpha variant 1	8	0	0	8
retinoid X nuclear receptor alpha	3	0	0	3
farnesoid X nuclear receptor	4	0	0	4
estrogen nuclear receptor alpha	14	0	0	14
vitamin D (1,25- dihydroxyvitamin D3) receptor	5	0	0	5
arylsulfatase A	9	0	0	9
euchromatic histone-lysine N-methyltransferase 2	16	0	0	16
Bloom syndrome protein isoform 1	11	0	0	11
D(1A) dopamine receptor	6	0	0	6
thyroid hormone receptor beta isoform a	5	0	0	5
thyroid hormone receptor beta isoform 2	5	0	0	5
heat shock protein beta-1	3	0	0	3
flap endonuclease 1	4	0	0	4
geminin	11	0	0	11
peripheral myelin protein 22	4	0	0	4
survival motor neuron protein isoform d	3	0	0	3
muscarinic acetylcholine receptor M1	6	0	0	6
Histone deacetylase 3	0	4	0	4
Solute carrier family 22 member 6	0	2	0	2
Histone deacetylase 4	0	4	0	4
Guanine nucleotide-binding protein G	2	0	0	2
Histone deacetylase 1	0	4	0	4
Histone deacetylase 7	0	4	0	4
Histone deacetylase 2	0	4	0	4
Polyamine deacetylase HDAC10	0	4	0	4
Histone deacetylase 11	0	4	0	4
Ataxin-2	4	0	0	4
Histone deacetylase 8	0	4	0	4
Histone deacetylase 6	0	4	0	4
Histone deacetylase 9	0	4	0	4
Histone deacetylase 5	0	4	0	4
ATP-dependent phosphofructokinase	5	0	0	5
thioredoxin reductase	11	0	0	11
ATAD5 protein, partial	3	0	0	3
TDP1 protein	11	0	0	11
estrogen-related nuclear receptor alpha	13	0	0	13
lamin isoform A-delta10	9	0	0	9
neuropeptide S receptor isoform A	3	0	0	3
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	4	0	0	4
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	4	0	0	4
Chain A, Ferritin light chain	3	0	0	3
aldehyde dehydrogenase 1 family, member A1	7	0	0	7
cytochrome P450 2C19 precursor	2	0	0	2
lethal factor (plasmid)	1	0	0	1
Metabotropic glutamate receptor 6	0	1	2	4
Excitatory amino acid transporter 4	0	2	0	2
Glutamate transporter homolog	0	0	1	1
Carbonic anhydrase 1	0	7	0	12
Carbonic anhydrase 2	0	7	1	13
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
5-hydroxytryptamine receptor 1D	0	0	0	1
Glutamate receptor ionotropic, NMDA 1	0	3	1	4
Excitatory amino acid transporter 1	0	3	0	4
Excitatory amino acid transporter 2	0	3	0	4
Excitatory amino acid transporter 3	0	3	0	4
Glutamate receptor ionotropic, NMDA 2A	0	3	1	4
Glutamate receptor ionotropic, NMDA 2B	0	4	1	5
Glutamate receptor ionotropic, NMDA 2C	0	3	1	4
Metabotropic glutamate receptor 1	0	1	2	4
Metabotropic glutamate receptor 2	0	1	2	4
Carbonic anhydrase-like protein, putative	0	0	0	3
Glutamate receptor ionotropic, NMDA 2D	0	3	1	4
Glutamate receptor ionotropic, NMDA 3B	0	3	1	4
Carbonic anhydrase 4	0	2	0	3
Glutamate receptor ionotropic, NMDA 3A	0	3	1	4
Chain A, Putative fructose-1,6-bisphosphate aldolase	3	0	0	3
Chain A, HADH2 protein	3	0	0	3
Chain B, HADH2 protein	3	0	0	3
Chain A, Cruzipain	1	0	0	1
vitamin D3 receptor isoform VDRA	3	0	0	3
DNA polymerase kappa isoform 1	3	0	0	3
caspase-1 isoform alpha precursor	1	0	0	1
Caspase-7	1	0	0	1
Inositol monophosphatase 1	2	0	0	2
Solute carrier organic anion transporter family member 1B3	0	2	0	3
Solute carrier organic anion transporter family member 1B1	0	2	0	3
Chain A, Beta-lactamase	2	0	0	2
thyroid stimulating hormone receptor	5	0	0	5
pregnane X nuclear receptor	9	0	0	9
IDH1	1	0	0	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	8	0	0	8
nuclear factor erythroid 2-related factor 2 isoform 2	5	0	0	5
mitogen-activated protein kinase 1	2	0	0	2
Vpr	1	0	0	1
ATP-binding cassette sub-family C member 3	0	12	0	12
Multidrug resistance-associated protein 4	0	12	0	12
Bile salt export pump	0	4	0	4
Bile salt export pump	0	17	0	17
Albumin	0	0	3	3
Major prion protein	0	0	1	1
Cellular tumor antigen p53	9	0	0	9
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	4	0	4
Sodium channel protein type 3 subunit alpha	0	3	0	3
Cytochrome P450 2C9	0	3	0	3
UDP-glucuronosyltransferase 2B7	0	1	0	3
Cytochrome P450 2B6	0	0	1	1
Sodium channel protein type 4 subunit alpha	0	3	0	6
Cytochrome P450 2J2	0	2	0	2
Potassium voltage-gated channel subfamily H member 2	0	7	0	7
Sodium channel protein type 9 subunit alpha	0	5	0	5
Frizzled-8	0	0	1	1
Canalicular multispecific organic anion transporter 1	0	11	0	11
P2X purinoceptor 4	0	2	0	2
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
Solute carrier family 22 member 1	0	1	0	2
Solute carrier family 22 member 2	0	1	0	2
Solute carrier family 22 member 1	0	0	0	1
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	3	0	3
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	3	0	3
Neuronal acetylcholine receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Acetylcholinesterase	0	2	0	2
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Choline O-acetyltransferase	0	0	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-9	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	3	0	3
Solute carrier family 22 member 1	0	1	0	2
High affinity choline transporter 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-10	0	1	0	1
Solute carrier family 22 member 2	0	1	0	2
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	0	6	0	6
Gamma-aminobutyric acid receptor subunit pi	2	7	2	11
Gamma-aminobutyric acid receptor subunit delta	0	6	0	6
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	0	4
Gamma-aminobutyric acid receptor subunit beta-1	0	3	0	4
Gamma-aminobutyric acid receptor subunit alpha-2	0	3	0	4
Gamma-aminobutyric acid receptor subunit alpha-3	0	3	0	4
Gamma-aminobutyric acid receptor subunit alpha-1	0	7	4	11
Gamma-aminobutyric acid receptor subunit beta-1	2	7	2	11
Gamma-aminobutyric acid receptor subunit beta-1	0	6	2	8
Gamma-aminobutyric acid receptor subunit delta	2	7	2	11
Gamma-aminobutyric acid receptor subunit gamma-2	0	7	3	10
Gamma-aminobutyric acid receptor subunit gamma-2	2	7	3	12
Gamma-aminobutyric acid receptor subunit alpha-5	2	7	2	11
Gamma-aminobutyric acid receptor subunit alpha-3	2	7	2	11
Gamma-aminobutyric acid receptor subunit alpha-4	0	3	0	4
Gamma-aminobutyric acid receptor subunit gamma-2	0	3	0	4
Gamma-aminobutyric acid receptor subunit gamma-1	2	7	2	11
Gamma-aminobutyric acid receptor subunit alpha-2	2	7	2	11
Gamma-aminobutyric acid receptor subunit alpha-4	2	7	2	11
Gamma-aminobutyric acid receptor subunit beta-3	0	7	3	10
Gamma-aminobutyric acid receptor subunit gamma-3	2	7	2	11
Gamma-aminobutyric acid receptor subunit alpha-6	2	7	2	11
Translocator protein	0	2	0	2
Translocator protein	0	2	0	2
Cholecystokinin receptor type A	0	2	0	2
Gastrin/cholecystokinin type B receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	6	4	10
Gamma-aminobutyric acid receptor subunit alpha-3	0	6	3	9
Gamma-aminobutyric acid receptor subunit alpha-2	0	6	3	9
Gamma-aminobutyric acid receptor subunit beta-2	0	6	3	9
Gamma-aminobutyric acid receptor subunit alpha-4	0	6	2	8
Gamma-aminobutyric acid receptor subunit alpha-1	2	7	3	12
Gamma-aminobutyric acid receptor subunit beta-3	2	7	2	11
Gamma-aminobutyric acid receptor subunit beta-2	2	7	3	12
Gamma-aminobutyric acid receptor subunit epsilon	0	6	0	6
Gamma-aminobutyric acid receptor subunit alpha-6	0	6	2	8
Gamma-aminobutyric acid receptor subunit gamma-1	0	6	0	6
GABA theta subunit	2	7	2	11
Gamma-aminobutyric acid receptor subunit gamma-3	0	6	0	6
Gamma-aminobutyric acid receptor subunit epsilon	2	7	2	11
Gamma-aminobutyric acid receptor subunit theta	0	6	0	6
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Proton-coupled amino acid transporter 1	0	2	0	2
cytochrome P450 family 3 subfamily A polypeptide 4	5	0	0	5
activating transcription factor 6	3	0	0	3
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	3	0	0	3
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
Gamma-aminobutyric acid	0	2	1	3
glp-1 receptor, partial	2	0	0	2
GLI family zinc finger 3	6	0	0	6
estrogen receptor 2 (ER beta)	3	0	0	3
nuclear receptor subfamily 1, group I, member 3	6	0	0	6
progesterone receptor	5	0	0	5
G	4	0	0	4
peroxisome proliferator activated receptor gamma	4	0	0	4
Voltage-dependent L-type calcium channel subunit alpha-1F	0	3	0	3
Voltage-dependent calcium channel gamma-2 subunit	3	0	0	3
Interferon beta	5	0	0	5
HLA class I histocompatibility antigen, B alpha chain	4	0	0	4
Fatty acid-binding protein, liver	0	2	0	2
Alpha-1-acid glycoprotein 1	0	0	0	1
Albumin	0	1	1	3
ATP-dependent translocase ABCB1	0	0	0	2
Translocator protein	0	1	1	3
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	1	3
5-hydroxytryptamine receptor 1A	0	5	1	6
Glutamate receptor 2	3	2	1	6
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit delta	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-3	0	2	1	3
Voltage-dependent L-type calcium channel subunit alpha-1D	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1S	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	5	0	5
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	1	3
Gamma-aminobutyric acid receptor subunit pi	0	2	1	3
Sphingosine-1-phosphate lyase 1	0	1	0	1
Inositol hexakisphosphate kinase 1	4	0	0	4
ATPase family AAA domain-containing protein 5	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	1	3
Gamma-aminobutyric acid receptor subunit theta	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	1	3
cytochrome P450 2C9, partial	4	0	0	4
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
GLS protein	6	0	0	6
EWS/FLI fusion protein	4	0	0	4
nuclear receptor ROR-gamma isoform 1	3	0	0	3
Voltage-dependent T-type calcium channel subunit alpha-1I	0	1	0	1
Luciferase	2	0	0	2
Histone H2A.x	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	6	0	0	6
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	2	3
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
transcriptional regulator ERG isoform 3	4	0	0	4
histone-lysine N-methyltransferase 2A isoform 2 precursor	3	0	0	3
histone acetyltransferase KAT2A isoform 1	3	0	0	3
Gamma-aminobutyric acid type B receptor subunit 2	0	1	1	2
Gamma-aminobutyric acid type B receptor subunit 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	2
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	2
TAR DNA-binding protein 43	2	0	0	2
Sterol O-acyltransferase 1	0	0	1	1
Platelet glycoprotein VI	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 1	0	1	1	2
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
beta-2 adrenergic receptor	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
Metabotropic glutamate receptor 8	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Glutathione reductase, mitochondrial	0	2	0	2
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	1	1
Integrin beta-3	0	0	1	1
Integrin alpha-IIb	0	0	1	1
ATP-citrate synthase	0	1	0	1
Glutamate receptor 1	0	2	1	3
Glutamate receptor 3	0	2	1	3
Glutamate receptor 4	0	2	1	3
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	3	1	4
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	2	0	2
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Chain A, Glutamine Binding Protein	0	0	1	1
peripheral myelin protein 22 isoform 1	4	0	0	4
Neutral amino acid transporter A	0	1	0	1
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Amino acid transporter	0	1	0	1
Chain B, Pulmonary surfactant-associated protein D	0	1	0	1
Chain A, Pulmonary surfactant-associated protein D	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
DNA polymerase iota isoform a (long)	2	0	0	2
Amyloid-beta precursor protein	0	1	0	1
Sodium/myo-inositol cotransporter 2	0	1	0	1
Carbonic anhydrase 12	0	4	0	6
Carbonic anhydrase 3	0	4	0	4
Potassium voltage-gated channel subfamily E member 1	0	2	0	2
Carbonic anhydrase 4	0	4	0	6
Carbonic anhydrase 6	0	4	0	6
Carbonic anhydrase 5A, mitochondrial	0	4	1	7
Carbonic anhydrase 7	0	4	0	6
Potassium voltage-gated channel subfamily KQT member 1	0	2	0	2
Sodium channel protein type 5 subunit alpha	0	4	0	4
Carbonic anhydrase 9	0	4	0	6
Sodium channel protein type 10 subunit alpha	0	1	0	1
Carbonic anhydrase 13	0	3	0	3
Carbonic anhydrase 15	0	4	0	4
Carbonic anhydrase 14	0	4	0	6
Carbonic anhydrase 5B, mitochondrial	0	4	0	6
GALC protein	2	0	0	2
cytochrome P450 2D6	2	0	0	2
cytochrome P450 2D6 isoform 1	2	0	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	3	0	0	3
Dihydrofolate reductase	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	3	0	3
Sodium channel protein type 3 subunit alpha	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	2	0	0	2
Synaptic vesicle glycoprotein 2A	0	2	0	2
Sodium-dependent noradrenaline transporter	0	4	0	4
Sodium-dependent dopamine transporter	0	2	0	2
Sodium-dependent serotonin transporter	0	3	0	3
Sodium-dependent dopamine transporter	0	2	0	2
67.9K protein	1	0	0	1
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
Rap guanine nucleotide exchange factor 4	1	0	0	1
nonstructural protein 1	1	0	0	1
polyadenylate-binding protein 1	0	1	0	1
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
bcl-2-related protein A1	0	1	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
cytochrome P450 3A4 isoform 1	2	0	0	2
Spike glycoprotein	3	0	0	3
Replicase polyprotein 1ab	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	2	0	2
endonuclease IV	2	0	0	2
cytochrome P450 2C9 precursor	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
chromobox protein homolog 1	3	0	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Histamine H2 receptor	1	0	0	1
M-phase phosphoprotein 8	1	0	0	1
luciferase	0	0	0	1
aryl hydrocarbon receptor	1	0	0	1
v-jun sarcoma virus 17 oncogene homolog (avian)	3	0	0	3
Estrogen receptor	0	2	0	2
Glucocorticoid receptor	0	4	2	11
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Glycine receptor subunit alpha-1	0	4	0	4
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Androgen receptor	0	1	0	1
Glycine receptor subunit beta	0	4	0	4
Glycine receptor subunit alpha-2	0	4	0	4
Glycine receptor subunit alpha-3	0	4	0	4
Histamine H1 receptor	0	1	1	2
Prostaglandin G/H synthase 2	0	2	0	2
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
thioredoxin glutathione reductase	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	2	0	0	2
Nuclear receptor ROR-gamma	2	0	0	2
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
caspase 7, apoptosis-related cysteine protease	1	0	0	1
caspase-3	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	3	0	0	3
Fatty-acid amide hydrolase 1	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	2
5-hydroxytryptamine receptor 4	0	4	0	4
Aldo-keto reductase family 1 member B1	0	3	0	3
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
5-hydroxytryptamine receptor 2C	0	4	0	4
5-hydroxytryptamine receptor 2B	0	4	0	4
UDP-glucuronosyltransferase 1A8	0	0	0	1
Pyridoxal kinase	0	0	0	1
Smad3	1	0	0	1
thyroid stimulating hormone receptor	1	0	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Cytochrome P450 3A4	0	2	0	2
5-hydroxytryptamine receptor 1A	0	1	2	3
5-hydroxytryptamine receptor 2C	0	2	0	2
Muscarinic acetylcholine receptor M5	0	1	0	1
Alpha-2A adrenergic receptor	0	2	0	2
Cytochrome P450 2D6	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
D(2) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	2	0	2
Beta-1 adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	2	0	2
D	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
Muscarinic acetylcholine receptor M3	0	2	0	2
D(1A) dopamine receptor	0	2	0	2
D(4) dopamine receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Glycine receptor subunit alpha-1	0	0	1	1
Alpha-1D adrenergic receptor	0	1	0	1
Histamine H2 receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	0	2
5-hydroxytryptamine receptor 2B	0	2	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Alpha-1A adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	1	0	1
Histamine H1 receptor	0	2	0	2
Alpha-1B adrenergic receptor	0	1	0	1
D(3) dopamine receptor	0	2	0	2
Alpha-1A adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 6	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
D(2) dopamine receptor	0	1	0	1
D(2) dopamine receptor	0	3	0	3
5-hydroxytryptamine receptor 2B	0	1	0	1
Transporter	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Multidrug and toxin extrusion protein 2	0	1	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
Transporter	0	1	0	1
Histamine H3 receptor	0	1	0	1
Sphingosine kinase 2	0	2	0	2
Sphingosine kinase 1	0	1	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Polyphenol oxidase 2	0	1	0	2
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 8	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
Carbonic anhydrase 13	0	2	0	4
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
Delta-type opioid receptor	0	2	0	2
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	2	0	2
Carbonic anhydrase	0	2	0	2
Mu-type opioid receptor	0	2	0	2
Beta-carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	2	0	2
Carbonic anhydrase, alpha family	0	2	0	2
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
Delta carbonic anhydrase	0	2	0	2
Chain A, Carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	0	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Cytochrome P450 2C8	0	1	0	1
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Cytochrome P450 2C19	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Cocaine esterase	0	1	0	1
Cytochrome P450 2A6	0	1	0	1
Tissue factor	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	0	0	1
Liver carboxylesterase 1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(14)

Research Excerpts

Overview

Treatment

Research

Studies (126)

Protein Targets (579)

BCECTS

Synonyms(14)

Research Excerpts

Overview

Treatment

Research

Studies (126)

Drugs Studied (50)

Protein Targets (579)