mono-n-octyl phthalate profile

Mono-n-octyl phthalate (monooctyl phthalate, MOP) is a plasticizer that is commonly used in polyvinyl chloride (PVC) products. It is synthesized by the reaction of phthalic anhydride with n-octanol. MOP is a colorless, oily liquid that is soluble in organic solvents. It is used to increase the flexibility and durability of PVC products. MOP is also used in other applications, such as lubricants, adhesives, and sealants. It is not considered to be a hazardous substance, but it has been shown to be harmful to aquatic organisms. MOP is studied because it is a widely used plasticizer and because it has been found to be persistent in the environment. It is also studied because it has been shown to have potential health effects, such as endocrine disruption.'

monooctyl phthalate : A phthalic acid monoester obtained by formal condensation of one of the carboxy groups of phthalic acid with the hydroxy group of octanol. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	79362
CHEBI ID	132583
SCHEMBL ID	149076
MeSH ID	M0122440

Synonym
unii-9ksh93uam4
9ksh93uam4 ,
3-09-00-04112 (beilstein handbook reference)
5393-19-1
nsc-4639
1, monooctyl ester
nsc4639
phthalic acid, octyl ester
mono-n-octyl phthalate
nsc 4639
brn 2280185
einecs 226-398-8
ai3-06031
octyl hydrogen phthalate
hydrogen octyl phthalate
monooctyl phthalate
phthalic acid, monooctyl ester
1,2-benzenedicarboxylic acid, monooctyl ester
2-(octyloxycarbonyl)benzoic acid
CHEBI:132583
2-octoxycarbonylbenzoic acid
FT-0672490
SCHEMBL149076
DTXSID4052714
1,2-benzenedicarboxylic acid, 1-octyl ester
Q27225611
phthalsa currencyure-monooctylester
monooctyl phthalate (mop)

Excerpt	Relevance	Reference
" Further, a significant dose-response relationship between MOP and self-reported eye affliction/retinopathy was demonstrable."	( Association of Urinary Phthalates with Self-Reported Eye Affliction/Retinopathy in Individuals with Diabetes: National Health and Nutrition Examination Survey, 2001-2010. Blangero, J; Curran, JE; Kulkarni, H; Mamtani, M, 2016)	0.43

Role	Description
human xenobiotic metabolite	Any human metabolite produced by metabolism of a xenobiotic compound in humans.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
phthalic acid monoester	A dicarboxylic acid monoester resulting from the formal condensation of an alcoholic or aromatic hydroxy group with just one of the two carboxy groups of phthalic acid.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	2 (22.22)	18.7374
1990's	1 (11.11)	18.2507
2000's	2 (22.22)	29.6817
2010's	4 (44.44)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	1 (11.11%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	8 (88.89%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
1-octanol 1-Octanol: A colorless, slightly viscous liquid used as a defoaming or wetting agent. It is also used as a solvent for protective coatings, waxes, and oils, and as a raw material for plasticizers. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed). octan-1-ol : An octanol carrying the hydroxy group at position 1.	2.08	1	0	octanol; primary alcohol	antifungal agent; bacterial metabolite; fuel additive; kairomone; plant metabolite
palmitic acid Palmitic Acid: A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids.. hexadecanoic acid : A straight-chain, sixteen-carbon, saturated long-chain fatty acid.	1.96	1	0	long-chain fatty acid; straight-chain saturated fatty acid	algal metabolite; Daphnia magna metabolite; EC 1.1.1.189 (prostaglandin-E2 9-reductase) inhibitor; plant metabolite
butylbenzyl phthalate spatozoate: structure in first source	3.39	1	1	benzyl ester
clofibrate angiokapsul: contains clofibrate & insoitolnicotinate	7.37	2	0	aromatic ether; ethyl ester; monochlorobenzenes	anticholesteremic drug; antilipemic drug; geroprotector; PPARalpha agonist
dibutyl phthalate Dibutyl Phthalate: A plasticizer used in most plastics and found in water, air, soil, plants and animals. It may have some adverse effects with long-term exposure.. dibutyl phthalate : A phthalate ester that is the diester obtained by the formal condensation of the carboxy groups of phthalic acid with two molecules of butan-1-ol. Although used extensively as a plasticiser, it is a ubiquitous environmental contaminant that poses a risk to humans.	3.83	2	1	diester; phthalate ester	EC 3.2.1.20 (alpha-glucosidase) inhibitor; environmental contaminant; metabolite; plasticiser; teratogenic agent
diethyl phthalate diethyl phthalate: structure. diethyl phthalate : The diethyl ester of benzene-1,2-dicarboxylic acid.	2.13	1	0	diester; ethyl ester; phthalate ester	neurotoxin; plasticiser; teratogenic agent
diethylhexyl phthalate Diethylhexyl Phthalate: An ester of phthalic acid. It appears as a light-colored, odorless liquid and is used as a plasticizer for many resins and elastomers.. bis(2-ethylhexyl) phthalate : A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.	4.63	6	1	diester; phthalate ester	androstane receptor agonist; apoptosis inhibitor; plasticiser
di-n-octyl phthalate di-n-octyl phthalate: plasticizer	2.92	4	0	diester; phthalate ester
dimethyl phthalate dimethyl phthalate: used as plasticizer in computer mouse; structure	2.13	1	0	diester; methyl ester; phthalate ester
monobutyl phthalate monobutyl phthalate: RN given refers to parent cpd	4.11	3	1	phthalic acid monoester
monomethyl phthalate monomethyl phthalate: structure in first source	2.13	1	0	methyl ester; phthalic acid monoester
mono-(2-ethylhexyl)phthalate mono-(2-ethylhexyl)phthalate: RN given refers to parent cpd. mono(2-ethylhexyl) phthalate : The mono(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.	2.91	4	0	phthalic acid monoester
interleukin-8 Interleukin-8: A member of the CXC chemokine family that plays a role in the regulation of the acute inflammatory response. It is secreted by variety of cell types and induces CHEMOTAXIS of NEUTROPHILS and other inflammatory cells.	2.02	1	0

Condition	Relationship Strength	Studies
Diabetes Mellitus, Adult-Onset [description not available]	2.13	1
Diabetes Mellitus, Type 2 A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.	2.13	1
Diabetic Retinopathy Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.	2.13	1

mono-n-octyl phthalate

Description

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Roles (1)

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Research

Studies (9)

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Research Demand Index: 12.40

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