melilotic acid: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
3-(2-hydroxyphenyl)propanoic acid : A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 3 is substituted by a 2-hydroxyphenyl group. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 873 |
| CHEBI ID | 16104 |
| SCHEMBL ID | 35529 |
| MeSH ID | M0502955 |
| Synonym |
|---|
| HMS1789F10 |
| OPREA1_380863 |
| 2-hydroxybenzenepropanoic acid |
| CHEBI:16104 , |
| o-hydroxyphenylpropionic acid |
| .beta.-(o-hydroxyphenyl)propionic acid |
| melilotic acid |
| 3-(2-hydroxyphenyl)propanoic acid |
| beta-(o-hydroxyphenyl)propionic acid |
| benzenepropanoic acid, 2-hydroxy- |
| inchi=1/c9h10o3/c10-8-4-2-1-3-7(8)5-6-9(11)12/h1-4,10h,5-6h2,(h,11,12 |
| C01198 |
| 495-78-3 |
| 3-(o-hydroxyphenyl) propionic acid |
| 3-(2-hydroxyphenyl)propionic acid |
| 3-(2-hydroxyphenyl) propionate |
| 2-hydroxyphenylpropanoate |
| 3-(2-hydroxyphenyl)propionic acid, 99% |
| propanoic acid, 3-(2-hydroxyphenyl)- |
| 4FD9685D-2A23-40E8-8F8B-013949003BDF |
| BMSE000331 |
| AKOS000121351 |
| A827753 |
| 3-(o-hydroxyphenyl)propionic acid |
| 2-hydroxyhydrocinnamic acid |
| o-hydrocoumaric acid |
| S3339 |
| cn1rk42mad , |
| unii-cn1rk42mad |
| FT-0613562 |
| FS-1546 |
| hydro-o-coumaric acid |
| o-hydroxyhydrocinnamic acid |
| hydrocoumaric acid |
| hydrocinnamic acid, o-hydroxy- |
| CJBDUOMQLFKVQC-UHFFFAOYSA-N |
| SCHEMBL35529 |
| MB00231 |
| DTXSID2075421 |
| J-510518 |
| mfcd00014026 |
| melilotsaure |
| 3-(o-hydroxyphenyl)propionic acid, 8ci |
| 3-(2-hydroxyphenyl) propanoic acid |
| beta -(o-hydroxyphenyl)propionic acid |
| 2-hydroxybenzenepropanoic acid, 9ci |
| 3(2-hydroxyphenyl)propanoate |
| 2-hydroxy-benzenepropanoic acid |
| HY-W017158 |
| SY101015 |
| F16128 |
| Q11751633 |
| 3-(2-hydroxyphenyl)propanoicacid |
| STL565788 |
| CS-W017874 |
| EN300-16621 |
| Z56347225 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " As both transient and prolonged exposure to environmental and dietary factors have the potential to lead to heritable alterations in epigenetic states and to modulate additional Sirtuin-dependent phenotypes, we examined the bioavailability and digestive stability of DHC using an in vivo rat model and in vitro digestive simulator." | ( Impacts on Sirtuin Function and Bioavailability of the Dietary Bioactive Compound Dihydrocoumarin. Chapple, C; Ferruzzi, MG; Jacobi, JL; Janle, EM; Kirchmaier, AL; Laurentz, SM; Li, X; McCabe, GP; Menze, AK; Yang, B, 2016) | 0.43 |
| Role | Description |
|---|---|
| human xenobiotic metabolite | Any human metabolite produced by metabolism of a xenobiotic compound in humans. |
| bacterial xenobiotic metabolite | Any bacterial metabolite produced by metabolism of a xenobiotic compound in bacteria. |
| fungal xenobiotic metabolite | Any fungal metabolite produced by metabolism of a xenobiotic compound in fungi. |
| plant metabolite | Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| phenols | Organic aromatic compounds having one or more hydroxy groups attached to a benzene or other arene ring. |
| monocarboxylic acid | An oxoacid containing a single carboxy group. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID540299 | A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21 | Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. |
| AID588519 | A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | 2011 | Antiviral research, Sep, Volume: 91, Issue:3 | High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 3 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (23.66) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 10 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||